Feature Name | Class | Elev. meters | County | Latitude DMS | Longitude DMS |
| Sewell Creek | Stream | | Pulaski | 37 56 24 N | 092 11 53 W |
| Sewell Ford | Populated Place | 238 | Gasconade | 38 11 19 N | 091 33 51 W |
| Sewell School (historical) | School | 107 | Ripley | 36 34 42 N | 090 39 20 W |
| Sewer Branch | Stream | | Pettis | 38 46 54 N | 093 14 17 W |
| Sewer Creek | Stream | | Macon | 39 45 09 N | 092 24 48 W |
| Sexton Lake | Reservoir | 246 | Johnson | 38 39 30 N | 093 37 07 W |
| Sexton Lake Dam | Dam | 246 | Johnson | 38 39 30 N | 093 37 07 W |
| Seyb Lake Dam | Dam | 197 | Clark | 40 27 06 N | 091 47 43 W |
| Seybert | Populated Place | 265 | Dade | 37 31 07 N | 093 46 26 W |
| Seyer Lake | Reservoir | 145 | Franklin | 38 26 12 N | 090 46 06 W |
| Seymour | Populated Place | 501 | Webster | 37 08 47 N | 092 46 08 W |
| Seymour Branch Hazel Creek | Stream | | Washington | 37 49 30 N | 090 57 35 W |
| Seymour State Wildlife Management Area | Park | 531 | Webster | 37 13 44 N | 092 44 29 W |
| Shackelford Branch | Stream | | Ray | 39 15 58 N | 094 12 16 W |
| Shackleford | Populated Place | 242 | Saline | 39 06 45 N | 093 17 49 W |
| Shackleford Cemetery | Cemetery | 248 | Cooper | 38 41 20 N | 092 59 19 W |
| Shackleford Crossing | Populated Place | 180 | Cooper | 38 53 31 N | 093 02 01 W |
| Shackleford School (historical) | School | 237 | Cooper | 38 54 06 N | 093 02 36 W |
| Shacklett Cemetery | Cemetery | 225 | Scotland | 40 23 18 N | 092 00 46 W |
| Shad Hollow | Valley | | Douglas | 36 56 05 N | 092 10 11 W |
| Shade | Populated Place | 81 | Pemiscot | 36 10 32 N | 089 46 00 W |
| Shadle Cemetery | Cemetery | 135 | Butler | 36 45 55 N | 090 26 57 W |
| Shadow Lake | Reservoir | 175 | Bollinger | 37 32 12 N | 089 58 06 W |
| Shadow Lake | Reservoir | 244 | McDonald | 36 33 11 N | 094 29 49 W |
| Shadow Lake Dam | Dam | 175 | Bollinger | 37 32 12 N | 089 58 06 W |
| Shadow Lake Dam | Dam | 213 | Cole | 38 33 18 N | 092 14 19 W |
| Shadow Rock | Cliff | 261 | Taney | 36 41 20 N | 093 05 44 W |
| Shadow Rock Public Use Area | Park | 212 | Taney | 36 41 05 N | 093 06 06 W |
| Shadow Valley Lake | Reservoir | 187 | Callaway | 38 36 00 N | 092 02 19 W |
| Shadow Valley Lake Dam | Dam | 187 | Callaway | 38 36 00 N | 092 02 19 W |
| Shadrack Bluff | Cliff | 258 | Laclede | 37 50 33 N | 092 50 23 W |
| Shady Acres Golf Course | Locale | 378 | Greene | 37 06 15 N | 093 16 42 W |
| Shady Church | Church | 427 | Wright | 37 22 40 N | 092 34 59 W |
| Shady Creek | Stream | | Pike | 39 15 13 N | 091 20 40 W |
| Shady Dell | Populated Place | 110 | Butler | 36 46 04 N | 090 26 31 W |
| Shady Dell | Populated Place | 94 | Stoddard | 36 57 50 N | 089 49 21 W |
| Shady Dell Church | Church | 107 | Wayne | 37 03 22 N | 090 08 32 W |
| Shady Dell School | School | 424 | Greene | 37 13 30 N | 093 14 20 W |
