Feature Name | Class | Elev. meters | County | Latitude DMS | Longitude DMS |
| Sacred Heart Church | Church | 90 | Barnwell | 33 21 12 N | 081 16 08 W |
| Sacred Heart Church | Church | 259 | Cherokee | 35 03 51 N | 081 38 43 W |
| Sacred Heart School | School | 4 | Charleston | 32 47 60 N | 079 56 50 W |
| Saddle Tunnel | Tunnel | 428 | Oconee | 34 49 18 N | 083 05 51 W |
| Saddler Swamp | Stream | | Orangeburg | 33 34 52 N | 080 52 05 W |
| Saddlers Creek Post Office (historical) | Post Office | 211 | Anderson | 34 27 00 N | 082 49 15 W |
| Sadler (historical) | Populated Place | 221 | Anderson | 34 26 35 N | 082 49 58 W |
| Sadlers Creek | Stream | | Anderson | 34 24 48 N | 082 50 49 W |
| Sadlers Creek State Park | Park | 216 | Anderson | 34 25 30 N | 082 49 40 W |
| Sadlers Ferry (historical) | Crossing | 137 | Anderson | 34 18 27 N | 082 47 05 W |
| Sage Mill Branch | Stream | | Aiken | 33 35 52 N | 081 48 39 W |
| Saint Agey Church | Church | 19 | Williamsburg | 33 35 13 N | 079 57 34 W |
| Saint Albans Church | Church | 89 | Barnwell | 33 21 23 N | 081 16 20 W |
| Saint Albans Episcopal Church | Church | 18 | Williamsburg | 33 40 01 N | 079 49 47 W |
| Saint Albans School (historical) | School | 244 | Greenville | 34 41 14 N | 082 19 04 W |
| Saint Albans School (historical) | School | 263 | Greenville | 34 42 40 N | 082 20 06 W |
| Saint Andrew Church | Church | 301 | Greenville | 34 51 35 N | 082 24 07 W |
| Saint Andrews | Populated Place | 1 | Charleston | 32 46 55 N | 079 59 06 W |
| Saint Andrews | Populated Place | 92 | Lexington | 34 02 44 N | 081 07 45 W |
| Saint Andrews African Methodist Episcopal Church | Church | 8 | Georgetown | 33 27 12 N | 079 33 47 W |
| Saint Andrews Catholic Church | Church | 223 | Pickens | 34 41 10 N | 082 50 19 W |
| Saint Andrews Cemetery | Cemetery | 90 | Lexington | 34 02 44 N | 081 08 08 W |
| Saint Andrews Church | Church | 3 | Beaufort | 32 18 08 N | 080 53 23 W |
| Saint Andrews Church | Church | 3 | Charleston | 32 48 49 N | 080 07 17 W |
| Saint Andrews Church | Church | 9 | Horry | 33 42 54 N | 078 51 28 W |
| Saint Andrews Church | Church | 124 | Lee | 34 09 44 N | 080 23 34 W |
| Saint Andrews Church | Church | 88 | Lexington | 34 02 43 N | 081 08 01 W |
| Saint Andrews Church | Church | 172 | Richland | 34 11 05 N | 081 02 18 W |
| Saint Andrews Church | Church | 93 | Richland | 34 01 47 N | 081 05 21 W |
| Saint Andrews Elementary School | School | 4 | Charleston | 32 46 41 N | 079 58 53 W |
| Saint Andrews Episcopal Church | Church | 9 | Charleston | 32 49 56 N | 080 02 41 W |
| Saint Andrews Episcopal Church | Church | 4 | Charleston | 32 47 18 N | 079 52 32 W |
| Saint Andrews Episcopal Church | Church | 304 | Greenville | 34 50 36 N | 082 24 35 W |
| Saint Andrews Episcopal Mission | Church | 5 | Charleston | 32 48 16 N | 079 57 02 W |
| Saint Andrews Heights (subdivision) | Populated Place | 7 | Charleston | 32 47 29 N | 080 00 43 W |
| Saint Andrews High School | School | 9 | Charleston | 32 47 29 N | 080 01 16 W |
| Saint Andrews Lutheran Church | Church | 6 | Charleston | 32 47 01 N | 079 55 51 W |
