Feature Name | Class | Elev. meters | County | Latitude DMS | Longitude DMS |
| Sanson Creek | Stream | | Polk | 30 36 21 N | 094 57 30 W |
| Sant Willow Church | Church | 486 | Coleman | 31 35 29 N | 099 26 26 W |
| Santa Alina Ranch Lake | Reservoir | 94 | Madison | 30 58 55 N | 096 00 55 W |
| Santa Alina Ranch Lake Dam | Dam | 94 | Madison | 30 58 55 N | 096 00 55 W |
| Santa Amalia Colonia | Populated Place | 22 | Hidalgo | 26 05 47 N | 097 58 24 W |
| Santa Ana National Wildlife Refuge | Park | 27 | Hidalgo | 26 04 12 N | 098 08 43 W |
| Santa Ana National Wildlife Refuge Trail | Trail | 27 | Hidalgo | 26 04 03 N | 098 08 53 W |
| Santa Anita Cemetery | Cemetery | 28 | Hidalgo | 26 35 14 N | 098 11 19 W |
| Santa Anita Ranch | Locale | 29 | Hidalgo | 26 35 37 N | 098 11 11 W |
| Santa Anna | Oilfield | 522 | Coleman | 31 43 30 N | 099 19 18 W |
| Santa Anna | Populated Place | 535 | Coleman | 31 44 32 N | 099 19 18 W |
| Santa Anna | Populated Place | 113 | Starr | 26 40 05 N | 098 33 52 W |
| Santa Anna Branch | Stream | | Coleman | 31 42 36 N | 099 24 15 W |
| Santa Anna Creek | Stream | | Atascosa | 29 00 48 N | 098 40 25 W |
| Santa Anna Gas and Oil Field | Oilfield | 477 | Coleman | 31 43 24 N | 099 13 26 W |
| Santa Anna Mound | Summit | 95 | Gonzales | 29 28 42 N | 097 27 03 W |
| Santa Anna Mountains | Summit | 595 | Coleman | 31 44 52 N | 099 19 36 W |
| Santa Anna South | Oilfield | 476 | Coleman | 31 40 25 N | 099 18 52 W |
| Santa Anna West Oil Field | Oilfield | 493 | Coleman | 31 43 51 N | 099 21 55 W |
| Santa Barbara Windmill | Locale | 167 | Starr | 26 46 24 N | 098 41 59 W |
| Santa Catarina | Populated Place | 115 | Starr | 26 39 19 N | 098 34 39 W |
| Santa Clara | Populated Place | 181 | Guadalupe | 29 30 43 N | 098 07 17 W |
| Santa Clara Catholic Church | Church | 193 | Dallas | 32 44 33 N | 096 53 37 W |
| Santa Clara Church | Church | 178 | Guadalupe | 29 30 47 N | 098 07 06 W |
| Santa Clara Creek | Stream | | Guadalupe | 29 28 54 N | 098 07 33 W |
| Santa Clara Windmill | Locale | 44 | Hidalgo | 26 31 54 N | 098 14 34 W |
| Santa Cruz | Populated Place | 74 | Duval | 27 24 12 N | 098 16 06 W |
| Santa Cruz | Populated Place | 49 | Starr | 26 21 16 N | 098 46 06 W |
| Santa Cruz Artesian Well | Well | 11 | Kenedy | 26 39 46 N | 097 53 09 W |
| Santa Cruz Banco Number 43 | Levee | 28 | Hidalgo | 26 05 10 N | 098 13 45 W |
| Santa Cruz Canal | Canal | 25 | Hidalgo | 26 21 33 N | 098 07 23 W |
| Santa Cruz Cemetery | Cemetery | 129 | McLennan | 31 30 56 N | 097 01 17 W |
| Santa Cruz Cemetery | Cemetery | 73 | Starr | 26 43 04 N | 098 24 17 W |
| Santa Cruz Church | Church | 227 | Hays | 30 04 49 N | 097 49 17 W |
| Santa Cruz Episcopal Church | Church | 11 | Harris | 29 43 14 N | 095 16 47 W |
| Santa Cruz Estates Colonia | Populated Place | 25 | Hidalgo | 26 20 32 N | 098 07 09 W |
