Feature Name | Class | Elev. meters | County | Latitude DMS | Longitude DMS |
| New Home Cemetery | Cemetery | 46 | Allendale | 32 58 24 N | 081 18 13 W |
| New Providence School (historical) | School | 46 | Darlington | 34 20 23 N | 079 46 17 W |
| Orangeburg National Fish Hatchery | Locale | 46 | Orangeburg | 33 24 33 N | 080 52 50 W |
| Parrotts Mill (historical) | Locale | 46 | Darlington | 34 18 41 N | 079 58 19 W |
| Pate School | School | 46 | Darlington | 34 17 16 N | 079 53 51 W |
| Pine Grove Church | Church | 46 | Darlington | 34 11 42 N | 079 56 02 W |
| Pugh Cemetery | Cemetery | 46 | Darlington | 34 21 46 N | 079 46 29 W |
| Reedy Branch Church (historical) | Church | 46 | Marlboro | 34 36 58 N | 079 29 01 W |
| Reedy Branch School (historical) | School | 46 | Marlboro | 34 36 57 N | 079 29 01 W |
| Rogers Crossroads | Populated Place | 46 | Darlington | 34 15 58 N | 079 53 16 W |
| Rogers Pond Dam D-3232 | Dam | 46 | Chesterfield | 34 35 43 N | 079 53 35 W |
| Saint James United Methodist Church | Church | 46 | Darlington | 34 18 04 N | 079 52 28 W |
| Saint John Historic District | Park | 46 | Darlington | 34 18 16 N | 079 52 31 W |
| Saint Johns School | School | 46 | Darlington | 34 18 19 N | 079 52 32 W |
| Saint Lukes Church | Church | 46 | Orangeburg | 33 20 43 N | 080 48 24 W |
| Saint Lukes School (historical) | School | 46 | Orangeburg | 33 20 44 N | 080 48 20 W |
| Saint Matthews Episcopal Church | Church | 46 | Darlington | 34 18 03 N | 079 52 12 W |
| Salem Baptist Church | Church | 46 | Darlington | 34 17 32 N | 079 51 51 W |
| Salkehatchie Cemetery | Cemetery | 46 | Allendale | 33 06 05 N | 081 11 39 W |
| Sandy Run | Populated Place | 46 | Calhoun | 33 47 60 N | 080 57 50 W |
| Scarborough Cemetery | Cemetery | 46 | Darlington | 34 08 01 N | 080 07 14 W |
| Second Baptist Church | Church | 46 | Darlington | 34 17 48 N | 079 52 55 W |
| Shehane Cabin Pond | Reservoir | 46 | Calhoun | 33 40 13 N | 080 39 23 W |
| Shehane Cabin Pond Dam D-2659 | Dam | 46 | Calhoun | 33 40 13 N | 080 39 23 W |
| Shehane Pump House Pond | Reservoir | 46 | Calhoun | 33 40 01 N | 080 38 59 W |
| Shiloh Church | Church | 46 | Orangeburg | 33 23 55 N | 080 42 31 W |
| Silver Lake | Reservoir | 46 | Lexington | 33 52 57 N | 081 02 49 W |
| Small School | School | 46 | Chesterfield | 34 42 09 N | 079 52 59 W |
| Solomons Store (historical) | Locale | 46 | Allendale | 32 48 13 N | 081 20 28 W |
| South Carolina Noname 09011 D-2625 Dam | Dam | 46 | Calhoun | 33 42 43 N | 080 48 47 W |
| South Carolina Noname 09032 D-2647 Dam | Dam | 46 | Calhoun | 33 37 01 N | 080 35 35 W |
| South Carolina Noname 09039 D-2654 Dam | Dam | 46 | Calhoun | 33 40 01 N | 080 38 59 W |
| South Carolina Noname 09045 D-2924 Dam | Dam | 46 | Calhoun | 33 47 13 N | 081 00 05 W |
| South Carolina Noname 31004 D-2423 Dam | Dam | 46 | Lee | 34 01 13 N | 080 11 53 W |
| South Carolina Noname 32041 D-0986 Dam | Dam | 46 | Lexington | 33 52 57 N | 081 02 49 W |
