Feature Name | Class | Elev. meters | County | Latitude DMS | Longitude DMS |
| Salem Davidian Church | Church | 370 | Oconee | 34 54 00 N | 082 57 36 W |
| Sand Branch | Stream | | Oconee | 34 45 59 N | 083 14 03 W |
| Sanders Lake | Reservoir | 258 | Oconee | 34 37 36 N | 082 59 43 W |
| Sawhead Branch | Stream | | Oconee | 34 45 20 N | 083 18 37 W |
| Sawyer Branch | Stream | | Oconee | 34 48 14 N | 083 10 34 W |
| Saxony Forest | Populated Place | 274 | Oconee | 34 46 15 N | 082 57 45 W |
| Scenic Plaza Shopping Center | Locale | 286 | Oconee | 34 45 14 N | 083 02 44 W |
| Seneca | Populated Place | 294 | Oconee | 34 41 08 N | 082 57 12 W |
| Seneca Baptist Church | Church | 304 | Oconee | 34 40 54 N | 082 57 13 W |
| Seneca City Hall | Building | 296 | Oconee | 34 41 08 N | 082 57 07 W |
| Seneca Creek | Stream | | Oconee | 34 40 42 N | 082 51 08 W |
| Seneca High School | School | 290 | Oconee | 34 40 32 N | 082 58 12 W |
| Seneca Historic District | Park | 300 | Oconee | 34 40 47 N | 082 57 10 W |
| Seneca Landing | Populated Place | 211 | Oconee | 34 38 41 N | 082 54 53 W |
| Seneca Marina | Locale | 201 | Oconee | 34 39 53 N | 082 51 32 W |
| Seneca Methodist Episcopal Church | Church | 299 | Oconee | 34 41 12 N | 082 57 18 W |
| Seneca Post Office | Post Office | 296 | Oconee | 34 41 07 N | 082 57 11 W |
| Seneca Presbyterian Church | Church | 305 | Oconee | 34 40 58 N | 082 57 21 W |
| Seneca Preschool | School | 295 | Oconee | 34 41 00 N | 082 56 39 W |
| Seneca Reservoir | Reservoir | 244 | Oconee | 34 42 45 N | 082 57 19 W |
| Seven Oaks | Populated Place | 232 | Oconee | 34 36 20 N | 082 55 14 W |
| Shadwick | Populated Place | 246 | Oconee | 34 37 55 N | 082 55 25 W |
| Shady Brook Hospital | Hospital | 263 | Oconee | 34 39 22 N | 082 57 48 W |
| Shelor Ferry (historical) | Crossing | 201 | Oconee | 34 30 50 N | 083 04 45 W |
| Shiloh | Populated Place | 277 | Oconee | 34 40 03 N | 082 53 36 W |
| Shiloh Branch | Stream | | Oconee | 34 39 58 N | 082 51 31 W |
| Shiloh Church | Church | 261 | Oconee | 34 39 54 N | 082 53 25 W |
| Shiloh Church | Church | 279 | Oconee | 34 40 09 N | 082 53 41 W |
| Shiloh Estates | Populated Place | 279 | Oconee | 34 41 08 N | 082 54 05 W |
| Shiloh School (historical) | School | 254 | Oconee | 34 39 50 N | 082 53 17 W |
| Shiloh School (historical) | School | 277 | Oconee | 34 40 08 N | 082 53 40 W |
| Shingle Mill Branch | Stream | | Oconee | 34 48 38 N | 083 11 47 W |
| Shoulder Bone Branch | Stream | | Oconee | 34 45 24 N | 083 18 27 W |
| Simpson Store | Locale | 292 | Oconee | 34 34 11 N | 083 01 45 W |
| Singing Pines | Populated Place | 288 | Oconee | 34 39 31 N | 082 55 42 W |
| Sixmile Creek | Stream | | Oconee | 34 43 57 N | 082 51 48 W |
| Slatten Branch | Stream | | Oconee | 35 00 13 N | 083 03 18 W |
