Feature Name | Class | Elev. meters | County | Latitude DMS | Longitude DMS |
| Darrell Creek | Stream | | Charleston | 32 55 06 N | 079 46 07 W |
| Darts Point | Cape | 1 | Charleston | 32 55 33 N | 079 48 02 W |
| Davidson-Moberry School (historical) | School | 7 | Charleston | 32 48 28 N | 080 09 19 W |
| Dawho Bridge | Bridge | 9 | Charleston | 32 38 12 N | 080 20 30 W |
| Dawho River | Stream | | Charleston | 32 37 38 N | 080 16 19 W |
| Deep Creek | Stream | | Charleston | 32 55 19 N | 079 46 15 W |
| Deepwater Creek | Stream | | Charleston | 33 03 27 N | 079 22 25 W |
| Deepwater Point | Cape | 0 | Charleston | 33 03 27 N | 079 22 26 W |
| Deer Park | Populated Place | 18 | Charleston | 32 58 17 N | 080 03 59 W |
| Deer Park Church | Church | 10 | Charleston | 32 58 18 N | 080 03 02 W |
| Deerwood Heights | Populated Place | 14 | Charleston | 32 57 33 N | 080 03 44 W |
| Delemar Crossroads | Populated Place | 13 | Charleston | 32 50 47 N | 080 17 03 W |
| Dellwood | Populated Place | 5 | Charleston | 32 44 01 N | 079 55 21 W |
| Deveaux Bank | Bar | 2 | Charleston | 32 32 43 N | 080 10 28 W |
| Devils Den Creek | Stream | | Charleston | 33 02 25 N | 079 22 31 W |
| Dewees Creek | Stream | | Charleston | 32 49 26 N | 079 43 23 W |
| Dewees Inlet | Bay | -12 | Charleston | 32 49 20 N | 079 43 14 W |
| Dewees Island | Island | 2 | Charleston | 32 50 25 N | 079 42 59 W |
| Deweys Hill | Populated Place | 3 | Charleston | 32 53 35 N | 079 58 39 W |
| Dill Creek | Stream | | Charleston | 32 45 44 N | 079 56 45 W |
| Dills Bluff | Cliff | 2 | Charleston | 32 44 50 N | 079 56 50 W |
| Dixie Plantation | Locale | 12 | Charleston | 32 44 19 N | 080 10 32 W |
| Dock Street Theatre | Building | 8 | Charleston | 32 46 41 N | 079 55 46 W |
| Dodge Plantation | Locale | 8 | Charleston | 32 36 07 N | 080 16 54 W |
| Doe Hall Creek | Stream | | Charleston | 33 02 35 N | 079 32 03 W |
| Dogwood Gardens | Populated Place | 7 | Charleston | 32 49 54 N | 080 02 02 W |
| Dogwood Park (subdivision) | Populated Place | 6 | Charleston | 32 45 29 N | 079 58 19 W |
| Dorchester | Populated Place | 4 | Charleston | 32 50 59 N | 079 59 17 W |
| Dorchester School (historical) | School | 11 | Charleston | 32 51 14 N | 080 00 59 W |
| Dorchester-Waylyn Baptist Church | Church | 9 | Charleston | 32 51 14 N | 079 59 42 W |
| Downs Creek | Stream | | Charleston | 32 43 18 N | 079 55 47 W |
| Drayton | Populated Place | 11 | Charleston | 32 50 46 N | 080 03 24 W |
| Drayton Hall | Locale | 7 | Charleston | 32 52 16 N | 080 04 35 W |
| Drayton Hall Middle School | School | 9 | Charleston | 32 51 19 N | 080 04 23 W |
| Drayton Swamp | Swamp | 8 | Charleston | 32 49 41 N | 080 17 43 W |
| Drum Island | Island | 7 | Charleston | 32 48 29 N | 079 55 31 W |
| Drum Island Reach | Channel | 3 | Charleston | 32 50 03 N | 079 55 17 W |
| Drum Islands | Island | -3 | Charleston | 33 08 07 N | 079 16 28 W |
