Feature Name | Class | Elev. meters | County | Latitude DMS | Longitude DMS |
| Enon Cemetery | Cemetery | 86 | Richland | 34 03 59 N | 080 52 43 W |
| Enon Church | Church | 24 | Hampton | 32 58 01 N | 081 06 12 W |
| Enon Church | Church | 150 | Lexington | 33 53 19 N | 081 28 16 W |
| Enon Church | Church | 326 | Pickens | 34 50 11 N | 082 38 57 W |
| Enon Church | Church | 94 | Richland | 34 03 24 N | 080 55 02 W |
| Enon Church | Church | 59 | Sumter | 33 50 02 N | 080 26 23 W |
| Enon Church (historical) | Church | 86 | Richland | 34 03 59 N | 080 52 41 W |
| Enon School (historical) | School | 44 | Florence | 34 07 56 N | 079 58 39 W |
| Enon Station Church (historical) | Church | 19 | Dorchester | 33 00 12 N | 080 23 08 W |
| Enoree | Populated Place | 178 | Spartanburg | 34 39 23 N | 081 57 54 W |
| Enoree Adult Vocational Center | School | 307 | Greenville | 34 54 37 N | 082 26 37 W |
| Enoree Baptist Church | Church | 298 | Greenville | 34 50 32 N | 082 24 26 W |
| Enoree Bridge | Bridge | 155 | Laurens | 34 39 00 N | 081 57 50 W |
| Enoree Cemetery | Cemetery | 328 | Greenville | 34 58 59 N | 082 24 09 W |
| Enoree Cemetery | Cemetery | 129 | Newberry | 34 21 33 N | 081 31 04 W |
| Enoree Church | Church | 332 | Greenville | 34 58 58 N | 082 24 11 W |
| Enoree Church | Church | 143 | Newberry | 34 20 43 N | 081 30 44 W |
| Enoree Church | Church | 124 | Newberry | 34 21 34 N | 081 31 06 W |
| Enoree Creek | Stream | | Spartanburg | 34 36 03 N | 081 54 07 W |
| Enoree Fork Baptist Church | Church | 287 | Greenville | 34 53 23 N | 082 16 18 W |
| Enoree Fork Branch | Stream | | Greenville | 34 52 55 N | 082 15 11 W |
| Enoree Hills | Populated Place | 263 | Greenville | 34 54 23 N | 082 16 54 W |
| Enoree Presbyterian Church (historical) | Church | 180 | Union | 34 36 05 N | 081 42 59 W |
| Enoree Ranger District Office | Building | 119 | Newberry | 34 25 14 N | 081 34 39 W |
| Enoree River | Stream | | Newberry | 34 25 60 N | 081 24 42 W |
| Enoree School (historical) | School | 328 | Greenville | 34 58 58 N | 082 24 09 W |
| Enoree Station | Locale | 173 | Spartanburg | 34 39 23 N | 081 57 59 W |
| Enoree Zion Church | Church | 137 | Greenwood | 34 08 00 N | 081 59 52 W |
| Enos | Populated Place | 71 | Calhoun | 33 47 51 N | 081 02 46 W |
| Ensenaka (historical) | Populated Place | 214 | Oconee | 34 40 48 N | 082 51 18 W |
| Enterprise Creek | Stream | | Horry | 33 40 14 N | 079 03 38 W |
| Enterprise Landing | Populated Place | 0 | Horry | 33 40 09 N | 079 03 38 W |
| Enterprise School | School | 32 | Clarendon | 33 49 36 N | 080 09 08 W |
| Enterprise School (historical) | School | 33 | Orangeburg | 33 19 34 N | 080 34 40 W |
| Entrance Channel | Channel | 0 | Beaufort | 32 08 01 N | 080 35 14 W |
| Entrance Lake | Reservoir | 95 | Richland | 34 06 07 N | 080 55 05 W |
| Entrance Lake Dam | Dam | 95 | Richland | 34 06 07 N | 080 55 05 W |
