Feature Name | Class | Elev. meters | County | Latitude DMS | Longitude DMS |
| Sandy Run (historical) | Populated Place | 19 | Berkeley | 33 07 51 N | 080 10 13 W |
| Sangaree | Populated Place | 26 | Berkeley | 33 02 08 N | 080 07 40 W |
| Sangaree Elementary School | School | 20 | Berkeley | 33 02 06 N | 080 06 32 W |
| Santee (historical) | Populated Place | 8 | Berkeley | 33 27 18 N | 079 54 16 W |
| Santee Branch | Stream | | Berkeley | 33 11 29 N | 080 17 49 W |
| Santee Canal | Canal | 24 | Berkeley | 33 25 36 N | 080 06 07 W |
| Santee Church | Church | 16 | Berkeley | 33 20 04 N | 079 49 52 W |
| Santee Circle | Populated Place | 22 | Berkeley | 33 14 38 N | 079 57 51 W |
| Santee Experimental Station | Locale | 6 | Berkeley | 33 08 11 N | 079 48 52 W |
| Sarah Drain | Stream | | Berkeley | 33 16 50 N | 079 38 16 W |
| Savanna Creek | Populated Place | 11 | Berkeley | 33 17 13 N | 079 45 26 W |
| Savanna Creek | Stream | | Berkeley | 33 19 20 N | 079 44 30 W |
| Saw Mill | Populated Place | 13 | Berkeley | 33 06 59 N | 079 54 10 W |
| Sawmill School (historical) | School | 13 | Berkeley | 33 06 57 N | 079 54 08 W |
| Scott Whaley Lake | Reservoir | 18 | Berkeley | 33 06 43 N | 080 02 11 W |
| Seaton | Populated Place | 10 | Berkeley | 33 07 04 N | 080 00 34 W |
| Sedgefield (subdivision) | Populated Place | 14 | Berkeley | 32 58 29 N | 080 00 39 W |
| Sedgefield Middle School | School | 13 | Berkeley | 32 58 48 N | 080 00 45 W |
| Shannon Park (subdivision) | Populated Place | 12 | Berkeley | 33 00 31 N | 080 02 26 W |
| Sheep Island School (historical) | School | 30 | Berkeley | 33 06 27 N | 080 08 39 W |
| Shulerville | Populated Place | 8 | Berkeley | 33 11 15 N | 079 37 55 W |
| Shulerville Post Office | Post Office | 9 | Berkeley | 33 11 57 N | 079 37 42 W |
| Silk Hope Plantation (historical) | Locale | 5 | Berkeley | 33 07 07 N | 079 49 04 W |
| Silk Hope Plantation Cemetery | Cemetery | 6 | Berkeley | 33 07 05 N | 079 49 05 W |
| Silver Cup Spring | Spring | 9 | Berkeley | 32 55 19 N | 079 59 04 W |
| Simmons Bay | Swamp | 21 | Berkeley | 33 09 35 N | 080 07 55 W |
| Simmonsville | Populated Place | 9 | Berkeley | 33 14 55 N | 079 38 25 W |
| Simpson Crossing | Populated Place | 22 | Berkeley | 33 14 59 N | 079 58 30 W |
| Sinkler Dam (historical) | Dam | 12 | Berkeley | 33 28 53 N | 080 07 26 W |
| Site of Francis Marion Tomb | Cemetery | 19 | Berkeley | 33 27 11 N | 080 05 15 W |
| Slack Reach | Channel | 0 | Berkeley | 32 56 23 N | 079 54 39 W |
| Slave Cemetery | Cemetery | 9 | Berkeley | 33 05 38 N | 079 48 57 W |
| Smith | Populated Place | 8 | Berkeley | 33 03 29 N | 079 46 11 W |
| Smith Branch | Stream | | Berkeley | 33 07 03 N | 080 11 35 W |
| Smith Swamp | Swamp | 5 | Berkeley | 33 00 51 N | 079 51 19 W |
| Smiths Chapel | Church | 22 | Berkeley | 33 26 09 N | 080 06 04 W |
| Smyrna Cemetery | Cemetery | 21 | Berkeley | 33 05 08 N | 080 03 28 W |