| South Lynchburg | Populated Place | 46 | Lee | 34 03 09 N | 080 03 39 W |
| Speigners Pond | Reservoir | 46 | Calhoun | 33 42 41 N | 080 48 42 W |
| Spring Acres (subdivision) | Populated Place | 46 | Darlington | 34 19 46 N | 079 52 54 W |
| Sunset Country Club | Locale | 46 | Sumter | 33 53 48 N | 080 22 44 W |
| Tabernacle Baptist Church (historical) | Church | 46 | Chesterfield | 34 41 50 N | 079 52 49 W |
| Taylor Pond | Reservoir | 46 | Lexington | 33 56 58 N | 081 04 31 W |
| Teal Chapel | Church | 46 | Chesterfield | 34 40 04 N | 080 01 24 W |
| Trinity United Methodist Church | Church | 46 | Darlington | 34 18 08 N | 079 52 21 W |
| Union Baptist Church | Church | 46 | Darlington | 34 17 29 N | 079 53 01 W |
| Venison Hunt Club | Locale | 46 | Allendale | 32 49 51 N | 081 21 28 W |
| Wallace | Populated Place | 46 | Marlboro | 34 43 13 N | 079 50 29 W |
| Wallace Crossroads | Populated Place | 46 | Darlington | 34 12 09 N | 079 54 54 W |
| Wallace Elementary School | School | 46 | Marlboro | 34 43 01 N | 079 50 12 W |
| Warwick Estates | Populated Place | 46 | Sumter | 33 53 07 N | 080 22 52 W |
| Westberry School (historical) | School | 46 | Sumter | 34 00 53 N | 080 33 27 W |
| Will of Faith Church | Church | 46 | Darlington | 34 08 56 N | 079 59 54 W |
| Wilson Crossroads | Populated Place | 46 | Darlington | 34 13 23 N | 079 53 47 W |
| Wilson Hospital | Hospital | 46 | Darlington | 34 18 53 N | 079 50 14 W |
| Winthrop Club (historical) | Locale | 46 | Allendale | 32 49 24 N | 081 21 33 W |
| Anderson Cemetery | Cemetery | 45 | Darlington | 34 10 52 N | 079 55 06 W |
| Asbury Church | Church | 45 | Marlboro | 34 32 33 N | 079 33 29 W |
| Atlas Road School | School | 45 | Richland | 33 56 34 N | 080 58 30 W |
| Ayers (historical) | Populated Place | 45 | Marlboro | 34 36 39 N | 079 42 09 W |
| B A Gary Middle School | School | 45 | Darlington | 34 17 23 N | 079 52 20 W |
| Barber Mill Church | Church | 45 | Lee | 34 01 07 N | 080 08 57 W |
| Barber Mill School (historical) | School | 45 | Lee | 34 01 06 N | 080 08 59 W |
| Barrett church (historical) | Church | 45 | Clarendon | 33 41 16 N | 080 17 10 W |
| Bethel African Methodist Episcopal Church | Church | 45 | Sumter | 33 55 29 N | 080 20 01 W |
| Bethel African Methodist Episcopal Churh | Church | 45 | Darlington | 34 17 41 N | 079 52 38 W |
| Beulah Methodist Church | Church | 45 | Marlboro | 34 36 13 N | 079 41 13 W |
| Bible Way Church | Church | 45 | Richland | 33 56 28 N | 080 58 28 W |
| Bluff Estates | Populated Place | 45 | Richland | 33 56 18 N | 080 58 24 W |
| Bostic Pond (historical) | Lake | 45 | Allendale | 32 58 08 N | 081 18 52 W |
| Bowens Manor (subdivision) | Populated Place | 45 | Darlington | 34 17 45 N | 079 51 19 W |
| Boykin Mill Pond | Reservoir | 45 | Kershaw | 34 07 55 N | 080 34 45 W |
| Boykin Millpond | Reservoir | 45 | Kershaw | 34 07 55 N | 080 34 47 W |
| Brockington Elementary School | School | 45 | Florence | 34 08 22 N | 079 56 37 W |
