Feature Name | Class | Elev. meters | County | Latitude DMS | Longitude DMS |
| McDaniels Pond Dam Number Two | Dam | 122 | Union | 34 39 00 N | 081 26 53 W |
| McDonald Elementary School | School | 5 | Georgetown | 33 23 48 N | 079 19 06 W |
| McDonald Green School | School | 180 | Lancaster | 34 39 15 N | 080 45 51 W |
| McDonald Park | Park | 5 | Georgetown | 33 23 51 N | 079 19 06 W |
| McDonald School (historical) | School | 50 | Lee | 34 05 28 N | 080 08 08 W |
| McDonalds | Populated Place | 57 | Marlboro | 34 37 19 N | 079 32 37 W |
| McDonalds Ferry (historical) | Crossing | 126 | Lancaster | 34 39 06 N | 080 53 17 W |
| McDonalds Ford (historical) | Crossing | 126 | Chester | 34 40 06 N | 080 53 19 W |
| McDonalds Pond | Reservoir | 359 | Greenville | 35 06 00 N | 082 31 29 W |
| McDow Creek | Stream | | Lancaster | 34 29 25 N | 080 49 02 W |
| McDowell Cemetery | Cemetery | 2 | Berkeley | 32 55 57 N | 079 50 03 W |
| McDowell Creek | Stream | | Lancaster | 34 30 50 N | 080 52 27 W |
| McDowell Grove School (historical) | School | 279 | Spartanburg | 35 05 50 N | 081 58 32 W |
| McDowell Island | Island | 70 | Lancaster | 34 30 53 N | 080 52 35 W |
| McDowell Plantation (historical) | Locale | 140 | Kershaw | 34 24 01 N | 080 41 04 W |
| McDuffie Pond | Reservoir | 52 | Sumter | 34 05 37 N | 080 30 47 W |
| McDuffie Pond Dam D-1974 | Dam | 52 | Sumter | 34 05 37 N | 080 30 47 W |
| McDuffie Street Church of God | Church | 240 | Anderson | 34 30 01 N | 082 38 50 W |
| McElhenny Shoal | Rapids | 259 | Greenville | 34 57 02 N | 082 31 24 W |
| McElmoyle School | School | 265 | Anderson | 34 42 26 N | 082 40 27 W |
| McElmurray Pond | Lake | 62 | Aiken | 33 25 06 N | 081 49 13 W |
| McElroy Branch | Stream | | Williamsburg | 33 34 39 N | 079 44 52 W |
| McElveen (subdivision) | Populated Place | 28 | Florence | 34 09 29 N | 079 44 29 W |
| McElwain Creek | Stream | | Spartanburg | 34 49 48 N | 081 46 28 W |
| McFadden Branch | Stream | | Chester | 34 46 38 N | 080 59 54 W |
| Mcfadden Pond Dam D-3483 | Dam | 29 | Clarendon | 33 50 43 N | 080 07 11 W |
| McFadden School (historical) | School | 38 | Clarendon | 33 45 03 N | 080 16 04 W |
| Mcfaddens Pond | Reservoir | 29 | Clarendon | 33 50 43 N | 080 07 11 W |
| McFall Cemetery | Cemetery | 228 | Anderson | 34 28 16 N | 082 33 38 W |
| McGee Acres | Populated Place | 251 | Anderson | 34 33 40 N | 082 38 04 W |
| McGee Branch | Stream | | Chesterfield | 34 27 51 N | 080 19 06 W |
| McGee Cemetery | Cemetery | 156 | Saluda | 33 56 09 N | 081 39 36 W |
| McGee Pond | Reservoir | 267 | Anderson | 34 44 00 N | 082 34 11 W |
| McGee Pond Dam D-3103 | Dam | 213 | Anderson | 34 26 42 N | 082 48 11 W |
| McGill Branch | Stream | | Abbeville | 34 06 53 N | 082 19 54 W |
| McGill School (historical) | School | 196 | Cherokee | 35 03 32 N | 081 28 50 W |
