Feature Name | Class | Elev. meters | County | Latitude DMS | Longitude DMS |
| Spartanburg Historic District | Park | 237 | Spartanburg | 34 57 03 N | 081 56 04 W |
| Spartanburg Memorial Auditorium | Building | 238 | Spartanburg | 34 57 24 N | 081 56 09 W |
| Spartanburg Senior High School | School | 213 | Spartanburg | 34 57 23 N | 081 53 52 W |
| Spartanburg Technical College | School | 257 | Spartanburg | 34 58 28 N | 081 59 25 W |
| Sparten Grain Pond Dam D-3381 | Dam | 215 | Spartanburg | 34 53 24 N | 081 48 11 W |
| Spaulding Elementary School | School | 53 | Darlington | 34 09 50 N | 080 03 43 W |
| Spaulding Heights | Populated Place | 42 | Florence | 34 13 19 N | 079 45 25 W |
| Spaulding High School | School | 52 | Darlington | 34 09 47 N | 080 03 39 W |
| Speaks Mill | Populated Place | 33 | Hampton | 32 46 23 N | 081 08 36 W |
| Spear Creek | Stream | | Union | 34 47 12 N | 081 43 22 W |
| Spearman (historical) | Populated Place | 157 | Newberry | 34 14 55 N | 081 41 09 W |
| Spearman Pond | Reservoir | 268 | Oconee | 34 34 15 N | 083 02 38 W |
| Spearman School | School | 293 | Anderson | 34 40 51 N | 082 32 50 W |
| Spearman School (historical) | School | 281 | Anderson | 34 41 05 N | 082 34 12 W |
| Spears Cemetery | Cemetery | 151 | Union | 34 52 15 N | 081 32 16 W |
| Spears Church | Church | 52 | Marlboro | 34 35 47 N | 079 36 37 W |
| Spears Creek | Populated Place | 76 | Kershaw | 34 06 59 N | 080 43 18 W |
| Spears Creek | Stream | | Kershaw | 34 00 02 N | 080 38 46 W |
| Spears Creek Church | Church | 104 | Richland | 34 06 14 N | 080 49 31 W |
| Spears Creek School (historical) | School | 104 | Richland | 34 06 14 N | 080 49 34 W |
| Speeds Creek | Stream | | Oconee | 34 37 02 N | 082 56 58 W |
| Speedwell Church | Church | 42 | Allendale | 33 05 03 N | 081 32 30 W |
| Speers Street School | School | 147 | Newberry | 34 16 46 N | 081 37 21 W |
| Speigner | Populated Place | 153 | Saluda | 33 54 15 N | 081 43 56 W |
| Speigner Church (historical) | Church | 154 | Saluda | 33 54 16 N | 081 43 54 W |
| Speigners Pond | Reservoir | 46 | Calhoun | 33 42 41 N | 080 48 42 W |
| Spell Cemetery | Cemetery | 29 | Colleton | 33 07 08 N | 080 42 43 W |
| Spell-Risher Cemetery | Cemetery | 30 | Colleton | 33 08 42 N | 080 45 02 W |
| Spells Fish Pond Dam D-2815 | Dam | 62 | Bamberg | 33 22 19 N | 081 09 35 W |
| Spence Pond | Reservoir | 312 | Greenville | 34 59 18 N | 082 22 53 W |
| Spence Pond Dam D-2868 | Dam | 312 | Greenville | 34 59 18 N | 082 22 53 W |
| Spence School (historical) | School | 53 | Chesterfield | 34 43 10 N | 080 00 50 W |
| Spencer Branch | Stream | | Charleston | 32 58 17 N | 080 07 28 W |
| Spencer Branch | Stream | | Cherokee | 35 00 52 N | 081 36 28 W |
| Spencer Cemetery | Cemetery | 21 | Marion | 34 10 16 N | 079 28 59 W |
