The Czech Republic became a member of the North Atlantic Treaty Organization, along with Poland and Hungary, on March 12, 1999. The Czech Republic became a full member of the European Union on May 1, 2004. Both events are milestones in the country's foreign policy and security orientation. The Czech Republic is scheduled to host the rotating EU Presidency during the first half of 2009.

The Czech Republic is a member of the United Nations and participates in its specialized agencies. It is a member of the World Trade Organization. It maintains diplomatic relations with more than 85 countries, of which 80 have permanent representation in Prague.