Feature Name | Class | Elev. meters | County | Latitude DMS | Longitude DMS |
| Southeast Landing | Populated Place | 1 | Queen Anne's | 39 09 27 N | 076 01 34 W |
| Southeast Middle School | School | | Baltimore (city) | 39 17 07 N | 076 31 58 W |
| Southeast Olney Park | Park | 160 | Montgomery | 39 08 38 N | 077 03 49 W |
| Southeast Station Baltimore Post Office | Post Office | 29 | Baltimore (city) | 39 17 16 N | 076 34 10 W |
| Southeastern District Police Station | Building | 30 | Baltimore (city) | 39 17 15 N | 076 32 50 W |
| Southern Avenue Metro Station | Locale | 47 | Prince George's | 38 50 25 N | 076 58 33 W |
| Southern Avenue Shopping Center | Locale | 28 | Prince George's | 38 49 41 N | 076 59 27 W |
| Southern Baptist Church | Church | 36 | Baltimore (city) | 39 18 19 N | 076 35 49 W |
| Southern Cemetery | Cemetery | 140 | Harford | 39 39 17 N | 076 15 57 W |
| Southern District Police Station | Building | 9 | Baltimore (city) | 39 16 30 N | 076 36 48 W |
| Southern Garrett County Senior High School | School | 725 | Garrett | 39 24 50 N | 079 25 04 W |
| Southern Health District Clinic | Hospital | 11 | Baltimore (city) | 39 16 32 N | 076 36 43 W |
| Southern High School | School | 49 | Anne Arundel | 38 49 25 N | 076 36 35 W |
| Southern High School | School | 12 | Baltimore (city) | 39 16 43 N | 076 36 39 W |
| Southern Maryland Hospital Center | Hospital | 71 | Prince George's | 38 44 54 N | 076 52 33 W |
| Southern Maryland Islamic Center | Church | 36 | Calvert | 38 33 36 N | 076 35 59 W |
| Southern Maryland Public Works Camp | Locale | 50 | Charles | 38 30 34 N | 076 49 05 W |
| Southern Maryland Trade Center | Locale | 36 | Charles | 38 31 01 N | 076 59 14 W |
| Southern Memorial Gardens | Cemetery | 34 | Calvert | 38 43 12 N | 076 39 11 W |
| Southern Park | Park | 4 | Charles | 38 16 40 N | 076 52 37 W |
| Southern Pines | Populated Place | 15 | Wicomico | 38 18 03 N | 075 29 19 W |
| Southern Prong Saint Jerome Creek | Bay | -3 | St. Mary's | 38 06 46 N | 076 20 54 W |
| Southern School | School | 35 | Calvert | 38 24 23 N | 076 26 46 W |
| Southern Senior High School | School | 52 | Anne Arundel | 38 52 07 N | 076 37 09 W |
| Southfield at Whitemarsh | Populated Place | 28 | Baltimore | 39 22 41 N | 076 28 29 W |
| Southgate | Populated Place | 27 | Anne Arundel | 39 07 44 N | 076 36 34 W |
| Southgate | Populated Place | 11 | St. Mary's | 38 15 19 N | 076 24 59 W |
| Southgate Elementary School | School | 22 | Anne Arundel | 39 07 43 N | 076 36 52 W |
| Southgate Marketplace Shopping Center | Locale | 25 | Anne Arundel | 39 08 28 N | 076 37 51 W |
| Southgate Old Mill Park | Park | 28 | Anne Arundel | 39 07 24 N | 076 36 59 W |
| Southgate Plaza Shopping Center | Locale | 24 | Anne Arundel | 39 08 32 N | 076 37 48 W |
| Southglenn Farms | Populated Place | 191 | Carroll | 39 31 15 N | 076 51 54 W |
| Southland Hills | Populated Place | 140 | Baltimore | 39 23 55 N | 076 36 38 W |
| Southminster Presbyterian Church | Church | 212 | Allegany | 39 38 02 N | 078 45 38 W |
