Feature Name | Class | Elev. meters | County | Latitude DMS | Longitude DMS |
| Sixmile Swamp | Swamp | 12 | St. Johns | 29 55 05 N | 081 24 37 W |
| Sixteen Mine | Mine | 7 | Citrus | 28 44 39 N | 082 18 51 W |
| Sixteen Section Pond | Swamp | 28 | Pasco | 28 20 03 N | 082 04 05 W |
| Sixteenmile Creek | Stream | | St. Johns | 29 41 01 N | 081 28 03 W |
| Sixteenth Hill | Summit | 61 | Jackson | 30 44 31 N | 084 56 13 W |
| Sixteenth Street School | School | 14 | Pinellas | 27 45 49 N | 082 39 22 W |
| Sixth Avenue Baptist Church | Church | 32 | Escambia | 30 27 06 N | 087 14 58 W |
| Sixth Avenue Trailer Park | Populated Place | | Miami-Dade | 25 54 39 N | 080 11 19 W |
| Skeen Elementary School (historical) | School | 28 | Lake | 28 48 28 N | 081 53 34 W |
| Skeet Key | Island | -1 | Manatee | 27 34 37 N | 082 36 33 W |
| Skeleton Key | Island | 0 | Pasco | 28 21 45 N | 082 42 34 W |
| Skillet Strand | Swamp | 1 | Collier | 25 51 59 N | 081 10 48 W |
| Skim Lake | Lake | 0 | Santa Rosa | 30 32 45 N | 086 59 35 W |
| Skinned Sapling Creek | Stream | | Polk | 27 52 34 N | 081 55 51 W |
| Skinner Bay | Swamp | 23 | Holmes | 30 45 60 N | 085 56 20 W |
| Skinner Lake | Lake | 21 | Hernando | 28 39 39 N | 082 27 51 W |
| Skinner Lake | Lake | 22 | Putnam | 29 33 02 N | 081 57 28 W |
| Skinners Wholesale Nursery Airport | Airport | 7 | Putnam | 29 24 18 N | 081 29 44 W |
| Skipper | Populated Place | 1 | Wakulla | 30 02 54 N | 084 21 37 W |
| Skipper Cemetery | Cemetery | 18 | Leon | 30 25 14 N | 084 05 30 W |
| Skipper Chuck Child Care Center | Building | | Miami-Dade | 25 56 13 N | 080 14 14 W |
| Skipper Chuck Day Care Center | Building | | Miami-Dade | 25 57 01 N | 080 15 37 W |
| Skipper Chuck's Child Care Number 4 | Building | | Miami-Dade | 25 53 01 N | 080 13 02 W |
| Skipper Creek | Stream | | Wakulla | 30 02 48 N | 084 21 36 W |
| Skipper Lake | Swamp | 41 | Washington | 30 45 23 N | 085 26 36 W |
| Skipper Palms Shopping Center | Locale | 7 | Hillsborough | 27 59 51 N | 082 32 14 W |
| Skunk Island | Island | 0 | Brevard | 28 35 30 N | 080 43 00 W |
| Sky Lake | Lake | 0 | Miami-Dade | 25 57 15 N | 080 09 33 W |
| Sky Lake | Populated Place | 30 | Orange | 28 27 26 N | 081 23 29 W |
| Sky Lake Baptist Church | Church | 30 | Orange | 28 27 56 N | 081 23 04 W |
| Sky Lake Mall | Locale | 4 | Miami-Dade | 25 56 40 N | 080 09 59 W |
| Sky Lake Plaza | Locale | 30 | Orange | 28 32 12 N | 081 23 53 W |
| Sky Ranch | Airport | 75 | Okaloosa | 30 51 15 N | 086 40 01 W |
| Skycrest Church | Church | 21 | Pinellas | 27 58 00 N | 082 45 10 W |
| Skycrest Park | Park | 20 | Pinellas | 27 57 52 N | 082 45 46 W |
| Skycrest School | School | 20 | Pinellas | 27 57 59 N | 082 45 37 W |
| Skylake Mall | Locale | 2 | Miami-Dade | 25 56 31 N | 080 10 34 W |