| Spencer Mill Creek | Stream | | Chesterfield | 34 41 40 N | 080 00 03 W |
| Spencer Park | Park | 193 | York | 34 55 21 N | 081 00 21 W |
| Spencer Pond Dam D-3669 | Dam | 194 | York | 34 58 31 N | 081 05 29 W |
| Spider Valley Creek | Stream | | Oconee | 34 46 01 N | 083 13 58 W |
| Spiderweb | Populated Place | 107 | Aiken | 33 24 37 N | 081 49 52 W |
| Spiderweb School (historical) | School | 82 | Aiken | 33 24 33 N | 081 49 13 W |
| Spigner Pond | Reservoir | 44 | Calhoun | 33 43 43 N | 080 42 29 W |
| Spires Church | Church | 75 | Orangeburg | 33 25 43 N | 081 03 54 W |
| Spires Pond | Reservoir | 118 | Lexington | 33 47 11 N | 081 08 43 W |
| Spires School (historical) | School | 64 | Orangeburg | 33 24 44 N | 081 04 15 W |
| Spivey Creek | Stream | | Spartanburg | 35 07 48 N | 082 10 30 W |
| Spiveys 917 Pond Dam D-3605 | Dam | 22 | Dillon | 34 16 37 N | 079 18 11 W |
| Spiveys Cemetery | Cemetery | 29 | Dillon | 34 21 07 N | 079 08 34 W |
| Spiveys Ferry (historical) | Crossing | 58 | Lee | 34 19 29 N | 080 14 34 W |
| Spiveys Millpond | Reservoir | 22 | Dillon | 34 21 19 N | 079 09 06 W |
| Spiveys Millpond Dam D-3601 | Dam | 22 | Dillon | 34 21 19 N | 079 09 06 W |
| Spooler Swamp | Swamp | 8 | Dorchester | 32 55 43 N | 080 22 57 W |
| Spoonauger Falls | Falls | 706 | Oconee | 34 58 28 N | 083 06 35 W |
| Sport Bridge School (historical) | School | 4 | Beaufort | 32 18 53 N | 080 56 03 W |
| Sportsman Pond | Stream | | Williamsburg | 33 27 46 N | 079 36 37 W |
| Sportsman Pond | Swamp | 11 | Williamsburg | 33 28 08 N | 079 37 43 W |
| Spot Mill Creek | Stream | | Darlington | 34 31 60 N | 079 50 37 W |
| Spout Spring Branch | Stream | | Greenville | 35 02 42 N | 082 31 35 W |
| Spreadoak Branch | Stream | | Clarendon | 33 37 53 N | 080 08 49 W |
| Sprigg Creek | Stream | | Greenville | 35 04 23 N | 082 28 05 W |
| Spring Acres (subdivision) | Populated Place | 46 | Darlington | 34 19 46 N | 079 52 54 W |
| Spring Bank Plantation | Locale | 26 | Williamsburg | 33 46 60 N | 079 54 14 W |
| Spring Bay | Swamp | 17 | Horry | 34 11 20 N | 079 07 49 W |
| Spring Bay | Swamp | 22 | Williamsburg | 33 49 52 N | 079 45 40 W |
| Spring Branch | Populated Place | 33 | Marion | 34 14 32 N | 079 23 34 W |
| Spring Branch | Stream | | Aiken | 33 29 39 N | 081 25 04 W |
| Spring Branch | Stream | | Chesterfield | 34 27 26 N | 080 08 44 W |
| Spring Branch | Stream | | Clarendon | 33 36 37 N | 080 23 21 W |
| Spring Branch | Stream | | Clarendon | 33 35 54 N | 080 25 38 W |
| Spring Branch | Stream | | Darlington | 34 23 26 N | 080 03 16 W |
| Spring Branch | Stream | | Dorchester | 33 12 21 N | 080 30 10 W |
| Spring Branch | Stream | | Edgefield | 33 39 52 N | 081 55 09 W |
| Spring Branch | Stream | | Fairfield | 34 32 47 N | 081 16 27 W |
| Spring Branch | Stream | | Florence | 34 05 58 N | 079 36 14 W |