| Duck Island | Island | 2 | Charleston | 32 49 42 N | 079 58 23 W |
| Duck Island Channel | Channel | -2 | Charleston | 32 49 38 N | 079 58 31 W |
| Dupont Station | Populated Place | 7 | Charleston | 32 47 18 N | 080 01 15 W |
| DuPre Creek | Gut | -3 | Charleston | 33 04 01 N | 079 25 19 W |
| DuPre Creek | Gut | 1 | Charleston | 33 06 01 N | 079 24 27 W |
| Dupre Creek | Gut | 0 | Charleston | 33 04 58 N | 079 25 13 W |
| Durant Avenue Church of Christ | Church | 10 | Charleston | 32 52 44 N | 079 59 16 W |
| Eagle Island | Island | 3 | Charleston | 32 49 26 N | 079 46 15 W |
| Eagle Point | Cape | 3 | Charleston | 32 37 11 N | 080 02 58 W |
| East Bay Playground | Park | 2 | Charleston | 32 46 29 N | 079 55 33 W |
| East Bay School | School | 3 | Charleston | 32 48 04 N | 079 56 17 W |
| East Cooper Airport | Airport | 3 | Charleston | 32 53 53 N | 079 46 58 W |
| East Cooper Community Hospital | Hospital | 1 | Charleston | 32 48 50 N | 079 51 23 W |
| East Cooper Plaza Shopping Center | Locale | 5 | Charleston | 32 48 23 N | 079 52 51 W |
| East Cooper Private School | School | 6 | Charleston | 32 48 04 N | 079 53 16 W |
| East Marsh Island | Island | 3 | Charleston | 32 50 27 N | 079 58 55 W |
| Ebenezer Church | Church | 6 | Charleston | 32 40 01 N | 080 20 34 W |
| Ebenezer Church | Church | 4 | Charleston | 32 47 46 N | 079 51 10 W |
| Edgewater Park | Populated Place | 4 | Charleston | 32 46 19 N | 080 00 05 W |
| Edings Island | Island | 1 | Charleston | 32 30 05 N | 080 18 10 W |
| Edingsville Beach | Beach | 2 | Charleston | 32 31 25 N | 080 15 49 W |
| Edisto Beach State Park | Park | 0 | Charleston | 32 30 21 N | 080 18 40 W |
| Edisto Church | Church | 12 | Charleston | 32 34 45 N | 080 17 48 W |
| Edisto Island | Island | 7 | Charleston | 32 33 34 N | 080 17 42 W |
| Edisto Island | Populated Place | 2 | Charleston | 32 33 37 N | 080 16 47 W |
| Edisto Island Church | Church | 11 | Charleston | 32 34 48 N | 080 18 30 W |
| Edisto Island Library | Building | 7 | Charleston | 32 34 23 N | 080 17 09 W |
| Edisto Island School | School | 7 | Charleston | 32 34 23 N | 080 17 09 W |
| Edisto River | Stream | | Charleston | 32 39 16 N | 080 23 17 W |
| Edisto Sand Pit | Mine | 2 | Charleston | 32 45 32 N | 080 26 14 W |
| Edith L Frierson Elementary School | School | 10 | Charleston | 32 38 24 N | 080 10 58 W |
| Edmund A Burns Elementary School | School | 11 | Charleston | 32 51 13 N | 079 59 28 W |
| Elliott Cut | Channel | -2 | Charleston | 32 46 08 N | 079 59 25 W |
| Elmwood Hunt Camp | Locale | 6 | Charleston | 33 11 53 N | 079 28 13 W |
| Emanuel African Methodist Episcopal Church | Church | 3 | Charleston | 32 47 15 N | 079 55 59 W |
| Emanuel School | School | 3 | Charleston | 32 48 18 N | 079 57 26 W |
| Emanuel Synagogue | Church | 2 | Charleston | 32 48 17 N | 079 57 28 W |