| Saint Andrews Middle School | School | 93 | Richland | 34 01 39 N | 081 05 16 W |
| Saint Andrews Presbyterian Church | Church | 8 | Charleston | 32 47 24 N | 080 01 11 W |
| Saint Andrews Roman Catholic Church | Church | 61 | Barnwell | 33 14 29 N | 081 21 43 W |
| Saint Andrews School | School | 9 | Horry | 33 42 53 N | 078 51 30 W |
| Saint Andrews School | School | 92 | Richland | 34 01 34 N | 081 05 15 W |
| Saint Andrews Shopping Center | Locale | 3 | Charleston | 32 46 53 N | 079 59 25 W |
| Saint Andrews Shopping Center | Locale | 74 | Lexington | 34 02 36 N | 081 07 16 W |
| Saint Angela Academy | School | 149 | Aiken | 33 32 46 N | 081 43 29 W |
| Saint Angela Convent | Church | 149 | Aiken | 33 32 48 N | 081 43 32 W |
| Saint Anne School | School | 50 | Sumter | 33 55 09 N | 080 20 14 W |
| Saint Annes Catholic Church | Church | 189 | York | 34 54 49 N | 081 01 09 W |
| Saint Annes Church | Church | 261 | Oconee | 34 31 40 N | 083 01 21 W |
| Saint Annes Roman Catholic Church | Church | 49 | Sumter | 33 55 12 N | 080 20 12 W |
| Saint Annes School | School | 191 | York | 34 54 51 N | 081 01 09 W |
| Saint Anns Catholic Church | Church | 19 | Williamsburg | 33 39 55 N | 079 49 27 W |
| Saint Anns Roman Catholic Church | Church | 42 | Florence | 34 11 49 N | 079 45 11 W |
| Saint Anthonys Catholic Church | Church | 301 | Greenville | 34 50 52 N | 082 24 58 W |
| Saint Anthonys Roman Catholic Church | Church | 43 | Florence | 34 11 38 N | 079 46 02 W |
| Saint Anthonys School | School | 42 | Florence | 34 11 57 N | 079 49 23 W |
| Saint Anthonys School | School | 303 | Greenville | 34 50 53 N | 082 25 01 W |
| Saint Augustine Catholic CHurch | Church | 188 | Union | 34 42 46 N | 081 37 22 W |
| Saint Augustine Church | Church | 61 | Sumter | 33 47 43 N | 080 32 14 W |
| Saint Augustine Episcopal Church (historical) | Church | 158 | Aiken | 33 33 36 N | 081 42 57 W |
| Saint Augustine Reformed Episcopal Church | Church | 3 | Georgetown | 33 22 08 N | 079 16 42 W |
| Saint Barnabas Church | Church | 134 | Fairfield | 34 17 46 N | 081 16 00 W |
| Saint Barnabas Episcopal Church | Church | 35 | Dillon | 34 24 56 N | 079 21 49 W |
| Saint Barnabas Evangelical Lutheran Church | Church | 5 | Charleston | 32 47 60 N | 079 57 05 W |
| Saint Barnabas School (historical) | School | 132 | Fairfield | 34 17 45 N | 081 15 59 W |
| Saint Bartholomews Church | Church | 118 | Aiken | 33 30 39 N | 081 58 31 W |
| Saint Bartholomews Episcopal Church | Church | 67 | Darlington | 34 22 33 N | 080 04 12 W |
| Saint Beulah Church | Church | 31 | Florence | 34 10 27 N | 079 42 24 W |
| Saint Boniface Catholic Church | Church | 180 | Laurens | 34 25 01 N | 081 48 49 W |
| Saint Catherines Church | Church | 55 | Aiken | 33 20 49 N | 081 49 42 W |
| Saint Charles | Populated Place | 50 | Lee | 34 03 60 N | 080 13 05 W |
| Saint Charlotte School (historical) | School | 140 | McCormick | 33 55 14 N | 082 25 20 W |
| Saint Charlottes Church | Church | 140 | McCormick | 33 55 14 N | 082 25 19 W |
