Feature Name | Class | Elev. meters | County | Latitude DMS | Longitude DMS |
| Sampson Island | Island | 2 | Colleton | 32 36 08 N | 080 24 25 W |
| Sampson Island Creek | Stream | | Colleton | 32 36 13 N | 080 25 35 W |
| Sand Hill Baptist Church | Church | 27 | Colleton | 32 55 21 N | 080 41 11 W |
| Sanders Cemetery | Cemetery | 9 | Colleton | 32 52 30 N | 080 28 24 W |
| Sandhill School (historical) | School | 19 | Colleton | 32 55 34 N | 080 26 54 W |
| Sandy Dam Branch | Stream | | Colleton | 32 51 56 N | 080 33 51 W |
| Sandy Dam Church | Church | 11 | Colleton | 32 52 51 N | 080 37 09 W |
| Sandy Run | Stream | | Colleton | 32 47 53 N | 080 51 49 W |
| Sandy Run | Stream | | Colleton | 32 58 34 N | 080 25 08 W |
| Savannah Creek | Stream | | Colleton | 33 01 13 N | 081 03 58 W |
| Sawyers Island | Island | 2 | Colleton | 32 33 49 N | 080 28 57 W |
| Seabrook | Populated Place | 6 | Colleton | 32 31 35 N | 080 24 26 W |
| Seabrook School (historical) | School | 3 | Colleton | 32 31 39 N | 080 24 31 W |
| Settlement Islands | Island | 2 | Colleton | 32 35 05 N | 080 28 32 W |
| Shereau Branch | Stream | | Colleton | 32 52 52 N | 080 34 33 W |
| Sheridan School (historical) | School | 12 | Colleton | 33 02 34 N | 080 26 12 W |
| Shiloh Cemetery | Cemetery | 21 | Colleton | 32 51 34 N | 080 51 05 W |
| Shiloh Church | Church | 20 | Colleton | 32 51 32 N | 080 51 08 W |
| Sidney | Populated Place | 31 | Colleton | 32 59 59 N | 080 34 06 W |
| Simmons Johnsville School (historical) | School | 37 | Colleton | 33 07 40 N | 080 46 47 W |
| Skull Branch | Stream | | Colleton | 33 03 27 N | 080 30 49 W |
| Skull Branch School | School | 33 | Colleton | 33 02 17 N | 080 33 24 W |
| Smith Cemetery | Cemetery | 36 | Colleton | 33 06 15 N | 080 52 13 W |
| Smith Cemetery | Cemetery | 34 | Colleton | 33 03 51 N | 080 51 55 W |
| Smoaks | Populated Place | 32 | Colleton | 33 05 23 N | 080 48 50 W |
| Smoaks Baptist Church | Church | 30 | Colleton | 33 05 21 N | 080 49 15 W |
| Smoaks Cemetery | Cemetery | 31 | Colleton | 33 05 20 N | 080 49 16 W |
| Smoaks Middle School | School | 35 | Colleton | 33 05 28 N | 080 47 54 W |
| Smokes Corners | Locale | 28 | Colleton | 32 57 37 N | 080 41 50 W |
| Smyly | Populated Place | 25 | Colleton | 33 01 34 N | 080 47 44 W |
| Smyly Cemetery | Cemetery | 26 | Colleton | 33 01 50 N | 080 47 28 W |
| Sniders Crossroads | Populated Place | 21 | Colleton | 32 53 21 N | 080 51 11 W |
| Sniders School (historical) | School | 24 | Colleton | 32 53 25 N | 080 50 17 W |
| Snipe School | School | 4 | Colleton | 32 53 28 N | 080 31 05 W |
| Snipe School (historical) | School | 11 | Colleton | 32 54 27 N | 080 31 03 W |
| Snuggedy Swamp | Swamp | 4 | Colleton | 32 39 53 N | 080 28 27 W |
| Social Hall Creek | Stream | | Colleton | 32 37 08 N | 080 32 02 W |