| Episcopal Church of the Good Shepherd | Church | 10 | Charleston | 32 52 55 N | 079 58 56 W |
| Ernest F. Hollings ACE Basin National Wildlife Refuge | Park | | Charleston | 32 38 00 N | 080 23 00 W |
| Essex Village (subdivision) | Populated Place | 7 | Charleston | 32 47 43 N | 080 02 34 W |
| Eureka School (historical) | School | 7 | Charleston | 32 47 25 N | 080 23 59 W |
| Evanston Estates (subdivision) | Populated Place | 11 | Charleston | 32 51 25 N | 080 02 57 W |
| Evanston Plaza Shopping Center | Locale | 12 | Charleston | 32 51 26 N | 080 02 39 W |
| Exchange and Provost Building | Building | 6 | Charleston | 32 46 37 N | 079 55 36 W |
| Exchange Landing | Locale | 2 | Charleston | 32 43 18 N | 080 00 29 W |
| Faber Place (subdivision) | Populated Place | 12 | Charleston | 32 50 47 N | 080 01 47 W |
| Fabian Shopping Center | Locale | 5 | Charleston | 32 52 21 N | 079 59 40 W |
| Fairfield Office Park | Locale | 6 | Charleston | 32 47 58 N | 080 01 06 W |
| Fairfield Plantation | Locale | 6 | Charleston | 33 10 58 N | 079 24 16 W |
| Fairmount Shopping Plaza Shopping Center | Locale | 2 | Charleston | 32 48 36 N | 079 52 01 W |
| Faith Church | Church | 20 | Charleston | 32 43 34 N | 080 21 01 W |
| Faith Church | Church | 13 | Charleston | 32 43 41 N | 080 04 12 W |
| Farmington | Populated Place | 3 | Charleston | 32 43 39 N | 079 57 09 W |
| Federwitz Branch | Stream | | Charleston | 32 58 15 N | 080 07 27 W |
| Fellowship Road Park | Park | 8 | Charleston | 32 52 13 N | 080 02 48 W |
| Fenwick Crossroads | Populated Place | 11 | Charleston | 32 43 15 N | 080 04 56 W |
| Fenwick Hall | Locale | 6 | Charleston | 32 45 03 N | 080 02 18 W |
| Fenwick Hills | Populated Place | 11 | Charleston | 32 44 06 N | 080 04 25 W |
| Ferndale (subdivision) | Populated Place | 10 | Charleston | 32 52 55 N | 080 00 16 W |
| Ferry Field Church | Church | 5 | Charleston | 32 46 46 N | 080 06 12 W |
| Ferry Field School (historical) | School | 5 | Charleston | 32 46 44 N | 080 06 12 W |
| Fetteressa (subdivision) | Populated Place | 11 | Charleston | 32 51 16 N | 080 02 36 W |
| Fickling Creek | Stream | | Charleston | 32 37 22 N | 080 09 55 W |
| Filbin Creek | Stream | | Charleston | 32 53 36 N | 079 57 56 W |
| Fire Station Number 1 | Building | 6 | Charleston | 32 46 39 N | 079 55 51 W |
| Fire Station Number 5 | Building | 5 | Charleston | 32 47 19 N | 079 56 29 W |
| Fireproof Building | Building | 6 | Charleston | 32 46 38 N | 079 55 50 W |
| First Assembly of God Church | Church | 6 | Charleston | 32 48 39 N | 079 57 05 W |
| First Baptist Church | Church | 7 | Charleston | 32 46 27 N | 079 55 45 W |
| First Baptist Church of Mount Pleasant | Church | 1 | Charleston | 32 47 12 N | 079 51 49 W |
| First Christian Church | Church | 5 | Charleston | 32 47 07 N | 079 56 19 W |
| First Church of Christ Scientist | Church | 4 | Charleston | 32 47 53 N | 079 57 18 W |