Feature Name | Class | Elev. meters | County | Latitude DMS | Longitude DMS |
| Saint James Methodist Episcopal Church (historical) | Church | 22 | Florence | 33 52 36 N | 079 44 58 W |
| Saint John Church | Church | 25 | Florence | 33 54 06 N | 079 37 40 W |
| Saint John Mission | Church | 29 | Florence | 34 08 32 N | 079 34 14 W |
| Saint John School | School | 30 | Florence | 33 53 58 N | 079 51 40 W |
| Saint Johns Cemetery | Cemetery | 24 | Florence | 33 54 09 N | 079 37 41 W |
| Saint Johns Church (historical) | Church | 16 | Florence | 33 46 33 N | 079 29 47 W |
| Saint Johns Episcopal Church | Church | 43 | Florence | 34 11 40 N | 079 45 55 W |
| Saint Luke Church | Church | 23 | Florence | 33 54 03 N | 079 29 23 W |
| Saint Lukes Church | Church | 27 | Florence | 34 01 32 N | 079 51 57 W |
| Saint Lukes Church | Church | 29 | Florence | 34 01 32 N | 079 52 00 W |
| Saint Lukes Lutheran Church | Church | 43 | Florence | 34 11 42 N | 079 46 49 W |
| Saint Mark Church | Church | 22 | Florence | 33 51 35 N | 079 39 12 W |
| Saint Mark School | School | 17 | Florence | 33 52 31 N | 079 27 03 W |
| Saint Marks Church | Church | 18 | Florence | 33 52 22 N | 079 26 53 W |
| Saint Paul Cemetery | Cemetery | 24 | Florence | 34 05 54 N | 079 38 19 W |
| Saint Paul Church | Church | 23 | Florence | 33 54 30 N | 079 41 49 W |
| Saint Paul Church | Church | 25 | Florence | 33 58 57 N | 079 44 42 W |
| Saint Paul Church | Church | 30 | Florence | 33 53 59 N | 079 51 44 W |
| Saint Paul Church | Church | 25 | Florence | 34 05 56 N | 079 38 21 W |
| Saint Paul School | School | 21 | Florence | 33 48 43 N | 079 35 41 W |
| Saint Paul School (historical) | School | 23 | Florence | 33 54 28 N | 079 41 47 W |
| Saint Paul United Methodist Church | Church | 44 | Florence | 34 11 28 N | 079 47 56 W |
| Saint Peter Church | Church | 24 | Florence | 33 54 01 N | 079 47 21 W |
| Saint Peters Holiness Church (historical) | Church | 44 | Florence | 34 12 17 N | 079 46 01 W |
| Salem | Populated Place | 22 | Florence | 33 53 17 N | 079 30 44 W |
| Salem | Populated Place | 29 | Florence | 33 57 44 N | 079 48 17 W |
| Salem Cemetery | Cemetery | 21 | Florence | 33 53 15 N | 079 30 45 W |
| Salem Church | Church | 29 | Florence | 33 57 45 N | 079 48 18 W |
| Salem Church | Church | 28 | Florence | 34 07 25 N | 079 36 46 W |
| Salem Church | Church | 44 | Florence | 34 08 32 N | 079 58 52 W |
| Salem Methodist Church | Church | 21 | Florence | 33 53 15 N | 079 30 45 W |
| Salem School (historical) | School | 27 | Florence | 33 57 19 N | 079 48 14 W |
| Sallie Hill Crossing | Locale | 44 | Florence | 34 09 08 N | 079 54 29 W |
| Sanctified Church (historical) | Church | 44 | Florence | 34 12 17 N | 079 46 01 W |
| Sand Hill Bay | Basin | 36 | Florence | 34 05 21 N | 079 49 32 W |
| Sand Hill Original Church | Church | 24 | Florence | 34 01 02 N | 079 47 22 W |
