Feature Name | Class | Elev. meters | County | Latitude DMS | Longitude DMS |
| Red Hill | Populated Place | 12 | Georgetown | 33 34 25 N | 079 25 42 W |
| Red Hill Church | Church | 12 | Charleston | 32 46 56 N | 080 11 50 W |
| River Hill | Summit | 12 | Horry | 34 06 30 N | 079 13 12 W |
| River Swamp | Swamp | 12 | Marion | 34 08 11 N | 079 13 12 W |
| Rogers Crossroads | Populated Place | 12 | Georgetown | 33 41 56 N | 079 20 57 W |
| Rogers Islands | Island | 12 | Marion | 34 08 48 N | 079 28 58 W |
| Rose Hill Cemetery | Cemetery | 12 | Beaufort | 32 28 08 N | 080 44 25 W |
| Rose Hill Church | Church | 12 | Georgetown | 33 35 34 N | 079 24 05 W |
| Round Pond Trailhead | Locale | 12 | Berkeley | 33 08 08 N | 079 38 08 W |
| Saint George Church Ruins | Church | 12 | Dorchester | 32 56 57 N | 080 10 13 W |
| Saint James Bethel Church | Church | 12 | Charleston | 32 40 51 N | 080 09 45 W |
| Saint James Estates (subdivision) | Populated Place | 12 | Berkeley | 32 57 37 N | 080 00 49 W |
| Saint James Goose Creek Cemetery | Cemetery | 12 | Berkeley | 32 58 32 N | 080 01 59 W |
| Saint James Goose Creek Church | Church | 12 | Berkeley | 32 58 33 N | 080 01 57 W |
| Saint Johns Church | Church | 12 | Berkeley | 32 55 19 N | 079 53 52 W |
| Saint Johns Church | Church | 12 | Horry | 33 55 23 N | 078 45 32 W |
| Saint Lukes Church | Church | 12 | Berkeley | 33 10 05 N | 079 57 23 W |
| Saint Paul Church | Church | 12 | Georgetown | 33 19 45 N | 079 28 19 W |
| Saint Paul School | School | 12 | Horry | 33 53 54 N | 079 01 37 W |
| Saint Pauls Church | Church | 12 | Charleston | 32 50 34 N | 080 16 56 W |
| Saint Peter Church | Church | 12 | Berkeley | 33 19 51 N | 079 55 21 W |
| Saint Phillips Church | Church | 12 | Charleston | 32 50 36 N | 080 03 30 W |
| Salem School | School | 12 | Horry | 33 49 19 N | 078 57 11 W |
| Sampit | Populated Place | 12 | Georgetown | 33 21 51 N | 079 27 31 W |
| Sampit Church | Church | 12 | Georgetown | 33 21 51 N | 079 27 30 W |
| Sampit Elementary School | School | 12 | Georgetown | 33 19 49 N | 079 28 24 W |
| Sampit Lookout Tower | Tower | 12 | Georgetown | 33 21 27 N | 079 29 06 W |
| Sampit Park | Park | 12 | Georgetown | 33 19 46 N | 079 28 24 W |
| Sampit Station | Locale | 12 | Georgetown | 33 25 15 N | 079 26 54 W |
| Sand Ridge | Ridge | 12 | Georgetown | 33 38 10 N | 079 15 39 W |
| Sandy Bluff Bridge | Bridge | 12 | Horry | 34 08 43 N | 079 12 28 W |
| Savannah Bluff Church | Church | 12 | Horry | 33 48 32 N | 079 01 09 W |
| Savannah Bluff School | School | 12 | Horry | 33 48 15 N | 079 01 02 W |
| Shannon Park (subdivision) | Populated Place | 12 | Berkeley | 33 00 31 N | 080 02 26 W |
| Sheridan School (historical) | School | 12 | Colleton | 33 02 34 N | 080 26 12 W |
| Simpson Creek School | School | 12 | Horry | 33 59 13 N | 078 50 16 W |
