Feature Name | Class | Elev. meters | County | Latitude DMS | Longitude DMS |
| Unity Church (historical) | Church | 23 | Berkeley | 33 24 51 N | 080 12 51 W |
| Unity Church (historical) | Church | 175 | York | 34 51 32 N | 081 22 08 W |
| Unity Methodist Church | Church | 192 | Union | 34 42 10 N | 081 37 10 W |
| Unity School (historical) | School | 195 | Lancaster | 34 47 24 N | 080 42 47 W |
| Unity School (historical) | School | 196 | Lancaster | 34 47 48 N | 080 42 01 W |
| Unity School (historical) | School | 31 | Orangeburg | 33 20 13 N | 080 22 20 W |
| Unity School (historical) | School | 193 | York | 34 52 08 N | 081 22 27 W |
| Universal Church | Church | 169 | Saluda | 34 07 05 N | 081 47 47 W |
| University Baptist Church | Church | 174 | Lancaster | 34 44 20 N | 080 47 08 W |
| University Forest | Populated Place | 12 | Horry | 33 48 36 N | 079 00 31 W |
| University Heights (subdivision) | Populated Place | 293 | Greenville | 34 52 02 N | 082 21 59 W |
| University Lutheran Church | Church | 219 | Pickens | 34 41 02 N | 082 50 18 W |
| University of South Carolina | School | 146 | Aiken | 33 33 16 N | 081 43 31 W |
| University of South Carolina | School | 92 | Richland | 33 59 57 N | 081 01 35 W |
| University of South Carolina at Aiken | School | 125 | Aiken | 33 34 24 N | 081 46 02 W |
| University of South Carolina Extension Colle | School | 169 | Lancaster | 34 44 12 N | 080 47 11 W |
| University of South Carolina Regional Campus | School | 193 | Union | 34 42 58 N | 081 37 11 W |
| University of South Carolina-Beaufort | School | 3 | Beaufort | 32 26 14 N | 080 40 09 W |
| University of South Carolina-Coastal Carolina College | School | 12 | Horry | 33 47 38 N | 079 00 43 W |
| University of South Carolina-Salkehatchie Campus | School | 55 | Allendale | 33 00 58 N | 081 18 02 W |
| University of South Carolina-Spartanburg | School | 259 | Spartanburg | 34 59 42 N | 081 58 12 W |
| University of South Carolina-Sumter | School | 53 | Sumter | 33 56 04 N | 080 22 25 W |
| University Park | Populated Place | 12 | Dorchester | 32 55 11 N | 080 05 42 W |
| University Ridge | Ridge | 304 | Greenville | 34 50 22 N | 082 24 18 W |
| University Ridge Homes (subdivision) | Populated Place | 264 | Greenville | 34 50 23 N | 082 23 42 W |
| University Square Shopping Center | Locale | 334 | Greenville | 34 54 45 N | 082 25 42 W |
| University Square Shopping Center | Locale | 213 | Pickens | 34 41 30 N | 082 50 52 W |
| University Union | Building | 227 | Pickens | 34 40 47 N | 082 50 19 W |
| Upper Bell Town School (historical) | School | 187 | Lancaster | 34 39 45 N | 080 49 35 W |
| Upper Center Hill School | School | 102 | Calhoun | 33 42 36 N | 080 59 40 W |
| Upper Chesnut Lake | Reservoir | 12 | Horry | 33 47 55 N | 078 46 53 W |
| Upper Davis Pond Dam D-1677 | Dam | 60 | Richland | 34 02 13 N | 080 45 05 W |
| Upper Deerwood Lake | Reservoir | 51 | Sumter | 33 55 55 N | 080 23 59 W |
| Upper Deerwood Lake Dam | Dam | 51 | Sumter | 33 55 55 N | 080 23 59 W |
