Feature Name | Class | Elev. meters | County | Latitude DMS | Longitude DMS |
| Sand Hill Pond | Lake | 6 | Horry | 33 46 03 N | 078 46 54 W |
| Sand Hill School | School | 102 | Orangeburg | 33 31 16 N | 081 08 38 W |
| Sand Hill School | School | 106 | Orangeburg | 33 32 43 N | 081 12 41 W |
| Sand Hill School (historical) | School | 7 | Charleston | 32 40 19 N | 080 06 35 W |
| Sand Hill School (historical) | School | 6 | Dorchester | 32 53 28 N | 080 19 56 W |
| Sand Hill School (historical) | School | 24 | Hampton | 32 41 07 N | 081 19 09 W |
| Sand Hill School (historical) | School | 27 | Jasper | 32 40 38 N | 081 05 13 W |
| Sand Hill School (historical) | School | 157 | Lancaster | 34 31 59 N | 080 33 41 W |
| Sand Hill School (historical) | School | 81 | Lexington | 33 52 22 N | 081 08 01 W |
| Sand Hill School (historical) | School | 150 | McCormick | 33 55 56 N | 082 08 46 W |
| Sand Hills | Range | 59 | Sumter | 33 49 07 N | 080 29 08 W |
| Sand Hills | Ridge | 11 | Jasper | 32 30 45 N | 081 13 10 W |
| Sand Hills State Forest | Forest | 85 | Chesterfield | 34 32 04 N | 080 05 27 W |
| Sand Island | Island | 1 | Georgetown | 33 11 03 N | 079 11 15 W |
| Sand Level Church | Church | 162 | Richland | 34 12 54 N | 080 59 24 W |
| Sand Level School (historical) | School | 130 | Richland | 34 09 59 N | 080 58 24 W |
| Sand Mountain | Summit | 125 | Lexington | 33 51 30 N | 081 03 07 W |
| Sand Ridge | Island | 24 | Sumter | 33 46 49 N | 080 34 12 W |
| Sand Ridge | Populated Place | 177 | Greenwood | 34 03 39 N | 082 00 49 W |
| Sand Ridge | Populated Place | 13 | Horry | 33 48 60 N | 079 05 30 W |
| Sand Ridge | Ridge | 12 | Georgetown | 33 38 10 N | 079 15 39 W |
| Sand Ridge Bay | Swamp | 33 | Dillon | 34 22 51 N | 079 16 59 W |
| Sand Ridge Church | Church | 29 | Berkeley | 33 14 25 N | 080 18 14 W |
| Sand Ridge Church | Church | 176 | Greenwood | 34 03 33 N | 082 00 24 W |
| Sand Ridge Church (historical) | Church | 32 | Dorchester | 33 05 42 N | 080 28 47 W |
| Sand Ridge School (historical) | School | 26 | Dorchester | 33 05 02 N | 080 28 16 W |
| Sand Ridge School (historical) | School | 32 | Dorchester | 33 05 43 N | 080 28 46 W |
| Sand Ridge School (historical) | School | 177 | Greenwood | 34 03 32 N | 082 00 23 W |
| Sand Ridge School (historical) | School | 13 | Jasper | 32 33 08 N | 081 15 59 W |
| Sand River | Stream | | Aiken | 33 33 01 N | 081 49 03 W |
| Sandbed School (historical) | School | 35 | Clarendon | 33 34 37 N | 080 16 29 W |
| Sanders (historical) | Populated Place | 44 | Allendale | 32 57 53 N | 081 17 54 W |
| Sanders Branch | Stream | | Hampton | 32 48 40 N | 081 05 29 W |
| Sanders Branch School | School | 33 | Hampton | 32 52 45 N | 081 04 55 W |
| Sanders Bridge (historical) | Bridge | 38 | Lee | 34 05 09 N | 080 04 20 W |