| Ephesus Church (historical) | Church | 23 | Florence | 33 54 49 N | 079 28 01 W |
| Ephriam Branch | Stream | | Saluda | 33 58 38 N | 081 57 12 W |
| Epiphany Church | Church | 32 | Orangeburg | 33 23 59 N | 080 20 25 W |
| Episcopal Childrens Home | Building | 244 | York | 35 00 15 N | 081 14 22 W |
| Episcopal Church of the Advent | Church | 21 | Marion | 34 10 32 N | 079 24 01 W |
| Episcopal Church of the Ascension | Church | 302 | Oconee | 34 40 56 N | 082 57 11 W |
| Episcopal Church of the Epiphany | Church | 228 | Spartanburg | 34 56 31 N | 081 55 33 W |
| Episcopal Church of the Good Shepherd | Church | 10 | Charleston | 32 52 55 N | 079 58 56 W |
| Episcopal Church of the Good Shepherd | Church | 229 | York | 34 59 33 N | 081 14 23 W |
| Episcopal Church of the Holy Apostles | Church | 58 | Barnwell | 33 14 24 N | 081 21 46 W |
| Episcopal Church of the Incarnation | Church | 251 | Cherokee | 35 04 02 N | 081 38 57 W |
| Episcopal Church of the Nativity | Church | 190 | Union | 34 42 35 N | 081 37 11 W |
| Episcopal Church of the Resurrection | Church | 200 | Greenwood | 34 11 10 N | 082 09 34 W |
| Episcopal Church of the Resurrection | Church | 6 | Horry | 33 36 42 N | 078 58 36 W |
| Eptings Pond | Reservoir | 132 | Newberry | 34 13 19 N | 081 27 41 W |
| Eptings Pond D-1477 Dam | Dam | 132 | Newberry | 34 13 19 N | 081 27 41 W |
| Epworth | Populated Place | 174 | Greenwood | 34 05 19 N | 082 02 31 W |
| Epworth Camp | Locale | 174 | Greenwood | 34 05 09 N | 082 02 53 W |
| Epworth Childrens Home | Building | 93 | Richland | 34 00 03 N | 081 00 02 W |
| Epworth Lookout Tower | Tower | 169 | Greenwood | 34 07 02 N | 082 01 33 W |
| Epworth Pines D-0362 Dam | Dam | 95 | Richland | 34 08 37 N | 080 57 29 W |
| Epworth Station (historical) | Locale | 158 | Greenwood | 34 04 50 N | 082 03 35 W |
| Epworth United Methodist Church | Church | 47 | Darlington | 34 17 53 N | 079 52 51 W |
| Epworth United Methodist Church | Church | 179 | Laurens | 34 24 40 N | 081 48 57 W |
| Epworth United Methodist Church | Church | 192 | York | 34 54 44 N | 081 01 22 W |
| Equality Post Office (historical) | Post Office | 278 | Anderson | 34 42 46 N | 082 36 37 W |
| Equinox Park | Park | 225 | Anderson | 34 30 55 N | 082 40 29 W |
| Erie (historical) | Populated Place | 222 | Laurens | 34 28 20 N | 082 16 14 W |
| Ernest F. Hollings ACE Basin National Wildlife Refuge | Park | | Charleston | 32 38 00 N | 080 23 00 W |
| Ernest Rand Memorial State Forest | Forest | 85 | Barnwell | 33 18 36 N | 081 29 30 W |
| Erskine College | School | 208 | Abbeville | 34 19 49 N | 082 23 26 W |
| Erskine College-Due West Historic District | Park | 209 | Abbeville | 34 19 50 N | 082 23 25 W |
| Erskine Estates | Populated Place | 238 | Anderson | 34 30 10 N | 082 34 21 W |
| Ervins Pond | Reservoir | 7 | Williamsburg | 33 40 55 N | 079 30 35 W |
| Erwin | Populated Place | 160 | Lancaster | 34 41 31 N | 080 48 54 W |