| Singletary Forks | Populated Place | 12 | Williamsburg | 33 21 26 N | 079 41 29 W |
| Singletary Islands | Island | 12 | Marion | 34 08 03 N | 079 27 53 W |
| Sinkler Dam (historical) | Dam | 12 | Berkeley | 33 28 53 N | 080 07 26 W |
| Smokey Lake | Lake | 12 | Marion | 34 06 42 N | 079 14 00 W |
| Snowbird Lake | Lake | 12 | Marion | 34 06 51 N | 079 13 56 W |
| South Carolina Gun Club | Locale | 12 | Williamsburg | 33 22 45 N | 079 45 35 W |
| South Carolina Noname 08046 D-3477 Dam | Dam | 12 | Berkeley | 33 06 25 N | 080 01 47 W |
| South Carolina Noname 15008 D-2385 Dam | Dam | 12 | Colleton | 32 52 31 N | 080 36 41 W |
| South Carolina Noname 26025 D-3632 Dam | Dam | 12 | Horry | 33 47 55 N | 078 46 53 W |
| South Carolina Noname 27005 D-2588 Dam | Dam | 12 | Jasper | 32 29 49 N | 081 08 47 W |
| South Conway Elementary School | School | 12 | Horry | 33 49 14 N | 079 04 36 W |
| Spring Grove Church (historical) | Church | 12 | Charleston | 32 47 46 N | 080 20 41 W |
| Sprucewood | Populated Place | 12 | Dorchester | 32 56 51 N | 080 12 59 W |
| Star Bluff Crossroads | Populated Place | 12 | Horry | 33 51 23 N | 078 45 27 W |
| Stave Landing | Populated Place | 12 | Marion | 34 10 38 N | 079 11 27 W |
| Summerville Lookout Tower | Tower | 12 | Dorchester | 32 56 02 N | 080 10 39 W |
| Suttons | Populated Place | 12 | Williamsburg | 33 23 39 N | 079 44 37 W |
| Swamp Fox Trail | Trail | 12 | Berkeley | 33 03 37 N | 079 41 19 W |
| Thompsons Cut Point | Cape | 12 | Hampton | 32 43 55 N | 081 25 00 W |
| Timber Lake | Lake | 12 | Horry | 34 04 33 N | 079 13 45 W |
| Trueway Church | Church | 12 | Horry | 33 54 41 N | 078 38 53 W |
| Tuckahoe Bay | Swamp | 12 | Horry | 33 46 11 N | 078 56 53 W |
| Turkey Pen Swamp | Swamp | 12 | Horry | 34 07 17 N | 079 12 05 W |
| Turkeypen Island | Island | 12 | Horry | 34 07 35 N | 079 12 48 W |
| Union Church | Church | 12 | Horry | 33 54 18 N | 078 39 45 W |
| University Forest | Populated Place | 12 | Horry | 33 48 36 N | 079 00 31 W |
| University of South Carolina-Coastal Carolina College | School | 12 | Horry | 33 47 38 N | 079 00 43 W |
| University Park | Populated Place | 12 | Dorchester | 32 55 11 N | 080 05 42 W |
| Upper Chesnut Lake | Reservoir | 12 | Horry | 33 47 55 N | 078 46 53 W |
| Vaught Lake | Lake | 12 | Horry | 34 04 60 N | 079 13 23 W |
| Waccamaw Elementary School | School | 12 | Horry | 33 49 10 N | 078 59 00 W |
| Waccamaw School | School | 12 | Horry | 33 54 24 N | 078 39 22 W |
| Wadboo | Populated Place | 12 | Berkeley | 33 11 28 N | 079 56 15 W |
| Wadmalaw School | School | 12 | Charleston | 32 40 02 N | 080 10 18 W |
| Wahee Cemetery | Cemetery | 12 | Marion | 34 03 59 N | 079 29 01 W |
| Wahee Neck | Cape | 12 | Marion | 34 02 59 N | 079 28 50 W |
| Wallace Swamp | Swamp | 12 | Berkeley | 33 16 01 N | 079 49 48 W |
| Wando Gardens (subdivision) | Populated Place | 12 | Charleston | 32 50 54 N | 080 01 34 W |
