Feature Name | Class | Elev. meters | County | Latitude DMS | Longitude DMS |
| Sea Pines Club | Locale | 3 | Beaufort | 32 09 03 N | 080 47 07 W |
| Sea Pines Forest Preserve | Park | 3 | Beaufort | 32 08 46 N | 080 46 19 W |
| Sea Pines Montessori School | School | 3 | Beaufort | 32 08 15 N | 080 46 56 W |
| Sea Pines Plantation | Locale | 3 | Beaufort | 32 08 06 N | 080 46 50 W |
| Sea Pines Plantation | Populated Place | 3 | Beaufort | 32 08 02 N | 080 46 21 W |
| Sea Side School (historical) | School | 6 | Charleston | 32 32 09 N | 080 17 52 W |
| Seaboard Industrial Park | Locale | 6 | Horry | 33 42 30 N | 078 54 14 W |
| Seaboard Park | Park | 84 | Richland | 34 00 24 N | 081 02 26 W |
| Seabreeze | Populated Place | 6 | Horry | 33 35 10 N | 079 00 58 W |
| Seabrook | Populated Place | 5 | Beaufort | 32 31 41 N | 080 45 59 W |
| Seabrook | Populated Place | 6 | Colleton | 32 31 35 N | 080 24 26 W |
| Seabrook Beach | Beach | 0 | Charleston | 32 34 06 N | 080 09 33 W |
| Seabrook Island | Island | 5 | Charleston | 32 35 18 N | 080 09 48 W |
| Seabrook Island | Populated Place | 5 | Charleston | 32 34 38 N | 080 10 14 W |
| Seabrook Landing | Populated Place | 3 | Beaufort | 32 15 34 N | 080 44 26 W |
| Seabrook Point | Cape | 1 | Beaufort | 32 31 33 N | 080 46 41 W |
| Seabrook Pond | Lake | 3 | Beaufort | 32 15 02 N | 080 43 51 W |
| Seabrook School (historical) | School | 6 | Beaufort | 32 31 08 N | 080 45 10 W |
| Seabrook School (historical) | School | 3 | Colleton | 32 31 39 N | 080 24 31 W |
| Seacroft | Populated Place | 7 | Horry | 33 36 40 N | 078 59 44 W |
| Searle Mill (historical) | Locale | 100 | McCormick | 33 52 11 N | 082 21 14 W |
| Searles School (historical) | School | 139 | McCormick | 33 51 31 N | 082 17 59 W |
| Sease Cemetery | Cemetery | 131 | Lexington | 34 00 45 N | 081 24 01 W |
| Seaside | Populated Place | 0 | Charleston | 32 42 42 N | 079 56 29 W |
| Seaside Creek | Stream | | Charleston | 32 42 42 N | 079 56 16 W |
| Seaside Farms Estates | Populated Place | 3 | Charleston | 32 48 41 N | 079 49 30 W |
| Seaton | Populated Place | 10 | Berkeley | 33 07 04 N | 080 00 34 W |
| Seaview Place (subdivision) | Populated Place | 6 | Horry | 33 40 19 N | 078 54 12 W |
| Seay Cemetery | Cemetery | 212 | Spartanburg | 34 55 53 N | 081 56 31 W |
| Secession Lake | Reservoir | 168 | Abbeville | 34 15 27 N | 082 36 35 W |
| Secessionville | Populated Place | 1 | Charleston | 32 42 21 N | 079 56 21 W |
| Secessionville Acres | Populated Place | 4 | Charleston | 32 42 03 N | 079 57 07 W |
| Secessionville Creek | Stream | | Charleston | 32 42 39 N | 079 55 53 W |
| Secessionville Historic District | Park | 1 | Charleston | 32 42 21 N | 079 56 22 W |
| Secona Cemetery | Cemetery | 323 | Pickens | 34 52 36 N | 082 43 14 W |
| Second Avenue Church | Church | 154 | Lancaster | 34 42 39 N | 080 46 03 W |
