Feature Name | Class | Elev. meters | County | Latitude DMS | Longitude DMS |
| Silent Grove School (historical) | School | 25 | Horry | 34 05 59 N | 078 58 50 W |
| Silk Hope Plantation (historical) | Locale | 5 | Berkeley | 33 07 07 N | 079 49 04 W |
| Silk Hope Plantation Cemetery | Cemetery | 6 | Berkeley | 33 07 05 N | 079 49 05 W |
| Siloam Baptist Church | Church | 19 | Williamsburg | 33 40 03 N | 079 49 15 W |
| Siloam Church | Church | 302 | Anderson | 34 46 48 N | 082 29 19 W |
| Siloam Church | Church | 78 | Barnwell | 33 10 08 N | 081 23 02 W |
| Siloam Church | Church | 159 | Greenwood | 34 12 34 N | 082 02 23 W |
| Siloam Church | Church | 73 | Richland | 33 56 06 N | 080 49 32 W |
| Siloam School (historical) | School | 74 | Richland | 33 56 08 N | 080 49 31 W |
| Siltons Gin (historical) | Locale | 278 | Anderson | 34 47 18 N | 082 32 02 W |
| Silver | Populated Place | 47 | Clarendon | 33 40 41 N | 080 21 26 W |
| Silver Bluff | Cliff | 36 | Aiken | 33 18 41 N | 081 51 14 W |
| Silver Bluff Church | Church | 58 | Aiken | 33 24 37 N | 081 53 33 W |
| Silver Bluff Estates | Populated Place | 144 | Aiken | 33 31 15 N | 081 43 54 W |
| Silver Bluff Ferry (historical) | Crossing | 30 | Aiken | 33 18 08 N | 081 52 48 W |
| Silver Bluff High School | School | 76 | Aiken | 33 24 41 N | 081 45 34 W |
| Silver Bluff Plantation (historical) | Locale | 36 | Aiken | 33 18 46 N | 081 51 01 W |
| Silver Bluff Shopping Center | Locale | 150 | Aiken | 33 31 20 N | 081 43 35 W |
| Silver Brook Cemetery | Cemetery | 225 | Anderson | 34 29 34 N | 082 38 09 W |
| Silver Creek | Stream | | Georgetown | 33 34 11 N | 079 05 35 W |
| Silver Creek | Stream | | York | 34 59 48 N | 081 20 26 W |
| Silver Cup Spring | Spring | 9 | Berkeley | 32 55 19 N | 079 59 04 W |
| Silver Dune School (historical) | School | 100 | Richland | 34 05 49 N | 080 54 58 W |
| Silver Hill Plantation | Locale | 4 | Charleston | 33 05 02 N | 079 28 50 W |
| Silver Hill School (historical) | School | 209 | Anderson | 34 15 13 N | 082 40 55 W |
| Silver Hill School (historical) | School | 219 | Anderson | 34 32 01 N | 082 23 19 W |
| Silver Hill School (historical) | School | 15 | Dorchester | 33 04 55 N | 080 21 58 W |
| Silver Island | Cape | 0 | Georgetown | 33 31 60 N | 079 06 41 W |
| Silver Lake | Lake | 4 | Georgetown | 33 46 14 N | 079 18 38 W |
| Silver Lake | Populated Place | 49 | Lexington | 33 52 56 N | 081 02 44 W |
| Silver Lake | Reservoir | 49 | Lexington | 33 52 49 N | 081 02 47 W |
| Silver Lake | Reservoir | 46 | Lexington | 33 52 57 N | 081 02 49 W |
| Silver Lake | Reservoir | 221 | Spartanburg | 34 53 04 N | 082 06 16 W |
| Silver Lake | Reservoir | 219 | Spartanburg | 34 53 06 N | 082 06 05 W |
| Silver Leaf | Populated Place | 284 | Greenville | 34 53 40 N | 082 16 55 W |
| Silver Mine Ridge | Ridge | 245 | Cherokee | 35 04 13 N | 081 32 30 W |