| Sanders Cemetery | Cemetery | 137 | Aiken | 33 45 26 N | 081 39 42 W |
| Sanders Cemetery | Cemetery | 69 | Barnwell | 33 09 46 N | 081 34 49 W |
| Sanders Cemetery | Cemetery | 9 | Colleton | 32 52 30 N | 080 28 24 W |
| Sanders Cemetery | Cemetery | 45 | Lee | 34 04 59 N | 080 05 31 W |
| Sanders Cemetery | Cemetery | 161 | Union | 34 41 11 N | 081 40 34 W |
| Sanders Corner | Populated Place | 54 | Sumter | 34 00 11 N | 080 32 26 W |
| Sanders Creek | Stream | | Kershaw | 34 18 34 N | 080 40 53 W |
| Sanders Creek Baptist Church | Church | 87 | Kershaw | 34 17 41 N | 080 37 17 W |
| Sanders Creek Church | Church | 93 | Kershaw | 34 17 59 N | 080 37 44 W |
| Sanders Ferry Bridge | Bridge | 132 | Anderson | 34 15 20 N | 082 44 44 W |
| Sanders Hall | Building | 214 | Pickens | 34 40 40 N | 082 50 27 W |
| Sanders Lake | Reservoir | 258 | Oconee | 34 37 36 N | 082 59 43 W |
| Sanders Landing | Locale | 1 | Horry | 33 44 42 N | 079 12 59 W |
| Sanders Old Mill (historical) | Locale | 51 | Barnwell | 33 12 11 N | 081 21 32 W |
| Sanders Pond | Reservoir | 130 | Aiken | 33 45 32 N | 081 39 29 W |
| Sanders Pond Dam D-2567 | Dam | 37 | Allendale | 32 57 43 N | 081 15 17 W |
| Sanders School | School | 193 | Laurens | 34 29 13 N | 082 00 33 W |
| Sanders Subdivision | Populated Place | 55 | Sumter | 33 54 34 N | 080 24 44 W |
| Sanderson Cemetery | Cemetery | 30 | Dillon | 34 23 24 N | 079 15 42 W |
| Sandfield Church (historical) | Church | 138 | Richland | 34 13 14 N | 080 56 19 W |
| Sandhill Bay | Basin | 39 | Marlboro | 34 31 03 N | 079 41 09 W |
| Sandhill Bay | Swamp | 34 | Clarendon | 33 36 42 N | 080 05 58 W |
| Sandhill Branch | Stream | | Edgefield | 33 56 35 N | 082 08 59 W |
| Sandhill Church | Church | 24 | Hampton | 32 41 13 N | 081 19 08 W |
| Sandhill Farms Pond | Reservoir | 160 | Newberry | 34 16 12 N | 081 45 59 W |
| Sandhill School | School | 24 | Florence | 34 13 50 N | 079 40 20 W |
| Sandhill School | School | 21 | Hampton | 32 47 13 N | 081 01 53 W |
| Sandhill School (historical) | School | 19 | Colleton | 32 55 34 N | 080 26 54 W |
| Sandhill School (historical) | School | 39 | Marlboro | 34 28 21 N | 079 37 17 W |
| Sandhills State Forest | Forest | 90 | Chesterfield | 34 28 03 N | 080 17 31 W |
| Sandhole Creek | Stream | | Georgetown | 33 31 36 N | 079 06 49 W |
| Sandhurst (subdivision) | Populated Place | 6 | Charleston | 32 49 24 N | 079 59 44 W |
| Sandhurst (subdivision) | Populated Place | 37 | Florence | 34 09 30 N | 079 47 34 W |
| Sandlewood | Populated Place | 126 | Aiken | 33 33 02 N | 081 54 49 W |
| Sandpit Cemetery | Cemetery | 253 | Cherokee | 35 10 21 N | 081 38 06 W |
| Sandridge | Populated Place | 24 | Berkeley | 33 15 19 N | 080 18 57 W |
| Sandridge | Populated Place | 27 | Florence | 34 14 46 N | 079 43 14 W |
