Feature Name | Class | Elev. meters | County | Latitude DMS | Longitude DMS |
| Shupe | Populated Place | 751 | Wythe | 36 59 00 N | 081 09 41 W |
| Siloam | Populated Place | 688 | