Feature Name | Class | Elev. meters | County | Latitude DMS | Longitude DMS |
| Saint Johns United Methodist Church | Church | 9 | Sussex | 38 38 36 N | 075 36 51 W |
| Saint Johnstown | Populated Place | 15 | Sussex | 38 48 18 N | 075 34 32 W |
| Saint Johnstown Church | Church | 15 | Sussex | 38 48 07 N | 075 34 26 W |
| Saint Jones Access Area | Locale | 3 | Kent | 39 05 03 N | 075 27 49 W |
| Saint Jones Center for Behavioral Health | Hospital | 5 | Kent | 39 09 09 N | 075 29 13 W |
| Saint Jones Neck | Cape | 4 | Kent | 39 05 16 N | 075 25 39 W |
| Saint Jones River | Stream | | Kent | 39 03 57 N | 075 24 03 W |
| Saint Joseph Industrial School (historical) | School | 11 | Kent | 39 17 37 N | 075 38 17 W |
| Saint Joseph on-the-Brandywine | Church | 79 | New Castle | 39 46 20 N | 075 35 19 W |
| Saint Josephs Catholic Church | Church | 11 | Kent | 39 17 37 N | 075 38 21 W |
| Saint Josephs Catholic Church | Church | 19 | New Castle | 39 44 40 N | 075 32 44 W |
| Saint Josephs Catholic Church | Church | 21 | New Castle | 39 27 03 N | 075 43 06 W |
| Saint Josephs Church | Church | 79 | New Castle | 39 46 20 N | 075 35 20 W |
| Saint Josephs School (historical) | School | 79 | New Castle | 39 46 20 N | 075 35 20 W |
| Saint Luke Baptist Church | Church | 6 | Sussex | 38 35 02 N | 075 16 58 W |
| Saint Lukes Church | Church | 9 | Sussex | 38 38 56 N | 075 36 33 W |
| Saint Marks Church | Church | 7 | Sussex | 38 35 30 N | 075 17 36 W |
| Saint Marks Episcopal Church | Church | 15 | Sussex | 38 29 55 N | 075 38 16 W |
| Saint Mary Coptic Orthodox Church | Church | 21 | New Castle | 39 34 19 N | 075 41 44 W |
| Saint Mary Magdalen Catholic Church | Church | 108 | New Castle | 39 47 39 N | 075 32 54 W |
| Saint Mary Magdalen School | School | 107 | New Castle | 39 47 37 N | 075 32 56 W |
| Saint Mary of the Assumption Church | Church | 111 | New Castle | 39 47 00 N | 075 41 06 W |
| Saint Marys Church | Church | 12 | Sussex | 38 44 39 N | 075 36 08 W |
| Saint Marys Holy Church | Church | 14 | Sussex | 38 42 47 N | 075 23 31 W |
| Saint Matthews by the Sea United Methodist Church | Church | 0 | Sussex | 38 27 35 N | 075 03 11 W |
| Saint Matthews Church | Church | 13 | New Castle | 39 44 29 N | 075 32 50 W |
| Saint Matthews First Baptist Church | Church | 9 | Sussex | 38 32 47 N | 075 34 28 W |
| Saint Matthews First Baptist Church | Church | 9 | Sussex | 38 32 48 N | 075 34 28 W |
| Saint Matthews School | School | 21 | New Castle | 39 43 19 N | 075 35 47 W |
| Saint Michaels Day Nursery, Incorporated | School | 20 | New Castle | 39 44 28 N | 075 33 05 W |
| Saint Michaels Orthodox Church | Church | 24 | New Castle | 39 42 57 N | 075 40 16 W |
| Saint Patrick Church (historical) | Church | 58 | New Castle | 39 48 19 N | 075 39 15 W |
| Saint Patricks Catholic Church | Church | 13 | New Castle | 39 44 55 N | 075 32 39 W |
