Feature Name | Class | Elev. meters | County | Latitude DMS | Longitude DMS |
| South Prong Swift Creek | Stream | | Chesterfield | 34 30 59 N | 080 18 16 W |
| South Rabon Creek | Stream | | Laurens | 34 28 41 N | 082 08 30 W |
| South Saluda Church | Church | 330 | Greenville | 35 03 31 N | 082 34 09 W |
| South Saluda River | Stream | | Pickens | 34 57 09 N | 082 31 32 W |
| South Sandy Boat Ramp | Locale | 90 | Fairfield | 34 34 22 N | 081 25 19 W |
| South Santee | Populated Place | 6 | Charleston | 33 10 25 N | 079 25 03 W |
| South Santee Inlet | Channel | -3 | Georgetown | 33 07 06 N | 079 16 38 W |
| South Santee River | Stream | | Charleston | 33 07 07 N | 079 16 34 W |
| South Sea Pines | Populated Place | 1 | Jasper | 32 06 44 N | 080 49 01 W |
| South Side | Populated Place | 31 | Florence | 34 07 51 N | 079 45 33 W |
| South Side Baptist Church | Church | 150 | Abbeville | 34 10 12 N | 082 22 32 W |
| South Side Church | Church | 44 | Darlington | 34 16 46 N | 079 51 07 W |
| South Street-South Church Street Historic District | Park | 182 | Union | 34 42 47 N | 081 37 34 W |
| South Sumter | Populated Place | 49 | Sumter | 33 54 21 N | 080 20 46 W |
| South Tower | Building | 78 | Richland | 33 59 45 N | 081 01 30 W |
| South Tyger River | Stream | | Spartanburg | 34 45 34 N | 081 55 53 W |
| South Tyger River WCD Dam 2c D-2865 | Dam | 308 | Greenville | 35 04 00 N | 082 22 47 W |
| South Tyger River WCD Dam 4c D-2915 | Dam | 287 | Greenville | 35 02 30 N | 082 22 29 W |
| South Union | Populated Place | 274 | Oconee | 34 33 04 N | 083 03 07 W |
| South Union Cemetery | Cemetery | 268 | Oconee | 34 32 50 N | 083 03 23 W |
| South Union Church | Church | 268 | Oconee | 34 32 47 N | 083 03 23 W |
| South Union School (historical) | School | 265 | Oconee | 34 32 33 N | 083 03 20 W |
| South Union School (historical) | School | 274 | Oconee | 34 32 59 N | 083 03 04 W |
| South Willow School (historical) | School | 75 | Orangeburg | 33 25 20 N | 081 04 57 W |
| South Wimbee Creek | Stream | | Beaufort | 32 32 39 N | 080 36 39 W |
| South Windermere Shopping Center | Locale | 4 | Charleston | 32 46 34 N | 079 58 29 W |
| South Windermire | Populated Place | 6 | Charleston | 32 46 34 N | 079 58 48 W |
| South Windmill | Locale | 3 | Charleston | 32 41 43 N | 079 59 00 W |
| Southeast Channel | Channel | -2 | Beaufort | 32 07 02 N | 080 33 30 W |
| Southeast Newberry | Populated Place | 177 | Newberry | 34 15 03 N | 081 34 21 W |
| Southeastern Memorial Gardens | Cemetery | 3 | Horry | 33 47 55 N | 078 44 51 W |
| Southern Aero Sports Airport | Airport | 187 | Spartanburg | 34 37 30 N | 081 53 54 W |
| Southern Bleachery Church | Church | 270 | Greenville | 34 55 21 N | 082 16 58 W |
| Southern Gold Mine | Mine | 183 | Cherokee | 35 02 58 N | 081 27 39 W |
| Southern Gold Mine | Mine | 147 | Edgefield | 33 58 09 N | 081 56 57 W |
| Southern Meadows (subdivision) | Populated Place | 288 | Oconee | 34 40 15 N | 082 55 33 W |
