Feature Name | Class | Elev. meters | County | Latitude DMS | Longitude DMS |
| Cannon Creek | Stream | | Pickens | 34 52 01 N | 082 45 19 W |
| Cannon Memorial Hospital | Hospital | 302 | Pickens | 34 52 28 N | 082 42 25 W |
| Cannon Mountain | Summit | 387 | Pickens | 34 53 02 N | 082 40 51 W |
| Cannon Mountain Church | Church | 349 | Pickens | 34 53 02 N | 082 40 34 W |
| Carlton Mountain | Summit | 479 | Pickens | 34 55 20 N | 082 48 54 W |
| Carmel Cemetery | Cemetery | 274 | Pickens | 34 45 21 N | 082 38 29 W |
| Carmel Church | Church | 275 | Pickens | 34 45 16 N | 082 38 25 W |
| Carmel Creek | Stream | | Pickens | 34 43 48 N | 082 37 31 W |
| Carolina Hills (subdivision) | Populated Place | 246 | Pickens | 34 40 50 N | 082 48 11 W |
| Carpenter Creek | Stream | | Pickens | 34 58 29 N | 082 32 42 W |
| Carrick Creek | Stream | | Pickens | 35 00 05 N | 082 40 49 W |
| Cateechee | Populated Place | 279 | Pickens | 34 46 14 N | 082 46 26 W |
| Cedar Creek | Stream | | Pickens | 34 54 05 N | 082 53 59 W |
| Cedar Creek Mountain | Summit | 539 | Pickens | 34 56 05 N | 082 50 49 W |
| Cedar Hill Church | Church | 328 | Pickens | 34 49 57 N | 082 49 13 W |
| Cedar Rock | Populated Place | 329 | Pickens | 34 52 26 N | 082 38 24 W |
| Cedar Rock Cemetery | Cemetery | 340 | Pickens | 34 52 19 N | 082 36 47 W |
| Cedar Rock Church | Church | 338 | Pickens | 34 52 19 N | 082 36 46 W |
| Cedar Rock Church of God | Church | 331 | Pickens | 34 52 21 N | 082 38 36 W |
| Cedar Rock Mountain | Summit | 421 | Pickens | 34 53 05 N | 082 37 14 W |
| Cedar Rock Mountain | Summit | 508 | Pickens | 34 56 46 N | 082 48 09 W |
| Cedar Rock School (historical) | School | 327 | Pickens | 34 52 07 N | 082 38 56 W |
| Cedar Rock School (historical) | School | 333 | Pickens | 34 52 23 N | 082 38 20 W |
| Central | Populated Place | 278 | Pickens | 34 43 27 N | 082 46 53 W |
| Central Church of God | Church | 278 | Pickens | 34 43 15 N | 082 46 15 W |
| Central Elementary School | School | 274 | Pickens | 34 43 23 N | 082 46 50 W |
| Central Post Office | Post Office | 276 | Pickens | 34 43 25 N | 082 46 53 W |
| Chadwick (subdivision) | Populated Place | 325 | Pickens | 34 49 17 N | 082 33 13 W |
| Chapman Bridge (historical) | Bridge | 244 | Pickens | 34 57 15 N | 082 54 32 W |
| Chapman Mountain | Summit | 504 | Pickens | 34 57 59 N | 082 43 09 W |
| Chastain Cemetery | Cemetery | 326 | Pickens | 34 59 36 N | 082 43 25 W |
| Cherokee Forest (subdivision) | Populated Place | 318 | Pickens | 34 48 48 N | 082 36 29 W |
| Cherry Farm | Locale | 215 | Pickens | 34 39 12 N | 082 50 23 W |
| Chestnut Ridge | Ridge | 915 | Pickens | 35 03 50 N | 082 50 43 W |
| Chimneytop | Summit | 852 | Pickens | 35 03 33 N | 082 48 13 W |
| Chimneytop Gap | Gap | 734 | Pickens | 35 03 43 N | 082 47 53 W |
| Chucky Branch | Stream | | Pickens | 34 59 05 N | 082 51 26 W |
