Feature Name | Class | Elev. meters | County | Latitude DMS | Longitude DMS |
| Southeast School | School | 283 | Platte | 39 11 55 N | 094 37 59 W |
| Southeast School | School | 230 | Saline | 39 06 45 N | 093 11 37 W |
| Southeastern Ozarks | Area | 222 | Bollinger | 37 30 01 N | 090 07 31 W |
| Southeastern Ridge and Basin | Area | 90 | Dunklin | 36 30 01 N | 090 37 31 W |
| Southerland Cemetery | Cemetery | 236 | Linn | 39 58 48 N | 093 09 45 W |
| Southern Heights Church | Church | 396 | Laclede | 37 39 19 N | 092 38 55 W |
| Southern Hills Church | Church | 300 | Howell | 36 41 44 N | 091 48 46 W |
| Southern Hills Shopping Center | Locale | 408 | Greene | 37 11 05 N | 093 15 41 W |
| Southern Hills Shopping Center | Locale | 295 | Howell | 36 43 52 N | 091 51 10 W |
| Southern School | School | 280 | Jackson | 39 02 30 N | 094 24 09 W |
| Southgate Shopping Center | Locale | 396 | Greene | 37 09 34 N | 093 17 43 W |
| Southhampton | Populated Place | 145 | St. Louis (city) | 38 35 36 N | 090 17 43 W |
| Southmoor Golf Course | Locale | 168 | St. Louis | 38 29 09 N | 090 23 17 W |
| Southridge Shopping Center | Locale | 252 | Cole | 38 33 13 N | 092 12 03 W |
| Southside Cemetery | Cemetery | 228 | Callaway | 38 50 33 N | 091 56 44 W |
| Southside Church | Church | 312 | Camden | 37 59 37 N | 092 43 06 W |
| Southside Church | Church | 173 | St. Louis | 38 29 22 N | 090 21 17 W |
| Southside School | School | 82 | Pemiscot | 36 10 50 N | 089 39 47 W |
| Southview Church | Church | 293 | Jackson | 38 58 33 N | 094 27 01 W |
| Southwest Baptist University | School | 331 | Polk | 37 36 29 N | 093 24 47 W |
| Southwest Cemetery | Cemetery | 227 | Osage | 38 34 09 N | 091 39 24 W |
| Southwest Church (historical) | Church | 226 | Osage | 38 34 07 N | 091 39 22 W |
| Southwest City Structure E-1 Dam | Dam | 298 | McDonald | 36 30 30 N | 094 37 01 W |
| Southwest Dam Number 1 | Dam | 228 | Cooper | 38 57 00 N | 092 45 01 W |
| Southwest High School | School | 292 | Jackson | 39 00 34 N | 094 35 37 W |
| Southwest High School | School | 167 | St. Louis (city) | 38 36 16 N | 090 16 15 W |
| Southwest Missouri State University | School | 403 | Greene | 37 11 54 N | 093 16 43 W |
| Southwest Missouri State University | School | 304 | Howell | 36 43 44 N | 091 51 39 W |
| Southwest Plaza | Locale | 171 | Cole | 38 34 46 N | 092 11 58 W |
| Southwest Research Center Dam | Dam | 401 | Lawrence | 37 04 42 N | 093 46 31 W |
| Southwest Research Center Lake | Reservoir | 401 | Lawrence | 37 04 42 N | 093 46 31 W |
| Southwest School | School | 190 | Cole | 38 34 48 N | 092 11 15 W |
| Southwest School | School | 290 | Jackson | 39 05 03 N | 094 25 60 W |
| Southwest School | School | 124 | Stoddard | 36 47 16 N | 089 58 20 W |
