Feature Name | Class | Elev. meters | County | Latitude DMS | Longitude DMS |
| Souls Harbor Church of God | Church | 5 | Dorchester | 38 33 41 N | 076 04 30 W |
| Sound Gut | Stream | | Somerset | 38 07 08 N | 076 01 06 W |
| Sound Point (historical) | Cape | 2 | Somerset | 38 08 03 N | 076 00 42 W |
| Sound Shore | Beach | 1 | Somerset | 37 58 26 N | 075 42 21 W |
| South Baltimore | Populated Place | 17 | Baltimore (city) | 39 16 22 N | 076 36 20 W |
| South Baltimore Memorial Methodist Church | Church | 30 | Baltimore (city) | 39 17 32 N | 076 38 09 W |
| South Baltimore Recreation Center | Park | 8 | Baltimore (city) | 39 16 40 N | 076 36 47 W |
| South Bar Point | Cape | 0 | Talbot | 38 44 59 N | 076 21 47 W |
| South Basin | Basin | 7 | Anne Arundel | 38 59 22 N | 076 33 53 W |
| South Beechwood | Populated Place | 13 | Talbot | 38 44 38 N | 076 03 49 W |
| South Bel Air (subdivision) | Populated Place | 116 | Harford | 39 31 59 N | 076 20 15 W |
| South Branch Bear Creek | Stream | | Garrett | 39 39 11 N | 079 23 04 W |
| South Branch Casselman River | Stream | | Garrett | 39 40 04 N | 079 10 36 W |
| South Branch Fishing Creek | Stream | | Dorchester | 38 31 40 N | 076 08 40 W |
| South Branch Gunpowder Falls | Stream | | Carroll | 39 42 45 N | 076 50 07 W |
| South Branch Laurel Run | Stream | | Garrett | 39 41 17 N | 079 26 57 W |
| South Branch Patapsco River | Stream | | Carroll | 39 20 59 N | 076 52 56 W |
| South Carroll Commercial Park | Locale | 170 | Carroll | 39 23 57 N | 076 55 39 W |
| South Carroll Estates | Populated Place | 237 | Carroll | 39 24 43 N | 077 01 59 W |
| South Carroll High School | School | 226 | Carroll | 39 26 36 N | 077 02 31 W |
| South Carroll Medical Center | Hospital | 185 | Carroll | 39 24 01 N | 076 57 07 W |
| South Chesapeake City Historic District | Park | 7 | Cecil | 39 31 38 N | 075 48 48 W |
| South Columbia Baptist Church | Church | 103 | Howard | 39 10 02 N | 076 51 30 W |
| South County Branch Library | Building | 2 | Anne Arundel | 38 47 01 N | 076 33 11 W |
| South County Park | Park | 225 | Washington | 39 23 56 N | 077 42 08 W |
| South Covell | Populated Place | 140 | Frederick | 39 19 56 N | 077 23 32 W |
| South Creek | Bay | -6 | Anne Arundel | 38 49 57 N | 076 31 50 W |
| South Creek View | Populated Place | 1 | Anne Arundel | 38 49 33 N | 076 31 44 W |
| South Cumberland | Populated Place | 212 | Allegany | 39 37 57 N | 078 45 21 W |
| South Davis Millpond Branch | Stream | | Dorchester | 38 39 54 N | 075 45 28 W |
| South Dorchester School | School | 0 | Dorchester | 38 23 52 N | 076 11 14 W |
| South Down Shores | Populated Place | 9 | Anne Arundel | 38 56 18 N | 076 34 14 W |
| South End Junior High School | School | 245 | Allegany | 39 38 17 N | 078 44 44 W |
| South End Park | Park | 99 | Frederick | 39 24 33 N | 077 25 23 W |
| South End Playground | Park | 218 | Allegany | 39 38 08 N | 078 45 22 W |
| South Ferry Point | Cape | 0 | Anne Arundel | 39 04 18 N | 076 30 10 W |
| South Forestville Park | Park | 79 | Prince George's | 38 50 08 N | 076 52 54 W |
