Feature Name | Class | Elev. meters | County | Latitude DMS | Longitude DMS |
| Little Sandy Creek | Stream | | Lincoln | 39 03 11 N | 090 47 21 W |
| Little Sandy Creek | Stream | | Lincoln | 39 12 08 N | 091 05 25 W |
| Little Sandy Creek | Stream | | Putnam | 40 29 40 N | 092 49 24 W |
| Little School (historical) | School | 99 | Butler | 36 45 02 N | 090 13 37 W |
| Little School (historical) | School | 198 | Saline | 39 15 45 N | 093 18 51 W |
| Little Scotia Campground | Locale | 413 | Dent | 37 31 46 N | 091 19 49 W |
| Little Scotia Pond | Reservoir | 400 | Dent | 37 31 40 N | 091 19 51 W |
| Little Shaver Creek | Stream | | Pettis | 38 44 38 N | 093 05 28 W |
| Little Shawnee Creek | Stream | | Shannon | 37 10 21 N | 091 17 32 W |
| Little Shawnee School (historical) | School | 200 | Shannon | 37 09 25 N | 091 17 35 W |
| Little Shoal Baptist Church (historical) | Church | 302 | Clay | 39 16 28 N | 094 27 52 W |
| Little Shoal Cemetery | Cemetery | 306 | Clay | 39 16 25 N | 094 27 54 W |
| Little Shoal Creek | Stream | | Clay | 39 11 00 N | 094 27 11 W |
| Little Shoal Creek | Stream | | Clinton | 39 37 42 N | 094 17 01 W |
| Little Shoal Creek | Stream | | Crawford | 37 50 44 N | 091 07 57 W |
| Little Shoal Creek | Stream | | Putnam | 40 33 01 N | 092 50 28 W |
| Little Shoal School | School | 283 | Clay | 39 17 18 N | 094 27 54 W |
| Little Sinking Creek | Stream | | Shannon | 37 25 00 N | 091 18 19 W |
| Little Skull Lick Creek | Stream | | Audrain | 39 13 22 N | 091 56 12 W |
| Little Sleuter Hollow | Valley | | Ripley | 36 41 26 N | 091 01 07 W |
| Little Sni-A-Bar Creek | Stream | | Lafayette | 39 09 03 N | 093 56 55 W |
| Little Sni-A-Bar Watershed Structure Number 1 Dam | Dam | 239 | Lafayette | 39 04 06 N | 093 54 07 W |
| Little Sni-A-Bar Watershed Structure Number 1-S Dam | Dam | 239 | Lafayette | 39 04 06 N | 093 54 07 W |
| Little Sni-A-Bar Watershed Structure Number 21 Dam | Dam | 246 | Lafayette | 39 09 12 N | 093 54 55 W |
| Little Sni-A-Bar Watershed Structure Number 22 Dam | Dam | 232 | Lafayette | 39 09 06 N | 093 55 43 W |
| Little Sni-A-Bar Watershed Structure Number 23 Dam | Dam | 219 | Lafayette | 39 08 48 N | 093 56 31 W |
| Little Sni-A-Bar Watershed Structure Number 27 Dam | Dam | 227 | Lafayette | 39 07 24 N | 093 09 31 W |
| Little Sni-A-Bar Watershed Structure Number 28 Dam | Dam | 257 | Lafayette | 39 06 12 N | 093 52 49 W |
| Little Sni-A-Bar Watershed Structure Number 29 Dam | Dam | 226 | Lafayette | 39 06 18 N | 093 53 55 W |
| Little Sni-A-Bar Watershed Structure Number 30 Dam | Dam | 229 | Lafayette | 39 06 18 N | 093 54 31 W |
| Little Sni-A-Bar Watershed Structure Number 31 Dam | Dam | 230 | Lafayette | 39 06 42 N | 093 54 43 W |
| Little Sni-A-Bar Watershed Structure Number 33 Dam | Dam | 224 | Lafayette | 39 06 24 N | 093 56 55 W |
| Little Sni-A-Bar Watershed Structure Number 39 Dam | Dam | 241 | Lafayette | 39 04 00 N | 093 53 55 W |
