Feature Name | Class | Elev. meters | County | Latitude DMS | Longitude DMS |
| South Row School | School | 37 | Middlesex | 42 34 42 N | 071 20 11 W |
| South Royalston | Populated Place | 262 | Worcester | 42 37 50 N | 072 08 50 W |
| South Salem | Populated Place | 14 | Essex | 42 30 40 N | 070 53 33 W |
| South Sandisfield | Populated Place | 434 | Berkshire | 42 04 06 N | 073 09 34 W |
| South School | School | 25 | Bristol | 41 53 52 N | 071 01 52 W |
| South School | School | 52 | Middlesex | 42 28 25 N | 071 06 00 W |
| South School | School | 61 | Middlesex | 42 21 47 N | 071 24 46 W |
| South School | School | 58 | Norfolk | 42 07 55 N | 071 00 18 W |
| South School | School | 34 | Plymouth | 42 12 02 N | 070 53 06 W |
| South School (historical) | School | 22 | Plymouth | 42 02 27 N | 070 52 12 W |
| South Seekonk | Populated Place | 13 | Bristol | 41 47 20 N | 071 19 08 W |
| South Sherborn | Populated Place | 44 | Middlesex | 42 13 25 N | 071 21 18 W |
| South Sherborn Cemetery | Cemetery | 47 | Middlesex | 42 13 29 N | 071 21 44 W |
| South Shore | Beach | 3 | Nantucket | 41 14 25 N | 070 05 58 W |
| South Shore Community Church | Church | 4 | Plymouth | 41 45 29 N | 070 42 54 W |
| South Shore Consumers Mall | Locale | 7 | Plymouth | 42 14 50 N | 070 55 27 W |
| South Shore Country Club | Locale | 15 | Plymouth | 42 14 10 N | 070 54 02 W |
| South Shore Hospital | Hospital | 57 | Norfolk | 42 10 33 N | 070 57 14 W |
| South Shore Industrial Park | Locale | 45 | Plymouth | 42 10 29 N | 070 55 00 W |
| South Shore Marshes Wildlife Management Area | Park | -3 | Bristol | 41 37 43 N | 070 51 21 W |
| South Shore Pentecostal Church | Church | 39 | Plymouth | 42 04 54 N | 070 56 23 W |
| South Shore Plaza | Locale | 25 | Norfolk | 42 13 20 N | 071 01 27 W |
| South Shore Plaza Shopping Center | Locale | 25 | Norfolk | 42 13 18 N | 071 01 27 W |
| South Shrewsbury | Populated Place | 170 | Worcester | 42 16 35 N | 071 42 58 W |
| South Somerset School | School | 47 | Bristol | 41 44 14 N | 071 09 56 W |
| South Spectacle Pond | Lake | 164 | Franklin | 42 30 55 N | 072 16 08 W |
| South Spencer | Populated Place | 210 | Worcester | 42 13 07 N | 072 00 53 W |
| South Stoughton | Populated Place | 79 | Norfolk | 42 06 55 N | 071 04 48 W |
| South Street Historic District | Park | 42 | Plymouth | 42 04 50 N | 071 01 47 W |
| South Street Mall Shopping Center | Locale | 72 | Hampden | 42 11 47 N | 072 37 16 W |
| South Street School | School | 50 | Hampshire | 42 18 45 N | 072 38 03 W |
| South Street School | School | 139 | Hampshire | 42 15 17 N | 072 14 30 W |
| South Street School | School | 196 | Worcester | 42 34 16 N | 071 47 51 W |
| South Sudbury | Populated Place | 56 | Middlesex | 42 21 45 N | 071 24 48 W |
| South Sugarloaf Mountain | Summit | 197 | Franklin | 42 28 12 N | 072 35 32 W |
| South Sutton | Populated Place | 138 | Worcester | 42 06 00 N | 071 42 43 W |
| South Sutton Cemetery | Cemetery | 135 | Worcester | 42 05 45 N | 071 42 38 W |