| South Fork Bens Branch | Stream | | Frederick | 39 24 45 N | 077 13 54 W |
| South Fork Crabtree Creek | Stream | | Garrett | 39 27 26 N | 079 13 44 W |
| South Fork Green Run | Stream | | Wicomico | 38 26 13 N | 075 21 10 W |
| South Fork Linganore Creek | Stream | | Frederick | 39 26 56 N | 077 13 17 W |
| South Fork Muddy Creek | Stream | | Anne Arundel | 38 52 48 N | 076 33 49 W |
| South Fork Muddy Creek Marsh | Swamp | 2 | Anne Arundel | 38 52 57 N | 076 33 39 W |
| South Fork Sand Run | Stream | | Garrett | 39 15 32 N | 079 24 33 W |
| South Frederick Elementary School | School | 98 | Frederick | 39 24 34 N | 077 24 60 W |
| South Frederick Primary School (historical) | School | 98 | Frederick | 39 24 34 N | 077 24 60 W |
| South Gate | Populated Place | 20 | Anne Arundel | 39 07 44 N | 076 37 33 W |
| South Germantown Greenbelt Park | Park | 128 | Montgomery | 39 09 02 N | 077 18 22 W |
| South Glen | Populated Place | 168 | Frederick | 39 22 48 N | 077 13 47 W |
| South Glen Burnie Fire Station Company 26 | Building | | Anne Arundel | 39 14 22 N | 077 03 40 W |
| South Grays Creek Bog | Swamp | 7 | Anne Arundel | 39 05 47 N | 076 28 46 W |
| South Gunners Branch Park | Park | 104 | Montgomery | 39 09 05 N | 077 16 25 W |
| South Hagerstown High School | School | 165 | Washington | 39 37 13 N | 077 43 57 W |
| South Hagerstown Shopping Center | Locale | 167 | Washington | 39 37 29 N | 077 44 00 W |
| South Hammocks | Island | 0 | Worcester | 38 25 49 N | 075 05 12 W |
| South Hampton | Populated Place | 37 | Calvert | 38 40 46 N | 076 39 39 W |
| South Hampton (historical) | Locale | 8 | St. Mary's | 38 21 53 N | 076 46 46 W |
| South Hampton Village | Populated Place | 47 | Charles | 38 37 40 N | 077 04 44 W |
| South Haven | Populated Place | 22 | Anne Arundel | 38 57 47 N | 076 34 57 W |
| South Kensington | Populated Place | 87 | Montgomery | 39 01 08 N | 077 04 48 W |
| South Lake Elementary School | School | 132 | Montgomery | 39 09 20 N | 077 11 50 W |
| South Laurel | Populated Place | 49 | Prince George's | 39 04 11 N | 076 51 01 W |
| South Laurel Neighborhood Park | Park | 46 | Prince George's | 39 02 50 N | 076 50 11 W |
| South Lawn | Populated Place | 52 | Prince George's | 38 47 34 N | 076 59 31 W |
| South Locust Point Marine Terminal | Locale | 1 | Baltimore (city) | 39 15 45 N | 076 35 29 W |
| South Marsh Island | Island | 0 | Somerset | 38 07 30 N | 076 01 09 W |
| South Mountain | Range | 453 | Washington | 39 10 00 N | 078 39 59 W |
| South Mountain Campground | Locale | 301 | Frederick | 39 31 50 N | 077 35 59 W |
| South Mountain Natural Environmental Area | Park | 474 | Washington | 39 33 15 N | 077 35 59 W |
| South Ocean Pines | Populated Place | 3 | Worcester | 38 22 58 N | 075 08 44 W |
| South Pennsfield (subdivision) | Populated Place | 7 | Talbot | 38 45 28 N | 076 04 24 W |
| South Piscataway | Populated Place | 24 | Prince George's | 38 41 09 N | 076 58 49 W |
| South Point | Cape | -2 | Anne Arundel | 38 57 21 N | 076 33 20 W |
| South Point | Cape | 0 | Worcester | 38 12 30 N | 075 11 30 W |