| Church of God | Church | 340 | Pickens | 34 49 53 N | 082 36 57 W |
| Cissom Creek | Stream | | Pickens | 35 02 05 N | 082 37 56 W |
| Clayton Cemetery | Cemetery | 294 | Pickens | 34 49 20 N | 082 43 44 W |
| Clearwater Branch | Stream | | Pickens | 34 57 36 N | 082 49 25 W |
| Clearwater Falls | Falls | 272 | Pickens | 34 55 13 N | 082 52 52 W |
| Clemson | Populated Place | 221 | Pickens | 34 41 00 N | 082 50 15 W |
| Clemson Gardens (subdivision) | Populated Place | 244 | Pickens | 34 41 03 N | 082 48 38 W |
| Clemson Heights (subdivision) | Populated Place | 228 | Pickens | 34 39 52 N | 082 50 20 W |
| Clemson Post Office | Post Office | 213 | Pickens | 34 41 26 N | 082 50 07 W |
| Clemson Shopping Center | Locale | 257 | Pickens | 34 42 05 N | 082 47 42 W |
| Clemson United Methodist Church | Church | 226 | Pickens | 34 40 58 N | 082 50 19 W |
| Clemson University Historic District | Park | 232 | Pickens | 34 40 40 N | 082 50 20 W |
| Cold Spring Church | Church | 337 | Pickens | 34 55 42 N | 082 43 06 W |
| Cold Spring School (historical) | School | 295 | Pickens | 34 55 27 N | 082 43 10 W |
| Concord Cemetery | Cemetery | 287 | Pickens | 34 53 05 N | 082 45 41 W |
| Concord Church | Church | 287 | Pickens | 34 53 05 N | 082 45 40 W |
| Cook Engineering Laboratory | Building | 221 | Pickens | 34 40 35 N | 082 50 17 W |
| Cool Springs School (historical) | School | 311 | Pickens | 34 55 35 N | 082 42 48 W |
| Cope Hall | Building | 220 | Pickens | 34 40 42 N | 082 50 25 W |
| Country Club Lake | Reservoir | 283 | Pickens | 34 50 25 N | 082 41 22 W |
| Country Club Lake | Reservoir | 301 | Pickens | 34 55 06 N | 082 50 30 W |
| Countryside Manor | Populated Place | 302 | Pickens | 34 47 40 N | 082 35 47 W |
| Cove Creek | Stream | | Pickens | 34 57 21 N | 082 45 08 W |
| Cove Creek Church | Church | 346 | Pickens | 34 57 39 N | 082 44 05 W |
| Cove Gap | Gap | 403 | Pickens | 34 58 41 N | 082 49 54 W |
| Cox Mini Farms Pond | Reservoir | 314 | Pickens | 34 56 36 N | 082 35 47 W |
| Cox Mini Farms Pond Dam D-1938 | Dam | 314 | Pickens | 34 56 36 N | 082 35 47 W |
| Cox Pond | Reservoir | 349 | Pickens | 34 55 48 N | 082 36 11 W |
| Cox Pond Dam D-1939 | Dam | 349 | Pickens | 34 55 48 N | 082 36 11 W |
| Craig Cemetery | Cemetery | 244 | Pickens | 34 50 23 N | 082 53 42 W |
| Cramer Wastewater Treatment Plant | Building | 273 | Pickens | 34 46 50 N | 082 43 23 W |
| Crescent Hill Church | Church | 359 | Pickens | 34 54 04 N | 082 42 03 W |
| Crestview Heights (subdivision) | Populated Place | 316 | Pickens | 34 48 43 N | 082 34 14 W |
| Cross Plains School (historical) | School | 341 | Pickens | 34 54 12 N | 082 35 49 W |
| Cross Roads Church | Church | 318 | Pickens | 34 51 39 N | 082 45 26 W |
| Cross Roads Church | Church | 332 | Pickens | 34 54 31 N | 082 35 54 W |
