Feature Name | Class | Elev. meters | County | Latitude DMS | Longitude DMS |
| Smithfields (subdivision) | Populated Place | 297 | Pickens | 34 48 21 N | 082 33 12 W |
| Smiths Chapel | Church | 314 | Pickens | 34 48 03 N | 082 44 16 W |
| Soapstone Church | Church | 331 | Pickens | 35 00 51 N | 082 37 53 W |
| Soapstone School (historical) | School | 331 | Pickens | 35 00 51 N | 082 37 53 W |
| Solid Rock Church | Church | 298 | Pickens | 34 46 22 N | 082 43 16 W |
| South Carolina Highway Patrol - Troop Three - Pickens County | Building | 338 | Pickens | 34 50 10 N | 082 40 15 W |
| South Carolina Noname 39001 D-1967 Dam | Dam | 201 | Pickens | 34 40 06 N | 082 51 34 W |
| South Carolina Noname 39003 D-1931 Dam | Dam | 279 | Pickens | 34 52 36 N | 082 33 11 W |
| South Carolina Noname 39004 D-1932 Dam | Dam | 295 | Pickens | 34 52 18 N | 082 32 53 W |
| South Carolina Noname 39005 D-1930 Dam | Dam | 296 | Pickens | 34 52 54 N | 082 33 41 W |
| South Carolina Noname 39006 D-1946 Dam | Dam | 932 | Pickens | 35 05 06 N | 082 41 29 W |
| South Carolina Noname 39007 D-1950 Dam | Dam | 317 | Pickens | 34 57 36 N | 082 42 09 W |
| South Carolina Noname 39008 D-1965 Dam | Dam | 285 | Pickens | 34 55 28 N | 082 49 26 W |
| South Carolina Noname 39009 D-1954 Dam | Dam | 301 | Pickens | 34 55 06 N | 082 50 30 W |
| South Carolina Noname 39010 D-1957 Dam | Dam | 292 | Pickens | 34 51 42 N | 082 43 05 W |
| South Carolina Noname 39011 D-1952 Dam | Dam | 300 | Pickens | 34 56 30 N | 082 41 29 W |
| South Carolina Noname 39012 D-1933 Dam | Dam | 322 | Pickens | 34 52 18 N | 082 35 11 W |
| South Carolina Noname 39013 D-1968 Dam | Dam | 282 | Pickens | 34 57 30 N | 082 50 60 W |
| South Carolina Noname 39017 Dam | Dam | 244 | Pickens | 34 48 00 N | 082 53 12 W |
| South Carolina Noname 39018 Dam | Dam | 254 | Pickens | 34 57 30 N | 082 54 48 W |
| South Carolina Noname 39019 D-1971 Dam | Dam | 264 | Pickens | 34 51 30 N | 082 50 60 W |
| South Carolina Noname 39021 D-1969 Dam | Dam | 278 | Pickens | 34 55 16 N | 082 52 02 W |
| South Carolina Noname 39022 D-1925 Dam | Dam | 288 | Pickens | 34 59 12 N | 082 33 53 W |
| South Carolina Noname 39023 D-1942 Dam | Dam | 278 | Pickens | 34 46 30 N | 082 35 11 W |
| South Carolina Noname 39024 D-1929 Dam | Dam | 327 | Pickens | 34 53 12 N | 082 33 11 W |
| South Carolina Noname 39025 D-1961 Dam | Dam | 294 | Pickens | 34 53 12 N | 082 46 23 W |
| South Carolina Noname 39026 D-1955 Dam | Dam | 286 | Pickens | 34 54 30 N | 082 44 11 W |
| South Carolina Noname 39027 D-1940 Dam | Dam | 335 | Pickens | 34 52 12 N | 082 37 41 W |
| South Carolina Noname 39028 D-1951 Dam | Dam | 323 | Pickens | 34 57 18 N | 082 42 11 W |
| South Carolina Noname 39029 D-1953 Dam | Dam | 315 | Pickens | 34 55 30 N | 082 42 29 W |
| South Carolina State Botanical Gardens | Park | 232 | Pickens | 34 40 29 N | 082 49 24 W |
| South Saluda River | Stream | | Pickens | 34 57 09 N | 082 31 32 W |
| Southside Water District Water Water Tower | Tower | 311 | Pickens | 34 45 36 N | 082 39 32 W |
