Feature Name | Class | Elev. meters | County | Latitude DMS | Longitude DMS |
| South Fork Weaubleau Creek | Stream | | St. Clair | 37 57 05 N | 093 36 25 W |
| South Fork Webb Creek | Stream | | Reynolds | 37 06 45 N | 090 52 52 W |
| South Fork Wright Creek | Stream | | St. Clair | 38 07 47 N | 093 34 03 W |
| South Fritz Island | Island | 139 | Pike | 39 31 04 N | 091 04 47 W |
| South Gabouri Creek | Stream | | Ste. Genevieve | 37 58 49 N | 090 02 14 W |
| South Gale School (historical) | Locale | 287 | Platte | 39 22 07 N | 094 37 50 W |
| South Grand River | Stream | | Benton | 38 16 35 N | 093 24 42 W |
| South Greenfield | Populated Place | 294 | Dade | 37 22 34 N | 093 50 28 W |
| South Grove School | School | 239 | Saline | 39 03 00 N | 093 20 59 W |
| South Guffy Creek | Stream | | Douglas | 36 51 21 N | 092 53 57 W |
| South Hollow | Valley | | Shannon | 37 04 40 N | 091 18 59 W |
| South Horn Branch | Stream | | Pike | 39 29 56 N | 091 13 24 W |
| South Indian Creek | Stream | | Newton | 36 47 41 N | 094 13 51 W |
| South Jacktar Hollow | Valley | | Texas | 37 28 14 N | 091 59 55 W |
| South Junction | Locale | 413 | Greene | 37 11 35 N | 093 15 17 W |
| South Junior High School | School | 321 | Jasper | 37 04 01 N | 094 31 02 W |
| South Koffer Hollow | Valley | | Crawford | 37 56 58 N | 091 07 48 W |
| South Lake | Lake | 218 | Daviess | 39 50 36 N | 093 48 20 W |
| South Lake | Reservoir | 200 | Chariton | 39 35 39 N | 093 12 54 W |
| South Lake | Reservoir | 234 | Johnson | 38 49 12 N | 093 44 07 W |
| South Lake Dam | Dam | 234 | Johnson | 38 49 12 N | 093 44 07 W |
| South Lakeview Plaza | Locale | 176 | St. Louis | 38 30 01 N | 090 19 57 W |
| South Lee | Populated Place | 307 | Jackson | 38 53 20 N | 094 22 41 W |
| South Levee | Dam | 260 | Holt | 40 03 06 N | 095 15 01 W |
| South Liberty | Populated Place | 223 | Clay | 39 12 04 N | 094 23 21 W |
| South Liberty School (historical) | School | 245 | Audrain | 39 04 26 N | 091 43 24 W |
| South Liberty School (historical) | School | 218 | Scotland | 40 21 48 N | 092 05 58 W |
| South Lineville | Populated Place | 333 | Mercer | 40 34 44 N | 093 31 26 W |
| South Lineville Cemetery | Cemetery | 323 | Mercer | 40 34 46 N | 093 31 05 W |
| South Linn Creek | Stream | | Clark | 40 28 41 N | 091 49 45 W |
| South Master School (historical) | School | 94 | Stoddard | 36 57 43 N | 089 45 04 W |
| South Moreau Creek | Stream | | Cole | 38 30 00 N | 092 18 27 W |
| South Moreland Park | Park | 263 | Jackson | 39 02 33 N | 094 34 49 W |
| South Mount Pleasant School (historical) | School | 230 | Scotland | 40 19 04 N | 092 03 37 W |
| South Mount Vernon School (historical) | School | 264 | Moniteau | 38 38 15 N | 092 37 43 W |
| South Mud Creek | Stream | | Ray | 39 29 36 N | 093 51 09 W |
| South New Home Cemetery | Cemetery | 300 | Hickory | 38 03 19 N | 093 16 50 W |
| South Newhall School | School | 256 | Chariton | 39 34 14 N | 093 01 54 W |
| South Oakland School (historical) | School | 291 | Grundy | 40 00 52 N | 093 44 40 W |
| South Ozark School (historical) | School | 402 | Dent | 37 31 57 N | 091 30 34 W |
| South Park | Park | 221 | Ralls | 39 39 01 N | 091 43 53 W |
| South Park | Park | 501 | Webster | 37 08 23 N | 092 45 57 W |
| South Park (historical) | Locale | 297 | Buchanan | 39 44 50 N | 094 47 26 W |
| South Park School | School | 265 | Randolph | 39 24 40 N | 092 26 29 W |
| South Pine School (historical) | School | 298 | Harrison | 40 18 34 N | 094 00 43 W |
| South Piney Creek | Stream | | Barry | 36 40 48 N | 093 33 58 W |
| South Platte Church | Church | 300 | Platte | 39 13 41 N | 094 44 03 W |
| South Pocket Hollow | Valley | | Ozark | 36 33 25 N | 092 31 59 W |
| South Point (historical) | Populated Place | 164 | Franklin | 38 32 38 N | 090 58 43 W |
| South Point Cemetery | Cemetery | 237 | Ray | 39 13 24 N | 094 05 53 W |
| South Point Church (historical) | Church | 224 | Ray | 39 13 14 N | 094 05 53 W |
| South Point Elementary School | School | 149 | St. Charles | 38 32 31 N | 090 58 49 W |
| South Pool | Reservoir | 201 | Chariton | 39 36 48 N | 093 12 49 W |
| South Prairie Lee Park | Park | 279 | Jackson | 38 56 03 N | 094 19 46 W |
| South Prong Beaverdam Creek | Stream | | Ripley | 36 45 53 N | 090 39 07 W |