| Saint Christophers Episcopal Church | Church | 217 | Spartanburg | 34 57 28 N | 081 53 48 W |
| Saint Cyprian Roman Catholic Church | Church | 5 | Georgetown | 33 22 28 N | 079 17 49 W |
| Saint Cyprian School | School | 5 | Georgetown | 33 22 28 N | 079 17 49 W |
| Saint Daniels Church | Church | 27 | Dorchester | 33 12 12 N | 080 23 38 W |
| Saint Davids Academy | School | 57 | Darlington | 34 30 19 N | 079 51 24 W |
| Saint Davids Cemetery | Cemetery | 48 | Chesterfield | 34 41 41 N | 079 52 47 W |
| Saint Davids Episcopal Church | Church | 53 | Chesterfield | 34 41 42 N | 079 53 21 W |
| Saint Delight Church | Church | 11 | Horry | 33 52 05 N | 078 38 15 W |
| Saint Denis Church | Church | 54 | Marlboro | 34 37 19 N | 079 40 14 W |
| Saint Elizabeth Ann Seton Church | Church | 288 | Greenville | 34 45 27 N | 082 17 49 W |
| Saint Elizabeth Church | Church | 26 | Horry | 33 59 33 N | 079 11 58 W |
| Saint Eugene Community Hospital | Hospital | 36 | Dillon | 34 25 17 N | 079 21 53 W |
| Saint Euphrasia School | School | 199 | Lexington | 33 55 26 N | 081 32 01 W |
| Saint Francis Catholic Church | Church | 317 | Oconee | 34 45 43 N | 083 04 03 W |
| Saint Francis Church | Church | 9 | Berkeley | 33 04 60 N | 079 46 26 W |
| Saint Francis Church | Church | 301 | Greenville | 34 52 54 N | 082 20 59 W |
| Saint Francis Hospital | Hospital | 309 | Greenville | 34 50 24 N | 082 25 15 W |
| Saint Francis Xavier Infirmary | Hospital | 3 | Charleston | 32 47 02 N | 079 56 44 W |
| Saint Francis Xaviers School | School | 4 | Charleston | 32 47 04 N | 079 56 45 W |
| Saint George | Populated Place | 32 | Dorchester | 33 11 10 N | 080 34 32 W |
| Saint George Cemetery | Cemetery | 25 | Dillon | 34 19 01 N | 079 30 04 W |
| Saint George Cemetery | Cemetery | 32 | Dorchester | 33 11 09 N | 080 34 32 W |
| Saint George Church | Church | 27 | Dorchester | 33 09 08 N | 080 33 08 W |
| Saint George Church | Church | 91 | Orangeburg | 33 27 55 N | 080 59 29 W |
| Saint George Church Ruins | Church | 12 | Dorchester | 32 56 57 N | 080 10 13 W |
| Saint George City Hall | Building | 30 | Dorchester | 33 11 18 N | 080 34 31 W |
| Saint George Elementary School | School | 30 | Dorchester | 33 11 19 N | 080 34 27 W |
| Saint George Greek Orthodox Church | Church | 304 | Greenville | 34 51 21 N | 082 23 58 W |
| Saint George High School | School | 31 | Dorchester | 33 11 41 N | 080 34 39 W |
| Saint George Lookout Tower | Tower | 27 | Dorchester | 33 10 36 N | 080 32 38 W |
| Saint George Municipal Airport | Airport | 25 | Dorchester | 33 11 44 N | 080 30 30 W |
| Saint George Post Office | Post Office | 31 | Dorchester | 33 11 14 N | 080 34 29 W |
| Saint George School (historical) | School | 95 | Orangeburg | 33 28 47 N | 080 59 44 W |
| Saint Gerard School | School | 157 | Aiken | 33 34 05 N | 081 42 12 W |
| Saint Gerards Catholic Church | Church | 158 | Aiken | 33 34 04 N | 081 42 13 W |
| Saint Gerards Catholic Mission (historical) | Church | 158 | Aiken | 33 33 39 N | 081 43 02 W |
| Saint Giles Church | Church | 313 | Greenville | 34 52 17 N | 082 18 43 W |