| McGinty Mall | Park | 224 | Pickens | 34 40 28 N | 082 50 05 W |
| McGirts Creek | Stream | | Lee | 34 06 38 N | 080 19 21 W |
| McGougans Bridge | Bridge | 67 | Kershaw | 34 23 39 N | 080 23 07 W |
| McGowan Island | Island | 133 | York | 34 58 17 N | 081 28 46 W |
| McGowan School (historical) | School | 188 | Union | 34 51 23 N | 081 33 45 W |
| McGowans Ferry (historical) | Crossing | 39 | Richland | 34 01 33 N | 081 04 09 W |
| McGowen School (historical) | School | 213 | Cherokee | 35 01 19 N | 081 30 59 W |
| McGrits Millpond | Reservoir | 62 | Lee | 34 08 05 N | 080 20 19 W |
| McGuirts Flint Hill Pond | Reservoir | 74 | Kershaw | 34 21 37 N | 080 40 59 W |
| McGuirts Flint Hill Pond Dam D-2500 | Dam | 74 | Kershaw | 34 21 37 N | 080 40 59 W |
| McGuirts House Pond Number One | Reservoir | 78 | Kershaw | 34 17 31 N | 080 38 05 W |
| McGuirts House Pond Number One Dam D-2524 | Dam | 78 | Kershaw | 34 17 31 N | 080 38 05 W |
| McGuirts House Pond Number Two | Reservoir | 77 | Kershaw | 34 17 25 N | 080 38 11 W |
| McGuirts House Pond Number Two Dam D-2525 | Dam | 77 | Kershaw | 34 17 25 N | 080 38 11 W |
| McGuirts Millpond | Reservoir | 61 | Lee | 34 08 07 N | 080 20 11 W |
| McGullion Mountain | Summit | 414 | Pickens | 34 54 30 N | 082 48 56 W |
| McIihenny School | School | 36 | Orangeburg | 33 12 34 N | 080 46 40 W |
| McInnis (historical) | Populated Place | 51 | Marlboro | 34 33 09 N | 079 30 45 W |
| McInnis Bridge | Bridge | 36 | Dillon | 34 34 59 N | 079 25 25 W |
| McInnis Pond Dam D-3434 | Dam | 49 | Marlboro | 34 35 43 N | 079 33 23 W |
| McIntosh Mill (historical) | Locale | 49 | Darlington | 34 24 54 N | 079 59 24 W |
| McIntosh Millpond | Reservoir | 44 | Darlington | 34 24 56 N | 079 59 24 W |
| McIver Pond | Reservoir | 114 | Lexington | 33 45 47 N | 081 20 41 W |
| McIver School (historical) | School | 43 | Sumter | 33 54 49 N | 080 18 48 W |
| Mcjunkins Pond | Reservoir | 296 | Pickens | 34 50 48 N | 082 46 24 W |
| Mcjunkins Pond Dam D-1963 | Dam | 296 | Pickens | 34 50 48 N | 082 46 24 W |
| McKay Airport | Airport | 39 | Florence | 34 06 39 N | 079 54 05 W |
| McKays Bridge | Bridge | 32 | Dillon | 34 32 47 N | 079 23 58 W |
| McKees Ferry (historical) | Crossing | 169 | Spartanburg | 34 41 45 N | 082 03 26 W |
| McKees Mill (historical) | Locale | 159 | Spartanburg | 34 39 02 N | 081 57 35 W |
| McKees Mill (historical) | Locale | 168 | Spartanburg | 34 41 50 N | 082 03 24 W |
| McKellar Farms | Populated Place | 177 | Greenwood | 34 11 16 N | 082 06 16 W |
| McKelvey Creek | Stream | | Chester | 34 47 15 N | 081 24 17 W |
| McKelvey Crossroads | Populated Place | 247 | Greenville | 34 36 28 N | 082 22 08 W |
| McKendree Church | Church | 128 | Edgefield | 33 56 03 N | 081 58 18 W |
| McKenley Creek | Stream | | Abbeville | 34 07 29 N | 082 32 16 W |