| South Prong Beaverdam Creek | Stream | | Ripley | 36 45 52 N | 090 39 07 W |
| South Prong Cedar Bluff Creek | Stream | | Carter | 36 50 22 N | 091 07 56 W |
| South Prong Crooked River | Stream | | Caldwell | 39 32 32 N | 094 10 06 W |
| South Prong Jacks Fork | Stream | | Texas | 37 04 34 N | 091 43 57 W |
| South Prong Leatherwood Creek | Stream | | Shannon | 37 06 04 N | 091 34 42 W |
| South Prong Little Black River | Stream | | Ripley | 36 44 48 N | 090 44 15 W |
| South Prong Sons Creek | Stream | | Dade | 37 27 19 N | 093 55 15 W |
| South Richland School | School | 90 | Stoddard | 36 47 56 N | 089 48 30 W |
| South Ridge Country Club (historical) | Locale | 304 | Jackson | 38 55 34 N | 094 32 17 W |
| South River | Populated Place | 145 | Marion | 39 49 57 N | 091 26 53 W |
| South River | Stream | | Marion | 39 51 06 N | 091 26 32 W |
| South River Bridge | Bridge | 164 | Marion | 39 45 26 N | 091 31 08 W |
| South River Levee | Levee | 145 | Marion | 39 49 25 N | 091 26 60 W |
| South Rock Branch | Stream | | Crawford | 37 45 07 N | 091 11 10 W |
| South School | School | 233 | Audrain | 39 18 11 N | 091 29 03 W |
| South School | School | 199 | Cole | 38 34 09 N | 092 11 12 W |
| South School | School | 253 | Morgan | 38 16 55 N | 092 49 34 W |
| South School | School | 82 | Pemiscot | 36 14 01 N | 089 45 00 W |
| South School | School | 99 | Scott | 36 52 28 N | 089 35 31 W |
| South Sebago School (historical) | School | 252 | Linn | 39 56 18 N | 093 19 51 W |
| South Shady Bend School | School | 372 | Dent | 37 26 02 N | 091 25 38 W |
| South Shore | Populated Place | 128 | St. Charles | 38 51 55 N | 090 31 23 W |
| South Side Cemetery | Cemetery | 232 | Osage | 38 18 18 N | 092 09 21 W |
| South Side School (historical) | School | 297 | Pettis | 38 33 50 N | 093 15 39 W |
| South Slash (historical) | Lake | 223 | Vernon | 38 02 17 N | 094 15 11 W |
| South Spencer Creek | Stream | | Pike | 39 29 26 N | 091 24 53 W |
| South Spring Creek | Stream | | Douglas | 36 51 42 N | 092 44 06 W |
| South Spring Hollow | Valley | | St. Francois | 37 43 47 N | 090 34 27 W |
| South Stone County Fire Station Number Two | Building | 405 | Stone | 36 39 33 N | 093 25 06 W |
| South Sugar Creek | Stream | | Buchanan | 39 32 33 N | 094 57 04 W |
| South Sycamore School (historical) | School | 359 | Lawrence | 37 14 25 N | 093 47 30 W |
| South Telegraph Church | Church | 170 | St. Louis | 38 28 33 N | 090 18 14 W |
| South Trails Shopping Center | Locale | 250 | Audrain | 39 08 48 N | 091 53 31 W |
| South Troy | Populated Place | 191 | Lincoln | 38 57 26 N | 090 59 40 W |
| South Upton School (historical) | School | 214 | Scotland | 40 36 12 N | 092 01 58 W |
| South Van Buren | Populated Place | 149 | Carter | 36 59 17 N | 091 00 49 W |
| South Victory School | School | 241 | Caldwell | 39 32 48 N | 093 48 51 W |
| South View School | School | 406 | Dallas | 37 32 03 N | 092 51 38 W |
| South Ward School | School | 233 | Macon | 39 50 02 N | 092 40 34 W |
| South Ward School | School | 322 | Polk | 37 36 35 N | 093 24 32 W |
| South West City | Populated Place | 286 | McDonald | 36 30 45 N | 094 36 41 W |
| South West City Cemetery | Cemetery | 290 | McDonald | 36 31 37 N | 094 36 56 W |
| South White Oak School | School | 105 | Stoddard | 36 39 08 N | 090 03 23 W |
| South Wyaconda River | Stream | | Clark | 40 24 17 N | 091 51 42 W |
| South York School | School | 332 | Atchison | 40 22 42 N | 095 16 25 W |
| Southard | Populated Place | 358 | Laclede | 37 32 21 N | 092 20 16 W |
| Southard Cemetery | Cemetery | 334 | Maries | 38 04 02 N | 091 42 42 W |
| Southeast High School | School | 290 | Jackson | 39 00 31 N | 094 32 45 W |
| Southeast Junior High School | School | 289 | Jackson | 39 00 33 N | 094 32 35 W |
| Southeast Lowlands | Area | 103 | Bollinger | 37 15 01 N | 089 37 31 W |
| Southeast Missouri Hospital Heliport | Airport | 137 | Cape Girardeau | 37 18 39 N | 089 32 25 W |
| Southeast Missouri Planning Region | Area | 212 | Bollinger | 38 00 01 N | 090 37 31 W |
| Southeast Missouri State University | School | 157 | Cape Girardeau | 37 18 45 N | 089 31 51 W |
| Southeast Park School | School | 265 | Randolph | 39 24 46 N | 092 25 41 W |
| Southeast School | School | 260 | Johnson | 38 45 25 N | 093 43 58 W |