| Upper Dog Bluff | Cliff | 10 | Marion | 33 58 06 N | 079 20 51 W |
| Upper Dog Bluff Landing | Locale | 7 | Marion | 33 58 11 N | 079 20 22 W |
| Upper Fairforest Cemetery | Cemetery | 207 | Union | 34 45 59 N | 081 38 27 W |
| Upper Fairforest Church | Church | 202 | Union | 34 46 03 N | 081 38 26 W |
| Upper Ford Lake | Lake | 11 | Marion | 34 06 45 N | 079 29 55 W |
| Upper Gap | Gap | 627 | Greenville | 35 05 46 N | 082 35 39 W |
| Upper Hope Station Church | Church | 169 | Fairfield | 34 33 16 N | 081 18 58 W |
| Upper Legion Lake | Reservoir | 66 | Richland | 33 59 58 N | 080 55 54 W |
| Upper Legion Lake | Reservoir | 63 | Richland | 33 59 55 N | 080 56 11 W |
| Upper Legion Lake Dam - Fort Jackson | Dam | 66 | Richland | 33 59 58 N | 080 55 54 W |
| Upper Limestone School | School | 93 | Orangeburg | 33 37 05 N | 080 57 12 W |
| Upper Long Cane Cemetery | Cemetery | 197 | Abbeville | 34 12 15 N | 082 23 29 W |
| Upper Long Cane Church | Church | 190 | Abbeville | 34 11 59 N | 082 23 17 W |
| Upper Pine Grove Cemetery | Cemetery | 88 | Lexington | 34 04 54 N | 081 10 19 W |
| Upper Pond | Reservoir | 87 | Aiken | 33 35 52 N | 081 30 22 W |
| Upper Pond Dam D-2027 | Dam | 87 | Aiken | 33 35 52 N | 081 30 22 W |
| Upper Price Mill (historical) | Locale | 76 | McCormick | 33 48 20 N | 082 12 30 W |
| Upper Reserve | Reservoir | 2 | Berkeley | 33 06 13 N | 079 50 52 W |
| Upper Reserve Pond | Reservoir | 4 | Berkeley | 33 06 19 N | 079 50 53 W |
| Upper Rice Bridge | Bridge | 126 | Union | 34 42 57 N | 081 42 35 W |
| Upper Rocky Ford Lake | Reservoir | 85 | Richland | 34 03 01 N | 080 56 59 W |
| Upper Shady Grove Church | Church | 260 | Spartanburg | 34 59 16 N | 082 04 38 W |
| Upper Summerhouse Pond | Reservoir | 2 | Charleston | 32 54 03 N | 079 36 55 W |
| Upper Three Runs | Stream | | Aiken | 33 13 17 N | 081 46 25 W |
| Upper Topsaw Landing | Populated Place | 1 | Georgetown | 33 37 30 N | 079 09 40 W |
| Upper Windsor Lake D-0570 Dam | Dam | 64 | Richland | 34 04 25 N | 080 55 47 W |
| Upper York Reservoir | Reservoir | 210 | York | 35 00 12 N | 081 15 11 W |
| Uriel Church | Church | 180 | Chester | 34 46 04 N | 081 08 30 W |
| Urquhart Pond | Reservoir | 77 | Lexington | 33 50 60 N | 081 07 18 W |
| US Army Reserve Center-Clemson Heliport | Airport | 256 | Oconee | 34 41 00 N | 082 49 05 W |
| Usher Pond | Reservoir | 64 | Marlboro | 34 45 22 N | 079 40 15 W |
| USS Yorktown State Park | Park | 6 | Charleston | 32 47 26 N | 079 54 18 W |
| Utica | Populated Place | 277 | Oconee | 34 40 41 N | 082 55 54 W |
| Utica Elementary School | School | 288 | Oconee | 34 40 29 N | 082 55 36 W |
| Utopia School | School | 143 | Saluda | 34 01 08 N | 081 30 03 W |
| Utopia School (historical) | School | 189 | Greenwood | 34 08 03 N | 082 07 43 W |
| Utopia School (historical) | School | 123 | Newberry | 34 10 35 N | 081 38 43 W |
| Utsey Cemetery | Cemetery | 27 | Dorchester | 33 06 02 N | 080 35 37 W |
