Feature Name | Class | Elev. meters | County | Latitude DMS | Longitude DMS |
| Salkehatchie Church | Church | 49 | Allendale | 33 06 05 N | 081 11 43 W |
| Sanders (historical) | Populated Place | 44 | Allendale | 32 57 53 N | 081 17 54 W |
| Sanders Pond Dam D-2567 | Dam | 37 | Allendale | 32 57 43 N | 081 15 17 W |
| Second Calvary Church | Church | 49 | Allendale | 33 02 19 N | 081 16 38 W |
| Seigling | Populated Place | 64 | Allendale | 33 02 40 N | 081 18 54 W |
| Seigling Church (historical) | Church | 65 | Allendale | 33 02 28 N | 081 19 24 W |
| Seigling School (historical) | School | 66 | Allendale | 33 02 29 N | 081 19 23 W |
| Shady Grove School | School | 47 | Allendale | 33 03 52 N | 081 10 39 W |
| Smart Cemeteries | Cemetery | 54 | Allendale | 32 55 38 N | 081 22 07 W |
| Smith Lake Creek | Stream | | Allendale | 33 00 51 N | 081 29 59 W |
| Smiths Lake | Swamp | 21 | Allendale | 33 01 24 N | 081 30 14 W |
| Smyrna Bay Church (historical) | Church | 64 | Allendale | 33 05 55 N | 081 18 40 W |
| Smyrna Cemetery | Cemetery | 49 | Allendale | 32 56 12 N | 081 21 05 W |
| Smyrna Church | Church | 49 | Allendale | 32 56 11 N | 081 21 06 W |
| Smyrna Church (historical) | Church | 64 | Allendale | 33 05 46 N | 081 18 29 W |
| Solomons Crossroads | Populated Place | 45 | Allendale | 32 47 41 N | 081 19 20 W |
| Solomons Store (historical) | Locale | 46 | Allendale | 32 48 13 N | 081 20 28 W |
| Speedwell Church | Church | 42 | Allendale | 33 05 03 N | 081 32 30 W |
| Spring Run | Stream | | Allendale | 32 55 33 N | 081 28 04 W |
| Spring Run | Swamp | 24 | Allendale | 32 57 51 N | 081 28 11 W |
| Springfield Church | Church | 23 | Allendale | 32 46 31 N | 081 22 09 W |
| Steel Creek Landing | Populated Place | 24 | Allendale | 33 05 43 N | 081 36 42 W |
| Still School (historical) | School | 43 | Allendale | 32 49 51 N | 081 18 14 W |
| Stillwood Plantation | Locale | 42 | Allendale | 32 54 11 N | 081 18 54 W |
| Stinson Bridge | Locale | 31 | Allendale | 33 08 02 N | 081 27 17 W |
| Stoney Bluff Ferry (historical) | Crossing | 22 | Allendale | 33 02 38 N | 081 33 23 W |
| Stony Creek | Stream | | Allendale | 32 58 31 N | 081 26 13 W |
| Striker Cemetery | Cemetery | 42 | Allendale | 32 53 54 N | 081 24 03 W |
| Stumpy Pond Church (historical) | Church | 41 | Allendale | 32 59 58 N | 081 09 14 W |
| Stumpy Pond School (historical) | School | 41 | Allendale | 32 59 58 N | 081 09 14 W |
| Sugar Hill Airport | Airport | 61 | Allendale | 33 02 21 N | 081 17 39 W |
| Swallow Savanna | Swamp | 48 | Allendale | 32 58 09 N | 081 19 17 W |
| Swallow Savanna Cemetery | Cemetery | 56 | Allendale | 32 59 35 N | 081 19 27 W |
| Sweet Bethel Church | Church | 50 | Allendale | 32 54 51 N | 081 22 55 W |
| Swift Gut | Stream | | Allendale | 33 03 38 N | 081 34 02 W |
| Sycamore | Populated Place | 45 | Allendale | 33 02 09 N | 081 13 19 W |
| Tabernacle Church (historical) | Church | 53 | Allendale | 33 05 32 N | 081 26 25 W |