| South Swamp | Swamp | 29 | Plymouth | 42 11 40 N | 070 47 54 W |
| South Swansea | Populated Place | 15 | Bristol | 41 43 05 N | 071 12 13 W |
| South Triangle Pond | Lake | 28 | Plymouth | 41 54 54 N | 070 39 43 W |
| South Truro | Populated Place | 7 | Barnstable | 41 57 54 N | 070 04 31 W |
| South Union School | School | 94 | Worcester | 42 16 04 N | 071 31 46 W |
| South Unitarian Church | Church | 163 | Worcester | 42 15 17 N | 071 48 48 W |
| South Village | Populated Place | 282 | Middlesex | 42 40 00 N | 071 49 28 W |
| South Village Pond Dam | Dam | 142 | Worcester | 42 03 18 N | 071 52 46 W |
| South Wachusett Brook | Stream | | Worcester | 42 24 25 N | 071 53 16 W |
| South Walpole | Populated Place | 69 | Norfolk | 42 06 15 N | 071 15 40 W |
| South Walpole United Methodist Church | Church | 79 | Norfolk | 42 06 16 N | 071 15 38 W |
| South Wareham | Populated Place | 11 | Plymouth | 41 46 20 N | 070 44 58 W |
| South Wareham Post Office (historical) | Post Office | 21 | Plymouth | 41 46 13 N | 070 44 29 W |
| South Wareham Station (historical) | Locale | 11 | Plymouth | 41 46 18 N | 070 44 54 W |
| South Watuppa Pond | Lake | 40 | Bristol | 41 39 30 N | 071 07 28 W |
| South Wellfleet | Populated Place | 12 | Barnstable | 41 55 05 N | 069 59 43 W |
| South Wellfleet Cemetery | Cemetery | 11 | Barnstable | 41 54 30 N | 069 59 05 W |
| South Wendell | Populated Place | 281 | Franklin | 42 31 15 N | 072 23 28 W |
| South West Rock | Island | 4 | Barnstable | 41 36 28 N | 070 18 58 W |
| South West Rock | Island | -3 | Bristol | 41 28 46 N | 071 02 15 W |
| South Westminster Post Office (historical) | Post Office | 335 | Worcester | 42 31 44 N | 071 55 13 W |
| South Westport | Populated Place | 18 | Bristol | 41 34 15 N | 071 03 28 W |
| South Weymouth | Populated Place | 55 | Norfolk | 42 10 30 N | 070 56 58 W |
| South Weymouth Church of the Nazarene | Church | 46 | Norfolk | 42 10 44 N | 070 55 44 W |
| South Weymouth Junior High School | School | 32 | Norfolk | 42 10 50 N | 070 56 13 W |
| South Weymouth Naval Air Station - Shea Field | Airport | 46 | Suffolk | 42 08 55 N | 070 56 21 W |
| South Weymouth Post Office | Post Office | 57 | Norfolk | 42 10 26 N | 070 57 10 W |
| South Williamstown | Populated Place | 265 | Berkshire | 42 39 38 N | 073 14 29 W |
| South Wilmington | Populated Place | 33 | Middlesex | 42 30 55 N | 071 09 23 W |
| South Worcester | Populated Place | 145 | Worcester | 42 14 37 N | 071 48 48 W |
| South Worcester Branch Library | Building | 145 | Worcester | 42 14 37 N | 071 48 38 W |
| South Worcester Playground | Park | 146 | Worcester | 42 14 36 N | 071 48 57 W |
| South Worthington | Populated Place | 290 | Hampshire | 42 20 37 N | 072 53 23 W |
| South Yarmouth | Populated Place | 8 | Barnstable | 41 40 00 N | 070 11 05 W |
| South Yarmouth Plaza | Locale | 6 | Barnstable | 41 39 28 N | 070 12 29 W |
| South Yarmouth Station | Building | 7 | Barnstable | 41 41 27 N | 070 11 03 W |