| Saint Patricks Monastery | Church | 69 | New Castle | 39 47 39 N | 075 29 16 W |
| Saint Paul American Methodist Episcopal Church | Church | 18 | Kent | 38 55 20 N | 075 34 58 W |
| Saint Paul Church | Church | 21 | New Castle | 39 34 41 N | 075 41 19 W |
| Saint Pauls Catholic Church | Church | 4 | New Castle | 39 34 30 N | 075 35 34 W |
| Saint Pauls Church | Church | 11 | Kent | 39 07 07 N | 075 32 39 W |
| Saint Pauls Church | Church | 93 | New Castle | 39 47 53 N | 075 31 24 W |
| Saint Pauls Church | Church | 16 | Sussex | 38 41 36 N | 075 22 53 W |
| Saint Pauls Lutheran Church | Church | 33 | New Castle | 39 40 28 N | 075 45 14 W |
| Saint Pauls Lutheran Church | Church | 29 | New Castle | 39 39 26 N | 075 45 01 W |
| Saint Pauls School | School | 23 | New Castle | 39 44 40 N | 075 33 44 W |
| Saint Pauls United Methodist Church | Church | 12 | Kent | 39 17 29 N | 075 38 07 W |
| Saint Pauls United Methodist Church | Church | 18 | New Castle | 39 27 24 N | 075 39 39 W |
| Saint Pauls United Methodist Church | Church | 12 | Sussex | 38 31 36 N | 075 32 60 W |
| Saint Peters Cathedral | Church | 21 | New Castle | 39 44 33 N | 075 33 10 W |
| Saint Peters Cathedral School | School | 20 | New Castle | 39 44 33 N | 075 33 09 W |
| Saint Peters Catholic Church | Church | 3 | New Castle | 39 39 42 N | 075 33 49 W |
| Saint Peters Church | Church | 15 | Kent | 39 17 55 N | 075 36 37 W |
| Saint Peters Church | Church | 4 | Sussex | 38 46 33 N | 075 08 27 W |
| Saint Peters Friends Church | Church | 10 | Sussex | 38 44 18 N | 075 15 45 W |
| Saint Peters School | School | 2 | New Castle | 39 39 47 N | 075 33 50 W |
| Saint Phillips Church | Church | 9 | Sussex | 38 33 14 N | 075 34 15 W |
| Saint Polycarp Catholic Church | Church | 11 | Kent | 39 17 40 N | 075 36 39 W |
| Saint Stephens Cemetery | Cemetery | 14 | Sussex | 38 27 22 N | 075 34 02 W |
| Saint Stephens Episcopal Church | Church | 16 | Kent | 38 56 03 N | 075 34 06 W |
| Saint Thomas Church | Church | 21 | New Castle | 39 35 46 N | 075 46 13 W |
| Saint Thomas Church | Church | 17 | Sussex | 38 35 27 N | 075 24 57 W |
| Saint Thomas Parish | Church | 39 | New Castle | 39 40 48 N | 075 45 14 W |
| Saint Thomas the Apostle Church | Church | 47 | New Castle | 39 44 59 N | 075 34 29 W |
| Saint Thomas the Apostle School | School | 47 | New Castle | 39 44 56 N | 075 34 35 W |
| Saints Peter and Paul Ukrainian Orthodox Church | Church | 26 | New Castle | 39 47 04 N | 075 28 48 W |
| Salem Cemetery | Cemetery | 22 | New Castle | 39 19 09 N | 075 40 58 W |
| Salem Cove | Bay | 2 | New Castle | 39 34 03 N | 075 31 11 W |
| Salem Methodist Church | Church | 18 | New Castle | 39 38 43 N | 075 42 10 W |
| Salem Village | Populated Place | 22 | New Castle | 39 40 00 N | 075 42 01 W |
| Salem Woods | Populated Place | 21 | New Castle | 39 38 40 N | 075 41 49 W |
