Ukraine maintains peaceful and constructive relations with all its neighbors, though there are some unresolved maritime issues along the Danube and in the Black Sea with Romania; it has especially close ties with Poland and Russia. Relations with Russia are complicated by differing foreign policy priorities in the region, energy dependence, payment arrears, disagreement over compliance with the 1997 agreement on the stationing of the Russian Black Sea Fleet in Sevastopol, and a dispute over bilateral boundaries in the Sea of Azov and the Kerch Strait. Ukraine co-founded the Commonwealth of Independent States (CIS) on December 8, 1991, but in January 1993 it refused to endorse a draft charter strengthening political, economic, and defense ties among CIS members. Ukraine was a founding member of GUAM (Georgia-Ukraine-Azerbaijan-Moldova) and has taken the lead with Georgia to promote cooperation among emerging democracies in the Community for Democratic Choice, which held its first summit meeting December 1-2, 2005 in Kiev.

In 1999-2001, Ukraine served as a non-permanent member of the UN Security Council. Soviet Ukraine joined the United Nations in 1945 as one of the original members following a Western compromise with the Soviet Union, which had asked for seats for all 15 of its union republics. Ukraine has consistently supported peaceful, negotiated settlements to disputes. It has participated in the five-sided (now "5+2") talks on the conflict in Moldova and under President Yushchenko has actively boosted efforts to seek a resolution. Ukraine has also promoted a peaceful resolution to conflict in the post-Soviet state of Georgia. Ukraine has also made a substantial contribution to UN peacekeeping operations since 1992.