| Springdale (subdivision) | Populated Place | 309 | Pickens | 34 49 57 N | 082 34 05 W |
| Stony Rock Church (historical) | Church | 228 | Pickens | 34 39 40 N | 082 49 51 W |
| Strode Tower | Building | 215 | Pickens | 34 40 36 N | 082 50 07 W |
| Summey Pond | Reservoir | 323 | Pickens | 34 55 18 N | 082 50 60 W |
| Summey Pond Dam D-1959 | Dam | 323 | Pickens | 34 55 18 N | 082 50 60 W |
| Summit Square Shopping Center | Locale | 326 | Pickens | 34 49 30 N | 082 33 00 W |
| Sunny Acres | Populated Place | 248 | Pickens | 34 40 08 N | 082 47 57 W |
| Sunrise Cemetery | Cemetery | 331 | Pickens | 34 53 06 N | 082 41 52 W |
| Sunset | Populated Place | 310 | Pickens | 34 58 39 N | 082 47 56 W |
| Symmes Church (historical) | Church | 255 | Pickens | 34 43 39 N | 082 43 29 W |
| Symmes Mill (historical) | Locale | 241 | Pickens | 34 43 35 N | 082 43 22 W |
| Symmes School (historical) | School | 256 | Pickens | 34 43 38 N | 082 43 29 W |
| Table Rock | Summit | 953 | Pickens | 35 03 02 N | 082 42 12 W |
| Table Rock State Park | Park | 470 | Pickens | 35 02 13 N | 082 42 26 W |
| Table Rock State Park Historic District | Park | 481 | Pickens | 35 02 20 N | 082 42 19 W |
| Tabor Cemetery | Cemetery | 344 | Pickens | 34 52 24 N | 082 38 56 W |
| Tabor Church | Church | 344 | Pickens | 34 52 26 N | 082 38 56 W |
| Tally Bridge | Bridge | 302 | Pickens | 35 04 02 N | 082 34 18 W |
| Taylor Branch | Stream | | Pickens | 34 53 45 N | 082 51 14 W |
| Terrapin Crossroads | Populated Place | 324 | Pickens | 34 49 50 N | 082 46 39 W |
| The Stool | Summit | 797 | Pickens | 35 03 01 N | 082 41 37 W |
| Tillman Hall | Building | 232 | Pickens | 34 40 48 N | 082 50 15 W |
| Timberlane | Populated Place | 299 | Pickens | 34 48 56 N | 082 33 59 W |
| Todd Creek | Stream | | Pickens | 34 44 12 N | 082 48 50 W |
| Town and Country Shopping Center | Locale | 311 | Pickens | 34 49 24 N | 082 34 38 W |
| Town Creek | Stream | | Pickens | 34 52 56 N | 082 44 31 W |
| Town Creek School (historical) | School | 312 | Pickens | 34 53 57 N | 082 41 33 W |
| Town Creek School (historical) | School | 341 | Pickens | 34 55 43 N | 082 40 09 W |
| Toxaway Lake | Reservoir | 254 | Pickens | 34 57 30 N | 082 54 48 W |
| Toxaway River | Stream | | Pickens | 34 58 36 N | 082 56 05 W |
| Traber | Populated Place | 298 | Pickens | 34 46 22 N | 082 42 25 W |
| Tri-City Baptist Church | Church | 330 | Pickens | 34 50 18 N | 082 39 51 W |
| Trinity Baptist Church | Church | 337 | Pickens | 34 49 08 N | 082 36 16 W |
| Turkey Cock Mountain | Summit | 504 | Pickens | 34 56 42 N | 082 46 49 W |
| Turner Hill | Summit | 427 | Pickens | 34 57 21 N | 082 46 03 W |
| Twelve Mile River Watershed Eight Reservoir | Reservoir | 323 | Pickens | 34 57 18 N | 082 42 11 W |
| Twelve Mile River Watershed Six Reservoir | Reservoir | 286 | Pickens | 34 54 30 N | 082 44 11 W |
| Twelve Mile School (historical) | School | 312 | Pickens | 34 55 22 N | 082 46 18 W |
| Twelve Mile School (historical) | School | 294 | Pickens | 34 54 30 N | 082 45 39 W |
