Feature Name | Class | Elev. meters | County | Latitude DMS | Longitude DMS |
| South Providence Oil Field | Oilfield | 109 | Franklin | 31 27 16 N | 090 59 25 W |
| South Rigolets | Gut | 0 | Jackson | 30 21 14 N | 088 24 04 W |
| South Rigolets Island | Island | 1 | Jackson | 30 20 58 N | 088 23 55 W |
| South Sammy Creek Oil Field | Oilfield | 22 | Adams | 31 21 21 N | 091 20 30 W |
| South Shady Grove Church | Church | 110 | Smith | 31 54 08 N | 089 37 51 W |
| South Side Baptist Church | Church | 105 | Itawamba | 34 15 50 N | 088 24 39 W |
| South Side Baptist Church | Church | 99 | Lauderdale | 32 21 29 N | 088 41 56 W |
| South Side Cemetery | Cemetery | 35 | Sunflower | 33 21 04 N | 090 33 50 W |
| South Side Elementary School | School | 68 | Clay | 33 35 31 N | 088 39 14 W |
| South Side High School | School | 124 | Jasper | 31 55 21 N | 088 59 43 W |
| South Side Missionary Baptist Church | Church | 51 | Lowndes | 33 28 57 N | 088 24 57 W |
| South Spit | Bar | 3 | Harrison | 30 11 57 N | 089 05 32 W |
| South Sunflower County Hospital | Hospital | 36 | Sunflower | 33 27 27 N | 090 38 58 W |
| South Thompson Creek Oil Field | Oilfield | 58 | Wayne | 31 31 51 N | 088 51 45 W |
| South Tippah Creek | Stream | | Tippah | 34 43 15 N | 089 03 31 W |
| South Tishomingo School (historical) | School | 120 | Tishomingo | 34 28 11 N | 088 16 03 W |
| South Tom Branch Oil Field | Oilfield | 114 | Franklin | 31 32 36 N | 090 57 35 W |
| South Tulip Creek | Stream | | Lee | 34 14 46 N | 088 39 30 W |
| South Twentyeighth Avenue Baptist Church | Church | 64 | Forrest | 31 18 19 N | 089 19 51 W |
| South Twistwood Creek | Stream | | Jasper | 32 06 34 N | 088 57 41 W |
| South Union Cemetery | Cemetery | 166 | Choctaw | 33 19 33 N | 089 13 52 W |
| South Union Cemetery | Cemetery | 133 | Webster | 33 35 07 N | 089 21 38 W |
| South Union Church | Church | 173 | Choctaw | 33 19 35 N | 089 13 46 W |
| South Union Church | Church | 127 | Webster | 33 34 53 N | 089 21 30 W |
| South Washington County Hospital | Hospital | 35 | Washington | 33 10 04 N | 090 50 39 W |
| South White Apple Oil Field | Oilfield | 48 | Franklin | 31 25 54 N | 091 05 19 W |
| Southall (subdivision) | Populated Place | 90 | Warren | 32 22 51 N | 090 47 00 W |
| Southall Lake | Reservoir | 58 | Warren | 32 11 31 N | 090 55 05 W |
| Southall Lake Dam | Dam | 58 | Warren | 32 13 01 N | 090 55 42 W |
| Southall Lake Dam | Dam | 89 | Warren | 32 23 55 N | 090 45 18 W |
| Southall Lake Dam | Dam | 87 | Warren | 32 24 19 N | 090 45 48 W |
| Southall Lake Dam | Dam | 86 | Warren | 32 24 31 N | 090 45 54 W |
| Southall Lake Dam | Dam | 63 | Warren | 32 25 01 N | 090 45 30 W |
| Southaven | Populated Place | 95 | DeSoto | 34 59 20 N | 090 00 45 W |
| Southaven City Hall | Building | 92 | DeSoto | 34 59 09 N | 090 01 05 W |
| Southaven Elementary School | School | 105 | DeSoto | 34 58 53 N | 090 00 36 W |
| Southaven High School | School | 94 | DeSoto | 34 58 35 N | 090 00 21 W |