| Southminster United Presbyterian Church | Church | 49 | Prince George's | 38 46 58 N | 076 59 34 W |
| Southside School | School | 220 | Allegany | 39 38 09 N | 078 45 31 W |
| Southview | Populated Place | 138 | Howard | 39 17 25 N | 076 50 09 W |
| Southview | Populated Place | 239 | Montgomery | 39 16 19 N | 077 12 10 W |
| Southview Regional Shopping Center | Locale | | Anne Arundel | 39 12 59 N | 076 37 00 W |
| Southwest Baptist Church | Church | 26 | Baltimore (city) | 39 17 13 N | 076 38 24 W |
| Southwest Branch Charles Branch | Stream | | Prince George's | 38 46 44 N | 076 46 30 W |
| Southwest Branch Western Branch Patuxent River | Stream | | Prince George's | 38 52 30 N | 076 47 55 W |
| Southwest District Police Station | Building | 28 | Baltimore (city) | 39 16 42 N | 076 39 51 W |
| Southwestern High School | School | 49 | Baltimore (city) | 39 17 01 N | 076 39 52 W |
| Southwind | Populated Place | 2 | Queen Anne's | 38 55 05 N | 076 18 01 W |
| Southwood | Populated Place | 220 | Carroll | 39 33 08 N | 076 51 20 W |
| Sowers Residence Hall | Building | 603 | Allegany | 39 39 04 N | 078 55 48 W |
| Spa Creek | Stream | | Anne Arundel | 38 58 45 N | 076 28 30 W |
| Spaldings Comfort | Locale | 42 | St. Mary's | 38 22 56 N | 076 38 04 W |
| Spaniard Neck | Cape | 7 | Queen Anne's | 39 05 48 N | 076 06 40 W |
| Spaniard Point | Cape | 0 | Queen Anne's | 39 05 33 N | 076 08 42 W |
| Spaniards Landing | Locale | 0 | Queen Anne's | 39 05 53 N | 076 08 15 W |
| Spark Matsunaga Elementary School | School | 149 | Montgomery | 39 09 04 N | 077 17 40 W |
| Sparks | Populated Place | 132 | Baltimore | 39 31 51 N | 076 38 45 W |
| Sparks Corner | Populated Place | 18 | Queen Anne's | 39 06 58 N | 076 01 17 W |
| Sparks Elementary School | School | 94 | Baltimore | 39 32 20 N | 076 38 41 W |
| Sparks Park | Park | 82 | Baltimore | 39 32 28 N | 076 38 37 W |
| Sparks Station | Locale | 89 | Baltimore | 39 32 20 N | 076 38 17 W |
| Sparr Spring | Spring | 244 | Howard | 39 21 13 N | 077 10 02 W |
| Sparrow Branch | Stream | | Anne Arundel | 38 53 37 N | 076 33 27 W |
| Sparrows Beach | Beach | 3 | Anne Arundel | 38 57 31 N | 076 28 17 W |
| Sparrows Point | Cape | 1 | Baltimore | 39 12 09 N | 076 29 33 W |
| Sparrows Point | Populated Place | 3 | Baltimore | 39 13 09 N | 076 28 34 W |
| Sparrows Point Channel | Channel | 26 | Baltimore | 39 12 04 N | 076 28 58 W |
| Sparrows Point Country Club | Locale | 4 | Baltimore | 39 15 19 N | 076 28 32 W |
| Sparrows Point Fire Department Station 57 | Building | | Baltimore | 39 13 14 N | 076 28 42 W |
| Sparrows Point High School | School | 6 | Baltimore | 39 14 18 N | 076 26 29 W |
| Sparrows Point Middle School | School | 6 | Baltimore | 39 14 19 N | 076 26 32 W |
| Sparrows Point Post Office | Post Office | 5 | Baltimore | 39 14 10 N | 076 26 29 W |
| Spaulding Junior High School | School | 79 | Prince George's | 38 50 12 N | 076 53 11 W |
| Spaulding Knolls | Populated Place | 33 | Anne Arundel | 39 07 43 N | 076 38 54 W |
