Feature Name | Class | Elev. meters | County | Latitude DMS | Longitude DMS |
| Doctor Hole | Lake | 10 | Williamsburg | 33 31 05 N | 080 01 27 W |
| Doctor Hole | Swamp | 10 | Williamsburg | 33 31 05 N | 080 01 19 W |
| Doctor Mays Pond | Reservoir | 38 | Marlboro | 34 43 31 N | 079 47 17 W |
| Doctor Pond | Swamp | 18 | Berkeley | 33 23 20 N | 079 52 39 W |
| Doctor Pond School | School | 16 | Berkeley | 33 22 57 N | 079 52 19 W |
| Doctor Sapps Crossroads | Populated Place | 203 | Lancaster | 34 47 56 N | 080 38 00 W |
| Doctor Scurrys Pond | Reservoir | 140 | Laurens | 34 20 00 N | 082 08 29 W |
| Doctor Taylors Pond D-1570 Dam | Dam | 133 | Fairfield | 34 27 13 N | 081 06 47 W |
| Doctors Branch | Stream | | McCormick | 33 55 08 N | 082 10 49 W |
| Doctors Creek | Stream | | Colleton | 32 54 43 N | 080 42 19 W |
| Doctors Creek Cemetery | Cemetery | 20 | Colleton | 32 56 18 N | 080 43 57 W |
| Doctors Creek Church | Church | 19 | Colleton | 32 56 18 N | 080 43 55 W |
| Doctors Memorial Hospital | Hospital | 233 | Spartanburg | 34 57 51 N | 081 56 12 W |
| Dodd Hill | Populated Place | 272 | Spartanburg | 35 00 57 N | 082 01 16 W |
| Dodd School (historical) | School | 264 | Spartanburg | 35 01 04 N | 082 01 11 W |
| Doddies Creek | Stream | | Pickens | 34 55 18 N | 082 31 54 W |
| Dodds Branch | Stream | | Union | 34 36 25 N | 081 45 29 W |
| Dodge Branch | Stream | | Kershaw | 34 13 35 N | 080 46 15 W |
| Dodge Mountain | Summit | 728 | Oconee | 34 54 42 N | 083 06 30 W |
| Dodge Plantation | Locale | 8 | Charleston | 32 36 07 N | 080 16 54 W |
| Dodge Plantation | Locale | 2 | Colleton | 32 33 19 N | 080 26 18 W |
| Dodgens Creek | Stream | | Oconee | 34 44 13 N | 082 58 36 W |
| Dodson School | School | 171 | Lancaster | 34 41 42 N | 080 47 05 W |
| Doe Bay | Swamp | 21 | Horry | 34 10 07 N | 079 06 20 W |
| Doe Hall Creek | Stream | | Charleston | 33 02 35 N | 079 32 03 W |
| Doe Landing | Locale | 6 | Berkeley | 33 16 42 N | 079 36 23 W |
| Doe Point | Cape | 3 | Beaufort | 32 25 55 N | 080 33 43 W |
| Doe Point Creek | Channel | 1 | Beaufort | 32 25 41 N | 080 33 55 W |
| Doe Pond Church | Church | 72 | Allendale | 33 02 25 N | 081 26 05 W |
| Dog Bluff | Populated Place | 25 | Horry | 33 57 10 N | 079 13 28 W |
| Dog Bluff Landing | Populated Place | 8 | Horry | 33 57 59 N | 079 20 10 W |
| Dog Creek Flats | Flat | 5 | Williamsburg | 33 24 11 N | 079 49 21 W |
| Dog Ferry (historical) | Crossing | 26 | Barnwell | 33 10 32 N | 081 46 10 W |
| Dog Lake | Lake | 6 | Marion | 33 53 32 N | 079 23 30 W |
| Dog Swamp | Swamp | 10 | Berkeley | 33 05 07 N | 079 44 46 W |
| Doggie Island | Island | 2 | Beaufort | 32 22 07 N | 080 44 09 W |
| Dogwood (subdivision) | Populated Place | 6 | Horry | 33 41 18 N | 078 54 02 W |
| Dogwood Acres | Populated Place | 287 | Greenville | 34 57 37 N | 082 14 56 W |
| Dogwood Acres (subdivision) | Populated Place | 64 | Darlington | 34 23 02 N | 080 01 59 W |