| Southaven Post Office | Post Office | 91 | DeSoto | 34 59 26 N | 090 00 48 W |
| Southdale (subdivision) | Populated Place | 113 | Oktibbeha | 33 27 12 N | 088 48 34 W |
| Southdale Church | Church | 32 | Sharkey | 32 57 27 N | 090 49 53 W |
| Southdale Shopping Center | Locale | 112 | Oktibbeha | 33 27 11 N | 088 48 25 W |
| Southeast Ellislie Oil Field | Oilfield | 23 | Adams | 31 20 56 N | 091 21 10 W |
| Southeast Fairview Oil Field | Oilfield | 14 | Adams | 31 17 26 N | 091 29 30 W |
| Southeast Lauderdale Elementary School | School | 131 | Lauderdale | 32 19 36 N | 088 34 15 W |
| Southeast Lauderdale High School | School | 129 | Lauderdale | 32 19 33 N | 088 34 19 W |
| Southeast Lauderdale Junior High School | School | 129 | Lauderdale | 32 19 33 N | 088 34 14 W |
| Southeast Moss Hill Oil Field | Oilfield | 85 | Adams | 31 28 51 N | 091 18 05 W |
| Southeast Woodlands Oil Field | Oilfield | 18 | Adams | 31 26 21 N | 091 27 40 W |
| Southeastern Baptist College | School | 91 | Jones | 31 44 55 N | 089 08 57 W |
| Southerland Hill | Summit | 177 | Alcorn | 34 45 25 N | 088 26 37 W |
| Southern Hill Church | Church | 70 | Madison | 32 37 57 N | 090 01 54 W |
| Southern Hills Baptist Church | Church | 45 | Adams | 31 32 16 N | 091 22 39 W |
| Southern Hills Church | Church | 105 | Hinds | 32 14 05 N | 090 16 51 W |
| Southern Memorial Park | Cemetery | 6 | Harrison | 30 23 38 N | 088 57 37 W |
| Southern Methodist Church of Waynesboro | Church | 68 | Wayne | 31 41 20 N | 088 38 44 W |
| Southern Mississippi Retardation Center | Hospital | 6 | Harrison | 30 20 34 N | 089 11 04 W |
| Southern Pine Hills | Area | 119 | Jackson | 31 10 01 N | 089 25 00 W |
| Southgate Baptist Church | Church | 71 | Lawrence | 31 32 26 N | 090 06 55 W |
| Southgate Shopping Center | Locale | 99 | Hinds | 32 15 58 N | 090 13 16 W |
| Southgate Shopping Center | Locale | 5 | Jackson | 30 23 26 N | 088 32 20 W |
| Southhaven | Populated Place | 87 | DeSoto | 34 59 30 N | 090 07 39 W |
| Southhaven (subdivision) | Populated Place | 80 | Warren | 32 15 46 N | 090 51 25 W |
| Southland Flying Service Airport | Airport | 35 | Holmes | 33 14 00 N | 090 14 00 W |
| Southland Park | Populated Place | 120 | Webster | 33 31 55 N | 089 16 02 W |
| Southport Mall Shopping Center | Locale | 90 | Hinds | 32 17 32 N | 090 13 35 W |
| Southside | Populated Place | 34 | Sunflower | 33 21 00 N | 090 33 47 W |
| Southside Assembly of God Church | Church | 108 | Hinds | 32 16 58 N | 090 13 32 W |
| Southside Baptist Church | Church | 108 | Hinds | 32 17 03 N | 090 13 50 W |
| Southside Baptist Church | Church | 5 | Jackson | 30 22 18 N | 088 38 49 W |
| Southside Baptist Church | Church | 53 | Lowndes | 33 29 23 N | 088 24 52 W |
| Southside Baptist Church | Church | 68 | Monroe | 33 48 39 N | 088 32 37 W |
| Southside Baptist Church | Church | 38 | Washington | 33 23 07 N | 091 03 13 W |
| Southside Church | Church | 80 | George | 30 54 24 N | 088 36 10 W |