| Santa Cruz Number 2 Colonia | Populated Place | 55 | Starr | 26 21 48 N | 098 46 17 W |
| Santa Cruz Orange Gardens Colonia | Populated Place | 27 | Hidalgo | 26 21 59 N | 098 08 54 W |
| Santa Cruz Ranch | Locale | 11 | Nueces | 27 35 05 N | 097 30 10 W |
| Santa Cruz Well | Well | 28 | Hidalgo | 26 28 22 N | 098 10 35 W |
| Santa Cruz Well | Well | 6 | Kenedy | 26 54 52 N | 097 39 19 W |
| Santa Cruz Windmill | Locale | 4 | Kenedy | 26 47 59 N | 097 34 28 W |
| Santa Cruz Windmill | Locale | 9 | Kleberg | 27 32 24 N | 097 29 04 W |
| Santa Elena | Populated Place | 87 | Starr | 26 45 36 N | 098 29 11 W |
| Santa Elena Artesian Well | Well | 5 | Kenedy | 27 03 42 N | 097 33 29 W |
| Santa Elena Canyon | Valley | | Brewster | 29 09 56 N | 103 36 44 W |
| Santa Elena Canyon Lookout | Locale | 680 | Brewster | 29 10 07 N | 103 36 10 W |
| Santa Elena Canyon Trail | Trail | 659 | Brewster | 29 10 03 N | 103 36 40 W |
| Santa Elena Cemetery | Cemetery | 88 | Starr | 26 44 19 N | 098 28 23 W |
| Santa Elena Colonia | Populated Place | 9 | Cameron | 26 14 50 N | 097 37 56 W |
| Santa Elena Crossing | Populated Place | 646 | Brewster | 29 07 18 N | 103 31 27 W |
| Santa Elena Ranch | Locale | 189 | Webb | 27 42 57 N | 099 33 22 W |
| Santa Elena Trap | Summit | 6 | Kenedy | 27 03 32 N | 097 33 36 W |
| Santa Fe | Populated Place | 9 | Galveston | 29 22 41 N | 095 06 21 W |
| Santa Fe Baptist Church | Church | 8 | Galveston | 29 23 04 N | 095 05 52 W |
| Santa Fe Drive Baptist Church | Church | 308 | Parker | 32 44 23 N | 097 46 39 W |
| Santa Fe Elementary School | School | 9 | Galveston | 29 23 03 N | 095 06 24 W |
| Santa Fe Episcopal Church | Church | 196 | Bexar | 29 22 17 N | 098 31 22 W |
| Santa Fe High School | School | 8 | Galveston | 29 23 03 N | 095 06 24 W |
| Santa Fe Intermediate School | School | 9 | Galveston | 29 23 03 N | 095 06 24 W |
| Santa Fe Junior High School | School | 8 | Galveston | 29 23 03 N | 095 06 24 W |
| Santa Fe Lake | Reservoir | 574 | Coleman | 31 53 49 N | 099 31 19 W |
| Santa Fe Lake | Reservoir | 422 | Lampasas | 31 13 44 N | 098 25 10 W |
| Santa Fe Lake | Reservoir | 629 | Nolan | 32 29 54 N | 100 23 18 W |
| Santa Fe Lake | Reservoir | 579 | Taylor | 32 07 42 N | 099 44 28 W |
| Santa Fe Oil Field | Oilfield | 21 | Brooks | 26 49 00 N | 098 05 44 W |
| Santa Fe Park | Park | 629 | Nolan | 32 29 26 N | 100 23 34 W |
| Santa Fe Park | Park | 555 | Tom Green | 31 27 22 N | 100 26 43 W |
| Santa Fe Passenger and Freight Depot | Locale | 563 | Tom Green | 31 27 15 N | 100 26 06 W |
| Santa Fe Passenger Depot | Locale | 224 | Cooke | 33 37 35 N | 097 08 26 W |
| Santa Fe Pasture | Flat | 28 | Hidalgo | 26 45 24 N | 098 07 23 W |
| Santa Fe Railroad Dam | Dam | 574 | Coleman | 31 53 49 N | 099 31 19 W |
| Santa Fe Railway Company Freight Depot | Locale | 103 | Washington | 30 09 56 N | 096 24 01 W |