| Dogwood Creek | Stream | | Pickens | 35 03 53 N | 082 48 16 W |
| Dogwood Gardens | Populated Place | 7 | Charleston | 32 49 54 N | 080 02 02 W |
| Dogwood Heights | Populated Place | 249 | Anderson | 34 31 55 N | 082 41 19 W |
| Dogwood Heights | Populated Place | 258 | Oconee | 34 46 14 N | 082 57 10 W |
| Dogwood Heights (subdivision) | Populated Place | 256 | Anderson | 34 39 48 N | 082 47 10 W |
| Dogwood Hill Church | Church | 29 | Horry | 34 06 51 N | 078 54 11 W |
| Dogwood Lake | Reservoir | 55 | Darlington | 34 23 17 N | 080 01 40 W |
| Dogwood Lake | Reservoir | 3 | Horry | 33 36 52 N | 078 57 56 W |
| Dogwood Lake | Reservoir | 39 | Sumter | 33 48 07 N | 080 19 47 W |
| Dogwood Lake Dam D-2065 | Dam | 39 | Sumter | 33 48 07 N | 080 19 47 W |
| Dogwood Lake Dam D-3520 | Dam | 53 | Darlington | 34 23 13 N | 080 01 41 W |
| Dogwood Manor | Populated Place | 147 | Aiken | 33 30 38 N | 081 42 02 W |
| Dogwood Neck (historical) | Populated Place | 10 | Horry | 33 51 15 N | 078 49 09 W |
| Dogwood Neck School | School | 9 | Horry | 33 51 07 N | 078 49 47 W |
| Dogwood Park (subdivision) | Populated Place | 6 | Charleston | 32 45 29 N | 079 58 19 W |
| Dogwood Park (subdivision) | Populated Place | 256 | Cherokee | 35 03 29 N | 081 38 04 W |
| Dogwood Plaza Shopping Center | Locale | 293 | Oconee | 34 41 22 N | 082 59 35 W |
| Dogwood Pond | Swamp | 19 | Clarendon | 33 43 31 N | 080 02 46 W |
| Dogwood Springs Park (subdivision) | Populated Place | 238 | Cherokee | 35 03 52 N | 081 37 37 W |
| Doil Creek | Stream | | Union | 34 31 03 N | 081 31 20 W |
| Dolphin Head | Cape | 2 | Beaufort | 32 15 60 N | 080 43 03 W |
| Dolphus M Grainger Steam Generating Electric Plant | Building | 2 | Horry | 33 49 33 N | 079 03 10 W |
| Dominick School (historical) | School | 164 | Newberry | 34 17 14 N | 081 49 02 W |
| Dominicks (historical) | Populated Place | 170 | Greenwood | 34 05 42 N | 082 04 08 W |
| Dominion Hills (subdivision) | Populated Place | 8 | Berkeley | 32 54 56 N | 079 59 46 W |
| Dominion Hills (subdivision) | Populated Place | 79 | Richland | 33 57 28 N | 080 54 08 W |
| Donalds | Populated Place | 232 | Abbeville | 34 22 37 N | 082 20 50 W |
| Donalds Baptist Church | Church | 232 | Abbeville | 34 22 50 N | 082 21 05 W |
| Donalds Cemetery | Cemetery | 232 | Abbeville | 34 22 47 N | 082 21 02 W |
| Donalds Elementary SChool | School | 221 | Abbeville | 34 22 19 N | 082 20 43 W |
| Donalds High School (historical) | School | 221 | Abbeville | 34 22 20 N | 082 20 44 W |
| Donalds United Methodist Church | Church | 231 | Abbeville | 34 22 42 N | 082 20 46 W |
| Donaldson Air Force Base (historical) | Military (Historical) | 285 | Greenville | 34 45 30 N | 082 22 28 W |
| Donaldson Air Force Base Recreation Area | Park | 135 | Greenwood | 34 19 36 N | 082 10 01 W |