| Second Baptist Church | Church | 161 | Aiken | 33 34 10 N | 081 43 16 W |
| Second Baptist Church | Church | 67 | Barnwell | 33 14 59 N | 081 21 27 W |
| Second Baptist Church | Church | 46 | Darlington | 34 17 48 N | 079 52 55 W |
| Second Baptist Church | Church | 281 | Greenville | 34 50 36 N | 082 23 48 W |
| Second Baptist Church | Church | 165 | Lancaster | 34 42 38 N | 080 46 25 W |
| Second Baptist Church | Church | 151 | Lancaster | 34 43 32 N | 080 46 05 W |
| Second Baptist Church | Church | 192 | Laurens | 34 30 14 N | 082 00 07 W |
| Second Baptist Church | Church | 22 | Williamsburg | 33 41 22 N | 079 48 56 W |
| Second Baptist Church (historical) | Church | 6 | Charleston | 32 46 59 N | 079 55 59 W |
| Second Calvary Church | Church | 49 | Allendale | 33 02 19 N | 081 16 38 W |
| Second Calvary Church | Church | 177 | Lancaster | 34 32 01 N | 080 39 30 W |
| Second Church | Church | 173 | Lancaster | 34 33 32 N | 080 35 08 W |
| Second Church | Church | 320 | Pickens | 34 52 36 N | 082 43 15 W |
| Second Creek | Stream | | Lexington | 33 53 39 N | 081 07 27 W |
| Second Creek | Stream | | Newberry | 34 20 32 N | 081 24 41 W |
| Second Euhaw Church | Church | 6 | Jasper | 32 25 39 N | 080 53 48 W |
| Second Millpond | Reservoir | 42 | Sumter | 33 55 05 N | 080 22 49 W |
| Second Millpond Dam D-1444 | Dam | 42 | Sumter | 33 55 05 N | 080 22 49 W |
| Second Mount Olive Church | Church | 76 | Barnwell | 33 09 45 N | 081 21 11 W |
| Second Presbyterian Church | Church | 5 | Charleston | 32 47 20 N | 079 56 02 W |
| Second Presbyterian Church | Church | 286 | Greenville | 34 50 44 N | 082 24 17 W |
| Second Presbyterian Church | Church | 55 | Kershaw | 34 14 34 N | 080 36 15 W |
| Second Presbyterian Church | Church | 245 | Spartanburg | 34 57 27 N | 081 56 19 W |
| Second Presbyterian Church | Church | 51 | Sumter | 33 54 45 N | 080 20 24 W |
| Second Sister Creek | Stream | | Charleston | 32 42 08 N | 079 54 50 W |
| Second Trinity Methodist Church | Church | 232 | Spartanburg | 34 57 40 N | 081 55 49 W |
| Second Wilson Baptist Church | Church | 158 | Chester | 34 41 51 N | 081 12 41 W |
| Sedalia | Populated Place | 177 | Union | 34 36 14 N | 081 43 28 W |
| Sedalia Hunt Camp | Locale | 112 | Union | 34 37 53 N | 081 37 44 W |
| Sedalia Lookout Tower | Tower | 196 | Union | 34 36 46 N | 081 42 50 W |
| Sedalia School (historical) | School | 183 | Union | 34 36 44 N | 081 44 10 W |
| Sedalia Tower Hunt Camp | Locale | 187 | Union | 34 36 45 N | 081 42 39 W |
| Sedge Marsh | Swamp | 3 | Marion | 33 48 56 N | 079 15 43 W |
| Sedgefield (subdivision) | Populated Place | 241 | Anderson | 34 31 58 N | 082 39 09 W |
| Sedgefield (subdivision) | Populated Place | 14 | Berkeley | 32 58 29 N | 080 00 39 W |
| Sedgefield (subdivision) | Populated Place | 204 | York | 34 57 16 N | 081 00 24 W |
