Feature Name | Class | Elev. meters | County | Latitude DMS | Longitude DMS |
| Sarah Drain | Stream | | Berkeley | 33 16 50 N | 079 38 16 W |
| Sarah Matthew School (historical) | School | 88 | Richland | 34 04 28 N | 081 03 21 W |
| Saratt | Populated Place | 192 | Cherokee | 34 53 45 N | 081 32 24 W |
| Sardinia | Populated Place | 31 | Clarendon | 33 50 04 N | 080 04 58 W |
| Sardinia Presbyterian Church | Church | 30 | Clarendon | 33 49 54 N | 080 04 57 W |
| Sardis | Populated Place | 40 | Florence | 34 02 26 N | 079 56 38 W |
| Sardis | Populated Place | 189 | Union | 34 40 17 N | 081 37 59 W |
| Sardis Baptist Church | Church | 40 | Dillon | 34 19 30 N | 079 25 58 W |
| Sardis Baptist Church | Church | 40 | Florence | 34 02 20 N | 079 56 21 W |
| Sardis Baptist Church | Church | 58 | Kershaw | 34 14 54 N | 080 36 47 W |
| Sardis Baptist Church Cemetery | Cemetery | 40 | Dillon | 34 19 31 N | 079 25 58 W |
| Sardis Cemetery | Cemetery | 40 | Orangeburg | 33 16 08 N | 080 49 03 W |
| Sardis Cemetery | Cemetery | 174 | Union | 34 40 03 N | 081 38 11 W |
| Sardis Church | Church | 201 | Cherokee | 35 00 43 N | 081 30 47 W |
| Sardis Church | Church | 115 | Lexington | 33 44 38 N | 081 02 33 W |
| Sardis Church | Church | 39 | Marlboro | 34 30 15 N | 079 39 54 W |
| Sardis Church | Church | 40 | Orangeburg | 33 16 08 N | 080 49 02 W |
| Sardis Church | Church | 137 | Saluda | 34 01 11 N | 081 38 52 W |
| Sardis Church | Church | 251 | Spartanburg | 34 59 33 N | 081 54 56 W |
| Sardis Church | Church | 166 | Union | 34 40 04 N | 081 38 10 W |
| Sardis Indian School (historical) | School | 40 | Dillon | 34 19 30 N | 079 25 58 W |
| Sardis Methodist Church (historical) | Church | 175 | Laurens | 34 29 50 N | 081 45 38 W |
| Sardis School | School | 41 | Orangeburg | 33 16 04 N | 080 49 02 W |
| Sardis School (historical) | School | 156 | Saluda | 34 00 06 N | 081 38 56 W |
| Sardis School (historical) | School | 177 | Union | 34 40 09 N | 081 37 34 W |
| Sarion Church | Church | 56 | Marlboro | 34 37 15 N | 079 32 34 W |
| Sarratt Cemetery | Cemetery | 232 | Cherokee | 35 10 05 N | 081 38 53 W |
| Sarratt Cemetery | Cemetery | 250 | Cherokee | 35 10 08 N | 081 38 42 W |
| Sarratt Cemetery | Cemetery | 199 | Cherokee | 35 08 45 N | 081 36 24 W |
| Sarratt Creek | Stream | | Cherokee | 35 09 31 N | 081 39 55 W |
| Sarratt School (historical) | School | 262 | Cherokee | 35 03 13 N | 081 44 38 W |
| Sartor Estates (subdivision) | Populated Place | 35 | Darlington | 34 18 51 N | 079 51 49 W |
| Sartor Town | Populated Place | 132 | Union | 34 31 04 N | 081 32 27 W |
| Sarvis Crossroads | Populated Place | 34 | Horry | 34 02 29 N | 078 58 01 W |
| Sarvis Pond | Reservoir | 19 | Horry | 34 04 19 N | 079 01 17 W |
| Sarvis Pond Dam D-3614 | Dam | 19 | Horry | 34 04 19 N | 079 01 17 W |
