Feature Name | Class | Elev. meters | County | Latitude DMS | Longitude DMS |
| Seneca | Populated Place | 294 | Oconee | 34 41 08 N | 082 57 12 W |
| Seneca Baptist Church | Church | 304 | Oconee | 34 40 54 N | 082 57 13 W |
| Seneca City Hall | Building | 296 | Oconee | 34 41 08 N | 082 57 07 W |
| Seneca Creek | Stream | | Oconee | 34 40 42 N | 082 51 08 W |
| Seneca High School | School | 290 | Oconee | 34 40 32 N | 082 58 12 W |
| Seneca Historic District | Park | 300 | Oconee | 34 40 47 N | 082 57 10 W |
| Seneca Landing | Populated Place | 211 | Oconee | 34 38 41 N | 082 54 53 W |
| Seneca Marina | Locale | 201 | Oconee | 34 39 53 N | 082 51 32 W |
| Seneca Methodist Episcopal Church | Church | 299 | Oconee | 34 41 12 N | 082 57 18 W |
| Seneca Post Office | Post Office | 296 | Oconee | 34 41 07 N | 082 57 11 W |
| Seneca Presbyterian Church | Church | 305 | Oconee | 34 40 58 N | 082 57 21 W |
| Seneca Preschool | School | 295 | Oconee | 34 41 00 N | 082 56 39 W |
| Seneca Reservoir | Reservoir | 244 | Oconee | 34 42 45 N | 082 57 19 W |
| Seneca River | Stream | | Anderson | 34 26 37 N | 082 51 22 W |
| Senn Branch | Stream | | Lexington | 34 01 01 N | 081 05 53 W |
| Septus Post Office (historical) | Post Office | 272 | Anderson | 34 37 59 N | 082 40 13 W |
| Serene Heights | Populated Place | 279 | Spartanburg | 34 57 03 N | 082 09 59 W |
| Service Branch | Stream | | Cherokee | 35 00 12 N | 081 31 29 W |
| Sesqui | Reservoir | 70 | Richland | 34 04 49 N | 080 54 41 W |
| Sesquicentennial Pond | Lake | 73 | Richland | 34 05 07 N | 080 54 15 W |
| Sesquicentennial State Park | Park | 74 | Richland | 34 05 19 N | 080 54 12 W |
| Sessions Lake | Lake | 1 | Horry | 33 49 35 N | 078 55 48 W |
| Sessions Lodge | Locale | 0 | Horry | 33 49 42 N | 078 54 47 W |
| Sett Creek | Stream | | Charleston | 33 02 08 N | 079 29 50 W |
| Settlement Islands | Island | 2 | Colleton | 32 35 05 N | 080 28 32 W |
| Seven Mile School (historical) | School | 10 | Charleston | 32 51 20 N | 079 48 03 W |
| Seven Oaks | Locale | 8 | Charleston | 32 44 18 N | 080 01 58 W |
| Seven Oaks | Populated Place | 291 | Greenville | 34 55 13 N | 082 19 06 W |
| Seven Oaks | Populated Place | 66 | Lexington | 34 02 56 N | 081 08 47 W |
| Seven Oaks | Populated Place | 232 | Oconee | 34 36 20 N | 082 55 14 W |
| Seven Oaks School | School | 93 | Lexington | 34 02 38 N | 081 07 32 W |
| Seven Oaks Shopping Center | Locale | 76 | Lexington | 34 03 28 N | 081 09 50 W |
| Seven Pines Baptist Church | Church | 71 | Barnwell | 33 14 28 N | 081 27 11 W |
| Seven Pines Cemetery | Cemetery | 75 | Barnwell | 33 15 12 N | 081 27 07 W |
| Seven Pines Church (historical) | Church | 74 | Barnwell | 33 15 10 N | 081 27 07 W |
| Seven Prongs | Gut | 1 | Horry | 33 39 57 N | 079 04 44 W |
| Seven Reaches | Gut | 3 | Charleston | 32 49 18 N | 079 44 45 W |