| Southwest School (historical) | School | 286 | Barton | 37 22 43 N | 094 35 38 W |
| Southwick Branch | Stream | | St. Clair | 37 55 18 N | 093 39 26 W |
| Southwood School | School | 287 | Jackson | 38 58 36 N | 094 27 51 W |
| Sow Coon Mountain | Summit | 403 | Stone | 36 38 43 N | 093 22 55 W |
| Sowers Cemetery | Cemetery | 223 | Cooper | 38 49 59 N | 093 01 54 W |
| Spain Lake | Reservoir | 348 | Dade | 37 20 00 N | 093 56 13 W |
| Spain Lake Dam | Dam | 348 | Dade | 37 20 00 N | 093 56 13 W |
| Spain School (historical) | School | 191 | Ripley | 36 30 50 N | 091 02 57 W |
| Spalding | Populated Place | 162 | Ralls | 39 37 07 N | 091 31 36 W |
| Spangler Hill | Summit | 293 | St. Clair | 37 55 00 N | 093 47 53 W |
| Spangler Hollow | Valley | | Morgan | 38 19 30 N | 092 58 49 W |
| Spanish Fort | Summit | 369 | Lawrence | 37 03 23 N | 093 49 59 W |
| Spanish Fort Cemetery | Cemetery | 370 | Lawrence | 37 03 15 N | 093 49 53 W |
| Spanish Lake | Lake | 148 | St. Louis | 38 47 50 N | 090 12 12 W |
| Spanish Lake | Populated Place | 165 | St. Louis | 38 47 16 N | 090 12 57 W |
| Spanish Needles School | School | 212 | Howard | 39 06 16 N | 092 42 56 W |
| Spargo Branch | Stream | | Texas | 37 07 05 N | 091 48 15 W |
| Spark Spring | Spring | 257 | Howell | 36 31 29 N | 092 06 29 W |
| Sparkle Brook School | School | 372 | Webster | 37 25 08 N | 092 53 29 W |
| Sparkling Hollow | Valley | | Douglas | 36 59 42 N | 092 05 42 W |
| Sparkman Cemetery | Cemetery | 116 | Butler | 36 48 23 N | 090 31 32 W |
| Sparkman Hollow | Valley | | Barry | 36 34 40 N | 093 55 47 W |
| Sparks Cemetery | Cemetery | 375 | Barry | 36 45 49 N | 093 48 54 W |
| Sparks Cemetery | Cemetery | 250 | Franklin | 38 13 49 N | 090 50 15 W |
| Sparks Cemetery | Cemetery | 164 | Wayne | 37 11 55 N | 090 37 05 W |
| Sparks School (historical) | School | 360 | Barry | 36 46 25 N | 093 48 45 W |
| Sparks Spring | Spring | 392 | Wright | 37 11 35 N | 092 26 14 W |
| Sparlin Lake Section 3 Dam | Dam | 420 | Wright | 37 09 00 N | 092 40 31 W |
| Sparlin Lake Section 35 Dam | Dam | 421 | Wright | 37 09 18 N | 092 39 43 W |
| Sparling Cemetery | Cemetery | 285 | Newton | 36 52 40 N | 094 33 31 W |
| Sparrow | Populated Place | 232 | Henry | 38 20 12 N | 093 42 55 W |
| Sparrow Creek | Stream | | Henry | 38 22 13 N | 093 35 13 W |
| Sparrow Foot Creek | Stream | | Henry | 38 18 19 N | 093 43 34 W |
| Sparrow Lake Dam | Dam | 210 | Marion | 39 56 54 N | 091 50 07 W |
| Sparrow Post Office (historical) | Post Office | 232 | Henry | 38 20 12 N | 093 42 55 W |
| Sparrowfoot Public Use Area | Park | 219 | Henry | 38 17 47 N | 093 43 36 W |
| Sparta | Populated Place | 348 | Buchanan | 39 39 01 N | 094 49 59 W |
| Sparta | Populated Place | 428 | Christian | 37 00 04 N | 093 04 54 W |
| Sparta Cemetery | Cemetery | 419 | Christian | 37 00 08 N | 093 05 40 W |