| Southern Methodist College | School | 61 | Orangeburg | 33 28 54 N | 080 51 34 W |
| Southern Palms | Populated Place | 21 | Dorchester | 32 58 56 N | 080 08 01 W |
| Southern Pines | Populated Place | 209 | Spartanburg | 34 59 03 N | 081 50 09 W |
| Southern Shops | Populated Place | 269 | Spartanburg | 34 59 09 N | 081 59 40 W |
| Southern Worsted Tabernacle | Church | 314 | Greenville | 34 54 17 N | 082 20 59 W |
| Southgate | Populated Place | 113 | Lexington | 33 56 18 N | 081 13 29 W |
| Southgate | Populated Place | 54 | Sumter | 33 50 25 N | 080 22 30 W |
| Southgate Shopping Center | Locale | 246 | Anderson | 34 28 29 N | 082 39 19 W |
| Southgate Shopping Center | Locale | 291 | Oconee | 34 40 44 N | 082 57 45 W |
| Southgate Shopping Center | Locale | 192 | York | 34 54 03 N | 081 01 51 W |
| Southland Medical Center | Hospital | 38 | Darlington | 34 18 51 N | 079 52 09 W |
| Southland Memorial Gardens | Cemetery | 69 | Lexington | 33 55 54 N | 081 08 16 W |
| Southland Park (subdivision) | Populated Place | 174 | York | 34 53 39 N | 081 01 16 W |
| Southoak Free Will Baptist Church | Church | 34 | Florence | 34 07 33 N | 079 46 37 W |
| Southport Estates (subdivision) | Populated Place | 238 | Spartanburg | 34 54 12 N | 081 57 59 W |
| Southside Baptist Church | Church | 3 | Charleston | 32 46 45 N | 079 56 19 W |
| Southside Baptist Church | Church | 237 | Cherokee | 35 03 45 N | 081 39 47 W |
| Southside Baptist Church | Church | 34 | Florence | 34 10 09 N | 079 46 00 W |
| Southside Baptist Church | Church | 53 | Kershaw | 34 14 31 N | 080 35 55 W |
| Southside Baptist Church | Church | 236 | Spartanburg | 34 56 38 N | 081 55 47 W |
| Southside Church | Church | 236 | Abbeville | 34 25 31 N | 082 23 12 W |
| Southside Church | Church | 76 | Aiken | 33 31 11 N | 081 49 51 W |
| Southside Church | Church | 251 | Anderson | 34 40 51 N | 082 27 09 W |
| Southside Church | Church | 241 | Anderson | 34 27 20 N | 082 39 50 W |
| Southside Church | Church | 62 | Darlington | 34 21 56 N | 080 01 47 W |
| Southside Elementary School | School | 22 | Marion | 34 10 21 N | 079 23 37 W |
| Southside Elementary School | School | 234 | Spartanburg | 34 56 30 N | 081 55 46 W |
| Southside High School | School | 274 | Greenville | 34 47 46 N | 082 23 47 W |
| Southside Junior High School | School | 193 | Greenwood | 34 10 57 N | 082 08 17 W |
| Southside Middle School | School | 35 | Florence | 34 07 59 N | 079 46 11 W |
| Southside Park | Park | 37 | Chesterfield | 34 41 32 N | 079 52 32 W |
| Southside Park | Park | 265 | Greenville | 34 44 38 N | 082 18 17 W |
| Southside School | School | 244 | Anderson | 34 29 03 N | 082 38 44 W |
| Southside School | School | 171 | Chester | 34 41 40 N | 081 11 38 W |
| Southside School | School | 67 | Darlington | 34 20 51 N | 080 04 46 W |
| Southside School | School | 165 | Lancaster | 34 42 40 N | 080 45 22 W |
| Southside School | School | 294 | Oconee | 34 40 37 N | 082 57 34 W |
