President Kaunda was a persistent and visible advocate of change in Southern Africa, supporting liberation movements in Angola, Mozambique, Namibia, Southern Rhodesia (Zimbabwe), and South Africa. Many of these organizations were based in Zambia during the 1970s and 1980s.

President Chiluba assumed a somewhat higher profile internationally in the mid- and late 1990s. His government played a constructive regional role sponsoring Angola peace talks that led to the 1994 Lusaka Protocols. Zambia has provided troops to UN peacekeeping initiatives in Mozambique, Rwanda, Angola, and Sierra Leone. Zambia was the first African state to cooperate with the International Tribunal investigation of the 1994 genocide in Rwanda.

In 1998, Zambia took the lead in efforts to establish a cease-fire in the Democratic Republic of Congo. Zambia was active in the Congolese peace effort after the signing of a cease-fire agreement in Lusaka in July and August 1999, although activity diminished considerably after the Joint Military Commission tasked with implementing the ceasefire relocated to Kinshasa in September 2001.