| Sparta Church | Church | 348 | Buchanan | 39 39 08 N | 094 50 04 W |
| Sparta School (historical) | School | 342 | Buchanan | 39 38 28 N | 094 49 58 W |
| Spatterdock Lake | Lake | 126 | St. Charles | 38 53 53 N | 090 14 20 W |
| Spaugh Pond | Lake | 202 | Wayne | 37 06 54 N | 090 18 17 W |
| Spaulding Cemetery | Cemetery | 314 | Pulaski | 37 51 24 N | 092 05 46 W |
| Speak Cemetery | Cemetery | 276 | Putnam | 40 29 48 N | 092 44 16 W |
| Spear School (historical) | School | 81 | Pemiscot | 36 11 37 N | 089 47 23 W |
| Spearman School | School | 269 | Miller | 38 04 56 N | 092 22 24 W |
| Spears Branch | Stream | | Sullivan | 40 20 11 N | 092 57 03 W |
| Spears Cemetery | Cemetery | 268 | Grundy | 40 13 08 N | 093 35 43 W |
| Spears Graveyard | Cemetery | 367 | Howell | 36 39 47 N | 091 55 08 W |
| Speckhart Lake | Reservoir | 197 | Marion | 39 55 30 N | 091 44 31 W |
| Spectra Site Communication Tower | Tower | 241 | Franklin | 38 28 08 N | 090 55 26 W |
| Spectrasite Communication Tower - Number MO-0051 | Tower | 245 | Franklin | 38 27 11 N | 091 04 31 W |
| Spectrasite Communication Tower Number MO-0165 | Tower | 200 | Franklin | 38 27 40 N | 091 00 54 W |
| Speed | Populated Place | 204 | Cooper | 38 50 53 N | 092 48 12 W |
| Speedwell Church | Church | 234 | St. Clair | 37 55 44 N | 093 57 56 W |
| Speer Cemetery | Cemetery | 167 | Bollinger | 37 10 09 N | 090 03 18 W |
| Speer Cemetery | Cemetery | 265 | Grundy | 40 13 07 N | 093 35 46 W |
| Speers Cemetery | Cemetery | 79 | Pemiscot | 36 13 21 N | 089 42 24 W |
| Spees Branch | Stream | | Lewis | 39 58 00 N | 091 55 43 W |
| Spees School (historical) | School | 260 | Scotland | 40 33 00 N | 092 20 25 W |
| Spell Branch | Stream | | Ripley | 36 41 37 N | 090 34 47 W |
| Spell School (historical) | School | 128 | Ripley | 36 40 33 N | 090 35 39 W |
| Spence Creek | Stream | | Wright | 37 08 26 N | 092 32 13 W |
| Spence School (historical) | School | 214 | Marion | 39 50 22 N | 091 46 51 W |
| Spence School (historical) | School | 440 | Wright | 37 06 40 N | 092 32 19 W |
| Spencer | Populated Place | 324 | Lawrence | 37 11 04 N | 093 42 09 W |
| Spencer Branch | Stream | | Newton | 36 56 34 N | 094 15 06 W |
| Spencer Cemetery | Cemetery | 214 | Clark | 40 32 20 N | 091 52 19 W |
| Spencer Cemetery | Cemetery | 267 | Phelps | 38 03 04 N | 091 49 52 W |
| Spencer Cemetery | Cemetery | 334 | Polk | 37 34 39 N | 093 29 13 W |
| Spencer Chapel Cemetery | Cemetery | 223 | Monroe | 39 37 03 N | 092 06 24 W |
| Spencer Chapel School (historical) | School | 229 | Monroe | 39 37 08 N | 092 06 24 W |
| Spencer Creek | Stream | | Camden | 37 58 11 N | 092 46 50 W |
| Spencer Creek | Stream | | Ralls | 39 33 10 N | 091 19 60 W |
| Spencer Creek | Stream | | Ripley | 36 28 50 N | 090 56 04 W |