| Santa Fe Ranch | Locale | 30 | Hidalgo | 26 44 39 N | 098 08 12 W |
| Santa Fe Ranch | Locale | 752 | Sterling | 31 39 48 N | 101 02 49 W |
| Santa Fe School | School | 8 | Galveston | 29 22 55 N | 095 06 21 W |
| Santa Fe Station | Locale | 6 | Jefferson | 30 05 12 N | 094 06 43 W |
| Santa Fe Station | Locale | 1116 | Potter | 35 12 30 N | 101 49 34 W |
| Santa Fe Terminal Buildings Number 1 and Number 2 | Building | 130 | Dallas | 32 46 43 N | 096 48 06 W |
| Santa Fe Trail | Trail | 183 | Collin | 33 02 11 N | 096 40 56 W |
| Santa Fe-Frisco Depot | Locale | 171 | Lamar | 33 39 44 N | 095 28 13 W |
| Santa Gertrudis Creek | Stream | | Kleberg | 27 27 13 N | 097 46 18 W |
| Santa Gertrudis Elementary School | School | 19 | Kleberg | 27 30 22 N | 097 51 48 W |
| Santa Gertrudis Windmill | Locale | 26 | Kleberg | 27 29 52 N | 097 56 17 W |
| Santa Guadalupe Cemetery | Cemetery | 62 | Hidalgo | 26 38 17 N | 098 19 53 W |
| Santa Isabel Creek | Stream | | Webb | 27 38 32 N | 099 37 36 W |
| Santa Josefa Windmill | Locale | 158 | Jim Hogg | 26 49 16 N | 098 46 24 W |
| Santa Juanita Banco Number 34 | Levee | 23 | Hidalgo | 26 04 07 N | 097 58 45 W |
| Santa Lucia Catholic Church | Church | 1123 | El Paso | 31 44 12 N | 106 21 08 W |
| Santa Lucia Windmill | Locale | 143 | Jim Hogg | 27 05 04 N | 098 38 25 W |
| Santa Margarita | Populated Place | 64 | Starr | 26 29 33 N | 099 05 34 W |
| Santa Margarita Banco Number 30 | Levee | 19 | Hidalgo | 26 04 03 N | 097 55 33 W |
| Santa Maria | Populated Place | 20 | Cameron | 26 04 43 N | 097 50 58 W |
| Santa Maria Aida Cemetery | Cemetery | 192 | Caldwell | 29 52 28 N | 097 48 06 W |
| Santa Maria Camp | Locale | 817 | Reagan | 31 04 53 N | 101 41 06 W |
| Santa Maria Cemetery | Cemetery | 124 | Starr | 26 38 06 N | 098 33 52 W |
| Santa Maria Elementary School | School | 128 | Webb | 27 32 03 N | 099 30 36 W |
| Santa Maria High School | School | 20 | Cameron | 26 04 35 N | 097 50 43 W |
| Santa Maria Main Canal | Canal | 19 | Cameron | 26 05 13 N | 097 51 33 W |
| Santa Maria Pumping Station | Locale | 16 | Cameron | 26 03 12 N | 097 51 18 W |
| Santa Maria School | School | 128 | Webb | 27 32 03 N | 099 30 34 W |
| Santa Maria Windmill | Locale | 32 | Brooks | 27 08 55 N | 098 07 39 W |
| Santa Maria Windmill | Locale | 51 | Hidalgo | 26 31 58 N | 098 15 55 W |
| Santa Marta Windmill | Locale | 52 | Hidalgo | 26 33 31 N | 098 17 02 W |
| Santa Martina Colonia | Populated Place | 1112 | El Paso | 31 37 08 N | 106 14 48 W |
| Santa Monica | Populated Place | 5 | Willacy | 26 21 44 N | 097 35 09 W |
| Santa Monica Catholic Cemetery | Cemetery | 123 | Milam | 30 51 08 N | 096 59 15 W |
| Santa Monica Cemetery | Cemetery | 58 | Hidalgo | 26 41 13 N | 098 19 47 W |
| Santa Monica Mausoleum | Cemetery | 124 | Milam | 30 51 07 N | 096 59 15 W |
| Santa Monica Springs | Spring | 244 | Travis | 30 21 31 N | 097 54 31 W |