| Spring Branch | Stream | | Horry | 34 03 31 N | 078 54 54 W |
| Spring Branch | Stream | | Kershaw | 34 13 09 N | 080 47 23 W |
| Spring Branch | Stream | | Lexington | 33 47 28 N | 081 20 34 W |
| Spring Branch | Stream | | Orangeburg | 33 16 41 N | 080 29 18 W |
| Spring Branch | Stream | | Williamsburg | 33 46 44 N | 079 53 42 W |
| Spring Branch | Stream | | Williamsburg | 33 33 01 N | 079 41 30 W |
| Spring Branch (historical) | Populated Place | 100 | Aiken | 33 27 21 N | 081 26 30 W |
| Spring Branch Bay | Swamp | 20 | Horry | 34 15 55 N | 079 02 13 W |
| Spring Branch Cemetery | Cemetery | 23 | Orangeburg | 33 17 47 N | 080 22 28 W |
| Spring Branch Church | Church | 96 | Aiken | 33 29 21 N | 081 26 29 W |
| Spring Branch Church | Church | 41 | Bamberg | 33 15 03 N | 081 00 13 W |
| Spring Branch Church | Church | 86 | Chesterfield | 34 27 25 N | 080 08 23 W |
| Spring Branch Church | Church | 24 | Florence | 34 04 51 N | 079 35 38 W |
| Spring Branch Church | Church | 32 | Horry | 34 15 33 N | 079 02 06 W |
| Spring Branch Church | Church | 33 | Marion | 34 14 31 N | 079 23 32 W |
| Spring Branch Church | Church | 149 | Saluda | 33 58 51 N | 081 58 31 W |
| Spring Branch Church (historical) | Church | 56 | Barnwell | 33 10 11 N | 081 35 41 W |
| Spring Branch School | School | 32 | Marion | 34 14 36 N | 079 24 01 W |
| Spring Branch School (historical) | School | 106 | Aiken | 33 29 54 N | 081 27 38 W |
| Spring Branch School (historical) | School | 50 | Bamberg | 33 20 09 N | 081 02 55 W |
| Spring Branch School (historical) | School | 56 | Barnwell | 33 10 11 N | 081 35 41 W |
| Spring Branch School (historical) | School | 32 | Horry | 34 15 32 N | 079 02 02 W |
| Spring Branch School (historical) | School | 22 | Williamsburg | 33 41 11 N | 079 41 18 W |
| Spring Brook Terrace | Populated Place | 289 | Greenville | 34 46 47 N | 082 24 47 W |
| Spring Cemetery | Cemetery | 116 | Aiken | 33 24 14 N | 081 42 44 W |
| Spring Church (historical) | Church | 113 | Aiken | 33 24 14 N | 081 42 46 W |
| Spring Creek | Stream | | Saluda | 34 04 49 N | 081 32 27 W |
| Spring Dale School (historical) | School | 189 | Lancaster | 34 49 48 N | 080 52 19 W |
| Spring Forest | Populated Place | 297 | Greenville | 34 52 34 N | 082 19 01 W |
| Spring Forest | Populated Place | 305 | Greenville | 34 52 15 N | 082 20 09 W |
| Spring Grove (historical) | Populated Place | 183 | Laurens | 34 16 00 N | 081 56 27 W |
| Spring Grove Church | Church | 32 | Dillon | 34 17 51 N | 079 21 27 W |
| Spring Grove Church | Church | 112 | Edgefield | 33 36 18 N | 082 03 28 W |
| Spring Grove Church | Church | 162 | McCormick | 33 59 13 N | 082 32 13 W |
| Spring Grove Church (historical) | Church | 12 | Charleston | 32 47 46 N | 080 20 41 W |
| Spring Grove Church (historical) | Church | 40 | Clarendon | 33 39 59 N | 080 28 41 W |