| Southside Church (historical) | Church | 104 | Panola | 34 15 57 N | 089 56 23 W |
| Southside Church of Christ | Church | 67 | Grenada | 33 45 01 N | 089 48 20 W |
| Southside Church of Christ | Church | 71 | Jones | 31 40 46 N | 089 07 58 W |
| Southside Church of God | Church | 94 | Hinds | 32 15 54 N | 090 12 52 W |
| Southside Elementary School | School | 18 | Pearl River | 30 31 19 N | 089 41 43 W |
| Southside Methodist Church | Church | 135 | Alcorn | 34 55 42 N | 088 31 00 W |
| Southside Plantation (historical) | Locale | 21 | Jefferson | 31 50 16 N | 091 12 50 W |
| Southside School | School | 48 | Quitman | 34 11 51 N | 090 17 13 W |
| Southside School (historical) | School | 106 | Panola | 34 16 02 N | 089 56 22 W |
| Southside School (historical) | School | 35 | Sunflower | 33 21 05 N | 090 33 48 W |
| Southward Bridge | Bridge | 136 | Tishomingo | 34 36 43 N | 088 11 27 W |
| Southway Baptist Church | Church | 146 | Lincoln | 31 34 00 N | 090 26 55 W |
| Southwest Academy | School | 95 | Hinds | 32 15 56 N | 090 13 59 W |
| Southwest Bayou | Stream | | Jackson | 30 22 51 N | 088 24 44 W |
| Southwest Cranfield Oil Field | Oilfield | 113 | Adams | 31 31 56 N | 091 13 05 W |
| Southwest Mississippi Junior College | School | 128 | Pike | 31 17 38 N | 090 26 51 W |
| Southwest Mississippi Mental Health Complex | Hospital | 150 | Lincoln | 31 35 18 N | 090 27 31 W |
| Southwest Mississippi Regional Medical Center | Hospital | 138 | Pike | 31 15 04 N | 090 28 24 W |
| Southwest Shopping Center | Locale | 139 | Pike | 31 14 56 N | 090 28 15 W |
| Southwood Church | Church | 111 | Adams | 31 26 53 N | 091 17 02 W |
| Southwood Estates (subdivision) | Populated Place | 95 | Hinds | 32 12 46 N | 090 14 17 W |
| Southwood Lodge Lake Dam | Dam | 79 | Adams | 31 27 25 N | 091 15 30 W |
| Southwood Oil Field | Oilfield | 112 | Adams | 31 27 41 N | 091 18 45 W |
| Southworths Ferry (historical) | Crossing | 30 | Leflore | 33 24 20 N | 090 15 54 W |
| Souva Lake | Lake | 51 | Tunica | 34 30 56 N | 090 15 21 W |
| Sovenlovie Church | Church | 106 | Clarke | 32 04 36 N | 088 51 02 W |
| Sovereign Grace Baptist Church | Church | 115 | Hinds | 32 20 26 N | 090 16 16 W |
| Sovereign Grace Church | Church | 74 | Lowndes | 33 27 41 N | 088 20 46 W |
| Sowashee Creek | Stream | | Lauderdale | 32 18 16 N | 088 45 04 W |
| Space Flight Plaza Shopping Center | Locale | 17 | Pearl River | 30 30 56 N | 089 40 51 W |
| Spade Fish Shoal | Bar | -3 | Harrison | 30 15 11 N | 089 01 52 W |
| Spains Lake | Lake | 38 | Marion | 31 05 44 N | 089 48 04 W |
| Spanish Bayou | Stream | | Adams | 31 31 09 N | 091 23 58 W |
| Spanish Fort | Populated Place | 29 | Sharkey | 32 45 34 N | 090 44 05 W |
| Spanish Fort Landing | Locale | 26 | Sharkey | 32 41 28 N | 090 42 10 W |
| Spanish Moss Bend | Bend | 29 | Washington | 33 23 30 N | 091 11 37 W |
| Spanish Oak Church | Church | 168 | Kemper | 32 43 52 N | 088 54 10 W |