| Sassafras Hill | Summit | 4 | Jasper | 32 20 56 N | 081 01 25 W |
| Sassafras Mountain | Summit | 1081 | Pickens | 35 03 53 N | 082 46 38 W |
| Satchel Ford Road School | School | 81 | Richland | 34 02 10 N | 080 58 21 W |
| Satchel Ford Terrace (subdivision) | Populated Place | 78 | Richland | 34 03 21 N | 080 58 08 W |
| Satcher Branch | Stream | | Edgefield | 33 46 39 N | 081 44 11 W |
| Sato | Populated Place | 69 | Bamberg | 33 19 19 N | 081 07 39 W |
| Saucie Cemetery | Cemetery | 4 | Jasper | 32 16 08 N | 081 06 43 W |
| Sauldan Church | Church | 13 | Charleston | 32 50 01 N | 080 13 47 W |
| Sauls Chapel Cemetery | Cemetery | 176 | Laurens | 34 14 41 N | 081 55 05 W |
| Savage Creek | Stream | | Beaufort | 32 11 11 N | 080 50 59 W |
| Savage Glover School | School | 50 | Sumter | 33 54 32 N | 080 20 49 W |
| Savage Island | Island | 3 | Beaufort | 32 10 56 N | 080 51 55 W |
| Savage Landing | Locale | 17 | Florence | 33 53 47 N | 079 25 37 W |
| Savana Branch | Stream | | Lexington | 33 56 05 N | 081 04 58 W |
| Savanna Branch | Stream | | Clarendon | 33 29 20 N | 080 19 42 W |
| Savanna Creek | Populated Place | 11 | Berkeley | 33 17 13 N | 079 45 26 W |
| Savanna Creek | Stream | | Berkeley | 33 19 20 N | 079 44 30 W |
| Savanna Town (historical) | Populated Place | 60 | Aiken | 33 25 31 N | 081 54 34 W |
| Savannah Bluff | Cliff | 1 | Horry | 33 48 56 N | 079 02 41 W |
| Savannah Bluff Church | Church | 12 | Horry | 33 48 32 N | 079 01 09 W |
| Savannah Bluff School | School | 12 | Horry | 33 48 15 N | 079 01 02 W |
| Savannah Branch | Stream | | Chesterfield | 34 48 30 N | 080 16 36 W |
| Savannah Branch | Stream | | Horry | 34 06 37 N | 078 53 03 W |
| Savannah Branch | Stream | | Jasper | 32 35 08 N | 081 06 39 W |
| Savannah Cemetery | Cemetery | 66 | Lee | 34 18 24 N | 080 12 04 W |
| Savannah Chapel | Church | 55 | Calhoun | 33 36 11 N | 080 36 46 W |
| Savannah Church | Church | 65 | Lee | 34 18 25 N | 080 12 06 W |
| Savannah Creek | Stream | | Colleton | 33 01 13 N | 081 03 58 W |
| Savannah Creek | Stream | | Horry | 34 00 16 N | 079 16 06 W |
| Savannah Creek Church | Church | 43 | Bamberg | 33 06 18 N | 081 01 38 W |
| Savannah Grove | Populated Place | 38 | Florence | 34 09 01 N | 079 49 45 W |
| Savannah Grove Baptist Church | Church | 38 | Florence | 34 09 01 N | 079 49 15 W |
| Savannah Grove Church | Church | 27 | Florence | 33 57 57 N | 079 44 56 W |
| Savannah Grove Elementary School | School | 38 | Florence | 34 08 51 N | 079 49 39 W |
| Savannah Grove School | School | 38 | Florence | 34 09 01 N | 079 49 17 W |
| Savannah Plaza Shopping Center | Locale | 48 | Sumter | 33 54 19 N | 080 22 52 W |
| Savannah River | Stream | | Jasper | 32 02 16 N | 080 51 00 W |
| Savannah River Ecology Laboratory | Building | 112 | Aiken | 33 20 38 N | 081 44 05 W |