| Little Sni-A-Bar Watershed Structure Number 4 Dam | Dam | 231 | Lafayette | 39 05 54 N | 093 54 01 W |
| Little Sni-A-Bar Watershed Structure Number 41 Dam | Dam | 253 | Lafayette | 39 03 12 N | 093 53 13 W |
| Little Sni-A-Bar Watershed Structure Number 42 Dam | Dam | 275 | Lafayette | 39 02 48 N | 093 57 13 W |
| Little Sni-A-Bar Watershed Structure Number 43 Dam | Dam | 271 | Lafayette | 39 01 42 N | 093 53 43 W |
| Little Sni-A-Bar Watershed Structure Number 44 Dam | Dam | 265 | Lafayette | 39 02 24 N | 093 57 19 W |
| Little Sni-A-Bar Watershed Structure Number 45 Dam | Dam | 277 | Lafayette | 39 01 00 N | 093 56 55 W |
| Little Sni-A-Bar Watershed Structure Number 47 Dam | Dam | 236 | Lafayette | 39 08 42 N | 093 54 25 W |
| Little Splice Creek | Stream | | Moniteau | 38 50 31 N | 092 26 58 W |
| Little Spring | Spring | 228 | Crawford | 37 59 24 N | 091 08 31 W |
| Little Spring Creek | Stream | | Franklin | 38 19 00 N | 091 10 38 W |
| Little Spring Creek | Stream | | Maries | 38 07 27 N | 091 51 15 W |
| Little Stag Island | Island | 133 | Lincoln | 39 05 04 N | 090 41 45 W |
| Little Stono Mountain | Summit | 442 | St. Francois | 37 44 32 N | 090 33 26 W |
| Little Stony Knob | Summit | 382 | Ozark | 36 39 46 N | 092 26 25 W |
| Little Sugar Camp Hollow | Valley | | Washington | 38 06 22 N | 090 58 04 W |
| Little Sugar Creek | Stream | | Buchanan | 39 33 06 N | 094 59 55 W |
| Little Sugar Creek | Stream | | Lewis | 40 09 20 N | 091 38 09 W |
| Little Sugar Creek | Stream | | Lincoln | 38 59 46 N | 090 55 56 W |
| Little Sugar Creek | Stream | | McDonald | 36 35 18 N | 094 22 58 W |
| Little Tabo Creek | Stream | | Lafayette | 39 10 11 N | 093 44 19 W |
| Little Tarkio Creek | Stream | | Holt | 40 00 07 N | 095 14 44 W |
| Little Taum Sauk Creek | Stream | | Iron | 37 30 29 N | 090 48 46 W |
| Little Tavern Creek | Stream | | Callaway | 38 42 32 N | 091 40 37 W |
| Little Tavern Creek | Stream | | Cole | 38 19 51 N | 092 18 28 W |
| Little Tavern Creek | Stream | | Franklin | 38 34 55 N | 090 46 32 W |
| Little Tavern Creek | Stream | | Miller | 38 04 38 N | 092 15 22 W |
| Little Tavern Creek | Stream | | Miller | 38 16 35 N | 092 14 01 W |
| Little Tebo Creek | Stream | | Benton | 38 17 03 N | 093 24 12 W |
| Little Tebo Creek | Stream | | Henry | 38 30 48 N | 093 40 32 W |
| Little Tebo Creek State Wildlife Management Area | Park | 242 | Benton | 38 19 51 N | 093 24 21 W |
| Little Third Creek | Stream | | Osage | 38 24 55 N | 091 39 37 W |
| Little Third Fork | Stream | | Buchanan | 39 46 15 N | 094 38 06 W |
| Little Thorny Hollow | Valley | | Shannon | 37 10 30 N | 091 14 25 W |
| Little Thorny Mountain | Summit | 324 | Carter | 37 04 35 N | 091 09 19 W |
| Little Troublesome Creek | Stream | | Lewis | 40 06 00 N | 091 55 55 W |
| Little Turkey Creek | Stream | | Benton | 38 13 20 N | 093 16 56 W |
| Little Turkey Creek | Stream | | Cedar | 37 49 23 N | 093 46 40 W |
| Little Turkey Creek | Stream | | Linn | 39 43 46 N | 093 09 35 W |