| McKenneys Ford (historical) | Crossing | 244 | Pickens | 34 57 35 N | 082 55 08 W |
| McKennon | Populated Place | 124 | Chesterfield | 34 32 49 N | 080 07 40 W |
| McKenzie Creek | Stream | | Richland | 33 48 26 N | 080 42 59 W |
| McKenzie Crossroads | Populated Place | 33 | Florence | 33 54 48 N | 079 54 30 W |
| McKenzie Pond | Lake | 29 | Dillon | 34 23 47 N | 079 14 05 W |
| McKenzie Pond | Reservoir | 20 | Hampton | 32 39 58 N | 081 19 36 W |
| McKenzie School | School | 44 | Florence | 34 11 43 N | 079 46 35 W |
| Mckenzies Pond | Reservoir | 20 | Hampton | 32 39 55 N | 081 19 35 W |
| McKeown | Populated Place | 191 | Chester | 34 37 04 N | 081 10 56 W |
| McKeown Branch | Stream | | Dorchester | 33 03 49 N | 080 20 36 W |
| McKie Cemetery | Cemetery | 98 | Edgefield | 33 39 35 N | 082 05 13 W |
| McKie Cemetery | Cemetery | 165 | McCormick | 33 37 24 N | 082 07 52 W |
| McKinney Chapel | Church | 286 | Pickens | 34 56 59 N | 082 53 48 W |
| McKinney Chapel Cemetery | Cemetery | 286 | Pickens | 34 56 59 N | 082 53 48 W |
| McKinney Creek | Stream | | Greenville | 35 04 35 N | 082 21 41 W |
| McKinney Mountain | Summit | 359 | Oconee | 34 56 26 N | 082 52 58 W |
| McKinney Mountain | Summit | 649 | Pickens | 35 00 59 N | 082 51 44 W |
| McKinneys Creek | Stream | | Oconee | 34 55 54 N | 082 54 25 W |
| McKinneys Mill (historical) | Locale | 34 | Aiken | 33 19 38 N | 081 51 51 W |
| McKinneys Mountain | Summit | 591 | Oconee | 34 57 54 N | 082 58 47 W |
| McKissick Cemetery | Cemetery | 189 | Union | 34 50 57 N | 081 33 05 W |
| McKissick Elementary School | School | 343 | Pickens | 34 50 57 N | 082 36 36 W |
| McKissick Memorial Chapel | Church | 137 | McCormick | 33 57 23 N | 082 25 11 W |
| McKissick Memorial Library | Building | 194 | Greenwood | 34 11 02 N | 082 10 38 W |
| McKissick Museum | Building | 94 | Richland | 33 59 56 N | 081 01 36 W |
| McKnight School | School | 30 | Florence | 34 03 07 N | 079 38 08 W |
| McKnight Swamp | Stream | | Williamsburg | 33 44 17 N | 079 37 11 W |
| McKowns Creek | Stream | | Cherokee | 35 02 37 N | 081 30 49 W |
| McKowns Mountain | Summit | 246 | Cherokee | 35 01 29 N | 081 31 20 W |
| McKowns Mountain Church | Church | 212 | Cherokee | 35 01 18 N | 081 30 59 W |
| McLain church | Church | 97 | Chesterfield | 34 47 16 N | 080 00 03 W |
| McLain Grove School (historical) | School | 100 | Chesterfield | 34 47 14 N | 080 00 10 W |
| McLains Pond D-3058 Dam | Dam | 79 | Barnwell | 33 22 19 N | 081 15 29 W |
| McLaughlin Crossroads | Populated Place | 55 | Darlington | 34 13 24 N | 080 03 29 W |
| McLaurin Bay | Basin | 49 | Marlboro | 34 35 30 N | 079 30 38 W |
| McLaurin Cemetery | Cemetery | 53 | Marlboro | 34 40 09 N | 079 32 29 W |
| McLaurin Elementary School | School | 38 | Florence | 34 10 37 N | 079 44 38 W |
| McLaurin Junior High School | School | 52 | Sumter | 33 55 32 N | 080 20 52 W |