| Shady Dell School (historical) | School | 263 | Bates | 38 17 20 N | 094 20 56 W |
| Shady Dell School (historical) | School | 254 | Harrison | 40 09 28 N | 094 11 55 W |
| Shady Eighty Ranch Lake | Reservoir | 204 | Lincoln | 39 04 36 N | 090 56 06 W |
| Shady Eighty Ranch Lake Dam | Dam | 204 | Lincoln | 39 04 36 N | 090 56 06 W |
| Shady Grove | Populated Place | 415 | Christian | 36 58 29 N | 093 08 09 W |
| Shady Grove | Populated Place | 381 | Dallas | 37 30 34 N | 092 52 48 W |
| Shady Grove | Populated Place | 308 | Pulaski | 37 51 31 N | 092 16 41 W |
| Shady Grove Cemetery | Cemetery | 127 | Cape Girardeau | 37 15 53 N | 089 37 33 W |
| Shady Grove Cemetery | Cemetery | 262 | Clay | 39 21 38 N | 094 18 02 W |
| Shady Grove Cemetery | Cemetery | 287 | Polk | 37 34 25 N | 093 35 41 W |
| Shady Grove Cemetery | Cemetery | 295 | Polk | 37 46 25 N | 093 34 30 W |
| Shady Grove Church | Church | 259 | Benton | 38 17 46 N | 093 29 47 W |
| Shady Grove Church | Church | 289 | Benton | 38 09 09 N | 093 05 34 W |
| Shady Grove Church | Church | 411 | Christian | 36 58 24 N | 093 08 07 W |
| Shady Grove Church | Church | 75 | Dunklin | 36 01 49 N | 089 58 19 W |
| Shady Grove Church | Church | 77 | Dunklin | 36 10 20 N | 090 04 35 W |
| Shady Grove Church | Church | 293 | Harrison | 40 16 24 N | 094 07 18 W |
| Shady Grove Church | Church | 281 | Howell | 36 31 25 N | 092 05 34 W |
| Shady Grove Church | Church | 274 | St. Clair | 38 07 12 N | 093 35 21 W |
| Shady Grove Church | Church | 401 | Webster | 37 26 35 N | 092 59 23 W |
| Shady Grove Church (historical) | Church | 262 | Clay | 39 21 38 N | 094 18 02 W |
| Shady Grove Church (historical) | Church | 238 | Madison | 37 32 42 N | 090 15 27 W |
| Shady Grove Church (historical) | Church | 213 | Shannon | 36 53 22 N | 091 18 54 W |
| Shady Grove Church (historical) | Church | 253 | St. Clair | 38 05 11 N | 093 51 42 W |
| Shady Grove Church and School (historical) | Locale | 78 | Dunklin | 36 10 22 N | 090 04 41 W |
| Shady Grove Creek | Stream | | St. Louis | 38 36 18 N | 090 21 07 W |
| Shady Grove Mill (historical) | Locale | 296 | Polk | 37 34 25 N | 093 36 02 W |
| Shady Grove Ridge | Ridge | 404 | Christian | 36 56 39 N | 093 07 54 W |
| Shady Grove School | School | 252 | Callaway | 38 46 40 N | 092 03 46 W |
| Shady Grove School | School | 276 | Daviess | 40 07 23 N | 094 00 55 W |
| Shady Grove School | School | 361 | Douglas | 37 02 11 N | 092 12 52 W |
| Shady Grove School | School | 254 | Henry | 38 19 57 N | 093 34 26 W |
| Shady Grove School | School | 256 | Howell | 36 31 00 N | 092 05 35 W |
| Shady Grove School | School | 236 | Madison | 37 32 36 N | 090 15 18 W |
| Shady Grove School | School | 103 | Scott | 36 58 58 N | 089 37 05 W |
| Shady Grove School | School | 249 | St. Clair | 37 58 58 N | 093 46 13 W |