| Sandhill School | School | 24 | Florence | 34 13 50 N | 079 40 20 W |
| Sandhurst (subdivision) | Populated Place | 37 | Florence | 34 09 30 N | 079 47 34 W |
| Sandridge | Populated Place | 27 | Florence | 34 14 46 N | 079 43 14 W |
| Sandy Hill School (historical) | School | 24 | Florence | 34 01 07 N | 079 47 16 W |
| Sandy Run | Stream | | Florence | 33 55 11 N | 079 45 34 W |
| Sansbury Crossroads | Populated Place | 37 | Florence | 34 03 39 N | 079 55 23 W |
| Sansbury Hill Cemetery | Cemetery | 35 | Florence | 34 03 35 N | 079 55 39 W |
| Sardis | Populated Place | 40 | Florence | 34 02 26 N | 079 56 38 W |
| Sardis Baptist Church | Church | 40 | Florence | 34 02 20 N | 079 56 21 W |
| Savage Landing | Locale | 17 | Florence | 33 53 47 N | 079 25 37 W |
| Savannah Grove | Populated Place | 38 | Florence | 34 09 01 N | 079 49 45 W |
| Savannah Grove Baptist Church | Church | 38 | Florence | 34 09 01 N | 079 49 15 W |
| Savannah Grove Church | Church | 27 | Florence | 33 57 57 N | 079 44 56 W |
| Savannah Grove Elementary School | School | 38 | Florence | 34 08 51 N | 079 49 39 W |
| Savannah Grove School | School | 38 | Florence | 34 09 01 N | 079 49 17 W |
| Schoolhouse Branch | Stream | | Florence | 34 16 33 N | 079 34 59 W |
| Scott Lake | Lake | 4 | Florence | 33 50 22 N | 079 20 53 W |
| Scotts Mill (historical) | Locale | 35 | Florence | 34 05 18 N | 079 59 21 W |
| Scranton | Populated Place | 29 | Florence | 33 55 04 N | 079 44 38 W |
| Scranton Elementary School | School | 27 | Florence | 33 55 18 N | 079 44 53 W |
| Scranton Post Office | Post Office | 29 | Florence | 33 54 58 N | 079 44 43 W |
| Siesta Village (subdivision) | Populated Place | 34 | Florence | 34 10 06 N | 079 45 29 W |
| Snow Hill Church | Church | 43 | Florence | 34 12 42 N | 079 51 17 W |
| Snow Island | Island | 4 | Florence | 33 49 39 N | 079 20 38 W |
| Snow Lake | Lake | 4 | Florence | 33 48 58 N | 079 21 54 W |
| Soccee Swamp | Stream | | Florence | 33 48 52 N | 079 21 43 W |
| South Carolina Industrial School | School | 40 | Florence | 34 10 59 N | 079 45 24 W |
| South Carolina Noname 21001 D-1627 Dam | Dam | 35 | Florence | 34 10 25 N | 079 52 41 W |
| South Carolina Noname 21002 D-3557 Dam | Dam | 31 | Florence | 34 09 31 N | 079 49 41 W |
| South Carolina Noname 21009 D-3563 Dam | Dam | 16 | Florence | 34 05 49 N | 079 36 05 W |
| South Carolina Noname 21010 D-3564 Dam | Dam | 14 | Florence | 33 53 31 N | 079 25 23 W |
| South Carolina Noname 21011 D-3565 Dam | Dam | 16 | Florence | 33 51 55 N | 079 24 47 W |
| South Carolina Noname 21022 D-3570 Dam | Dam | 26 | Florence | 34 08 19 N | 079 46 11 W |
| South Carolina Noname 21037 D-3572 Dam | Dam | 42 | Florence | 34 11 55 N | 079 53 23 W |
| South Florence Church | Church | 29 | Florence | 34 08 33 N | 079 46 09 W |
| South Florence High School | School | 34 | Florence | 34 07 55 N | 079 46 18 W |