| Salesianum School | School | 35 | New Castle | 39 45 39 N | 075 32 58 W |
| Salisbury (historical) | Locale | 6 | Kent | 39 18 25 N | 075 37 14 W |
| Sally Burton Ponds | Lake | 0 | Sussex | 38 40 24 N | 075 08 23 W |
| Sally Cove | Bay | -3 | Sussex | 38 39 05 N | 075 07 39 W |
| Salt Pond | Lake | 0 | Sussex | 38 33 04 N | 075 03 60 W |
| Salt Pond Ditch | Gut | 0 | Kent | 39 15 56 N | 075 25 29 W |
| Salt Works Marsh | Swamp | 0 | Sussex | 38 35 34 N | 075 03 57 W |
| Salvation Army Church | Church | 9 | Kent | 39 09 34 N | 075 31 30 W |
| Salvation Army Church | Church | 5 | New Castle | 39 44 25 N | 075 32 09 W |
| Sand Ditch | Gut | 0 | Kent | 39 06 42 N | 075 24 56 W |
| Sand Dunes Village | Populated Place | 6 | Sussex | 38 45 24 N | 075 10 49 W |
| Sand Hill | Populated Place | 14 | Sussex | 38 43 55 N | 075 21 37 W |
| Sand Hill | Summit | 12 | Sussex | 38 46 30 N | 075 05 50 W |
| Sand Hill Church | Church | 14 | Sussex | 38 43 55 N | 075 21 37 W |
| Sand Island | Island | -3 | Sussex | 38 36 15 N | 075 05 47 W |
| Sand Point | Cape | -3 | Sussex | 38 37 08 N | 075 06 25 W |
| Sandom Branch | Stream | | New Castle | 39 22 27 N | 075 39 10 W |
| Sandtown | Populated Place | 18 | Kent | 39 02 00 N | 075 43 08 W |
| Sandtown Branch | Stream | | Kent | 39 02 20 N | 075 44 41 W |
| Sandy Beach | Populated Place | 7 | Sussex | 38 34 31 N | 075 15 36 W |
| Sandy Brae | Populated Place | 8 | Sussex | 38 44 15 N | 075 08 54 W |
| Sandy Brae | Summit | 34 | New Castle | 39 37 42 N | 075 45 42 W |
| Sandy Branch | Stream | | New Castle | 39 27 39 N | 075 46 54 W |
| Sandy Branch | Stream | | Sussex | 38 27 41 N | 075 13 02 W |
| Sandy Bray | Summit | 56 | New Castle | 39 37 40 N | 075 46 41 W |
| Sandy Cove Camping | Locale | 1 | Sussex | 38 34 24 N | 075 05 35 W |
| Sandy Fork | Populated Place | 9 | Sussex | 38 33 14 N | 075 31 56 W |
| Sandy Landing | Populated Place | -5 | Sussex | 38 34 15 N | 075 10 44 W |
| Sandy Point | Cape | 0 | Kent | 39 02 33 N | 075 22 11 W |
| Sanford School | School | 90 | New Castle | 39 46 20 N | 075 40 40 W |
| Sangston Prong | Stream | | Kent | 38 58 49 N | 075 44 06 W |
| Sarah Run | Stream | | Sussex | 38 40 08 N | 075 10 56 W |
| Sassafras Landing | Populated Place | 0 | Sussex | 38 29 56 N | 075 04 58 W |
| Saulsbury Creek | Stream | | Kent | 38 50 02 N | 075 41 08 W |
| Saulsbury Road Park | Park | 13 | Kent | 39 09 21 N | 075 32 29 W |
| Saulsbury Switch | Populated Place | 14 | Sussex | 38 42 06 N | 075 20 36 W |
| Saunders Branch | Stream | | Sussex | 38 31 00 N | 075 26 11 W |
| Savannah Ditch | Stream | | Sussex | 38 43 06 N | 075 22 29 W |
| Savannah Place | Populated Place | 4 | Sussex | 38 45 50 N | 075 09 41 W |
| Sawmill Branch | Stream | | New Castle | 39 20 55 N | 075 33 27 W |
| Sawmill Pond | Lake | 0 | Sussex | 38 29 19 N | 075 04 28 W |
| Sawpit Cove | Bay | -3 | Sussex | 38 37 06 N | 075 04 52 W |