| Southampton | Populated Place | 71 | Hampshire | 42 13 45 N | 072 43 48 W |
| Southampton Center Cemetery | Cemetery | 86 | Hampshire | 42 14 07 N | 072 43 45 W |
| Southampton Center Historic District | Park | 77 | Hampshire | 42 13 27 N | 072 43 58 W |
| Southampton Country Club | Locale | 75 | Hampshire | 42 12 30 N | 072 43 28 W |
| Southampton Post Office | Post Office | 87 | Hampshire | 42 14 16 N | 072 43 31 W |
| Southampton Road Elementary School | School | 79 | Hampden | 42 09 03 N | 072 43 41 W |
| Southampton Road School | School | 77 | Hampden | 42 09 00 N | 072 43 41 W |
| Southampton Town Hall | Building | 70 | Hampshire | 42 13 36 N | 072 43 54 W |
| Southborough | Populated Place | 94 | Worcester | 42 18 20 N | 071 31 28 W |
| Southborough School | School | 82 | Worcester | 42 18 06 N | 071 31 43 W |
| Southbridge | Populated Place | 149 | Worcester | 42 04 30 N | 072 02 00 W |
| Southbridge Christian Academy | School | 207 | Worcester | 42 05 25 N | 072 00 03 W |
| Southbridge Church of God | Church | 130 | Worcester | 42 04 14 N | 072 00 58 W |
| Southbridge High School | School | 177 | Worcester | 42 04 30 N | 072 02 28 W |
| Southbridge Industrial Park | Locale | 254 | Berkshire | 42 16 32 N | 073 17 41 W |
| Southbridge Methodist Church | Church | 164 | Worcester | 42 04 37 N | 072 02 13 W |
| Southbridge Municipal Airport | Airport | 210 | Worcester | 42 06 03 N | 072 02 16 W |
| Southbridge Plaza | Locale | 121 | Worcester | 42 04 13 N | 072 00 30 W |
| Southbridge Post Office | Post Office | 146 | Worcester | 42 04 26 N | 072 01 58 W |
| Southbridge Town Hall | Building | 155 | Worcester | 42 04 24 N | 072 02 02 W |
| Southbridge Townhall | Building | 157 | Worcester | 42 04 23 N | 072 02 03 W |
| Southeast Bay | Bay | 427 | Hampden | 42 08 15 N | 073 01 58 W |
| Southeast Breakers | Bar | 4 | Essex | 42 30 50 N | 070 45 38 W |
| Southeast Harbor | Bay | -13 | Essex | 42 35 45 N | 070 39 23 W |
| Southeast Pond | Lake | 0 | Barnstable | 41 56 24 N | 069 59 53 W |
| Southeast Ridge | Ridge | 89 | Norfolk | 42 12 45 N | 071 03 13 W |
| Southeast Wilmington Industrial Park | Locale | 33 | Middlesex | 42 31 43 N | 071 08 35 W |
| Southeastern Massachusetts University | School | 41 | Bristol | 41 37 46 N | 071 00 06 W |
| Southeastern Technical Institute | School | 34 | Bristol | 42 00 41 N | 071 04 53 W |
| Southend Farm Heliport | Airport | 42 | Norfolk | 42 11 24 N | 071 21 20 W |
| Southern Artery Shopping Center | Locale | 8 | Norfolk | 42 15 13 N | 070 59 42 W |
| Southern Junior High School | School | 8 | Middlesex | 42 22 59 N | 071 05 55 W |
| Southern Simmons Pond | Lake | 4 | Barnstable | 41 43 22 N | 070 09 51 W |
| Southfield | Populated Place | 371 | Berkshire | 42 06 05 N | 073 13 58 W |
| Southfield Post Office | Post Office | 374 | Berkshire | 42 06 04 N | 073 14 00 W |
| Southgate Plaza | Locale | 25 | Plymouth | 42 02 46 N | 071 00 44 W |
| Southgate Shopping Plaza | Locale | 41 | Hampden | 42 03 37 N | 072 38 03 W |