| Brown Cemetery | Cemetery | 45 | Clarendon | 33 37 55 N | 080 23 57 W |
| Browns Pond | Reservoir | 45 | Allendale | 33 06 25 N | 081 32 03 W |
| Bull Pond | Reservoir | 45 | Calhoun | 33 33 34 N | 080 44 17 W |
| Bulls Pond Dam D-3774 | Dam | 45 | Orangeburg | 33 26 31 N | 080 32 53 W |
| Buycls Swamp Pond | Reservoir | 45 | Calhoun | 33 42 49 N | 080 46 41 W |
| Buycls Swamp Pond Dam D-2928 | Dam | 45 | Calhoun | 33 42 49 N | 080 46 41 W |
| Cain School | School | 45 | Darlington | 34 17 32 N | 079 51 35 W |
| Calhoun Street Church of God | Church | 45 | Bamberg | 33 17 15 N | 081 02 30 W |
| Calvary Church | Church | 45 | Marlboro | 34 36 39 N | 079 41 45 W |
| Campbell Mill (historical) | Locale | 45 | Chesterfield | 34 35 45 N | 079 59 03 W |
| Canaan | Populated Place | 45 | Orangeburg | 33 19 44 N | 080 56 27 W |
| Canaan School (historical) | School | 45 | Orangeburg | 33 19 56 N | 080 56 15 W |
| Carmichael Crossroads | Populated Place | 45 | Dillon | 34 27 50 N | 079 17 15 W |
| Carolina Presbyterian Church Cemetery | Cemetery | 45 | Dillon | 34 34 25 N | 079 26 19 W |
| Cartersville Baptist Church | Church | 45 | Florence | 34 04 59 N | 080 01 28 W |
| Center Point School (historical) | School | 45 | Lee | 34 01 29 N | 080 10 32 W |
| Center School | School | 45 | Darlington | 34 11 48 N | 079 54 50 W |
| Central Baptist Church | Church | 45 | Darlington | 34 18 18 N | 079 52 22 W |
| Chapmans Pond | Reservoir | 45 | Darlington | 34 25 12 N | 079 56 31 W |
| Cheathan Lake Dam D-3219 | Dam | 45 | Chesterfield | 34 40 25 N | 079 54 35 W |
| Cheraw State Park Two Dam D-3224 | Dam | 45 | Chesterfield | 34 38 13 N | 079 55 05 W |
| Chestnuts Mill (historical) | Locale | 45 | Kershaw | 34 18 39 N | 080 40 38 W |
| Christ Temple Holiness Church | Church | 45 | Darlington | 34 17 24 N | 079 51 46 W |
| Church of God | Church | 45 | Darlington | 34 17 46 N | 079 52 17 W |
| Clearwater | Populated Place | 45 | Aiken | 33 29 48 N | 081 53 31 W |
| Clifton Church | Church | 45 | Hampton | 32 47 41 N | 081 19 17 W |
| Cohen Cemetery | Cemetery | 45 | Allendale | 32 54 04 N | 081 23 42 W |
| Columbia Reservoir | Reservoir | 45 | Richland | 34 02 01 N | 081 04 11 W |
| Columbia Water Reservoir Dam | Dam | 45 | Richland | 34 02 01 N | 081 04 11 W |
| Corner School (historical) | School | 45 | Orangeburg | 33 19 39 N | 080 54 35 W |
| Darlington | Populated Place | 45 | Darlington | 34 17 60 N | 079 52 34 W |
| Darlington County Library | Building | 45 | Darlington | 34 18 16 N | 079 52 21 W |
| Eastside Junior High School | School | 45 | Marlboro | 34 37 48 N | 079 40 32 W |
| Ehrhardt Cemetery | Cemetery | 45 | Bamberg | 33 05 43 N | 081 06 38 W |
| Ellerbees Millpond | Reservoir | 45 | Sumter | 34 04 07 N | 080 31 53 W |
| Ellerbees Millpond Dam D-1460 | Dam | 45 | Sumter | 34 04 07 N | 080 31 53 W |
| Emily Kearse Community House (historical) | Building | 45 | Bamberg | 33 06 35 N | 081 05 44 W |
| Evans Church | Church | 45 | Marlboro | 34 36 21 N | 079 41 20 W |