| Twelve Mile Watershed Structure | Reservoir | 300 | Pickens | 34 56 30 N | 082 41 29 W |
| Twelvemile Creek | Stream | | Pickens | 34 41 44 N | 082 50 58 W |
| Twelvemile River Watershed 12 Reservoir | Reservoir | 335 | Pickens | 34 52 12 N | 082 37 41 W |
| Twinbrook (subdivision) | Populated Place | 303 | Pickens | 34 48 15 N | 082 34 44 W |
| Twisting Pine Mountain | Summit | 545 | Pickens | 35 01 33 N | 082 49 15 W |
| Union Grove Church | Church | 290 | Pickens | 34 48 45 N | 082 43 24 W |
| Union United Methodist Church | Church | 289 | Pickens | 34 48 45 N | 082 43 23 W |
| United Wesleyan Church | Church | 306 | Pickens | 34 51 08 N | 082 38 41 W |
| University Lutheran Church | Church | 219 | Pickens | 34 41 02 N | 082 50 18 W |
| University Square Shopping Center | Locale | 213 | Pickens | 34 41 30 N | 082 50 52 W |
| University Union | Building | 227 | Pickens | 34 40 47 N | 082 50 19 W |
| Village Library | Building | 336 | Pickens | 34 52 57 N | 082 42 42 W |
| Vineland School | School | 315 | Pickens | 34 53 16 N | 082 30 54 W |
| Vista Heights (subdivision) | Populated Place | 302 | Pickens | 34 48 25 N | 082 36 58 W |
| Wadakoe Mountain | Summit | 565 | Pickens | 34 58 49 N | 082 50 10 W |
| Walnut Cove Mountain | Summit | 540 | Pickens | 34 58 46 N | 082 43 53 W |
| Wannamaker Hall | Building | 220 | Pickens | 34 40 52 N | 082 50 22 W |
| Watsons Pond | Reservoir | 295 | Pickens | 34 47 24 N | 082 33 53 W |
| Watsons Pond Dam D-1936 | Dam | 295 | Pickens | 34 47 24 N | 082 33 53 W |
| Wattacoo (historical) | Populated Place | 299 | Pickens | 35 03 38 N | 082 35 42 W |
| Wayside Church | Church | 322 | Pickens | 34 52 29 N | 082 35 01 W |
| WCCP-AM (Clemson) | Tower | 232 | Pickens | 34 42 04 N | 082 49 30 W |
| Weaver Creek | Stream | | Pickens | 35 00 13 N | 082 38 22 W |
| Welcome Cemetery | Cemetery | 288 | Pickens | 34 45 28 N | 082 48 14 W |
| Welcome Church | Church | 288 | Pickens | 34 45 28 N | 082 48 16 W |
| WELP-AM (Easley) | Tower | 358 | Pickens | 34 50 20 N | 082 38 23 W |
| Wesleyan Methodist College | School | 283 | Pickens | 34 43 42 N | 082 45 43 W |
| Wesleyan Methodist Episcopal Church (historical) | Church | 340 | Pickens | 34 49 51 N | 082 37 06 W |
| West End School | School | 330 | Pickens | 34 49 36 N | 082 36 34 W |
| West End Shopping Center | Locale | 332 | Pickens | 34 49 47 N | 082 36 44 W |
| West Fork Gregory Creek | Stream | | Pickens | 34 52 52 N | 082 46 21 W |
| West View Cemetery | Cemetery | 337 | Pickens | 34 49 49 N | 082 36 29 W |
| Westwood Church | Church | 278 | Pickens | 34 51 15 N | 082 29 20 W |
| Whispering Pines | Populated Place | 317 | Pickens | 34 48 24 N | 082 38 47 W |
| White Oak School (historical) | School | 246 | Pickens | 34 43 03 N | 082 44 03 W |
| White Oak Spring Church | Church | 243 | Pickens | 34 43 04 N | 082 44 03 W |
| White Oak Springs Baptist Church | Church | 274 | Pickens | 34 43 13 N | 082 46 20 W |
| Wild Hog Creek | Stream | | Pickens | 35 03 53 N | 082 49 03 W |