| V T Truck Pond Dam D-3266 | Dam | 231 | Anderson | 34 31 12 N | 082 50 36 W |
| V Taylor Pond | Reservoir | 196 | Spartanburg | 34 52 48 N | 081 59 53 W |
| Valencia Heights | Populated Place | 62 | Richland | 33 58 36 N | 080 59 06 W |
| Valencia Playground | Park | 64 | Richland | 33 58 54 N | 080 59 19 W |
| Valentine | Populated Place | 42 | Hampton | 32 49 25 N | 081 15 27 W |
| Valentine Church | Church | 42 | Hampton | 32 49 24 N | 081 15 19 W |
| Vall Branch | Stream | | McCormick | 33 56 23 N | 082 22 06 W |
| Vallentine Pond Dam D-3767 | Dam | 54 | Orangeburg | 33 25 31 N | 081 02 23 W |
| Valley Dale Park | Populated Place | 207 | Spartanburg | 34 53 20 N | 082 01 29 W |
| Valley Falls | Populated Place | 247 | Spartanburg | 35 00 57 N | 081 58 29 W |
| Valley Falls Baptist Church | Church | 265 | Spartanburg | 35 01 09 N | 081 58 26 W |
| Valley Falls Grade School (historical) | School | 244 | Spartanburg | 35 00 49 N | 081 58 34 W |
| Valley Forge School | School | 31 | Horry | 33 59 35 N | 079 03 53 W |
| Valley Haven | Populated Place | 274 | Greenville | 34 58 26 N | 082 15 43 W |
| Valley Lake | Reservoir | 322 | Greenville | 35 02 09 N | 082 26 16 W |
| Valley Park (subdivision) | Populated Place | 86 | Kershaw | 34 16 38 N | 080 32 42 W |
| Valley View | Populated Place | 235 | Oconee | 34 39 10 N | 082 52 51 W |
| Valley View Shores | Populated Place | 216 | Oconee | 34 40 50 N | 082 52 51 W |
| Van Cemetery | Cemetery | 60 | Darlington | 34 23 58 N | 079 58 41 W |
| Van Cemetery | Cemetery | 125 | Fairfield | 34 14 20 N | 081 09 45 W |
| Van Patton Shoals | Rapids | 199 | Spartanburg | 34 45 24 N | 082 06 40 W |
| Van Pattons Bridge | Bridge | 190 | Laurens | 34 45 11 N | 082 06 29 W |
| Van Wyck | Populated Place | 155 | Lancaster | 34 51 31 N | 080 50 45 W |
| Van Wyck Ferry (historical) | Crossing | 134 | Lancaster | 34 51 14 N | 080 52 03 W |
| Vance | Populated Place | 40 | Orangeburg | 33 26 02 N | 080 25 22 W |
| Vance-Providence Elementary School | School | 39 | Orangeburg | 33 25 53 N | 080 25 16 W |
| Vances Pond | Reservoir | 136 | Saluda | 34 01 06 N | 081 35 41 W |
| Vances Pond Dam D-1602 | Dam | 136 | Saluda | 34 01 06 N | 081 35 41 W |
| Vandale Place | Populated Place | 214 | Anderson | 34 27 43 N | 082 43 13 W |
| Vanderbilt Hills (subdivision) | Populated Place | 229 | Spartanburg | 34 56 36 N | 081 58 10 W |
| Vanderford Branch | Stream | | Union | 34 44 49 N | 081 28 59 W |
| Vanderhorst Creek | Stream | | Charleston | 32 58 03 N | 079 36 20 W |
| Vanderhorst Memorial Christian Methodist Episcopal Church | Church | 4 | Charleston | 32 47 48 N | 079 56 16 W |
| Vanderhorst Row | Locale | 7 | Charleston | 32 46 30 N | 079 55 37 W |
| Vandore Bay | Swamp | 28 | Berkeley | 33 15 45 N | 080 15 04 W |
| Vanilla Bay | Swamp | 15 | Berkeley | 33 09 22 N | 079 53 53 W |
| Varennes (historical) | Populated Place | 225 | Anderson | 34 26 15 N | 082 36 34 W |
| Varennes Church | Church | 213 | Anderson | 34 22 13 N | 082 35 28 W |