| Warren Crossroads | Populated Place | 12 | Charleston | 32 49 14 N | 080 16 23 W |
| Warsaw | Populated Place | 12 | Williamsburg | 33 30 31 N | 079 33 01 W |
| Washington School (historical) | School | 12 | Berkeley | 33 12 16 N | 079 33 35 W |
| Wiggins | Populated Place | 12 | Colleton | 32 36 17 N | 080 32 37 W |
| Wiggins Swamp | Swamp | 12 | Marion | 34 07 42 N | 079 29 39 W |
| Willie Towne | Populated Place | 12 | Georgetown | 33 32 26 N | 079 25 59 W |
| Willow Springs Church | Church | 12 | Horry | 33 48 47 N | 079 05 51 W |
| Wilsons Landing | Populated Place | 12 | Berkeley | 33 26 55 N | 080 09 42 W |
| WKQB-FM (Saint George) | Tower | 12 | Dorchester | 33 05 12 N | 080 22 32 W |
| WWWZ-FM (Summerville) | Tower | 12 | Dorchester | 32 56 56 N | 080 12 31 W |
| WYFH-FM (North Charleston) | Tower | 12 | Dorchester | 32 56 56 N | 080 12 31 W |
| Yeamans Hall Plantation (historical) | Locale | 12 | Berkeley | 32 55 35 N | 079 58 41 W |
| Zion Church | Church | 12 | Charleston | 32 51 14 N | 080 01 05 W |
| A H Parsons Pond Dam D-3088 | Dam | 11 | Williamsburg | 33 33 19 N | 079 44 35 W |
| Ackerman Pond | Reservoir | 11 | Williamsburg | 33 28 37 N | 079 37 59 W |
| Ackerman Pond Dam D-3096 | Dam | 11 | Williamsburg | 33 28 37 N | 079 37 59 W |
| Airy Hall Airport | Airport | 11 | Colleton | 32 37 56 N | 080 30 14 W |
| Arch Dale Hall | Locale | 11 | Dorchester | 32 53 59 N | 080 06 07 W |
| Archdale | Populated Place | 11 | Dorchester | 32 54 01 N | 080 05 47 W |
| Ashepoo Siding | Populated Place | 11 | Colleton | 32 38 13 N | 080 30 02 W |
| Ashley Phosphate | Locale | 11 | Charleston | 32 55 49 N | 080 03 33 W |
| Avenue of Oaks | Populated Place | 11 | Dorchester | 32 57 51 N | 080 08 50 W |
| Aviation Square Shopping Center | Locale | 11 | Charleston | 32 54 24 N | 080 01 28 W |
| Baker Swamp | Swamp | 11 | Williamsburg | 33 34 56 N | 079 30 30 W |
| Baptist Hill High School | School | 11 | Charleston | 32 43 42 N | 080 15 43 W |
| Barnhill | Populated Place | 11 | Georgetown | 33 42 09 N | 079 22 32 W |
| Bass Lake | Lake | 11 | Marion | 34 06 08 N | 079 14 17 W |
| Baxley Cemetery | Cemetery | 11 | Florence | 33 49 57 N | 079 32 29 W |
| Beaufort County Training School (historical) | School | 11 | Beaufort | 32 27 53 N | 080 44 32 W |
| Bethel Church (historical) | Church | 11 | Marion | 33 54 46 N | 079 21 03 W |
| Bethel School | School | 11 | Marion | 33 54 44 N | 079 20 31 W |
| Bethlehem Church | Church | 11 | Horry | 33 49 18 N | 079 06 25 W |
| Black River Church | Church | 11 | Williamsburg | 33 30 20 N | 079 31 15 W |
| Blanket Point | Cape | 11 | Hampton | 32 39 33 N | 081 24 16 W |
| Boyle School (historical) | School | 11 | Charleston | 32 49 13 N | 080 17 45 W |
| Brittons Neck | Populated Place | 11 | Marion | 33 54 46 N | 079 20 29 W |