| Sevenmile | Locale | 3 | Charleston | 32 51 57 N | 079 59 52 W |
| Sevenmile Branch | Stream | | Chesterfield | 34 35 57 N | 080 16 17 W |
| Sevenmile Swamp | Swamp | 6 | Jasper | 32 22 46 N | 081 03 25 W |
| Sevenmile Viaduct | Canal | 6 | Charleston | 32 52 23 N | 079 59 51 W |
| Seventh Day Adventist Church | Church | 52 | Sumter | 33 55 02 N | 080 21 13 W |
| Seventh Day Adventist Church of Pickens | Church | 332 | Pickens | 34 51 51 N | 082 41 16 W |
| Seventieth Avenue North Shopping Center | Locale | 6 | Horry | 33 44 33 N | 078 49 29 W |
| Sevier Middle School | School | 327 | Greenville | 34 54 24 N | 082 21 49 W |
| Sewee Bay | Bay | 8 | Charleston | 32 56 08 N | 079 38 59 W |
| Sewee Camp | Locale | 5 | Charleston | 32 59 24 N | 079 36 56 W |
| Sewee Church | Church | 6 | Charleston | 32 56 33 N | 079 42 22 W |
| Sexton Airport | Airport | 167 | Newberry | 34 21 00 N | 081 46 59 W |
| Sexton Pond | Reservoir | 73 | Chesterfield | 34 27 54 N | 080 18 14 W |
| Shackleford Lake | Lake | 7 | Marion | 33 56 27 N | 079 28 37 W |
| Shad Cemetery | Cemetery | 6 | Jasper | 32 08 51 N | 080 59 53 W |
| Shad Moss village | Populated Place | 26 | Clarendon | 33 33 46 N | 080 12 19 W |
| Shad School (historical) | School | 3 | Jasper | 32 10 39 N | 081 02 54 W |
| Shadblow (subdivision) | Populated Place | 63 | Lexington | 33 56 55 N | 081 05 40 W |
| Shadow Brook | Populated Place | 72 | Lexington | 34 03 49 N | 081 08 46 W |
| Shadow Grove Cemetery | Cemetery | 255 | Anderson | 34 32 13 N | 082 26 16 W |
| Shadow Wood | Populated Place | 240 | Anderson | 34 34 10 N | 082 49 27 W |
| Shadowbrook (subdivision) | Populated Place | 186 | York | 34 57 19 N | 081 01 42 W |
| Shadowmoss | Populated Place | 10 | Charleston | 32 50 38 N | 080 03 54 W |
| Shadowmoss Golf Club | Locale | 10 | Charleston | 32 50 33 N | 080 04 30 W |
| Shadwick | Populated Place | 246 | Oconee | 34 37 55 N | 082 55 25 W |
| Shady Acres | Populated Place | 113 | Lexington | 34 06 06 N | 081 21 54 W |
| Shady Brook Hospital | Hospital | 263 | Oconee | 34 39 22 N | 082 57 48 W |
| Shady Creek | Populated Place | 315 | Greenville | 34 53 50 N | 082 21 26 W |
| Shady Grove | Populated Place | 52 | Sumter | 33 53 21 N | 080 23 24 W |
| Shady Grove (historical) | Populated Place | 169 | Union | 34 34 20 N | 081 39 47 W |
| Shady Grove (subdivision) | Populated Place | 9 | Charleston | 32 53 15 N | 080 00 50 W |
| Shady Grove (subdivision) | Populated Place | 311 | Pickens | 34 46 52 N | 082 41 12 W |
| Shady Grove Baptist Church | Church | 303 | Pickens | 34 54 55 N | 082 50 36 W |
| Shady Grove Campground | Locale | 34 | Dorchester | 33 16 35 N | 080 35 45 W |
| Shady Grove Campground | Locale | 5 | Horry | 33 41 03 N | 078 53 59 W |
| Shady Grove Cemetery | Cemetery | 255 | Anderson | 34 32 13 N | 082 26 16 W |
| Shady Grove Cemetery | Cemetery | 259 | Cherokee | 35 06 05 N | 081 45 31 W |
