Feature Name | Class | Elev. meters | County | Latitude DMS | Longitude DMS |
| Smithville School | School | 183 | Abbeville | 34 11 16 N | 082 16 24 W |
| Smithville School (historical) | School | 80 | Chesterfield | 34 42 30 N | 079 58 03 W |
| Smithy Cemetery | Cemetery | 26 | Marion | 34 08 38 N | 079 20 39 W |
| Smoaks | Populated Place | 32 | Colleton | 33 05 23 N | 080 48 50 W |
| Smoaks Baptist Church | Church | 30 | Colleton | 33 05 21 N | 080 49 15 W |
| Smoaks Cemetery | Cemetery | 31 | Colleton | 33 05 20 N | 080 49 16 W |
| Smoaks Middle School | School | 35 | Colleton | 33 05 28 N | 080 47 54 W |
| Smoaks Pond Dam D-3714 | Dam | 72 | Orangeburg | 33 33 25 N | 080 53 29 W |
| Smoke Pond | Reservoir | 61 | Calhoun | 33 39 01 N | 080 46 29 W |
| Smoke Pond Dam D-2929 | Dam | 61 | Calhoun | 33 39 01 N | 080 46 29 W |
| Smoke Rise | Populated Place | 183 | Lancaster | 34 40 16 N | 080 44 18 W |
| Smokes Corners | Locale | 28 | Colleton | 32 57 37 N | 080 41 50 W |
| Smokey Lake | Lake | 12 | Marion | 34 06 42 N | 079 14 00 W |
| Smoky Lake | Lake | 13 | Marion | 34 09 40 N | 079 12 25 W |
| Smyly | Populated Place | 25 | Colleton | 33 01 34 N | 080 47 44 W |
| Smyly Cemetery | Cemetery | 26 | Colleton | 33 01 50 N | 080 47 28 W |
| Smyrles Cemetery | Cemetery | 128 | Kershaw | 34 22 58 N | 080 41 23 W |
| Smyrles Plantation (historical) | Locale | 122 | Kershaw | 34 22 54 N | 080 41 34 W |
| Smyrna | Populated Place | 159 | Newberry | 34 16 24 N | 081 42 28 W |
| Smyrna | Populated Place | 232 | York | 35 02 33 N | 081 24 22 W |
| Smyrna Associate Reformed Presbyterian Church | Church | 229 | York | 35 02 23 N | 081 24 50 W |
| Smyrna Bay Church (historical) | Church | 64 | Allendale | 33 05 55 N | 081 18 40 W |
| Smyrna Camp Ground (historical) | Locale | 132 | Kershaw | 34 16 18 N | 080 49 14 W |
| Smyrna Cemetery | Cemetery | 193 | Abbeville | 34 13 31 N | 082 40 01 W |
| Smyrna Cemetery | Cemetery | 192 | Abbeville | 34 13 32 N | 082 39 54 W |
| Smyrna Cemetery | Cemetery | 49 | Allendale | 32 56 12 N | 081 21 05 W |
| Smyrna Cemetery | Cemetery | 21 | Berkeley | 33 05 08 N | 080 03 28 W |
| Smyrna Cemetery | Cemetery | 178 | Laurens | 34 20 48 N | 082 04 29 W |
| Smyrna Cemetery | Cemetery | 163 | Newberry | 34 16 21 N | 081 42 19 W |
| Smyrna Church | Church | 82 | Aiken | 33 32 37 N | 081 24 45 W |
| Smyrna Church | Church | 49 | Allendale | 32 56 11 N | 081 21 06 W |
| Smyrna Church | Church | 21 | Berkeley | 33 05 08 N | 080 03 29 W |
| Smyrna Church | Church | 223 | Cherokee | 35 03 07 N | 081 25 22 W |
| Smyrna Church | Church | 180 | Chesterfield | 34 48 04 N | 080 25 19 W |
| Smyrna Church | Church | 79 | Kershaw | 34 10 54 N | 080 41 45 W |
| Smyrna Church | Church | 134 | Kershaw | 34 16 16 N | 080 49 17 W |
