Feature Name | Class | Elev. meters | County | Latitude DMS | Longitude DMS |
| Shiloh Church | Church | 37 | Sumter | 33 56 24 N | 080 02 25 W |
| Shiloh Church | Church | 184 | York | 34 53 35 N | 081 24 45 W |
| Shiloh Church (historical) | Church | 134 | Aiken | 33 37 44 N | 081 41 56 W |
| Shiloh Church (historical) | Church | 76 | Barnwell | 33 17 07 N | 081 20 41 W |
| Shiloh Church (historical) | Church | 101 | Fairfield | 34 12 30 N | 081 11 49 W |
| Shiloh Church (historical) | Church | 110 | Fairfield | 34 13 49 N | 081 06 59 W |
| Shiloh Church (historical) | Church | 42 | Orangeburg | 33 23 18 N | 080 37 59 W |
| Shiloh Estates | Populated Place | 249 | Greenville | 34 43 58 N | 082 18 45 W |
| Shiloh Estates | Populated Place | 279 | Oconee | 34 41 08 N | 082 54 05 W |
| Shiloh Heights | Populated Place | 150 | Aiken | 33 36 14 N | 081 42 54 W |
| Shiloh Methodist Church | Church | 171 | Lexington | 33 58 39 N | 081 22 30 W |
| Shiloh School | School | 180 | Abbeville | 34 14 53 N | 082 17 15 W |
| Shiloh School | School | 54 | Darlington | 34 14 04 N | 079 58 46 W |
| Shiloh School | School | 102 | Richland | 33 54 01 N | 080 40 09 W |
| Shiloh School (historical) | School | 156 | Aiken | 33 38 39 N | 081 41 34 W |
| Shiloh School (historical) | School | 209 | Anderson | 34 23 29 N | 082 48 29 W |
| Shiloh School (historical) | School | 84 | Chesterfield | 34 40 28 N | 080 06 18 W |
| Shiloh School (historical) | School | 128 | Fairfield | 34 15 28 N | 081 07 50 W |
| Shiloh School (historical) | School | 101 | Fairfield | 34 12 31 N | 081 11 50 W |
| Shiloh School (historical) | School | 7 | Georgetown | 33 17 23 N | 079 19 54 W |
| Shiloh School (historical) | School | 162 | Newberry | 34 12 58 N | 081 32 32 W |
| Shiloh School (historical) | School | 254 | Oconee | 34 39 50 N | 082 53 17 W |
| Shiloh School (historical) | School | 277 | Oconee | 34 40 08 N | 082 53 40 W |
| Shiloh School (historical) | School | 169 | Saluda | 34 04 24 N | 081 51 22 W |
| Shiloh School (historical) | School | 273 | Spartanburg | 34 58 40 N | 082 08 18 W |
| Shiloh School (historical) | School | 217 | Spartanburg | 34 49 32 N | 081 50 11 W |
| Shiloh School (historical) | School | 170 | York | 34 54 46 N | 081 24 49 W |
| Shiloh United Methodist Church | Church | 200 | Abbeville | 34 17 40 N | 082 31 24 W |
| Shimmys Pond | Lake | 75 | Richland | 34 02 18 N | 081 05 01 W |
| Shinburg Mill (historical) | Locale | 115 | McCormick | 33 55 27 N | 082 10 49 W |
| Shingle Creek | Stream | | Charleston | 32 33 21 N | 080 20 23 W |
| Shingle Mill Branch | Stream | | Oconee | 34 48 38 N | 083 11 47 W |
| Shingle Swamp | Swamp | 4 | Jasper | 32 21 55 N | 081 00 12 W |
| Shipp Hall | Building | 249 | Spartanburg | 34 57 34 N | 081 56 10 W |
| Shipyard Creek | Stream | | Charleston | 32 49 46 N | 079 56 09 W |