| Southside School | School | 220 | Spartanburg | 34 43 39 N | 082 02 15 W |
| Southside Shopping Center | Locale | 180 | Greenwood | 34 22 39 N | 082 13 29 W |
| Southside Water District Water Water Tower | Tower | 311 | Pickens | 34 45 36 N | 082 39 32 W |
| Southway Church | Church | 34 | Florence | 34 08 01 N | 079 43 21 W |
| Southway Shopping Center | Locale | 255 | Cherokee | 35 03 25 N | 081 38 23 W |
| Southwood | Populated Place | 138 | Aiken | 33 31 27 N | 081 45 59 W |
| Southwood Middle School | School | 236 | Anderson | 34 29 25 N | 082 39 43 W |
| Southwood Park | Park | 231 | Anderson | 34 29 22 N | 082 39 44 W |
| Sowells Pond Dam D-1832 | Dam | 112 | Chesterfield | 34 24 43 N | 080 13 53 W |
| Sowells Pond Dam D-3205 | Dam | 49 | Chesterfield | 34 39 43 N | 080 05 35 W |
| Sox Ponds | Reservoir | 64 | Lexington | 33 56 45 N | 081 08 26 W |
| Spalding (historical) | Populated Place | 73 | Kershaw | 34 16 29 N | 080 35 31 W |
| Spanish Point | Cape | 4 | Beaufort | 32 24 30 N | 080 40 47 W |
| Spanish Wells | Populated Place | 3 | Beaufort | 32 11 31 N | 080 46 42 W |
| Spann Branch | Stream | | Saluda | 33 50 00 N | 081 43 35 W |
| Spann Branch | Stream | | Sumter | 33 59 33 N | 080 28 47 W |
| Spann Church | Church | 200 | Saluda | 33 51 23 N | 081 43 40 W |
| Spann Elementary School | School | 19 | Dorchester | 33 00 34 N | 080 10 47 W |
| Sparks Creek | Stream | | Union | 34 38 31 N | 081 42 19 W |
| Sparks Ferry (historical) | Crossing | 20 | Marlboro | 34 31 54 N | 079 49 49 W |
| Sparrow Nest Creek | Stream | | Beaufort | 32 26 48 N | 080 35 30 W |
| Sparrow Swamp | Stream | | Florence | 34 02 38 N | 079 47 42 W |
| Sparrow Swamp Cemetery | Cemetery | 32 | Florence | 34 03 16 N | 079 52 37 W |
| Sparrow Swamp Church | Church | 32 | Florence | 34 03 13 N | 079 52 34 W |
| Sparrows Crossroads | Populated Place | 32 | Florence | 34 03 15 N | 079 52 47 W |
| Spartan Plaza Shopping Center | Locale | 238 | Spartanburg | 34 58 27 N | 081 56 04 W |
| Spartanburg | Populated Place | 246 | Spartanburg | 34 56 58 N | 081 55 55 W |
| Spartanburg Boys Home | Building | 191 | Spartanburg | 34 49 13 N | 081 49 49 W |
| Spartanburg City Hall | Building | 240 | Spartanburg | 34 56 52 N | 081 55 57 W |
| Spartanburg Country Club | Locale | 210 | Spartanburg | 34 56 24 N | 081 52 15 W |
| Spartanburg County | Civil | 238 | Spartanburg | 34 55 50 N | 081 58 59 W |
| Spartanburg County Courthouse | Building | 238 | Spartanburg | 34 57 06 N | 081 56 07 W |
| Spartanburg County Jail | Building | 233 | Spartanburg | 34 57 02 N | 081 56 06 W |
| Spartanburg County Public Library | Building | 241 | Spartanburg | 34 56 52 N | 081 54 54 W |
| Spartanburg Day School | School | 247 | Spartanburg | 34 58 35 N | 081 53 34 W |
| Spartanburg Downtown Memorial Airport | Airport | 241 | Spartanburg | 34 54 58 N | 081 57 26 W |
| Spartanburg General Hospital | Hospital | 248 | Spartanburg | 34 58 01 N | 081 56 24 W |