| Sandridge Cemetery | Cemetery | 29 | Berkeley | 33 14 24 N | 080 18 11 W |
| Sandridge Church | Church | 21 | Williamsburg | 33 39 49 N | 079 47 51 W |
| Sandridge School | School | 29 | Berkeley | 33 15 42 N | 080 15 26 W |
| Sandwood (subdivision) | Populated Place | 88 | Richland | 34 02 49 N | 080 56 48 W |
| Sandwood Hills | Populated Place | 90 | Kershaw | 34 12 46 N | 080 44 17 W |
| Sandy | Populated Place | 5 | Charleston | 32 48 55 N | 080 05 00 W |
| Sandy Bay | Stream | | Charleston | 32 46 32 N | 080 00 18 W |
| Sandy Bay | Swamp | 22 | Williamsburg | 33 45 16 N | 079 51 56 W |
| Sandy Bay Church | Church | 22 | Williamsburg | 33 44 59 N | 079 52 04 W |
| Sandy Bay School | School | 21 | Williamsburg | 33 44 52 N | 079 51 17 W |
| Sandy Bay School | School | 20 | Williamsburg | 33 45 14 N | 079 50 06 W |
| Sandy Bluff Bridge | Bridge | 12 | Horry | 34 08 43 N | 079 12 28 W |
| Sandy Bluff School (historical) | School | 71 | Lee | 34 16 19 N | 080 11 48 W |
| Sandy Branch | Stream | | Aiken | 33 41 24 N | 081 36 20 W |
| Sandy Branch | Stream | | Lancaster | 34 46 16 N | 080 49 02 W |
| Sandy Branch | Stream | | Newberry | 34 29 39 N | 081 38 14 W |
| Sandy Branch | Stream | | Richland | 34 11 32 N | 080 49 49 W |
| Sandy Branch Church (historical) | Church | 33 | Hampton | 32 52 44 N | 081 05 02 W |
| Sandy Creek | Stream | | Sumter | 33 47 43 N | 080 35 02 W |
| Sandy Dam Branch | Stream | | Colleton | 32 51 56 N | 080 33 51 W |
| Sandy Dam Church | Church | 11 | Colleton | 32 52 51 N | 080 37 09 W |
| Sandy Drain Church (historical) | Church | 35 | Hampton | 32 43 29 N | 081 10 18 W |
| Sandy Drain School (historical) | School | 35 | Hampton | 32 43 35 N | 081 10 16 W |
| Sandy Flat | Populated Place | 316 | Greenville | 34 59 38 N | 082 20 41 W |
| Sandy Ford | Crossing | 132 | Laurens | 34 36 05 N | 081 54 24 W |
| Sandy Ford Bridge | Bridge | 208 | Spartanburg | 35 05 20 N | 081 53 21 W |
| Sandy Fork | Stream | | Fairfield | 34 28 16 N | 081 20 22 W |
| Sandy Grove Church | Church | 108 | Kershaw | 34 20 27 N | 080 23 38 W |
| Sandy Grove Church | Church | 151 | Kershaw | 34 35 45 N | 080 25 56 W |
| Sandy Grove Church | Church | 55 | Lee | 34 11 13 N | 080 08 33 W |
| Sandy Grove Church | Church | 27 | Marion | 34 10 07 N | 079 20 52 W |
| Sandy Grove Church | Church | 52 | Marlboro | 34 35 14 N | 079 37 35 W |
| Sandy Grove Church | Church | 24 | Williamsburg | 33 48 59 N | 079 53 56 W |
| Sandy Grove Park | Park | 82 | Kershaw | 34 21 42 N | 080 18 22 W |
| Sandy Grove School (historical) | School | 25 | Williamsburg | 33 46 60 N | 079 56 12 W |
| Sandy Hill Backwater | Lake | 6 | Jasper | 32 22 09 N | 080 55 14 W |
| Sandy Hill Church | Church | 194 | Lancaster | 34 36 41 N | 080 33 54 W |
| Sandy Hill Plantation (historical) | Locale | 69 | Kershaw | 34 11 11 N | 080 29 26 W |