Feature Name | Class | Elev. meters | County | Latitude DMS | Longitude DMS |
| McLaurin Pond | Reservoir | 44 | Sumter | 33 50 31 N | 080 20 23 W |
| McLaurin Pond Dam D-2062 | Dam | 44 | Sumter | 33 50 31 N | 080 20 23 W |
| McLaurin School (historical) | School | 143 | Aiken | 33 42 28 N | 081 34 19 W |
| McLaurins Mill (historical) | Locale | 48 | Marlboro | 34 40 32 N | 079 45 33 W |
| McLaurins Mill (historical) | Locale | 46 | Marlboro | 34 39 14 N | 079 32 11 W |
| McLaurins Millpond | Lake | 48 | Marlboro | 34 40 46 N | 079 45 31 W |
| McLaurins Millpond | Reservoir | 46 | Marlboro | 34 39 16 N | 079 32 09 W |
| McLaurins Pond | Reservoir | 76 | Sumter | 33 54 37 N | 080 30 47 W |
| McLean Cemetery | Cemetery | 112 | Darlington | 34 22 51 N | 080 13 23 W |
| McLean Park | Park | 4 | Horry | 33 49 14 N | 078 40 35 W |
| McLean Pond | Reservoir | 56 | Chesterfield | 34 36 21 N | 080 05 58 W |
| McLean Pond Dam D-3208 | Dam | 58 | Chesterfield | 34 36 25 N | 080 05 59 W |
| McLean School (historical) | School | 33 | Allendale | 32 55 28 N | 081 25 31 W |
| McLeans Branch Cemetery | Cemetery | 104 | Kershaw | 34 24 23 N | 080 30 44 W |
| McLees School (historical) | School | 228 | Anderson | 34 27 49 N | 082 45 34 W |
| McLellan Cemetery | Cemetery | 65 | Lee | 34 11 20 N | 080 17 04 W |
| McLenalhan High School | School | 42 | Florence | 34 11 24 N | 079 45 51 W |
| McLeod Chapel | Church | 83 | Sumter | 34 06 11 N | 080 31 46 W |
| McLeod Church | Church | 113 | Richland | 33 56 26 N | 080 42 15 W |
| McLeod Infirmary (historical) | Hospital | 43 | Florence | 34 11 46 N | 079 46 01 W |
| McLeod Memorial Hospital | Hospital | 40 | Florence | 34 14 10 N | 079 48 39 W |
| McLeod Pond Dam D-3175 | Dam | 122 | Chesterfield | 34 40 13 N | 080 21 23 W |
| McLeod Regional Medical Center | Hospital | 43 | Florence | 34 11 49 N | 079 45 32 W |
| McLeod School (historical) | School | 84 | Kershaw | 34 11 04 N | 080 28 43 W |
| McLeods Lower Pond | Reservoir | 78 | Lee | 34 11 49 N | 080 24 23 W |
| McLeods Mill (historical) | Locale | 95 | Chesterfield | 34 36 55 N | 080 24 33 W |
| McLeods Pond | Lake | 75 | Lee | 34 11 47 N | 080 24 27 W |
| McLeods Pond | Reservoir | 54 | Sumter | 34 05 48 N | 080 30 42 W |
| McLeods Upper Pond | Reservoir | 84 | Lee | 34 11 55 N | 080 24 35 W |
| McLeods Upper Pond Dam D-2409 | Dam | 84 | Lee | 34 11 55 N | 080 24 35 W |
| McMahons Mill Pond (historical) | Reservoir | 244 | Oconee | 34 43 55 N | 082 58 27 W |
| McManns Ford | Crossing | 112 | Chesterfield | 34 43 28 N | 080 29 30 W |
| McMaster School | School | 95 | Richland | 34 00 10 N | 081 01 32 W |
| McMeekin Pond | Reservoir | 41 | Marlboro | 34 44 19 N | 079 47 59 W |
| McMeekin Pond Dam D-3430 | Dam | 41 | Marlboro | 34 44 19 N | 079 47 59 W |
| McMillan Mill (historical) | Locale | 120 | Chesterfield | 34 40 27 N | 080 22 00 W |