| Slatten Ridge | Ridge | 920 | Oconee | 34 59 54 N | 083 03 54 W |
| Sloan Bridge Campground | Locale | 853 | Oconee | 35 00 13 N | 083 03 12 W |
| Smeltzer Creek | Stream | | Oconee | 34 54 18 N | 082 59 30 W |
| Smeltzer Mountain | Summit | 522 | Oconee | 34 56 14 N | 082 58 07 W |
| Smeltzer School (historical) | School | 339 | Oconee | 34 56 03 N | 082 59 40 W |
| Smith Pond | Reservoir | 250 | Oconee | 34 33 26 N | 083 00 13 W |
| Smith Pond | Reservoir | 270 | Oconee | 34 41 37 N | 083 11 12 W |
| Snead Mill (historical) | Locale | 215 | Oconee | 34 40 50 N | 083 08 55 W |
| Snow Creek | Stream | | Oconee | 34 37 04 N | 082 57 05 W |
| Snow Creek Church | Church | 228 | Oconee | 34 37 00 N | 082 59 06 W |
| Snow Creek School (historical) | School | 215 | Oconee | 34 37 00 N | 082 58 08 W |
| Snug Harbor | Populated Place | 226 | Oconee | 34 36 22 N | 082 56 19 W |
| Snyder Cemetery | Cemetery | 550 | Oconee | 34 53 27 N | 083 11 25 W |
| Sourwood Branch | Stream | | Oconee | 34 41 43 N | 083 13 36 W |
| South Carolina Noname 37011 D-1651 Dam | Dam | 284 | Oconee | 34 46 18 N | 083 02 57 W |
| South Carolina Noname 37024 D-1635 Dam | Dam | 324 | Oconee | 34 55 00 N | 083 00 60 W |
| South Carolina Noname 37026 D-1631 Dam | Dam | 566 | Oconee | 34 55 24 N | 083 07 24 W |
| South Carolina Noname 37030 D-1644 Dam | Dam | 504 | Oconee | 34 51 00 N | 083 10 24 W |
| South Carolina Noname 37031 D-1643 Dam | Dam | 510 | Oconee | 34 51 30 N | 083 06 12 W |
| South Cove | Populated Place | 258 | Oconee | 34 42 58 N | 082 57 37 W |
| South Union | Populated Place | 274 | Oconee | 34 33 04 N | 083 03 07 W |
| South Union Cemetery | Cemetery | 268 | Oconee | 34 32 50 N | 083 03 23 W |
| South Union Church | Church | 268 | Oconee | 34 32 47 N | 083 03 23 W |
| South Union School (historical) | School | 265 | Oconee | 34 32 33 N | 083 03 20 W |
| South Union School (historical) | School | 274 | Oconee | 34 32 59 N | 083 03 04 W |
| Southern Meadows (subdivision) | Populated Place | 288 | Oconee | 34 40 15 N | 082 55 33 W |
| Southgate Shopping Center | Locale | 291 | Oconee | 34 40 44 N | 082 57 45 W |
| Southside School | School | 294 | Oconee | 34 40 37 N | 082 57 34 W |
| Spearman Pond | Reservoir | 268 | Oconee | 34 34 15 N | 083 02 38 W |
| Speeds Creek | Stream | | Oconee | 34 37 02 N | 082 56 58 W |
| Spider Valley Creek | Stream | | Oconee | 34 46 01 N | 083 13 58 W |
| Spoonauger Falls | Falls | 706 | Oconee | 34 58 28 N | 083 06 35 W |
| Spring Valley | Populated Place | 227 | Oconee | 34 38 58 N | 082 53 14 W |
| Springbrook (subdivision) | Populated Place | 278 | Oconee | 34 40 00 N | 082 57 47 W |
| Springdale | Populated Place | 289 | Oconee | 34 46 17 N | 083 01 41 W |
| Spy Rock Creek | Stream | | Oconee | 34 45 17 N | 083 11 49 W |