| Terry Pond | Lake | 30 | Allendale | 33 04 60 N | 081 30 06 W |
| Thankful Church | Church | 31 | Allendale | 33 04 29 N | 081 28 37 W |
| The Bay | Swamp | 41 | Allendale | 33 05 20 N | 081 32 50 W |
| The Big Bay | Swamp | 27 | Allendale | 33 03 59 N | 081 31 26 W |
| The Gaul | Stream | | Allendale | 32 51 51 N | 081 27 09 W |
| Trinity Cemetery | Cemetery | 32 | Allendale | 32 52 27 N | 081 24 20 W |
| Trinity Church | Church | 32 | Allendale | 32 52 28 N | 081 24 19 W |
| Trinity School (historical) | School | 34 | Allendale | 32 54 03 N | 081 24 54 W |
| Tuten (historical) | Populated Place | 44 | Allendale | 33 02 18 N | 081 08 49 W |
| Tutens Mill Pond Dam D-2569 | Dam | 45 | Allendale | 33 00 49 N | 081 12 59 W |
| Tutens Millpond | Reservoir | 45 | Allendale | 33 00 49 N | 081 12 59 W |
| Ulmer | Populated Place | 49 | Allendale | 33 05 51 N | 081 12 29 W |
| Ulmers Lookout Tower | Tower | 45 | Allendale | 33 05 19 N | 081 10 45 W |
| Union Church (historical) | Church | 42 | Allendale | 32 50 26 N | 081 16 59 W |
| Union School | School | 43 | Allendale | 33 01 45 N | 081 07 54 W |
| Union School (historical) | School | 41 | Allendale | 33 01 32 N | 081 07 27 W |
| University of South Carolina-Salkehatchie Campus | School | 55 | Allendale | 33 00 58 N | 081 18 02 W |
| Venison Hunt Club | Locale | 46 | Allendale | 32 49 51 N | 081 21 28 W |
| Virgin Mary Church | Church | 53 | Allendale | 32 58 21 N | 081 23 06 W |
| Warren Branch | Swamp | 36 | Allendale | 32 56 51 N | 081 26 00 W |
| Watchcaw Creek | Stream | | Allendale | 32 53 59 N | 081 25 34 W |
| WDOG-AM (Allendale) | Tower | 64 | Allendale | 33 01 23 N | 081 19 57 W |
| WDOG-FM (Allendale) | Tower | 64 | Allendale | 33 01 23 N | 081 19 57 W |
| Weekleys Store (historical) | Locale | 51 | Allendale | 33 04 30 N | 081 12 32 W |
| Wells Branch | Stream | | Allendale | 33 07 14 N | 081 11 40 W |
| Wildcat Point | Cape | 15 | Allendale | 32 49 04 N | 081 25 38 W |
| Willingham Plantation | Locale | 41 | Allendale | 32 58 12 N | 081 27 19 W |
| Winthrop Club (historical) | Locale | 46 | Allendale | 32 49 24 N | 081 21 33 W |
| Woods Crossroads | Populated Place | 65 | Allendale | 32 59 07 N | 081 20 51 W |
| Youngs School | School | 37 | Allendale | 32 59 59 N | 081 12 03 W |
| Zion Grove Church | Church | 43 | Allendale | 33 04 44 N | 081 31 58 W |
| Zion Hill Church | Church | 70 | Allendale | 33 02 37 N | 081 26 23 W |
| Aaron Post Office (historical) | Post Office | 270 | Anderson | 34 34 37 N | 082 37 24 W |
| Abiding Savior Lutheran Church | Church | 238 | Anderson | 34 32 07 N | 082 37 53 W |
| Abney Mills Park | Park | 220 | Anderson | 34 30 10 N | 082 39 26 W |
| Airy Spring School (historical) | School | 279 | Anderson | 34 44 26 N | 082 32 17 W |
| Alfords Bridge (historical) | Bridge | 201 | Anderson | 34 23 01 N | 082 50 14 W |
| Allen Hills (subdivision) | Populated Place | 234 | Anderson | 34 31 05 N | 082 38 29 W |