| Smyrna Church | Church | 21 | Berkeley | 33 05 08 N | 080 03 29 W |
| Snow Point | Cape | 4 | Berkeley | 32 56 32 N | 079 55 44 W |
| Solomon Lake | Lake | 9 | Berkeley | 33 29 46 N | 080 03 35 W |
| Sophia Swamp | Swamp | 7 | Berkeley | 33 02 22 N | 080 00 57 W |
| South Carolina Noname 08001 D-3473 Dam | Dam | 7 | Berkeley | 33 01 37 N | 079 45 41 W |
| South Carolina Noname 08013 D-3470 Dam | Dam | 5 | Berkeley | 33 02 07 N | 079 58 53 W |
| South Carolina Noname 08015 Dam | Dam | 5 | Berkeley | 33 01 25 N | 079 59 29 W |
| South Carolina Noname 08016 D-3466 Dam | Dam | 15 | Berkeley | 33 13 25 N | 080 00 47 W |
| South Carolina Noname 08019 D-3467 Dam | Dam | 31 | Berkeley | 33 09 07 N | 080 25 11 W |
| South Carolina Noname 08021 D-3463 Dam | Dam | 19 | Berkeley | 33 12 33 N | 080 18 30 W |
| South Carolina Noname 08024 D-3471 Dam | Dam | 2 | Berkeley | 33 04 31 N | 079 54 35 W |
| South Carolina Noname 08025 D-3472 Dam | Dam | 4 | Berkeley | 33 06 19 N | 079 50 53 W |
| South Carolina Noname 08027 D-3464 Dam | Dam | 23 | Berkeley | 33 11 25 N | 080 17 23 W |
| South Carolina Noname 08032 D-3468 Dam | Dam | 18 | Berkeley | 33 06 43 N | 080 02 11 W |
| South Carolina Noname 08033 D-3474 Dam | Dam | 17 | Berkeley | 33 03 13 N | 080 04 41 W |
| South Carolina Noname 08041 D-0037 Dam | Dam | 23 | Berkeley | 33 05 55 N | 080 04 59 W |
| South Carolina Noname 08042 D-3469 Dam | Dam | 22 | Berkeley | 33 05 31 N | 080 04 59 W |
| South Carolina Noname 08045 D-3465 Dam | Dam | 11 | Berkeley | 33 09 37 N | 080 09 41 W |
| South Carolina Noname 08046 D-3477 Dam | Dam | 12 | Berkeley | 33 06 25 N | 080 01 47 W |
| South Pinckney Plantation | Locale | 10 | Berkeley | 33 08 06 N | 079 59 16 W |
| South Pointe | Populated Place | 27 | Berkeley | 33 01 28 N | 080 08 56 W |
| Spring Grove Plantation | Locale | 11 | Berkeley | 33 18 02 N | 079 54 19 W |
| Spring Grove Swamp | Swamp | 14 | Berkeley | 33 17 08 N | 079 56 32 W |
| Spring Head (historical) | Populated Place | 15 | Berkeley | 33 10 44 N | 079 48 24 W |
| Spring Hill | Populated Place | 25 | Berkeley | 33 13 53 N | 080 19 28 W |
| Spring Hill (historical) | Populated Place | 9 | Berkeley | 33 06 46 N | 079 47 36 W |
| Spring Hill Church | Church | 25 | Berkeley | 33 13 53 N | 080 19 33 W |
| Spring Hill Plantation | Locale | 6 | Berkeley | 33 01 48 N | 079 51 58 W |
| Spring Plain (historical) | Populated Place | 24 | Berkeley | 33 22 37 N | 080 10 40 W |
| Springhill Cemetery | Cemetery | 26 | Berkeley | 33 13 52 N | 080 19 31 W |
| Springwood Swamp (historical) | Swamp | 24 | Berkeley | 33 24 01 N | 080 08 04 W |
| Stanley Branch | Stream | | Berkeley | 33 04 32 N | 080 14 43 W |
| Stewart Chapel | Church | 7 | Berkeley | 33 01 25 N | 079 51 18 W |
| Stewart Creek | Stream | | Berkeley | 33 16 23 N | 079 54 25 W |
| Stewarton School (historical) | School | 23 | Berkeley | 33 22 06 N | 080 04 29 W |
