Feature Name | Class | Elev. meters | County | Latitude DMS | Longitude DMS |
| Sandy Hill Pond Number One | Reservoir | 78 | Kershaw | 34 17 25 N | 080 37 29 W |
| Sandy Hill Pond Number Two | Reservoir | 76 | Kershaw | 34 17 19 N | 080 37 35 W |
| Sandy Hill School (historical) | School | 24 | Florence | 34 01 07 N | 079 47 16 W |
| Sandy Hill School (historical) | School | 6 | Jasper | 32 30 21 N | 080 53 15 W |
| Sandy Hill School (historical) | School | 7 | Jasper | 32 23 42 N | 080 54 24 W |
| Sandy Island | Island | 68 | Aiken | 33 30 21 N | 081 23 10 W |
| Sandy Island | Island | 1 | Georgetown | 33 34 04 N | 079 09 01 W |
| Sandy Island | Summit | 18 | Georgetown | 33 35 24 N | 079 07 04 W |
| Sandy Island Bridge | Bridge | 32 | Bamberg | 33 10 42 N | 080 48 06 W |
| Sandy Island Lake | Lake | 4 | Horry | 33 49 01 N | 079 15 01 W |
| Sandy Island School | School | 4 | Georgetown | 33 31 16 N | 079 07 46 W |
| Sandy Isle Lake | Lake | 9 | Horry | 34 00 13 N | 079 18 17 W |
| Sandy Level Cemetery | Cemetery | 93 | Kershaw | 34 25 21 N | 080 21 37 W |
| Sandy Level Church | Church | 94 | Kershaw | 34 25 30 N | 080 20 48 W |
| Sandy Ocean | Swamp | 57 | Marlboro | 34 37 21 N | 079 34 43 W |
| Sandy Plains Church | Church | 18 | Horry | 34 03 51 N | 079 13 15 W |
| Sandy Plains School | School | 18 | Horry | 34 04 12 N | 079 12 34 W |
| Sandy Point | Cape | 2 | Charleston | 32 37 08 N | 080 00 24 W |
| Sandy Point | Cape | -5 | Charleston | 33 00 05 N | 079 29 30 W |
| Sandy Point | Cape | 7 | Hampton | 32 34 38 N | 081 21 59 W |
| Sandy Point Beach | Beach | 5 | Charleston | 33 00 32 N | 079 27 24 W |
| Sandy Point Creek | Stream | | Charleston | 33 02 26 N | 079 32 34 W |
| Sandy Ridge | Ridge | 9 | Horry | 34 00 36 N | 079 17 17 W |
| Sandy River | Populated Place | 111 | Chester | 34 39 24 N | 081 19 36 W |
| Sandy River | Stream | | Chester | 34 34 20 N | 081 25 20 W |
| Sandy River Church | Church | 151 | Chester | 34 44 07 N | 081 14 20 W |
| Sandy Rum Church | Church | 35 | Hampton | 32 53 29 N | 081 02 32 W |
| Sandy Run | Populated Place | 46 | Calhoun | 33 47 60 N | 080 57 50 W |
| Sandy Run | Populated Place | 45 | Orangeburg | 33 19 23 N | 080 42 56 W |
| Sandy Run | Stream | | Berkeley | 33 07 16 N | 080 11 18 W |
| Sandy Run | Stream | | Calhoun | 33 50 09 N | 080 56 48 W |
| Sandy Run | Stream | | Colleton | 32 47 53 N | 080 51 49 W |
| Sandy Run | Stream | | Colleton | 32 58 34 N | 080 25 08 W |
| Sandy Run | Stream | | Florence | 33 55 11 N | 079 45 34 W |
| Sandy Run | Stream | | Hampton | 32 54 37 N | 081 01 51 W |
| Sandy Run | Stream | | Orangeburg | 33 16 37 N | 080 43 43 W |
| Sandy Run | Stream | | Orangeburg | 33 16 45 N | 080 17 22 W |
| Sandy Run (historical) | Populated Place | 19 | Berkeley | 33 07 51 N | 080 10 13 W |