| Donaldson Center Airport | Airport | 286 | Greenville | 34 45 30 N | 082 22 35 W |
| Donaldson Golf Course | Locale | 273 | Greenville | 34 46 10 N | 082 21 54 W |
| Donaldson Hall | Building | 220 | Pickens | 34 40 52 N | 082 50 20 W |
| Donaldson Heights | Populated Place | 284 | Greenville | 34 46 37 N | 082 22 23 W |
| Donaldson School (historical) | School | 300 | Greenville | 34 50 01 N | 082 24 07 W |
| Donaldson Vocational Center | School | 275 | Greenville | 34 46 00 N | 082 22 49 W |
| Donford Branch | Stream | | Horry | 33 59 40 N | 078 44 29 W |
| Dongola | Populated Place | 5 | Horry | 33 45 27 N | 079 11 13 W |
| Donnington Branch | Stream | | Kershaw | 34 14 05 N | 080 50 08 W |
| Donohoe Bay | Swamp | 47 | Dillon | 34 31 35 N | 079 29 12 W |
| Donora (historical) | Populated Place | 54 | Barnwell | 33 13 16 N | 081 30 59 W |
| Dons Pond | Reservoir | 301 | Pickens | 34 55 00 N | 082 44 11 W |
| Dons Pond Dam D-1956 | Dam | 301 | Pickens | 34 55 00 N | 082 44 11 W |
| Doodle Hill Pond | Reservoir | 91 | Calhoun | 33 42 04 N | 080 50 47 W |
| Doods Pond Dam D-1755 | Dam | 166 | Lancaster | 34 47 55 N | 080 49 23 W |
| Dooleys Ferry (historical) | Crossing | 201 | Anderson | 34 21 44 N | 082 49 49 W |
| Doolittle Creek | Stream | | Cherokee | 35 03 53 N | 081 32 50 W |
| Dora Jones-Gayle Elementary School | School | 150 | Chester | 34 42 02 N | 081 12 38 W |
| Doran Creek | Stream | | Oconee | 34 45 46 N | 083 13 23 W |
| Dorange | Populated Place | 38 | Dorchester | 33 13 22 N | 080 42 24 W |
| Dorange School (historical) | School | 39 | Dorchester | 33 13 21 N | 080 42 39 W |
| Dorch Cemetery | Cemetery | 92 | Aiken | 33 21 03 N | 081 33 44 W |
| Dorchee (historical) | Populated Place | 24 | Orangeburg | 33 24 51 N | 080 17 24 W |
| Dorchester | Populated Place | 4 | Charleston | 32 50 59 N | 079 59 17 W |
| Dorchester | Populated Place | 31 | Dorchester | 33 08 24 N | 080 23 39 W |
| Dorchester (historical) | Populated Place | 11 | Dorchester | 32 57 01 N | 080 10 16 W |
| Dorchester Academy | School | 27 | Dorchester | 33 11 09 N | 080 33 03 W |
| Dorchester Baptist Cemetery | Cemetery | 255 | Anderson | 34 32 43 N | 082 31 12 W |
| Dorchester Cemetery | Cemetery | 25 | Dorchester | 33 09 17 N | 080 23 14 W |
| Dorchester Church | Church | 253 | Anderson | 34 32 42 N | 082 31 13 W |
| Dorchester Congregational Church Ruins | Church | 16 | Dorchester | 32 57 21 N | 080 10 42 W |
| Dorchester County | Civil | 13 | Dorchester | 33 06 01 N | 080 22 59 W |
| Dorchester County Airport | Airport | 16 | Dorchester | 33 03 49 N | 080 16 45 W |
| Dorchester County Courthouse | Building | 31 | Dorchester | 33 11 06 N | 080 34 39 W |
| Dorchester Creek | Stream | | Dorchester | 32 56 55 N | 080 09 55 W |
| Dorchester Crossing | Populated Place | 12 | Dorchester | 32 57 31 N | 080 09 53 W |
| Dorchester Estates | Populated Place | 23 | Dorchester | 32 58 05 N | 080 11 48 W |