| Allen Park | Park | 197 | Anderson | 34 27 25 N | 082 35 30 W |
| Allendale | Populated Place | 210 | Anderson | 34 25 47 N | 082 45 29 W |
| American Legion Memorial Athletic Field | Park | 240 | Anderson | 34 29 40 N | 082 38 38 W |
| Anderson | Populated Place | 240 | Anderson | 34 30 12 N | 082 39 00 W |
| Anderson Army Air Field (historical) | Military (Historical) | 229 | Anderson | 34 29 40 N | 082 42 30 W |
| Anderson City Hall | Building | 234 | Anderson | 34 30 04 N | 082 38 58 W |
| Anderson College | School | 232 | Anderson | 34 30 49 N | 082 38 19 W |
| Anderson College Library | Building | 234 | Anderson | 34 30 50 N | 082 38 23 W |
| Anderson Country Club | Locale | 226 | Anderson | 34 29 50 N | 082 40 29 W |
| Anderson County | Civil | 237 | Anderson | 34 32 00 N | 082 38 59 W |
| Anderson County Airport | Airport | 230 | Anderson | 34 29 41 N | 082 42 31 W |
| Anderson County Courthouse | Building | 240 | Anderson | 34 30 12 N | 082 38 59 W |
| Anderson County Health Center | Building | 234 | Anderson | 34 30 07 N | 082 39 10 W |
| Anderson County Jail | Building | 242 | Anderson | 34 32 00 N | 082 40 59 W |
| Anderson County Library | Building | 242 | Anderson | 34 30 35 N | 082 38 58 W |
| Anderson Downtown Historic District | Park | 240 | Anderson | 34 30 13 N | 082 39 00 W |
| Anderson First Presbyterian Cemetery | Cemetery | 233 | Anderson | 34 30 15 N | 082 39 15 W |
| Anderson Gardens (subdivision) | Populated Place | 225 | Anderson | 34 29 20 N | 082 37 03 W |
| Anderson Mall Shopping Center | Locale | 244 | Anderson | 34 32 22 N | 082 40 12 W |
| Anderson Memorial Gardens | Cemetery | 235 | Anderson | 34 30 18 N | 082 42 25 W |
| Anderson Memorial Hospital | Hospital | 236 | Anderson | 34 30 48 N | 082 38 47 W |
| Anderson Mennonite Church | Church | 240 | Anderson | 34 28 21 N | 082 39 46 W |
| Anderson Post Office | Post Office | 244 | Anderson | 34 30 30 N | 082 38 56 W |
| Anderson Reservoir | Reservoir | 230 | Anderson | 34 37 18 N | 082 34 59 W |
| Anderson Speedway | Locale | 271 | Anderson | 34 39 39 N | 082 35 07 W |
| Anderson Village (subdivision) | Populated Place | 225 | Anderson | 34 33 00 N | 082 39 42 W |
| Andersonville (historical) | Populated Place | 201 | Anderson | 34 26 50 N | 082 51 19 W |
| Andersonville Cemetery | Cemetery | 213 | Anderson | 34 29 02 N | 082 48 14 W |
| Andersonville Church | Church | 213 | Anderson | 34 29 02 N | 082 48 14 W |
| Andersonville Ferry (historical) | Crossing | 201 | Anderson | 34 26 46 N | 082 51 28 W |
| Asaville School (historical) | School | 212 | Anderson | 34 21 11 N | 082 32 46 W |
| Asbury Church | Church | 227 | Anderson | 34 32 21 N | 082 46 48 W |
| Asbury Clark Memorial Church | Church | 227 | Anderson | 34 32 21 N | 082 46 47 W |
| Asbury Memorial Baptist Church | Church | 230 | Anderson | 34 31 00 N | 082 39 38 W |
| Ashley Downs | Populated Place | 229 | Anderson | 34 34 38 N | 082 39 17 W |