| Little Turkey Creek | Stream | | Macon | 39 52 30 N | 092 41 21 W |
| Little Union | Populated Place | 203 | Marion | 39 49 51 N | 091 39 16 W |
| Little Union Church | Church | 201 | Marion | 39 49 52 N | 091 39 42 W |
| Little Union Church | Church | 253 | Ray | 39 29 50 N | 093 51 58 W |
| Little Union Churchyard | Cemetery | 202 | Marion | 39 49 54 N | 091 39 42 W |
| Little Union School (historical) | School | 202 | Marion | 39 49 50 N | 091 39 45 W |
| Little Union School (historical) | School | 277 | Ray | 39 30 13 N | 093 53 19 W |
| Little Valley Church | Church | 120 | Bollinger | 37 12 10 N | 089 58 40 W |
| Little Valley Hollow | Valley | | Benton | 38 15 03 N | 093 15 27 W |
| Little Vine Church | Church | 96 | Butler | 36 41 20 N | 090 13 42 W |
| Little Vine Church | Church | 251 | Madison | 37 30 40 N | 090 23 52 W |
| Little Vine Church | Church | 92 | New Madrid | 36 48 12 N | 089 31 11 W |
| Little Vine Church | Church | 361 | Reynolds | 37 28 33 N | 091 11 55 W |
| Little Vine Church | Church | 299 | Ste. Genevieve | 37 53 18 N | 090 20 08 W |
| Little Vine Church | Church | 410 | Wright | 37 24 28 N | 092 38 60 W |
| Little Vine Church (historical) | Church | 179 | Bollinger | 37 12 59 N | 090 09 08 W |
| Little Vine Hill | Summit | 298 | Ste. Genevieve | 37 53 23 N | 090 20 04 W |
| Little Vine School | School | 181 | Bollinger | 37 13 05 N | 090 09 16 W |
| Little Vine School | School | 249 | Madison | 37 30 41 N | 090 23 53 W |
| Little Vine School | School | 108 | Stoddard | 37 04 47 N | 089 55 07 W |
| Little Vine School (historical) | School | 273 | Ste. Genevieve | 37 53 07 N | 090 20 07 W |
| Little Wakenda Creek | Stream | | Carroll | 39 19 40 N | 093 24 27 W |
| Little Walnut Creek | Stream | | Adair | 40 02 56 N | 092 44 09 W |
| Little Walnut Creek | Stream | | Johnson | 38 36 11 N | 094 03 28 W |
| Little Walnut Creek | Stream | | Johnson | 38 51 25 N | 093 33 49 W |
| Little Walnut Creek | Stream | | Macon | 40 00 46 N | 092 42 60 W |
| Little Walnut School (historical) | School | 83 | New Madrid | 36 29 42 N | 089 54 55 W |
| Little Walnut School (historical) | School | 82 | New Madrid | 36 28 01 N | 089 54 51 W |
| Little Weaubleau Creek | Stream | | St. Clair | 37 55 59 N | 093 31 29 W |
| Little West Locust Creek | Stream | | Putnam | 40 23 03 N | 093 16 35 W |
| Little Wet Hollow | Valley | | Franklin | 38 14 22 N | 091 03 48 W |
| Little White Church | Church | 332 | Stone | 36 57 22 N | 093 23 60 W |
| Little Whitewater Church | Church | 174 | Bollinger | 37 27 15 N | 089 57 03 W |
| Little Whitewater Creek | Stream | | Cape Girardeau | 37 24 06 N | 089 48 48 W |
| Little Wilson Creek | Stream | | Polk | 37 28 36 N | 093 13 59 W |
| Little Wolf Creek | Stream | | Montgomery | 39 01 17 N | 091 24 22 W |
| Little Wolfpen Hollow | Valley | | Stone | 36 36 55 N | 093 29 35 W |
| Little Wyaconda River | Stream | | Clark | 40 17 16 N | 091 41 18 W |
| Little Yoeman | Summit | 378 | Douglas | 36 56 02 N | 092 08 30 W |