| Sandy Run Academy | School | 141 | Lexington | 33 48 52 N | 081 05 31 W |
| Sandy Run Church | Church | 43 | Bamberg | 33 11 07 N | 080 50 40 W |
| Sandy Run Church | Church | 45 | Calhoun | 33 48 02 N | 080 57 50 W |
| Sandy Run Church | Church | 113 | Chesterfield | 34 34 08 N | 080 21 33 W |
| Sandy Run Church | Church | 156 | Lexington | 33 49 12 N | 081 06 21 W |
| Sandy Run Creek | Stream | | Newberry | 34 14 54 N | 081 49 01 W |
| Sandy Run Creek | Stream | | Union | 34 52 31 N | 081 37 40 W |
| Sandy Run School | School | 35 | Bamberg | 33 10 60 N | 080 49 08 W |
| Sandy Run School | School | 41 | Hampton | 32 52 31 N | 081 02 24 W |
| Sandy Run School | School | 36 | Hampton | 32 53 39 N | 081 02 30 W |
| Sandy Run School | School | 42 | Orangeburg | 33 17 39 N | 080 43 10 W |
| Sandy Run School (historical) | School | 114 | Calhoun | 33 47 01 N | 080 57 04 W |
| Sandy Run School (historical) | School | 107 | Chesterfield | 34 31 48 N | 080 20 18 W |
| Sandy Slough | Gut | 9 | Horry | 34 00 59 N | 079 17 37 W |
| Sandy Springs | Populated Place | 243 | Anderson | 34 35 43 N | 082 44 59 W |
| Sandy Springs (subdivision) | Populated Place | 82 | Kershaw | 34 17 36 N | 080 37 04 W |
| Sandy Springs Cemetery | Cemetery | 210 | Laurens | 34 34 03 N | 081 56 32 W |
| Sandy Springs Church | Church | 243 | Anderson | 34 35 59 N | 082 45 17 W |
| Sandy Springs Church | Church | 263 | Greenville | 34 41 09 N | 082 22 35 W |
| Sandy Springs Church | Church | 210 | Laurens | 34 34 04 N | 081 56 33 W |
| Sandy Springs Church (historical) | Church | 209 | Laurens | 34 31 48 N | 081 58 35 W |
| Sandy Springs School (historical) | School | 208 | Laurens | 34 34 05 N | 081 56 36 W |
| Sangaree | Populated Place | 26 | Berkeley | 33 02 08 N | 080 07 40 W |
| Sangaree Elementary School | School | 20 | Berkeley | 33 02 06 N | 080 06 32 W |
| Sangster Village | Populated Place | 5 | Beaufort | 32 25 03 N | 080 39 47 W |
| Sanoma School (historical) | School | 270 | Greenville | 34 39 45 N | 082 23 12 W |
| Sans Souci | Populated Place | 309 | Greenville | 34 52 40 N | 082 25 26 W |
| Sans Souci Baptist Church | Church | 301 | Greenville | 34 52 57 N | 082 25 08 W |
| Sans Souci Elementary School | School | 308 | Greenville | 34 53 04 N | 082 24 47 W |
| Sans Souci Heights | Populated Place | 315 | Greenville | 34 53 46 N | 082 25 04 W |
| Sansbury Crossroads | Populated Place | 37 | Florence | 34 03 39 N | 079 55 23 W |
| Sansbury Hill Cemetery | Cemetery | 35 | Florence | 34 03 35 N | 079 55 39 W |
| Santa Elena (historical) | Populated Place | 2 | Beaufort | 32 18 24 N | 080 40 31 W |
| Santarosa (subdivision) | Populated Place | 187 | Lancaster | 34 40 48 N | 080 46 55 W |
| Santee | Populated Place | 42 | Orangeburg | 33 28 31 N | 080 29 11 W |
