Mali is a member of the UN and many of its specialized agencies, including the International Monetary Fund (IMF) and the World Bank; the International Labor Organization (ILO); the International Telecommunications Union (ITU); and the Universal Postal Union (UPU). It also belongs to the African Union (AU); the Organization of the Islamic Conference (OIC); the Non-Aligned Movement (NAM); and the African Development Bank (ADB). Mali also is an associate member of the European Union (EU).

Mali is active in regional organizations. It participates in the Economic Community of West African States (ECOWAS) and the West African Economic Monetary Union (UEMOA) for regional economic integration; Liptako-Gourma Authority, which seeks to develop the contiguous areas of Mali, Niger, and Burkina Faso; the Niger River Commission; the Permanent Interstate Committee for Drought Control in the Sahel (CILSS); and the Senegal River Valley Development Organization (OMVS).