| Cross Roads School (historical) | School | 317 | Pickens | 34 51 39 N | 082 45 27 W |
| Crossroads Cemetery | Cemetery | 337 | Pickens | 34 54 28 N | 082 35 59 W |
| Crosswell | Populated Place | 290 | Pickens | 34 50 58 N | 082 29 38 W |
| Crosswell Apostolic Church | Church | 301 | Pickens | 34 50 25 N | 082 31 39 W |
| Crosswell Church | Church | 266 | Pickens | 34 49 43 N | 082 29 13 W |
| Crosswell School | School | 305 | Pickens | 34 50 08 N | 082 30 40 W |
| Crosswell School (historical) | School | 284 | Pickens | 34 50 35 N | 082 29 40 W |
| Crow Creek | Populated Place | 316 | Pickens | 34 55 14 N | 082 46 19 W |
| Crow Creek Church | Church | 302 | Pickens | 34 52 08 N | 082 50 19 W |
| Dacusville | Populated Place | 330 | Pickens | 34 56 07 N | 082 33 31 W |
| Dacusville Cemetery | Cemetery | 327 | Pickens | 34 55 52 N | 082 33 26 W |
| Dacusville Elementary School | School | 333 | Pickens | 34 56 21 N | 082 33 21 W |
| Dacusville Junior High School | School | 333 | Pickens | 34 56 19 N | 082 33 20 W |
| Dacusville United Methodist Church | Church | 327 | Pickens | 34 55 53 N | 082 33 27 W |
| Dammo Branch | Stream | | Pickens | 34 58 14 N | 082 53 47 W |
| Daniel Hall | Building | 218 | Pickens | 34 40 38 N | 082 50 07 W |
| Daniel High School | School | 289 | Pickens | 34 44 19 N | 082 49 55 W |
| Day Star Baptist Fellowship | Church | 305 | Pickens | 34 51 00 N | 082 39 38 W |
| Dayton School | School | 323 | Pickens | 34 49 20 N | 082 33 30 W |
| Dayton School (historical) | School | 297 | Pickens | 34 47 46 N | 082 33 51 W |
| Dellwood (subdivision) | Populated Place | 233 | Pickens | 34 40 10 N | 082 47 34 W |
| Devils Hole Creek | Stream | | Pickens | 35 00 36 N | 082 54 44 W |
| Diana Mountain | Summit | 673 | Pickens | 35 01 28 N | 082 50 41 W |
| Dillard Building | Building | 214 | Pickens | 34 40 44 N | 082 50 26 W |
| Doddies Creek | Stream | | Pickens | 34 55 18 N | 082 31 54 W |
| Dogwood Creek | Stream | | Pickens | 35 03 53 N | 082 48 16 W |
| Donaldson Hall | Building | 220 | Pickens | 34 40 52 N | 082 50 20 W |
| Dons Pond | Reservoir | 301 | Pickens | 34 55 00 N | 082 44 11 W |
| Dons Pond Dam D-1956 | Dam | 301 | Pickens | 34 55 00 N | 082 44 11 W |
| Douthels Ford | Crossing | 339 | Pickens | 35 03 39 N | 082 38 59 W |
| Douthit Hills (subdivision) | Populated Place | 248 | Pickens | 34 40 53 N | 082 49 45 W |
| Dug Mountain | Summit | 374 | Pickens | 34 57 44 N | 082 51 51 W |
| Earle Hall | Building | 216 | Pickens | 34 40 33 N | 082 50 25 W |
| Earls Bridge | Bridge | 259 | Pickens | 34 58 20 N | 082 32 15 W |
| Easley | Populated Place | 329 | Pickens | 34 49 47 N | 082 36 05 W |
| Easley Baptist Hospital | Hospital | 309 | Pickens | 34 50 26 N | 082 36 24 W |
| Easley Chapel United Methodist Church | Church | 337 | Pickens | 34 49 55 N | 082 36 29 W |