| Shipyard Plantation | Populated Place | 3 | Beaufort | 32 09 16 N | 080 44 51 W |
| Shirley | Populated Place | 23 | Hampton | 32 39 37 N | 081 18 58 W |
| Shirley Branch | Stream | | Lexington | 33 47 55 N | 081 28 34 W |
| Shirley Branch Church (historical) | Church | 127 | Aiken | 33 47 21 N | 081 29 20 W |
| Shirley Creek | Stream | | Kershaw | 34 27 47 N | 080 28 58 W |
| Shirley School (historical) | School | 23 | Hampton | 32 39 34 N | 081 18 57 W |
| Shirleys Store (historical) | Locale | 244 | Anderson | 34 26 57 N | 082 32 59 W |
| Shiver Millpond | Lake | 66 | Lee | 34 10 31 N | 080 27 44 W |
| Shoal Creek | Stream | | Pickens | 34 46 48 N | 082 46 14 W |
| Shoal Creek | Stream | | Pickens | 34 56 50 N | 082 32 06 W |
| Shoal Creek | Stream | | Union | 34 39 37 N | 081 40 13 W |
| Shoal Creek Church | Church | 313 | Pickens | 34 57 27 N | 082 33 40 W |
| Shoal Creek School (historical) | School | 315 | Pickens | 34 57 23 N | 082 33 43 W |
| Shoally Creek | Populated Place | 257 | Spartanburg | 35 00 58 N | 081 57 04 W |
| Shoals Creek Subdivision | Populated Place | 282 | Pickens | 34 50 35 N | 082 31 09 W |
| Shoals Junction | Populated Place | 213 | Greenwood | 34 21 22 N | 082 18 10 W |
| Shoals Lake | Reservoir | 218 | Spartanburg | 34 53 12 N | 082 06 05 W |
| Shoe Heel Creek | Stream | | Dillon | 34 31 53 N | 079 23 41 W |
| Shoe Lake | Lake | 24 | Sumter | 33 46 56 N | 080 35 28 W |
| Shoe Quarter Swamp | Swamp | 0 | Beaufort | 32 12 31 N | 080 57 14 W |
| Shooting Tree Ridge | Ridge | 341 | Pickens | 34 58 43 N | 082 51 56 W |
| Shop Branch | Stream | | Lancaster | 34 43 05 N | 080 29 07 W |
| Shoppers Port Shopping Center | Locale | 8 | Charleston | 32 47 19 N | 080 01 45 W |
| Shoreline Farms | Populated Place | 6 | Charleston | 32 43 40 N | 080 01 08 W |
| Shores Brook Lake (historical) | Reservoir | 229 | Spartanburg | 34 56 21 N | 082 01 10 W |
| Shoresbrook | Populated Place | 254 | Spartanburg | 34 56 18 N | 082 00 37 W |
| Shoresbrook Golf Club | Locale | 235 | Spartanburg | 34 56 24 N | 082 01 17 W |
| Short Branch | Stream | | Greenville | 35 07 16 N | 082 26 34 W |
| Short Staple Plantation (historical) | Locale | 70 | Barnwell | 33 13 05 N | 081 18 27 W |
| Shot Pouch Branch | Stream | | Sumter | 33 54 54 N | 080 22 14 W |
| Shoulder Bone Branch | Stream | | Oconee | 34 45 24 N | 083 18 27 W |
| Showerbath Branch | Stream | | Kershaw | 34 29 03 N | 080 43 24 W |
| Shrine Club Lake Dam D-3415 | Dam | 241 | Cherokee | 35 02 06 N | 081 38 41 W |
| Shriners Hospital | Hospital | 336 | Greenville | 34 53 21 N | 082 22 22 W |
| Shrocks Mill (historical) | Locale | 79 | Kershaw | 34 19 15 N | 080 22 59 W |
| Shrocks Mill School (historical) | School | 96 | Lee | 34 17 05 N | 080 24 25 W |
| Shrocks Plantation (historical) | Locale | 82 | Kershaw | 34 19 16 N | 080 22 58 W |