| Santee (historical) | Populated Place | 8 | Berkeley | 33 27 18 N | 079 54 16 W |
| Santee Branch | Stream | | Berkeley | 33 11 29 N | 080 17 49 W |
| Santee Canal | Canal | 24 | Berkeley | 33 25 36 N | 080 06 07 W |
| Santee Church | Church | 16 | Berkeley | 33 20 04 N | 079 49 52 W |
| Santee Church | Church | 41 | Orangeburg | 33 27 04 N | 080 29 01 W |
| Santee Circle | Populated Place | 22 | Berkeley | 33 14 38 N | 079 57 51 W |
| Santee Coastal Reserve | Park | 1 | Georgetown | 33 09 16 N | 079 16 27 W |
| Santee Cooper Regional Airport | Airport | 28 | Clarendon | 33 35 14 N | 080 12 30 W |
| Santee Cooper Reservation | Reserve | 23 | Sumter | 33 40 30 N | 080 32 08 W |
| Santee Dam | Dam | 13 | Clarendon | 33 27 14 N | 080 09 50 W |
| Santee Experimental Station | Locale | 6 | Berkeley | 33 08 11 N | 079 48 52 W |
| Santee Golf Air Strip | Airport | 37 | Orangeburg | 33 29 08 N | 080 27 26 W |
| Santee Gun Club | Locale | 3 | Charleston | 33 09 15 N | 079 21 43 W |
| Santee National Wildlife Refuge | Park | 24 | Clarendon | 33 29 54 N | 080 18 01 W |
| Santee Park | Park | 6 | Georgetown | 33 14 51 N | 079 23 49 W |
| Santee Pass | Channel | 1 | Charleston | 32 52 39 N | 079 40 56 W |
| Santee Path Creek | Gut | 1 | Charleston | 33 01 51 N | 079 27 16 W |
| Santee Point | Cape | 1 | Georgetown | 33 08 16 N | 079 14 23 W |
| Santee River | Stream | | Georgetown | 33 14 07 N | 079 27 34 W |
| Santee Rosenwald School (historical) | School | 27 | Clarendon | 33 33 33 N | 080 05 54 W |
| Santee School | School | 2 | Charleston | 33 12 06 N | 079 23 25 W |
| Santee School (historical) | School | 6 | Charleston | 33 11 06 N | 079 25 38 W |
| Santee School (historical) | School | 29 | Clarendon | 33 29 39 N | 080 23 03 W |
| Santee Shores Pond Dam D-3746 | Dam | 30 | Orangeburg | 33 29 19 N | 080 29 05 W |
| Santee State Park | Park | 38 | Orangeburg | 33 31 15 N | 080 29 27 W |
| Santee Swamp | Swamp | 3 | Georgetown | 33 17 39 N | 079 36 07 W |
| Santiago School (historical) | School | 229 | Greenville | 34 33 40 N | 082 15 56 W |
| Santiago School (historical) | School | 253 | York | 35 05 23 N | 081 20 42 W |
| Santo Sotille Ranch | Locale | 2 | Charleston | 32 55 36 N | 079 40 37 W |
| Santuc | Populated Place | 161 | Union | 34 38 04 N | 081 31 21 W |
| Santuck School (historical) | School | 170 | Union | 34 38 02 N | 081 31 37 W |
| Sapps Crossroads | Populated Place | 207 | Lancaster | 34 48 33 N | 080 37 52 W |
| Sara Collins Elementary School | School | 271 | Greenville | 34 48 51 N | 082 21 56 W |
| Sara Lake | Lake | 8 | Marion | 33 59 47 N | 079 29 10 W |
| Sarah Branch | Stream | | Horry | 33 45 33 N | 079 11 21 W |
| Sarah Copeland Pond | Reservoir | 187 | Laurens | 34 27 12 N | 081 52 05 W |
| Sarah Copeland Pond Dam D-2998 | Dam | 187 | Laurens | 34 27 12 N | 081 52 05 W |