| McMillan Park | Park | 214 | Laurens | 34 29 22 N | 082 01 06 W |
| McMillan Pond Dam D-2579 | Dam | 52 | Allendale | 33 06 19 N | 081 17 11 W |
| McMillan School (historical) | School | 36 | Orangeburg | 33 18 01 N | 080 53 30 W |
| McMillans Mill (historical) | Locale | 233 | Spartanburg | 35 07 23 N | 081 59 21 W |
| McMillans Pond Dam D-2818 | Dam | 41 | Bamberg | 33 09 37 N | 081 04 05 W |
| McMillen Lower Pond Dam D-0515 | Dam | 20 | Marion | 34 10 25 N | 079 14 11 W |
| McMillen Upper Pond Dam D-0514 | Dam | 23 | Marion | 34 10 25 N | 079 14 23 W |
| McMillian Branch | Stream | | Bamberg | 33 09 19 N | 081 01 00 W |
| McMillian Cemetery | Cemetery | 41 | Bamberg | 33 08 59 N | 081 03 33 W |
| McMillian Cemetery | Cemetery | 46 | Bamberg | 33 09 53 N | 081 05 04 W |
| McNairs Mill (historical) | Locale | 58 | Marlboro | 34 41 43 N | 079 35 16 W |
| McNairs Millpond | Reservoir | 57 | Marlboro | 34 41 49 N | 079 35 11 W |
| McNamee Swamp | Stream | | Williamsburg | 33 46 46 N | 079 43 14 W |
| McNeely Church | Church | 290 | Anderson | 34 47 03 N | 082 28 17 W |
| McNeil Airport | Airport | 52 | Calhoun | 33 33 26 N | 080 38 54 W |
| McNeils (historical) | Populated Place | 36 | Chesterfield | 34 40 05 N | 079 56 29 W |
| McPherson Cemetery | Cemetery | 33 | Florence | 34 09 16 N | 079 42 30 W |
| McPherson Creek | Stream | | Hampton | 32 43 35 N | 080 59 16 W |
| McPherson Park | Park | 284 | Greenville | 34 51 25 N | 082 23 35 W |
| McPhersonville | Populated Place | 26 | Hampton | 32 41 31 N | 080 55 09 W |
| McPhersonville Church | Church | 24 | Hampton | 32 41 32 N | 080 54 52 W |
| McPhersonville School (historical) | School | 24 | Hampton | 32 41 25 N | 080 55 00 W |
| McQuage Cemetery | Cemetery | 64 | Marlboro | 34 40 50 N | 079 46 02 W |
| McQueen Bridge | Bridge | 13 | Horry | 34 05 18 N | 079 08 43 W |
| McQueen Crossroads | Populated Place | 19 | Horry | 34 04 27 N | 079 08 37 W |
| McQueens Mill (historical) | Locale | 45 | Chesterfield | 34 35 26 N | 079 59 54 W |
| McRae Mill (historical) | Locale | 36 | Dillon | 34 35 56 N | 079 25 45 W |
| McSwain Gardens | Populated Place | 302 | Greenville | 34 52 31 N | 082 19 59 W |
| McTeer Memorial Bridge | Bridge | -27 | Beaufort | 32 23 40 N | 080 40 30 W |
| McTier Creek | Stream | | Aiken | 33 41 40 N | 081 36 45 W |
| McWhitner School (historical) | School | 254 | Spartanburg | 34 59 11 N | 081 52 53 W |
| Mead Hall School | School | 144 | Aiken | 33 32 58 N | 081 43 27 W |
| Meador (historical) | Populated Place | 125 | Union | 34 41 07 N | 081 30 28 W |
| Meador School (historical) | School | 160 | Union | 34 42 09 N | 081 29 57 W |
| Meadow Branch | Stream | | Bamberg | 33 05 46 N | 081 06 10 W |
| Meadow Branch | Stream | | Chesterfield | 34 40 08 N | 080 16 30 W |
| Meadow Branch | Stream | | Lee | 34 05 34 N | 080 12 56 W |