| Skylake Plaza | Locale | 2 | Miami-Dade | 25 56 36 N | 080 10 34 W |
| Skyland Church | Church | 51 | Polk | 28 03 14 N | 081 59 19 W |
| Skylark Plaza | Locale | | Marion | 29 12 10 N | 082 06 08 W |
| Skyline Heights | Populated Place | 2 | Martin | 27 14 51 N | 080 13 36 W |
| Skytop | Populated Place | 30 | Lake | 28 34 02 N | 081 42 59 W |
| Skyview Church | Church | 44 | Polk | 28 01 35 N | 081 53 30 W |
| Skyview Elementary School | School | 4 | Pinellas | 27 51 04 N | 082 42 56 W |
| Skyview Lake | Lake | 41 | Polk | 28 01 48 N | 081 53 47 W |
| Skyway Elementary Head Start | School | | Miami-Dade | 25 57 40 N | 080 16 38 W |
| Skyway Elementary School | School | 1 | Miami-Dade | 25 57 41 N | 080 16 39 W |
| Skyway Fishing Pier State Park | Park | 1 | Hillsborough | 27 40 41 N | 082 40 39 W |
| Skyway Memorial Gardens | Cemetery | 3 | Manatee | 27 33 44 N | 082 33 44 W |
| Skyway Memorial Gardens | Cemetery | 3 | Manatee | 27 31 11 N | 082 34 54 W |
| Slade | Populated Place | 33 | Suwannee | 30 17 36 N | 082 59 56 W |
| Slagle Ditch | Canal | 0 | Monroe | 25 08 15 N | 081 01 34 W |
| Slate Island | Island | 0 | Citrus | 28 43 13 N | 082 40 01 W |
| Slate Prairie | Flat | 3 | Collier | 26 05 12 N | 081 27 41 W |
| Slater | Populated Place | 6 | Lee | 26 44 23 N | 081 51 03 W |
| Slater Bible Chapel | Church | 1 | Lee | 26 33 51 N | 081 53 44 W |
| Slater Cox Bridge | Bridge | 19 | Lake | 28 48 56 N | 081 45 34 W |
| Slaughter Hill | Summit | 24 | Holmes | 30 51 44 N | 085 52 50 W |
| Slaughter Sand Pond | Lake | 22 | Holmes | 30 48 52 N | 085 53 19 W |
| Slave Canal | Canal | | Jefferson | 30 09 55 N | 083 58 07 W |
| Slavia | Populated Place | 12 | Seminole | 28 38 53 N | 081 13 49 W |
| Slavia Cemetery | Cemetery | 14 | Seminole | 28 38 25 N | 081 13 55 W |
| Sleiman North Shopping Center | Locale | 3 | Duval | 30 18 09 N | 081 23 43 W |
| Sleiman South Shopping Center | Locale | 3 | Duval | 30 16 53 N | 081 23 23 W |
| Sligh Junior High School | School | 17 | Hillsborough | 28 00 36 N | 082 26 11 W |
| Slim Pines | Woods | 9 | Volusia | 29 10 47 N | 081 08 06 W |
| Slippery Creek | Gut | 0 | Volusia | 28 53 39 N | 080 50 13 W |
| Slippery Slough | Gut | 21 | DeSoto | 27 09 49 N | 081 39 25 W |
| Sloman Branch | Stream | | Hillsborough | 27 53 24 N | 082 04 14 W |
| Slones Ridge | Populated Place | 32 | Lake | 28 34 44 N | 081 56 40 W |
| Slones Ridge | Ridge | 36 | Lake | 28 34 50 N | 081 56 59 W |
| Slough Island | Island | 4 | Wakulla | 30 05 13 N | 084 07 57 W |
| Smack Bayou | Bay | 8 | Bay | 30 07 45 N | 085 39 58 W |
| Smack Point | Cape | 1 | Okaloosa | 30 25 38 N | 086 35 30 W |
| Smacks Bayou | Bay | -1 | Pinellas | 27 48 22 N | 082 36 37 W |