| Shady Grove School | School | 388 | Texas | 37 10 49 N | 092 04 14 W |
| Shady Grove School (historical) | Locale | 465 | Barry | 36 43 41 N | 093 53 24 W |
| Shady Grove School (historical) | School | 411 | Barry | 36 54 55 N | 093 57 49 W |
| Shady Grove School (historical) | School | 294 | Barton | 37 32 39 N | 094 15 35 W |
| Shady Grove School (historical) | School | 131 | Cape Girardeau | 37 15 51 N | 089 37 32 W |
| Shady Grove School (historical) | School | 409 | Christian | 36 58 20 N | 093 08 08 W |
| Shady Grove School (historical) | School | 305 | Dade | 37 23 41 N | 093 46 48 W |
| Shady Grove School (historical) | School | 392 | Dallas | 37 30 19 N | 092 52 50 W |
| Shady Grove School (historical) | School | 319 | Hickory | 37 51 01 N | 093 29 22 W |
| Shady Grove School (historical) | School | 354 | Howell | 36 58 45 N | 091 44 29 W |
| Shady Grove School (historical) | School | 279 | McDonald | 36 37 21 N | 094 17 38 W |
| Shady Grove School (historical) | School | 282 | Polk | 37 34 21 N | 093 35 45 W |
| Shady Grove School (historical) | School | 229 | St. Clair | 38 07 49 N | 093 36 59 W |
| Shady Grove School (historical) | School | 404 | Webster | 37 26 32 N | 092 59 24 W |
| Shady Hill School | School | 295 | Cedar | 37 48 38 N | 093 42 49 W |
| Shady Hollow Dams Dam | Dam | 308 | Clay | 39 31 54 N | 094 26 19 W |
| Shady Hollow Lakes | Reservoir | 264 | Clay | 39 26 12 N | 094 31 60 W |
| Shady Hollow Lakes | Reservoir | 308 | Clay | 39 31 54 N | 094 26 19 W |
| Shady Lake | Reservoir | 215 | Boone | 38 58 24 N | 092 18 55 W |
| Shady Lake | Reservoir | 263 | Jackson | 38 59 35 N | 094 26 35 W |
| Shady Lake Dam | Dam | 215 | Boone | 38 58 24 N | 092 18 55 W |
| Shady Lake Dam | Dam | 263 | Jackson | 38 59 35 N | 094 26 35 W |
| Shady Nook Church | Church | 150 | Wayne | 37 04 08 N | 090 44 55 W |
| Shady Nook School | School | 266 | St. Clair | 37 55 55 N | 093 38 46 W |
| Shady Nook School (historical) | School | 149 | Wayne | 37 04 08 N | 090 44 54 W |
| Shady Oaks Lake | Reservoir | 227 | Randolph | 39 13 42 N | 092 32 07 W |
| Shady Oaks Lake Dam | Dam | 227 | Randolph | 39 13 42 N | 092 32 07 W |
| Shady Rest | Locale | 231 | Pulaski | 37 55 07 N | 092 08 19 W |
| Shafer Cemetery | Cemetery | 360 | Texas | 37 33 32 N | 091 52 55 W |
| Shafer Hollow | Valley | | Madison | 37 21 42 N | 090 25 19 W |
| Shafer Slough | Gut | 136 | Pike | 39 19 10 N | 090 50 21 W |
| Shaffer Cemetery | Cemetery | 208 | Clark | 40 31 51 N | 091 44 44 W |
| Shaffer Creek | Stream | | Clark | 40 16 54 N | 091 54 05 W |
| Shaffer Lake Dam | Dam | 215 | Clark | 40 36 24 N | 091 37 55 W |
| Shaffer School (historical) | School | 362 | Lawrence | 37 12 23 N | 093 58 43 W |
| Shafter | Populated Place | 249 | Linn | 39 59 02 N | 093 17 06 W |