| Smyrna Church | Church | 177 | Laurens | 34 20 50 N | 082 04 27 W |
| Smyrna Church (historical) | Church | 195 | Abbeville | 34 13 28 N | 082 40 02 W |
| Smyrna Church (historical) | Church | 64 | Allendale | 33 05 46 N | 081 18 29 W |
| Smyrna Presbyterian Church | Church | 163 | Newberry | 34 16 23 N | 081 42 19 W |
| Smyrna School (historical) | School | 141 | Lexington | 33 46 38 N | 081 23 58 W |
| Smyrna School (historical) | School | 220 | York | 35 01 55 N | 081 24 19 W |
| Smyrna United Methodist Church | Church | 186 | Abbeville | 34 12 44 N | 082 38 58 W |
| Smythes School (historical) | School | 95 | Aiken | 33 31 24 N | 081 22 00 W |
| Snake Branch | Stream | | Bamberg | 33 24 21 N | 081 10 18 W |
| Snake Branch | Stream | | Darlington | 34 23 11 N | 080 03 55 W |
| Snake Island | Island | 2 | Charleston | 32 38 23 N | 080 00 34 W |
| Snake Swamp | Stream | | Orangeburg | 33 20 21 N | 081 00 48 W |
| Snake Swamp School (historical) | School | 86 | Orangeburg | 33 27 57 N | 080 59 08 W |
| Snap Branch | Stream | | Newberry | 34 10 23 N | 081 28 07 W |
| Snead Mill (historical) | Locale | 215 | Oconee | 34 40 50 N | 083 08 55 W |
| Snell Branch | Stream | | Orangeburg | 33 16 55 N | 080 37 02 W |
| Snell Branch School (historical) | School | 38 | Orangeburg | 33 16 58 N | 080 39 11 W |
| Snelling | Populated Place | 70 | Barnwell | 33 14 24 N | 081 27 21 W |
| Sniders Crossroads | Populated Place | 21 | Colleton | 32 53 21 N | 080 51 11 W |
| Sniders School (historical) | School | 24 | Colleton | 32 53 25 N | 080 50 17 W |
| Snipe Bog Pond Dam D-2935 | Dam | 1 | Beaufort | 32 38 31 N | 080 40 59 W |
| Snipe School | School | 4 | Colleton | 32 53 28 N | 080 31 05 W |
| Snipe School (historical) | School | 11 | Colleton | 32 54 27 N | 080 31 03 W |
| Snipes Pond | Reservoir | 104 | Aiken | 33 38 28 N | 081 35 35 W |
| Snoddy | Populated Place | 241 | Spartanburg | 34 56 11 N | 082 04 25 W |
| Snooks Lake | Lake | 7 | Jasper | 32 29 59 N | 081 13 07 W |
| Snow Branch | Stream | | Williamsburg | 33 39 18 N | 079 28 52 W |
| Snow Creek | Stream | | Oconee | 34 37 04 N | 082 57 05 W |
| Snow Creek Church | Church | 228 | Oconee | 34 37 00 N | 082 59 06 W |
| Snow Creek School (historical) | School | 215 | Oconee | 34 37 00 N | 082 58 08 W |
| Snow Hill Church | Church | 239 | Anderson | 34 30 39 N | 082 57 27 W |
| Snow Hill Church | Church | 43 | Florence | 34 12 42 N | 079 51 17 W |
| Snow Hill Church | Church | 14 | Williamsburg | 33 35 17 N | 079 30 59 W |
| Snow Hill Church (historical) | Church | 114 | Chesterfield | 34 47 41 N | 080 01 32 W |
| Snow Hill School | School | 26 | Williamsburg | 33 40 55 N | 079 58 45 W |
| Snow Hill School (historical) | School | 227 | Anderson | 34 22 39 N | 082 31 11 W |
| Snow Hill School (historical) | School | 115 | Chesterfield | 34 47 41 N | 080 01 30 W |