| South Carolina Noname 15007 D-2384 Dam | Dam | 6 | Colleton | 32 52 55 N | 080 36 59 W |
| South Carolina Noname 15008 D-2385 Dam | Dam | 12 | Colleton | 32 52 31 N | 080 36 41 W |
| South Carolina Noname 15028 D-2383 Dam | Dam | 20 | Colleton | 33 01 07 N | 080 50 17 W |
| South Carolina Noname 15033 D-2388 Dam | Dam | 25 | Colleton | 33 07 19 N | 080 42 17 W |
| South Edisto River | Stream | | Colleton | 32 28 56 N | 080 21 11 W |
| Spell Cemetery | Cemetery | 29 | Colleton | 33 07 08 N | 080 42 43 W |
| Spell-Risher Cemetery | Cemetery | 30 | Colleton | 33 08 42 N | 080 45 02 W |
| Springhill Church | Church | 11 | Colleton | 32 57 53 N | 080 28 51 W |
| Springtown | Populated Place | 24 | Colleton | 33 05 57 N | 080 40 34 W |
| Springtown Church | Church | 25 | Colleton | 33 06 06 N | 080 40 51 W |
| Springtown School | School | 26 | Colleton | 33 06 05 N | 080 40 52 W |
| Steedley Branch | Stream | | Colleton | 33 06 24 N | 080 49 03 W |
| Stokes | Populated Place | 26 | Colleton | 32 57 34 N | 080 43 32 W |
| Stokes Bridge | Bridge | 15 | Colleton | 33 03 41 N | 080 31 33 W |
| Stokes Lookout Tower | Tower | 23 | Colleton | 33 00 29 N | 080 42 04 W |
| Stokes School (historical) | School | 24 | Colleton | 32 57 58 N | 080 43 28 W |
| Stone Branch School (historical) | School | 30 | Colleton | 32 52 51 N | 080 42 31 W |
| Strickland Cemetery | Cemetery | 35 | Colleton | 33 03 39 N | 080 50 55 W |
| Strickland School | School | 36 | Colleton | 33 04 57 N | 080 51 12 W |
| Sykes Savannah Church | Church | 23 | Colleton | 32 59 06 N | 080 51 37 W |
| Tabernacle Cemetery | Cemetery | 34 | Colleton | 33 07 27 N | 080 48 35 W |
| Tabernacle Church | Church | 35 | Colleton | 33 07 29 N | 080 48 36 W |
| Tabor Cemetery | Cemetery | 26 | Colleton | 32 56 59 N | 080 46 31 W |
| Tabor Methodist Church | Church | 26 | Colleton | 32 56 60 N | 080 46 33 W |
| Tabor School | School | 26 | Colleton | 32 57 15 N | 080 47 06 W |
| Tabor School (historical) | School | 23 | Colleton | 32 52 38 N | 080 46 41 W |
| Thayer | Populated Place | 13 | Colleton | 32 52 29 N | 080 37 43 W |
| The Church of Jesus Christ of Latter Day Saints | Church | 26 | Colleton | 32 55 42 N | 080 40 56 W |
| Tilly Island | Island | 3 | Colleton | 32 38 04 N | 080 34 18 W |
| Toby Bluff | Cliff | 19 | Colleton | 32 54 44 N | 080 59 21 W |
| Tobys Bluff | Populated Place | 16 | Colleton | 32 54 40 N | 080 59 20 W |
| Tobys Bluff Church | Church | 23 | Colleton | 32 55 09 N | 080 57 37 W |
| Tobys Bluff School (historical) | School | 23 | Colleton | 32 55 09 N | 080 57 36 W |
| Trinity Cemetery | Cemetery | 32 | Colleton | 33 05 33 N | 080 48 50 W |
| Trinity Church | Church | 6 | Colleton | 32 40 23 N | 080 37 48 W |
| Trinity Church | Church | 7 | Colleton | 32 51 59 N | 080 29 21 W |
| Trinity Methodist Church | Church | 33 | Colleton | 33 05 33 N | 080 48 51 W |