| Meadow Brook | Populated Place | 231 | Anderson | 34 29 13 N | 082 33 59 W |
| Meadow Brook | Populated Place | 32 | Darlington | 34 15 40 N | 079 46 36 W |
| Meadow Brook | Populated Place | 242 | Pickens | 34 40 42 N | 082 48 35 W |
| Meadow Creek | Stream | | Spartanburg | 35 00 46 N | 082 12 05 W |
| Meadow Creek | Stream | | Spartanburg | 35 01 15 N | 082 00 56 W |
| Meadow Creek Industrial Center | Locale | 214 | Cherokee | 35 06 25 N | 081 36 01 W |
| Meadow Fields | Populated Place | 240 | Anderson | 34 26 20 N | 082 38 29 W |
| Meadow Fork | Stream | | Greenville | 35 03 12 N | 082 22 21 W |
| Meadow Fork Church | Church | 306 | Greenville | 35 02 54 N | 082 23 25 W |
| Meadow Fork School (historical) | School | 305 | Greenville | 35 02 56 N | 082 23 26 W |
| Meadow Haven Nursing Center | Building | 197 | York | 34 57 18 N | 081 03 17 W |
| Meadow Hill School (historical) | School | 29 | Marion | 34 17 08 N | 079 26 04 W |
| Meadow Lake | Populated Place | 82 | Richland | 34 04 42 N | 081 00 12 W |
| Meadow Lakes | Populated Place | 193 | York | 34 56 26 N | 081 04 30 W |
| Meadow Oaks | Populated Place | 67 | Darlington | 34 19 59 N | 080 06 16 W |
| Meadow Park | Populated Place | 241 | Anderson | 34 27 30 N | 082 39 17 W |
| Meadow Prong | Stream | | Florence | 34 03 24 N | 079 49 31 W |
| Meadow Prong Cemetery | Cemetery | 32 | Florence | 34 02 15 N | 079 49 36 W |
| Meadow Prong Church | Church | 32 | Florence | 34 02 14 N | 079 49 35 W |
| Meadow Rose | Populated Place | 243 | Pickens | 34 40 50 N | 082 48 49 W |
| Meadow Spring | Populated Place | 260 | Spartanburg | 35 00 49 N | 081 55 00 W |
| Meadow View | Populated Place | 61 | Kershaw | 34 07 11 N | 080 42 39 W |
| Meadow Woods | Area | 166 | Union | 34 41 41 N | 081 46 39 W |
| Meadowbrook (subdivision) | Populated Place | 26 | Dorchester | 33 01 03 N | 080 09 53 W |
| Meadowbrook Farms | Populated Place | 261 | Spartanburg | 35 02 14 N | 082 01 51 W |
| Meadowbrook Heights | Populated Place | 242 | Anderson | 34 31 03 N | 082 42 04 W |
| Meadowbrook Park | Park | 291 | Greenville | 34 51 02 N | 082 24 17 W |
| Meadowfield (subdivision) | Populated Place | 62 | Richland | 33 57 45 N | 080 57 52 W |
| Meadowfield School | School | 76 | Richland | 33 58 17 N | 080 57 43 W |
| Meadowridge (subdivision) | Populated Place | 67 | Orangeburg | 33 31 21 N | 080 54 19 W |
| Mealing Grove Church | Church | 161 | Aiken | 33 35 12 N | 081 57 40 W |
| Mealing Heights (subdivision) | Populated Place | 63 | Aiken | 33 29 28 N | 081 57 48 W |
| Mealing Park | Park | 67 | Aiken | 33 29 31 N | 081 57 47 W |
| Mean Crossroads | Populated Place | 172 | Union | 34 48 29 N | 081 43 55 W |
| Means Branch | Stream | | Newberry | 34 23 30 N | 081 32 59 W |
| Means Chapel | Church | 211 | Spartanburg | 34 52 12 N | 082 01 57 W |
| Means Creek | Stream | | Beaufort | 32 18 33 N | 080 39 57 W |