On the San Juan River there have been disagreements regarding navigational rights in the Nicaragua-Costa Rica border area. Nicaragua and Costa Rica signed a three-year agreement in September of 2002 to defer presenting these issues before the International Court of Justice (ICJ) for resolution. The governments of Nicaragua and Costa Rica agreed to work toward an amicable solution and to jointly fund community development projects in the border area. At the 1994 Summit of the Americas, Nicaragua joined six Central American neighbors in signing the Alliance for Sustainable Development, known as the Conjunta Centroamerica-USA, or CONCAUSA, to promote sustainable economic development in the region.

Nicaragua belongs to the United Nations and several specialized and related agencies, including the World Bank, the International Monetary Fund (IMF), World Trade Organization (WTO), UN Educational, Scientific, and Cultural Organization (UNESCO), World Health Organization (WHO), Food and Agriculture Organization (FAO), International Labor Organization (ILO), and UN Human Rights Commission (UNHRC). Nicaragua also is a member of the Organization of American States (OAS), the Non-aligned Movement (NAM), the International Atomic Energy Commission (IAEA), the Inter-American Development Bank (IDB), and the Central American Bank for Economic Integration (CABEI). In July 2004, Nicaraguaís ambassador to the OAS assumed chairmanship of the Permanent Council (the Organizationís second-highest decision-making body) for a 3-month period.