| Shrub Branch | Stream | | Barnwell | 33 19 55 N | 081 21 00 W |
| Shrub Branch Church | Church | 100 | Barnwell | 33 21 44 N | 081 20 07 W |
| Shrub Branch School (historical) | School | 101 | Barnwell | 33 21 46 N | 081 20 09 W |
| Shubra Canal | Canal | 0 | Jasper | 32 07 04 N | 081 04 22 W |
| Shuler (historical) | Populated Place | 99 | Lexington | 33 52 49 N | 081 09 38 W |
| Shuler Pond Dam D-1577 | Dam | 47 | Sumter | 33 50 55 N | 080 24 53 W |
| Shuler-Lewis Cemetery | Cemetery | 33 | Orangeburg | 33 23 05 N | 080 32 35 W |
| Shulers Pond | Reservoir | 47 | Sumter | 33 50 55 N | 080 24 53 W |
| Shulerville | Populated Place | 8 | Berkeley | 33 11 15 N | 079 37 55 W |
| Shulerville Post Office | Post Office | 9 | Berkeley | 33 11 57 N | 079 37 42 W |
| Shull Island | Island | 118 | Lexington | 34 03 14 N | 081 21 09 W |
| Shullbred Point | Cape | 2 | Charleston | 32 36 49 N | 080 05 41 W |
| Shuller Pond | Reservoir | 44 | Orangeburg | 33 30 43 N | 080 42 11 W |
| Shulls Pond | Reservoir | 95 | Lexington | 33 44 33 N | 081 20 51 W |
| Shulls Pond Dam D-3685 | Dam | 81 | Orangeburg | 33 39 37 N | 081 03 11 W |
| Shumans Store | Locale | 37 | Hampton | 32 45 22 N | 081 07 12 W |
| Shumate Branch | Stream | | McCormick | 33 42 43 N | 082 10 37 W |
| Shumpert Pond | Reservoir | 87 | Lexington | 33 43 09 N | 081 14 37 W |
| Shutes Folly Island | Island | 3 | Charleston | 32 46 35 N | 079 54 43 W |
| Shutes Reach | Channel | -8 | Charleston | 32 46 51 N | 079 54 35 W |
| Side-of-Mountain Creek | Stream | | Pickens | 35 01 39 N | 082 49 31 W |
| Sidney | Populated Place | 31 | Colleton | 32 59 59 N | 080 34 06 W |
| Sidney Horton Pond | Reservoir | 115 | Kershaw | 34 30 07 N | 080 26 05 W |
| Sidney Horton Pond Dam D-1074 | Dam | 115 | Kershaw | 34 30 07 N | 080 26 05 W |
| Sidney Park Christian Methodist Episcopal Church | Church | 91 | Richland | 34 00 28 N | 081 02 14 W |
| Siesta Village (subdivision) | Populated Place | 34 | Florence | 34 10 06 N | 079 45 29 W |
| Sightler Cemetery | Cemetery | 61 | Lexington | 33 54 16 N | 081 04 13 W |
| Sigmon Pond | Reservoir | 42 | Clarendon | 33 39 19 N | 080 23 11 W |
| Sign Board Crossroads | Locale | 198 | Laurens | 34 23 11 N | 082 00 42 W |
| Sign Creek | Gut | 1 | Georgetown | 33 16 53 N | 079 11 45 W |
| Sigsbee | Populated Place | 272 | Spartanburg | 34 59 12 N | 082 00 31 W |
| Sikes Creek | Stream | | Calhoun | 33 45 01 N | 080 49 04 W |
| Sikes Hall | Building | 228 | Pickens | 34 40 46 N | 082 50 07 W |
| Sikes Pond | Reservoir | 40 | Calhoun | 33 45 37 N | 080 49 55 W |
| Silas Church | Church | 29 | Orangeburg | 33 23 60 N | 080 17 03 W |
| Silas N Pearman Bridge | Bridge | 54 | Charleston | 32 48 12 N | 079 54 50 W |
| Silent Grove Cemetery | Cemetery | 26 | Horry | 34 06 45 N | 078 58 42 W |
| Silent Grove Church | Church | 23 | Horry | 34 06 02 N | 078 59 01 W |