| Silver Run | Stream | | Chesterfield | 34 41 16 N | 080 18 43 W |
| Silver Run | Stream | | Lancaster | 34 47 58 N | 080 35 15 W |
| Silver Run Cemetery | Cemetery | 208 | Lancaster | 35 00 55 N | 080 51 21 W |
| Silver Run Church (historical) | Church | 204 | Lancaster | 35 00 52 N | 080 51 22 W |
| Silver School (historical) | School | 50 | Clarendon | 33 40 41 N | 080 21 07 W |
| Silver Spring Church | Church | 98 | Barnwell | 33 25 49 N | 081 23 57 W |
| Silver Spring School (historical) | School | 95 | Barnwell | 33 25 51 N | 081 23 59 W |
| Silver Street School (historical) | School | 149 | Newberry | 34 13 09 N | 081 42 54 W |
| Silverhill United Methodist Church | Church | 227 | Spartanburg | 34 57 18 N | 081 55 45 W |
| Silvers Creek | Stream | | Horry | 33 37 08 N | 079 05 30 W |
| Silverstreet | Populated Place | 150 | Newberry | 34 13 04 N | 081 42 55 W |
| Silverstreet Lookout Tower | Tower | 177 | Newberry | 34 15 45 N | 081 46 15 W |
| Silverstreet Lutheran Church | Church | 150 | Newberry | 34 13 05 N | 081 42 44 W |
| Simkin Cemetery | Cemetery | 164 | Edgefield | 33 49 39 N | 081 54 55 W |
| Simmon Ridge Church | Church | 170 | Edgefield | 33 49 38 N | 081 54 14 W |
| Simmon Tree (historical) | Populated Place | 176 | Union | 34 50 47 N | 081 30 14 W |
| Simmons | Populated Place | 203 | Greenwood | 34 18 27 N | 082 16 04 W |
| Simmons Bay | Swamp | 21 | Berkeley | 33 09 35 N | 080 07 55 W |
| Simmons Creek | Stream | | Georgetown | 33 31 01 N | 079 16 43 W |
| Simmons Creek | Stream | | Laurens | 34 20 15 N | 081 52 48 W |
| Simmons Creek | Stream | | Richland | 34 13 08 N | 080 55 25 W |
| Simmons Creek | Stream | | Richland | 34 14 59 N | 080 55 54 W |
| Simmons Johnsville School (historical) | School | 37 | Colleton | 33 07 40 N | 080 46 47 W |
| Simmons Ridge School (historical) | School | 171 | Edgefield | 33 49 42 N | 081 54 14 W |
| Simmonsville | Populated Place | 9 | Berkeley | 33 14 55 N | 079 38 25 W |
| Simmonsville | Populated Place | 7 | Georgetown | 33 25 11 N | 079 10 41 W |
| Simons Lake | Reservoir | 147 | Aiken | 33 38 48 N | 081 52 28 W |
| Simons Lake | Reservoir | 147 | Edgefield | 33 38 48 N | 081 52 29 W |
| Simons Siding | Locale | 58 | Orangeburg | 33 23 54 N | 080 57 49 W |
| Simonton School | School | 4 | Charleston | 32 47 19 N | 079 56 37 W |
| Simpson | Populated Place | 185 | Fairfield | 34 18 31 N | 081 02 43 W |
| Simpson | Populated Place | 14 | Horry | 33 59 11 N | 078 49 48 W |
| Simpson (historical) | Populated Place | 167 | Laurens | 34 27 50 N | 082 07 26 W |
| Simpson Branch | Stream | | Lancaster | 34 49 05 N | 080 42 57 W |
| Simpson Cemetery | Cemetery | 249 | Anderson | 34 38 48 N | 082 43 28 W |
| Simpson Creek | Stream | | Charleston | 32 44 44 N | 079 57 09 W |
| Simpson Creek | Stream | | Horry | 33 53 43 N | 078 49 23 W |