| Savannah River Forest Station | Locale | 119 | Aiken | 33 21 47 N | 081 41 01 W |
| Savannah River Laboratory | Building | 115 | Aiken | 33 20 41 N | 081 44 16 W |
| Savannah River Plant Heliport | Airport | 90 | Aiken | 33 17 06 N | 081 43 39 W |
| Savannah River Plant Pond B D-3078 Dam | Dam | 75 | Barnwell | 33 17 34 N | 081 32 45 W |
| Savannah River Plant Pond Dam Number Five D-3076 | Dam | 73 | Barnwell | 33 15 40 N | 081 33 35 W |
| Savannah River Plant Pond Dam Number Four D-3075 | Dam | 80 | Barnwell | 33 16 13 N | 081 34 04 W |
| Savannah River Plant Pond Number 25-288-F D-3156 Dam | Dam | 92 | Aiken | 33 17 19 N | 081 40 17 W |
| Savannah River Plant Pond Number Two D-3074 Dam | Dam | 77 | Barnwell | 33 15 19 N | 081 35 05 W |
| Savannah Terrace (subdivision) | Populated Place | 59 | Aiken | 33 29 51 N | 081 59 02 W |
| Savany Hunt Creek | Stream | | Calhoun | 33 51 09 N | 080 59 25 W |
| Save All Cemetery | Cemetery | 192 | Greenwood | 34 10 40 N | 082 08 25 W |
| Saw Dust Landing | Locale | 27 | Calhoun | 33 43 53 N | 080 37 42 W |
| Saw Mill | Populated Place | 13 | Berkeley | 33 06 59 N | 079 54 10 W |
| Sawhead Branch | Stream | | Oconee | 34 45 20 N | 083 18 37 W |
| Sawmill Branch | Stream | | Dorchester | 32 58 46 N | 080 12 37 W |
| Sawmill Church | Church | 30 | Marlboro | 34 37 37 N | 079 46 27 W |
| Sawmill Creek | Gut | 1 | Georgetown | 33 19 06 N | 079 12 25 W |
| Sawmill Creek | Stream | | Beaufort | 32 17 29 N | 080 49 58 W |
| Sawmill Pond | Reservoir | 50 | Sumter | 33 57 13 N | 080 25 14 W |
| Sawmill Pond Dam D-1987 | Dam | 50 | Sumter | 33 57 13 N | 080 25 14 W |
| Sawmill School (historical) | School | 13 | Berkeley | 33 06 57 N | 079 54 08 W |
| Sawmill Terrace (subdivision) | Populated Place | 21 | Dorchester | 33 00 28 N | 080 10 29 W |
| Sawney Creek | Stream | | McCormick | 34 03 07 N | 082 29 25 W |
| Sawneys Creek | Stream | | Kershaw | 34 19 14 N | 080 41 35 W |
| Sawneys Creek Cemetery | Cemetery | 140 | Fairfield | 34 16 48 N | 080 52 57 W |
| Sawneys Creek Church | Church | 140 | Fairfield | 34 16 47 N | 080 52 53 W |
| Sawpit Creek | Stream | | Charleston | 32 53 08 N | 080 05 47 W |
| Sawscapel Bay | Basin | 19 | Horry | 34 17 21 N | 079 03 40 W |
| Sawyer Branch | Stream | | Oconee | 34 48 14 N | 083 10 34 W |
| Sawyer Cemetery | Cemetery | 166 | Aiken | 33 46 60 N | 081 33 45 W |
| Sawyer Cemetery | Cemetery | 187 | Lexington | 33 52 38 N | 081 33 32 W |
| Sawyerdale | Populated Place | 121 | Orangeburg | 33 35 29 N | 081 13 51 W |
| Sawyerdale School | School | 123 | Orangeburg | 33 35 30 N | 081 14 00 W |
| Sawyers Island | Island | 2 | Colleton | 32 33 49 N | 080 28 57 W |
| Sawyers Mill (historical) | Locale | 50 | Marlboro | 34 45 42 N | 079 46 55 W |
| Sawyers Pond | Reservoir | 124 | Aiken | 33 46 31 N | 081 33 47 W |