| Snow Island | Island | 4 | Florence | 33 49 39 N | 079 20 38 W |
| Snow Island | Island | 48 | Orangeburg | 33 22 51 N | 081 05 12 W |
| Snow Junction | Populated Place | 11 | Williamsburg | 33 40 09 N | 079 28 17 W |
| Snow Lake | Lake | 4 | Florence | 33 48 58 N | 079 21 54 W |
| Snow Point | Cape | 4 | Berkeley | 32 56 32 N | 079 55 44 W |
| Snow Town | Populated Place | 13 | Williamsburg | 33 35 04 N | 079 30 54 W |
| Snowbird Lake | Lake | 12 | Marion | 34 06 51 N | 079 13 56 W |
| Snowden | Populated Place | 6 | Charleston | 32 50 30 N | 079 50 47 W |
| Snowden Pond | Reservoir | 13 | Williamsburg | 33 43 01 N | 079 31 29 W |
| Snowden Pond Dam D-3098 | Dam | 13 | Williamsburg | 33 43 01 N | 079 31 29 W |
| Snowhill Cemetery | Cemetery | 242 | Anderson | 34 30 38 N | 082 57 29 W |
| Snowhill Cemetery | Cemetery | 67 | Darlington | 34 18 54 N | 080 06 26 W |
| Snows Lake | Reservoir | 229 | Greenville | 34 40 04 N | 082 21 21 W |
| Snowville School | School | 147 | Aiken | 33 41 12 N | 081 27 43 W |
| Snug Harbor | Populated Place | 121 | Lexington | 34 07 11 N | 081 24 43 W |
| Snug Harbor | Populated Place | 226 | Oconee | 34 36 22 N | 082 56 19 W |
| Snuggedy Swamp | Swamp | 4 | Colleton | 32 39 53 N | 080 28 27 W |
| Snyder Athletic Field | Park | 234 | Spartanburg | 34 57 36 N | 081 55 54 W |
| Snyder Cemetery | Cemetery | 550 | Oconee | 34 53 27 N | 083 11 25 W |
| Snyder Hall | Building | 246 | Spartanburg | 34 57 29 N | 081 56 16 W |
| Snyder Pond | Reservoir | 318 | Greenville | 34 55 00 N | 082 25 17 W |
| Snyder Pond Dam D-2856 | Dam | 318 | Greenville | 34 55 00 N | 082 25 17 W |
| Soapstone Church | Church | 331 | Pickens | 35 00 51 N | 082 37 53 W |
| Soapstone School (historical) | School | 331 | Pickens | 35 00 51 N | 082 37 53 W |
| Socastee | Populated Place | 5 | Horry | 33 41 01 N | 078 59 54 W |
| Socastee Church (historical) | Church | 6 | Horry | 33 40 31 N | 079 00 18 W |
| Socastee Creek | Stream | | Horry | 33 40 19 N | 079 03 37 W |
| Socastee High School | School | 4 | Horry | 33 41 03 N | 079 00 01 W |
| Socastee Middle School | School | 4 | Horry | 33 40 60 N | 079 00 00 W |
| Socastee Swamp | Stream | | Horry | 33 42 04 N | 078 58 32 W |
| Socastee United Methodist Church | Church | 3 | Horry | 33 41 01 N | 079 00 09 W |
| Soccee Swamp | Stream | | Florence | 33 48 52 N | 079 21 43 W |
| Social Hall Creek | Stream | | Colleton | 32 37 08 N | 080 32 02 W |
| Society Corner School (historical) | School | 2 | Charleston | 32 42 55 N | 079 57 25 W |
| Society Hill | Populated Place | 51 | Darlington | 34 30 46 N | 079 51 03 W |
| Society Hill Church | Church | 53 | Chesterfield | 34 30 46 N | 079 55 16 W |
| Society Hill Church | Church | 26 | Clarendon | 33 32 12 N | 080 11 22 W |