| Simpson Creek Church | Church | 14 | Horry | 33 59 14 N | 078 50 12 W |
| Simpson Creek School | School | 12 | Horry | 33 59 13 N | 078 50 16 W |
| Simpson Crossing | Populated Place | 22 | Berkeley | 33 14 59 N | 079 58 30 W |
| Simpson Lookout Tower | Tower | 189 | Fairfield | 34 18 30 N | 081 01 33 W |
| Simpson Pond | Reservoir | 79 | York | 34 05 13 N | 080 56 47 W |
| Simpson Pond Dam D-3651 | Dam | 79 | York | 34 05 13 N | 080 56 47 W |
| Simpson School | School | 325 | Pickens | 34 50 02 N | 082 36 32 W |
| Simpson Store | Locale | 292 | Oconee | 34 34 11 N | 083 01 45 W |
| Simpsonville | Populated Place | 262 | Greenville | 34 44 13 N | 082 15 15 W |
| Simpsonville Elementary School | School | 263 | Greenville | 34 44 25 N | 082 15 11 W |
| Simpsonville Municipal Cemetery | Cemetery | 259 | Greenville | 34 44 28 N | 082 15 06 W |
| Simpsonville Plaza Shopping Center | Locale | 269 | Greenville | 34 43 22 N | 082 15 17 W |
| Simpsonville Post Office | Post Office | 259 | Greenville | 34 44 20 N | 082 15 25 W |
| Simpsonville Shopping Center | Locale | 248 | Greenville | 34 44 27 N | 082 16 29 W |
| Sims | Populated Place | 53 | Richland | 33 57 18 N | 080 57 25 W |
| Sims Cemetery | Cemetery | 104 | Union | 34 32 17 N | 081 32 45 W |
| Sims Cemetery | Cemetery | 137 | Union | 34 40 35 N | 081 27 48 W |
| Sims Chapel | Church | 224 | Spartanburg | 34 54 55 N | 081 55 56 W |
| Sims Chapel School | School | 223 | Spartanburg | 34 54 56 N | 081 55 57 W |
| Sims Chapel School (historical) | School | 118 | Union | 34 33 05 N | 081 27 17 W |
| Sims High School | School | 183 | Union | 34 42 03 N | 081 36 36 W |
| Sims Park | Park | 83 | Richland | 33 59 31 N | 080 59 30 W |
| Sims Pond | Reservoir | 63 | Orangeburg | 33 34 13 N | 080 51 35 W |
| Sinai Church | Church | 38 | Hampton | 32 52 24 N | 081 01 33 W |
| Sinai Church | Church | 38 | Hampton | 32 53 34 N | 081 01 22 W |
| Sinai Church | Church | 116 | Kershaw | 34 14 16 N | 080 47 35 W |
| Sinai Church (historical) | Church | 178 | Greenwood | 34 01 31 N | 082 15 38 W |
| Sinai School (historical) | School | 211 | Anderson | 34 25 19 N | 082 45 07 W |
| Sinai School (historical) | School | 38 | Hampton | 32 52 24 N | 081 01 32 W |
| Sinclair Crossroads | Populated Place | 48 | Dillon | 34 31 39 N | 079 27 53 W |
| Sinclair Pond Dam D-1328 | Dam | 58 | Kershaw | 34 15 37 N | 080 33 29 W |
| Sinclairs Pond | Reservoir | 58 | Kershaw | 34 15 37 N | 080 33 29 W |
| Singing Pines | Populated Place | 288 | Oconee | 34 39 31 N | 082 55 42 W |
| Singing Pines (subdivision) | Populated Place | 17 | Charleston | 32 53 42 N | 080 00 44 W |
| Singletary Church | Church | 15 | Marion | 34 07 58 N | 079 27 14 W |
| Singletary Forks | Populated Place | 12 | Williamsburg | 33 21 26 N | 079 41 29 W |
| Singletary Islands | Island | 12 | Marion | 34 08 03 N | 079 27 53 W |