| Stamp Creek | Stream | | Oconee | 34 50 07 N | 082 56 28 W |
| Stamp Creek Cemetery | Cemetery | 308 | Oconee | 34 50 30 N | 082 55 30 W |
| Stamp Creek Church | Church | 307 | Oconee | 34 50 30 N | 082 55 31 W |
| Station Creek | Stream | | Oconee | 34 50 22 N | 083 04 09 W |
| Station Creek Cove Botanical Area | Park | 339 | Oconee | 34 50 22 N | 083 05 08 W |
| Station Mountain | Summit | 557 | Oconee | 34 51 53 N | 083 05 28 W |
| Stephens Coneross Dam | Dam | 223 | Oconee | 34 38 06 N | 082 58 12 W |
| Steps Mountain | Summit | 425 | Oconee | 34 42 53 N | 083 13 53 W |
| Stewart Cemetery | Cemetery | 240 | Oconee | 34 39 04 N | 083 11 34 W |
| Stone Haven | Populated Place | 215 | Oconee | 34 42 50 N | 082 51 60 W |
| Stribbling Cemetery | Cemetery | 244 | Oconee | 34 43 01 N | 082 56 28 W |
| Stribling Ferry (historical) | Crossing | 201 | Oconee | 34 32 51 N | 083 06 38 W |
| Stump Branch | Stream | | Oconee | 34 49 08 N | 083 15 41 W |
| Stumphouse Mountain | Summit | 531 | Oconee | 34 50 06 N | 083 06 22 W |
| Stumphouse Mountain Tunnel | Tunnel | 536 | Oconee | 34 48 59 N | 083 07 48 W |
| Sugar Creek | Stream | | Oconee | 34 34 02 N | 083 08 21 W |
| Sugar Hill | Populated Place | 259 | Oconee | 34 46 05 N | 082 56 40 W |
| Sumter National Forest Lake | Reservoir | 360 | Oconee | 34 55 48 N | 083 04 12 W |
| Sunset Shores | Populated Place | 280 | Oconee | 34 44 13 N | 082 57 55 W |
| Swaford Creek | Stream | | Oconee | 34 51 21 N | 083 13 51 W |
| Swaneys Landing | Locale | 201 | Oconee | 34 38 24 N | 082 51 60 W |
| Tabernacle Holiness Church (historical) | Church | 295 | Oconee | 34 41 01 N | 082 56 26 W |
| Tabor | Populated Place | 233 | Oconee | 34 35 38 N | 083 08 29 W |
| Tamassee | Populated Place | 326 | Oconee | 34 52 49 N | 083 01 11 W |
| Tamassee Creek | Stream | | Oconee | 34 52 34 N | 083 02 52 W |
| Tamassee DAR School | School | 326 | Oconee | 34 53 00 N | 083 01 04 W |
| Tamassee Daughters of the American Revolution Church | Church | 330 | Oconee | 34 52 55 N | 083 01 06 W |
| Tamassee Knob | Summit | 537 | Oconee | 34 52 18 N | 083 04 30 W |
| Tamassee/Salem Middle-High School | School | 337 | Oconee | 34 53 23 N | 082 58 45 W |
| Tanyard Bridge | Bridge | 245 | Oconee | 34 50 11 N | 082 58 48 W |
| Tater Hill | Summit | 508 | Oconee | 34 57 21 N | 082 59 05 W |
| Taylor Creek | Stream | | Oconee | 34 51 03 N | 083 09 04 W |
| The Meadows | Populated Place | 247 | Oconee | 34 38 08 N | 082 55 23 W |
| The Woods | Populated Place | 268 | Oconee | 34 39 18 N | 082 59 40 W |
| Thompson River | Stream | | Oconee | 34 59 39 N | 082 58 55 W |
| Thriftwood (subdivision) | Populated Place | 262 | Oconee | 34 40 12 N | 082 58 37 W |
| Tilly Branch | Stream | | Oconee | 34 49 10 N | 083 16 54 W |