| Shady Grove Cemetery | Cemetery | 189 | Laurens | 34 26 38 N | 081 46 20 W |
| Shady Grove Cemetery | Cemetery | 147 | Newberry | 34 13 10 N | 081 44 19 W |
| Shady Grove Cemetery | Cemetery | 82 | Orangeburg | 33 33 25 N | 081 02 24 W |
| Shady Grove Cemetery | Cemetery | 301 | Pickens | 34 54 54 N | 082 50 38 W |
| Shady Grove Church | Church | 173 | Abbeville | 34 08 27 N | 082 29 29 W |
| Shady Grove Church | Church | 255 | Anderson | 34 32 13 N | 082 26 10 W |
| Shady Grove Church | Church | 56 | Calhoun | 33 35 22 N | 080 40 34 W |
| Shady Grove Church | Church | 257 | Cherokee | 35 06 05 N | 081 45 30 W |
| Shady Grove Church | Church | 109 | Chesterfield | 34 25 57 N | 080 13 16 W |
| Shady Grove Church | Church | 34 | Dorchester | 33 16 35 N | 080 35 42 W |
| Shady Grove Church | Church | 120 | Edgefield | 33 46 26 N | 082 07 27 W |
| Shady Grove Church | Church | 159 | Fairfield | 34 24 50 N | 081 09 42 W |
| Shady Grove Church | Church | 253 | Greenville | 34 38 06 N | 082 24 13 W |
| Shady Grove Church | Church | 295 | Greenville | 34 47 08 N | 082 25 42 W |
| Shady Grove Church | Church | 33 | Hampton | 32 56 11 N | 081 05 38 W |
| Shady Grove Church | Church | 188 | Laurens | 34 26 39 N | 081 46 21 W |
| Shady Grove Church | Church | 72 | Lee | 34 16 17 N | 080 11 46 W |
| Shady Grove Church | Church | 88 | Richland | 34 09 21 N | 081 13 03 W |
| Shady Grove Church | Church | 110 | Richland | 34 13 05 N | 080 52 11 W |
| Shady Grove Church | Church | 156 | Saluda | 33 56 40 N | 081 34 23 W |
| Shady Grove Church | Church | 228 | Spartanburg | 34 48 57 N | 082 04 30 W |
| Shady Grove Church | Church | 187 | York | 34 53 54 N | 081 24 01 W |
| Shady Grove Church (historical) | Church | 82 | Orangeburg | 33 33 24 N | 081 02 22 W |
| Shady Grove Methodist Church (historical) | Church | 148 | Newberry | 34 13 12 N | 081 44 20 W |
| Shady Grove School | School | 159 | Abbeville | 34 07 34 N | 082 29 15 W |
| Shady Grove School | School | 47 | Allendale | 33 03 52 N | 081 10 39 W |
| Shady Grove School | School | 82 | Orangeburg | 33 33 21 N | 081 02 30 W |
| Shady Grove School (historical) | School | 204 | Abbeville | 34 25 08 N | 082 17 04 W |
| Shady Grove School (historical) | School | 231 | Anderson | 34 39 30 N | 082 43 48 W |
| Shady Grove School (historical) | School | 268 | Cherokee | 35 06 03 N | 081 45 32 W |
| Shady Grove School (historical) | School | 159 | Fairfield | 34 24 49 N | 081 09 42 W |
| Shady Grove School (historical) | School | 260 | Greenville | 34 38 01 N | 082 24 08 W |
| Shady Grove School (historical) | School | 175 | Laurens | 34 26 18 N | 081 45 49 W |
| Shady Grove School (historical) | School | 174 | Laurens | 34 26 36 N | 081 45 26 W |
| Shady Grove School (historical) | School | 286 | Pickens | 34 54 58 N | 082 50 25 W |
| Shady Grove School (historical) | School | 101 | Richland | 34 12 60 N | 080 53 06 W |