| Trinity School (historical) | School | 7 | Colleton | 32 49 34 N | 080 29 30 W |
| Tupelo Swamp | Swamp | 2 | Colleton | 32 47 34 N | 080 30 19 W |
| Two Sisters Creek | Stream | | Colleton | 32 30 13 N | 080 26 32 W |
| Ulmer Cemetery | Cemetery | 22 | Colleton | 32 55 05 N | 080 51 46 W |
| Varntown (historical) | Populated Place | 19 | Colleton | 32 51 55 N | 080 53 56 W |
| WALD-FM (Walterboro) | Tower | 15 | Colleton | 32 52 53 N | 080 41 23 W |
| Walterboro | Populated Place | 18 | Colleton | 32 54 19 N | 080 40 00 W |
| Walterboro Army Air Field (historical) | Military (Historical) | 29 | Colleton | 32 55 15 N | 080 38 30 W |
| Walterboro Historic District | Park | 26 | Colleton | 32 54 08 N | 080 39 52 W |
| Walterboro Municipal Airport | Airport | 30 | Colleton | 32 55 14 N | 080 38 28 W |
| Walterboro Plaza Shopping Center | Locale | 27 | Colleton | 32 55 23 N | 080 40 34 W |
| Walterboro Senior High School | School | 21 | Colleton | 32 54 53 N | 080 39 12 W |
| Walters Store | Locale | 4 | Colleton | 32 38 06 N | 080 35 29 W |
| Wards Cross School (historical) | School | 10 | Colleton | 32 49 51 N | 080 35 46 W |
| Warren Island | Island | 1 | Colleton | 32 33 48 N | 080 31 49 W |
| Warren-Key Cemetery | Cemetery | 33 | Colleton | 33 02 21 N | 080 49 15 W |
| Warrens Savanna | Swamp | 5 | Colleton | 32 54 14 N | 080 28 38 W |
| Weeks | Populated Place | 26 | Colleton | 33 02 49 N | 080 37 35 W |
| Welch Green School (historical) | School | 32 | Colleton | 32 57 43 N | 080 36 17 W |
| Wesley Cemetery | Cemetery | 36 | Colleton | 33 01 56 N | 081 02 42 W |
| Wesley Chapel | Church | 37 | Colleton | 33 01 50 N | 081 02 49 W |
| Wesley Church | Church | 22 | Colleton | 32 59 05 N | 080 32 00 W |
| Wesley School (historical) | School | 22 | Colleton | 32 59 06 N | 080 32 02 W |
| Wesley United Methodist Church | Church | 27 | Colleton | 32 54 12 N | 080 39 22 W |
| Westglow Haven Lake | Reservoir | 19 | Colleton | 32 56 25 N | 080 45 23 W |
| Westglow Haven Lake Dam D-2389 | Dam | 19 | Colleton | 32 56 25 N | 080 45 23 W |
| White Hall | Populated Place | 4 | Colleton | 32 43 19 N | 080 41 25 W |
| White Hall Church | Church | 6 | Colleton | 32 43 01 N | 080 40 37 W |
| White Hall Plantation | Locale | 5 | Colleton | 32 43 30 N | 080 41 36 W |
| White Hall School (historical) | School | 8 | Colleton | 32 42 45 N | 080 37 57 W |
| White House Woods | Woods | 3 | Colleton | 32 34 51 N | 080 27 32 W |
| White Meeting Cemetery | Cemetery | 3 | Colleton | 32 47 52 N | 080 29 28 W |
| Whitehouse Plantation | Locale | 4 | Colleton | 32 45 12 N | 080 34 14 W |
| Wiggins | Populated Place | 12 | Colleton | 32 36 17 N | 080 32 37 W |
| Wiggins School (historical) | School | 9 | Colleton | 32 36 06 N | 080 33 01 W |
| Williams | Populated Place | 32 | Colleton | 33 02 05 N | 080 50 33 W |