| South Park (subdivision) | Populated Place | 37 | Florence | 34 09 46 N | 079 47 49 W |
| South Park Shopping Center | Locale | 35 | Florence | 34 09 51 N | 079 45 47 W |
| South Point | Populated Place | 37 | Florence | 34 08 43 N | 079 48 35 W |
| South Side | Populated Place | 31 | Florence | 34 07 51 N | 079 45 33 W |
| Southoak Free Will Baptist Church | Church | 34 | Florence | 34 07 33 N | 079 46 37 W |
| Southside Baptist Church | Church | 34 | Florence | 34 10 09 N | 079 46 00 W |
| Southside Middle School | School | 35 | Florence | 34 07 59 N | 079 46 11 W |
| Southway Church | Church | 34 | Florence | 34 08 01 N | 079 43 21 W |
| Sparrow Swamp | Stream | | Florence | 34 02 38 N | 079 47 42 W |
| Sparrow Swamp Cemetery | Cemetery | 32 | Florence | 34 03 16 N | 079 52 37 W |
| Sparrow Swamp Church | Church | 32 | Florence | 34 03 13 N | 079 52 34 W |
| Sparrows Crossroads | Populated Place | 32 | Florence | 34 03 15 N | 079 52 47 W |
| Spaulding Heights | Populated Place | 42 | Florence | 34 13 19 N | 079 45 25 W |
| Spring Branch | Stream | | Florence | 34 05 58 N | 079 36 14 W |
| Spring Branch Church | Church | 24 | Florence | 34 04 51 N | 079 35 38 W |
| Spring Lake | Lake | 9 | Florence | 33 48 47 N | 079 31 06 W |
| Spring Run Branch | Stream | | Florence | 33 54 05 N | 079 45 33 W |
| Springdale Place | Populated Place | 41 | Florence | 34 11 21 N | 079 51 54 W |
| Stone Chapel | Church | 22 | Florence | 33 53 49 N | 079 37 22 W |
| Stone Chapel Cemetery | Cemetery | 22 | Florence | 33 53 49 N | 079 37 22 W |
| Stone Landing | Locale | 6 | Florence | 33 55 53 N | 079 28 34 W |
| Suburbia (subdivision) | Populated Place | 37 | Florence | 34 10 15 N | 079 48 13 W |
| Sugarfoot Bay | Basin | 29 | Florence | 33 59 53 N | 079 38 04 W |
| Summerville School | School | 31 | Florence | 34 12 58 N | 079 36 54 W |
| Sunset Acres | Populated Place | 40 | Florence | 34 10 22 N | 079 49 49 W |
| Sunset Memory Gardens | Cemetery | 38 | Florence | 34 09 06 N | 079 49 09 W |
| Sweetbriar (subdivision) | Populated Place | 35 | Florence | 34 10 22 N | 079 48 00 W |
| Tabernacle Cemetery | Cemetery | 23 | Florence | 34 03 34 N | 079 38 47 W |
| Tabernacle Church | Church | 24 | Florence | 34 03 32 N | 079 38 48 W |
| Tabernacle School | School | 28 | Florence | 34 03 16 N | 079 38 59 W |
| Tans Bay | Swamp | 37 | Florence | 34 06 51 N | 079 49 51 W |
| Tans Bay High School | School | 35 | Florence | 34 06 54 N | 079 46 58 W |
| Tans Bay School | School | 34 | Florence | 34 07 22 N | 079 47 16 W |
| Tara Hills | Populated Place | 27 | Florence | 34 08 10 N | 079 45 06 W |
| Tara Lake | Reservoir | 30 | Florence | 34 08 03 N | 079 45 08 W |
| Tara Village | Populated Place | 34 | Florence | 34 07 47 N | 079 45 09 W |
| Tarleton Estates (subdivision) | Populated Place | 37 | Florence | 34 09 51 N | 079 47 07 W |
| Taylor Branch | Stream | | Florence | 34 03 24 N | 079 43 36 W |