| Erwin Elementary School | School | 158 | Lancaster | 34 41 29 N | 080 49 57 W |
| Erwin Park | Populated Place | 64 | Darlington | 34 20 25 N | 080 02 50 W |
| Erwinton Church | Church | 46 | Allendale | 32 58 28 N | 081 25 05 W |
| Erwinton Plantation | Locale | 57 | Allendale | 32 57 27 N | 081 24 48 W |
| Erwinwood Acres (subdivision) | Populated Place | 166 | Lancaster | 34 41 26 N | 080 48 16 W |
| Eskridge Pond Dam D-3221 | Dam | 46 | Chesterfield | 34 39 25 N | 079 56 47 W |
| Essex Village (subdivision) | Populated Place | 7 | Charleston | 32 47 43 N | 080 02 34 W |
| Esther Andrews Hall | Building | 241 | Spartanburg | 34 57 24 N | 081 55 03 W |
| Estherville Minim Creek Canal | Canal | -11 | Georgetown | 33 13 37 N | 079 16 16 W |
| Estherville Plantation | Locale | 2 | Georgetown | 33 15 55 N | 079 16 29 W |
| Estill | Populated Place | 34 | Hampton | 32 45 18 N | 081 14 31 W |
| Estill Elementary School | School | 33 | Hampton | 32 45 20 N | 081 14 07 W |
| Estill High School | School | 33 | Hampton | 32 45 16 N | 081 14 07 W |
| Estill Industrial Park | Locale | 32 | Hampton | 32 45 59 N | 081 14 22 W |
| Estill Middle School | School | 33 | Hampton | 32 45 12 N | 081 15 07 W |
| Estill Post Office | Post Office | 33 | Hampton | 32 45 14 N | 081 14 24 W |
| Ethel Plyler Pond Dam D-3171 | Dam | 167 | Chesterfield | 34 43 01 N | 080 25 53 W |
| Etheredge Cemetery | Cemetery | 149 | Saluda | 33 59 36 N | 081 32 29 W |
| Etheredge Millpond | Reservoir | 69 | Orangeburg | 33 37 37 N | 081 03 00 W |
| Etheredge Plantation Airport | Airport | 138 | Saluda | 33 59 16 N | 081 47 34 W |
| Etheredge Pond | Reservoir | 138 | Aiken | 33 50 25 N | 081 32 42 W |
| Etheridge Mill (historical) | Locale | 70 | Orangeburg | 33 37 37 N | 081 02 54 W |
| Etheridge School (historical) | School | 141 | Saluda | 33 59 42 N | 081 32 34 W |
| Ethon Crossroads | Populated Place | 140 | Lexington | 33 55 53 N | 081 18 46 W |
| Etta (historical) | Populated Place | 167 | Cherokee | 34 55 45 N | 081 29 24 W |
| Etters Cemetery | Cemetery | 223 | Cherokee | 35 08 05 N | 081 28 44 W |
| Eubanks Pond Dam D-2820 | Dam | 55 | Bamberg | 33 14 13 N | 081 08 59 W |
| Euhaw Church | Church | 16 | Jasper | 32 28 06 N | 080 57 58 W |
| Euhaw Church | Church | 15 | Jasper | 32 28 60 N | 080 57 28 W |
| Euhaw Creek | Stream | | Beaufort | 32 23 44 N | 080 48 13 W |
| Eulala | Populated Place | 173 | Saluda | 34 01 50 N | 081 55 09 W |
| Eulala School (historical) | School | 169 | Saluda | 34 02 07 N | 081 55 23 W |
| Eulala School (historical) | School | 163 | Saluda | 34 01 33 N | 081 55 32 W |
| Eulonia | Populated Place | 13 | Marion | 33 59 12 N | 079 23 00 W |
| Eureka | Populated Place | 159 | Aiken | 33 41 38 N | 081 46 01 W |
| Eureka Baptist Cemetery | Cemetery | 249 | Anderson | 34 30 43 N | 082 35 46 W |
| Eureka Baptist Church | Church | 159 | Chester | 34 43 11 N | 081 11 44 W |
| Eureka Church | Church | 158 | Aiken | 33 41 45 N | 081 45 58 W |