| Sedgefield Middle School | School | 13 | Berkeley | 32 58 48 N | 080 00 45 W |
| Seed Branch | Stream | | Darlington | 34 24 17 N | 079 56 07 W |
| Seed Tick Branch | Stream | | Horry | 34 06 50 N | 078 59 00 W |
| Seekwell Cemetery | Cemetery | 138 | Newberry | 34 26 54 N | 081 29 46 W |
| Seekwell Church | Church | 140 | Newberry | 34 26 58 N | 081 29 44 W |
| Seekwell School (historical) | School | 141 | Newberry | 34 26 51 N | 081 29 45 W |
| Seeley Creek | Stream | | Chester | 34 39 30 N | 081 19 16 W |
| Seeleys Creek School (historical) | School | 147 | Chester | 34 43 03 N | 081 16 52 W |
| Segars | Populated Place | 74 | Darlington | 34 23 03 N | 080 07 54 W |
| Segars Mill (historical) | Locale | 53 | Darlington | 34 22 22 N | 080 08 02 W |
| Segars Mill Stream | Stream | | Darlington | 34 22 28 N | 080 07 42 W |
| Segars Millpond | Reservoir | 53 | Darlington | 34 22 22 N | 080 08 02 W |
| Seigler Cemetery | Cemetery | 150 | Aiken | 33 38 31 N | 081 39 25 W |
| Seigler Cemetery | Cemetery | 159 | Aiken | 33 38 50 N | 081 39 47 W |
| Seigler Cemetery | Cemetery | 147 | Aiken | 33 38 54 N | 081 38 38 W |
| Seigler Cemetery | Cemetery | 25 | Dorchester | 33 07 08 N | 080 34 37 W |
| Seiglers Crossroads | Populated Place | 154 | Aiken | 33 38 42 N | 081 39 25 W |
| Seigling | Populated Place | 64 | Allendale | 33 02 40 N | 081 18 54 W |
| Seigling Church (historical) | Church | 65 | Allendale | 33 02 28 N | 081 19 24 W |
| Seigling School (historical) | School | 66 | Allendale | 33 02 29 N | 081 19 23 W |
| Seivern | Populated Place | 125 | Aiken | 33 42 55 N | 081 24 35 W |
| Seivern Church | Church | 132 | Aiken | 33 42 51 N | 081 24 36 W |
| Seivern Lake | Reservoir | 135 | Aiken | 33 44 01 N | 081 28 59 W |
| Seivern School (historical) | School | 135 | Aiken | 33 42 09 N | 081 24 11 W |
| Self Memorial Hospital | Hospital | 199 | Greenwood | 34 10 32 N | 082 09 23 W |
| Sellars Heights | Populated Place | 56 | Sumter | 33 55 26 N | 080 24 09 W |
| Sellers | Populated Place | 26 | Marion | 34 17 02 N | 079 28 22 W |
| Sellers Indian School (historical) | School | 20 | Dillon | 34 16 41 N | 079 29 10 W |
| Sellers Pond | Reservoir | 94 | Chesterfield | 34 44 01 N | 080 10 17 W |
| Sellkirk Plantation | Locale | 8 | Charleston | 32 39 22 N | 080 12 04 W |
| Selma | Populated Place | 41 | Dillon | 34 26 44 N | 079 22 28 W |
| Selma Church | Church | 244 | Spartanburg | 34 46 25 N | 082 04 50 W |
| Seloc | Populated Place | 28 | Clarendon | 33 52 53 N | 080 00 30 W |
| Selwood Shores | Populated Place | 120 | Lexington | 34 05 39 N | 081 13 39 W |
| Seminole Road School | School | 97 | Richland | 34 02 37 N | 081 06 09 W |
| Semmes Lake | Reservoir | 64 | Richland | 34 00 17 N | 080 56 29 W |
| Semmes Lake Dam - Fort Jackson | Dam | 64 | Richland | 34 00 17 N | 080 56 29 W |
| Sends Mill Bridge | Bridge | 134 | Newberry | 34 18 35 N | 081 43 10 W |