| Spauldings Branch Library | Building | 88 | Prince George's | 38 51 13 N | 076 54 23 W |
| Spauldings Branch Prince George's County Memorial Library | Building | 88 | Prince George's | 38 51 12 N | 076 54 24 W |
| Spears Creek | Stream | | Dorchester | 38 34 09 N | 075 46 48 W |
| Special Needs Library | Building | 114 | Montgomery | 39 01 22 N | 077 07 43 W |
| Speddens Church | Church | 1 | Dorchester | 38 35 09 N | 076 15 30 W |
| Speeden Wharf (historical) | Locale | 5 | Dorchester | 38 35 13 N | 076 14 58 W |
| Speelman Mills (historical) | Locale | 443 | Garrett | 39 42 51 N | 079 23 05 W |
| Spence | Populated Place | 6 | Worcester | 38 09 43 N | 075 18 35 W |
| Spence Baptist Church | Church | 11 | Worcester | 38 09 40 N | 075 18 52 W |
| Spence Cove | Bay | -2 | Worcester | 38 13 59 N | 075 11 55 W |
| Spencer Creek | Bay | -5 | Talbot | 38 46 18 N | 076 12 06 W |
| Spencer Gardens | Populated Place | 15 | Anne Arundel | 39 09 11 N | 076 35 09 W |
| Spencer Island | Island | 12 | Harford | 39 36 28 N | 076 07 58 W |
| Spencer Science Hall | Building | 71 | Baltimore (city) | 39 20 47 N | 076 34 57 W |
| Spencers Wharf | Locale | -3 | St. Mary's | 38 19 22 N | 076 29 02 W |
| Spencers Wharf | Populated Place | 5 | St. Mary's | 38 19 16 N | 076 28 44 W |
| Spencerville | Populated Place | 152 | Montgomery | 39 06 51 N | 076 58 42 W |
| Spencerville Free Methodist Church | Church | 158 | Montgomery | 39 07 03 N | 076 58 08 W |
| Spencerville Junior Academy | School | 157 | Montgomery | 39 07 01 N | 076 58 39 W |
| Spencerville Knolls | Populated Place | 155 | Montgomery | 39 07 17 N | 076 58 19 W |
| Spencerville Recreation Center | Park | 141 | Montgomery | 39 06 42 N | 076 58 38 W |
| Spesutie Cemetery | Cemetery | 11 | Harford | 39 28 26 N | 076 12 15 W |
| Spesutie Church | Church | 8 | Harford | 39 28 29 N | 076 12 14 W |
| Spesutie Island | Island | 2 | Harford | 39 27 21 N | 076 04 36 W |
| Spesutie Island Bridge | Bridge | 0 | Harford | 39 28 30 N | 076 05 48 W |
| Spesutie Narrows | Channel | -3 | Harford | 39 27 44 N | 076 05 32 W |
| Spice Creek | Stream | | Prince George's | 38 41 37 N | 076 42 12 W |
| Spicebush Valley | Valley | | Anne Arundel | 38 54 04 N | 076 34 03 W |
| Spicer Creek | Channel | 0 | Dorchester | 38 23 58 N | 076 13 22 W |
| Spickler | Populated Place | 146 | Washington | 39 39 29 N | 077 52 12 W |
| Spiderbush Nature Trail | Trail | 519 | Frederick | 39 38 55 N | 077 28 36 W |
| Spielman | Populated Place | 125 | Washington | 39 32 13 N | 077 45 50 W |
| Spiker Run | Stream | | Garrett | 39 40 46 N | 079 10 08 W |
| Spinks Ferry (historical) | Crossing | 59 | Montgomery | 39 13 08 N | 077 27 30 W |
| Spirit and Life Bible Church | Church | 116 | Cecil | 39 40 12 N | 075 54 08 W |
| Spit Neck | Cape | 3 | Anne Arundel | 39 07 49 N | 076 27 50 W |
| Spit Point | Cape | 1 | Anne Arundel | 39 07 41 N | 076 26 43 W |
| Split Branch | Stream | | Anne Arundel | 38 53 18 N | 076 33 31 W |
| Split Point | Cape | -2 | St. Mary's | 38 07 15 N | 076 20 56 W |