| Stokes (historical) | Populated Place | 10 | Berkeley | 33 01 06 N | 079 59 54 W |
| Stony Branch | Stream | | Berkeley | 33 08 50 N | 080 03 04 W |
| Stony Landing | Populated Place | 1 | Berkeley | 33 11 36 N | 079 58 09 W |
| Stony Landing Plantation | Locale | 9 | Berkeley | 33 11 36 N | 079 58 12 W |
| Stratford Forest (subdivision) | Populated Place | 17 | Berkeley | 33 01 09 N | 080 03 25 W |
| Stratford High School | School | 20 | Berkeley | 33 00 46 N | 080 05 09 W |
| Strawberry | Populated Place | 15 | Berkeley | 33 05 30 N | 080 01 50 W |
| Strawberry Chapel | Church | 9 | Berkeley | 33 05 37 N | 079 56 06 W |
| Strawberry Chapel Cemetery | Cemetery | 9 | Berkeley | 33 05 38 N | 079 56 06 W |
| Strawberry Landing | Populated Place | 2 | Berkeley | 33 05 32 N | 079 56 39 W |
| Stroberfield Branch | Stream | | Berkeley | 33 00 43 N | 080 05 41 W |
| Sugar Hill | Populated Place | 27 | Berkeley | 33 12 29 N | 080 02 44 W |
| Sugar Loaf Plantation (historical) | Locale | 11 | Berkeley | 33 19 05 N | 079 49 14 W |
| Sumter Chapel | Church | 21 | Berkeley | 33 21 18 N | 079 57 28 W |
| Sumter School (historical) | School | 21 | Berkeley | 33 21 18 N | 079 57 27 W |
| Sun Down School (historical) | School | 28 | Berkeley | 33 10 21 N | 080 03 16 W |
| Sunset Memorial Cemetery | Cemetery | 23 | Berkeley | 33 24 22 N | 079 54 39 W |
| Swamp Fox | Populated Place | 15 | Berkeley | 33 26 26 N | 079 59 09 W |
| Swamp Fox Ranger Station | Building | 20 | Berkeley | 33 15 03 N | 079 57 45 W |
| Swamp Fox Ranger Station | Locale | 19 | Berkeley | 33 15 13 N | 079 57 44 W |
| Swamp Fox Trail | Trail | 12 | Berkeley | 33 03 37 N | 079 41 19 W |
| Swamp Fox Trailhead | Locale | 7 | Berkeley | 33 07 35 N | 079 48 22 W |
| Tabo Church | Church | 9 | Berkeley | 33 06 22 N | 079 56 22 W |
| Tailrace Canal | Canal | 1 | Berkeley | 33 13 25 N | 079 58 42 W |
| Tall PInes | Populated Place | 15 | Berkeley | 33 00 37 N | 080 06 19 W |
| Tarry Town | Populated Place | 8 | Berkeley | 33 04 53 N | 079 59 34 W |
| Taylor Cemetery | Cemetery | 15 | Berkeley | 33 16 08 N | 079 51 19 W |
| The Barrows | Populated Place | 25 | Berkeley | 33 08 27 N | 080 03 49 W |
| The Big Opening | Swamp | 9 | Berkeley | 33 12 05 N | 079 41 22 W |
| The Cottage | Populated Place | 24 | Berkeley | 33 08 49 N | 080 03 29 W |
| The Droze Cemetery | Cemetery | 19 | Berkeley | 33 01 49 N | 080 03 24 W |
| The Farms | Populated Place | 16 | Berkeley | 32 54 28 N | 080 00 22 W |
| The Grove | Locale | 6 | Berkeley | 32 58 49 N | 079 53 35 W |
| The Oak Chapel | Church | 24 | Berkeley | 33 08 38 N | 080 03 42 W |
| The Oaks (subdivision) | Populated Place | 14 | Berkeley | 32 58 51 N | 080 02 06 W |
| The Tee | Locale | -3 | Berkeley | 33 03 60 N | 079 55 22 W |
| Thomas Corner | Populated Place | 9 | Berkeley | 33 09 39 N | 079 42 53 W |
| Thomas Island | Island | 4 | Berkeley | 32 52 13 N | 079 55 47 W |