| Small Fry Day Care - Fourth Campus | School | 4 | Miami-Dade | 25 39 04 N | 080 17 37 W |
| Small Fry Day Care Center | Building | | Miami-Dade | 25 29 59 N | 080 25 09 W |
| Small Fry Day Care Center | Building | | Miami-Dade | 25 37 43 N | 080 21 00 W |
| Small Fry Day Care Center - Fifth Campus | School | 2 | Miami-Dade | 25 37 16 N | 080 19 50 W |
| Small Fry Education Center | Building | | Miami-Dade | 25 35 18 N | 080 21 22 W |
| Small Fry Educational Center | Building | | Miami-Dade | 25 55 46 N | 080 09 58 W |
| Small Fry Educational Day Care - Third Campus | School | 3 | Miami-Dade | 25 50 35 N | 080 11 13 W |
| Small Fry Educational Day Care School | School | 1 | Broward | 26 09 57 N | 080 11 08 W |
| Small Fry School - First Campus | School | 3 | Miami-Dade | 25 57 19 N | 080 12 13 W |
| Small Fry School - Second Campus | School | 4 | Miami-Dade | 25 53 45 N | 080 12 09 W |
| Small People Academy | School | | Miami-Dade | 25 51 07 N | 080 11 42 W |
| Small Talk Academy | Building | | Miami-Dade | 25 56 30 N | 080 13 32 W |
| Small Wonders Child Care Center | Building | | Miami-Dade | 25 53 42 N | 080 11 01 W |
| Small Wonders of Miami Day Care Center | Building | | Miami-Dade | 25 39 19 N | 080 24 24 W |
| Small World Christian Day Care Center | Building | | Miami-Dade | 25 45 20 N | 080 18 35 W |
| Small World Day Care Center | Building | | Miami-Dade | 25 31 14 N | 080 25 32 W |
| Small World Learning Center | School | 5 | Martin | 27 13 16 N | 080 13 22 W |
| Smallpox Tommies Camp | Locale | 2 | Miami-Dade | 25 50 22 N | 080 49 49 W |
| Smallpox Tommies Old Place | Populated Place | 2 | Miami-Dade | 25 50 38 N | 080 46 12 W |
| Smallpox Tommies Seminole Village | Locale | 2 | Miami-Dade | 25 46 59 N | 080 45 58 W |
| Smallwood Island | Island | 4 | Collier | 26 16 21 N | 081 23 13 W |
| Smart School Charter Middle School | School | | Broward | 26 08 40 N | 080 11 52 W |
| Smathers Beach | Beach | 0 | Monroe | 24 33 07 N | 081 46 13 W |
| Smiling Faces Day Care Center | Building | | Miami-Dade | 25 44 15 N | 080 22 26 W |
| Smith | Locale | 35 | Madison | 30 37 42 N | 083 21 13 W |
| Smith Bay | Swamp | 43 | Hamilton | 30 33 12 N | 082 56 01 W |
| Smith Bayou | Bay | 28 | Pinellas | 28 03 31 N | 082 46 49 W |
| Smith Bayou | Stream | | Bay | 30 05 00 N | 085 29 27 W |
| Smith Branch | Stream | | Okaloosa | 30 35 18 N | 086 24 51 W |
| Smith Branch | Stream | | Walton | 30 30 41 N | 086 23 21 W |
| Smith Cemetery | Cemetery | 75 | Gadsden | 30 33 40 N | 084 33 39 W |
| Smith Cemetery | Cemetery | 87 | Gadsden | 30 36 34 N | 084 48 41 W |
| Smith Cemetery | Cemetery | 50 | Holmes | 30 51 50 N | 086 00 46 W |
| Smith Cemetery | Cemetery | 25 | Levy | 29 22 49 N | 082 36 46 W |
| Smith Cemetery | Cemetery | 48 | Madison | 30 30 23 N | 083 35 44 W |