| South Potomac Junior High School | School | 161 | Washington | 39 37 58 N | 077 43 20 W |
| South Prong Leonard Pond Run | Stream | | Wicomico | 38 25 26 N | 075 33 29 W |
| South Prong Lostland Run | Stream | | Garrett | 39 22 17 N | 079 15 16 W |
| South Prong Shipping Creek | Gut | 0 | Queen Anne's | 38 53 40 N | 076 20 37 W |
| South Prong Wicomico River | Stream | | Wicomico | 38 21 53 N | 075 36 23 W |
| South Prospect Street Historic District | Park | 177 | Washington | 39 38 29 N | 077 43 34 W |
| South River | Populated Place | 32 | Anne Arundel | 38 54 11 N | 076 33 38 W |
| South River | Stream | | Anne Arundel | 38 53 44 N | 076 28 27 W |
| South River Bridge | Bridge | -5 | Anne Arundel | 38 57 06 N | 076 33 14 W |
| South River Estates | Populated Place | 28 | Anne Arundel | 38 54 16 N | 076 33 58 W |
| South River Farms Park | Park | 9 | Anne Arundel | 38 55 03 N | 076 30 54 W |
| South River Headwaters Marsh | Swamp | 1 | Anne Arundel | 38 59 00 N | 076 36 29 W |
| South River Heights | Populated Place | 7 | Anne Arundel | 38 57 10 N | 076 34 29 W |
| South River Manor | Populated Place | 28 | Anne Arundel | 38 58 14 N | 076 34 42 W |
| South River Park | Park | 6 | Anne Arundel | 38 56 24 N | 076 33 28 W |
| South River Senior High School | School | 18 | Anne Arundel | 38 55 18 N | 076 33 36 W |
| South River Spring Lakes | Populated Place | 23 | Anne Arundel | 38 57 40 N | 076 37 09 W |
| South River Towers | Populated Place | 31 | Anne Arundel | 38 58 29 N | 076 35 25 W |
| South River Yacht Club | Locale | -3 | Anne Arundel | 38 56 53 N | 076 33 11 W |
| South Salisbury Baptist Church | Church | 10 | Wicomico | 38 21 00 N | 075 35 51 W |
| South Shore Elementary School | School | 45 | Anne Arundel | 39 02 03 N | 076 36 20 W |
| South Shore Health Center | Hospital | 45 | Anne Arundel | 39 02 31 N | 076 36 20 W |
| South Side Fire Station Number 2 | Building | 218 | Allegany | 39 38 09 N | 078 45 35 W |
| South Station Baltimore Post Office | Post Office | 4 | Baltimore (city) | 39 16 30 N | 076 37 07 W |
| South Stirrup Run | Stream | | Harford | 39 36 53 N | 076 24 05 W |
| South Timber | Populated Place | 204 | Frederick | 39 26 08 N | 077 10 15 W |
| South Trail | Trail | 57 | Charles | 38 37 55 N | 076 49 50 W |
| South Woodside Park | Populated Place | 77 | Montgomery | 39 00 18 N | 077 01 12 W |
| Southampton | Populated Place | 94 | Harford | 39 33 06 N | 076 19 35 W |
| Southampton | Populated Place | 34 | St. Mary's | 38 15 12 N | 076 26 01 W |
| Southampton Middle School | School | 96 | Harford | 39 32 47 N | 076 19 59 W |
| Southdale Shopping Center | Locale | 21 | Anne Arundel | 39 08 13 N | 076 35 46 W |
| Southdown Estates | Populated Place | 10 | Anne Arundel | 38 56 11 N | 076 34 14 W |
| Southeast Baltimore Catholic Academy Father Kolbe Campus | School | | Baltimore (city) | 39 16 49 N | 076 34 37 W |
| Southeast Branch Fishing Creek | Stream | | Dorchester | 38 31 58 N | 076 08 50 W |
| Southeast Creek | Stream | | Queen Anne's | 39 09 41 N | 076 02 45 W |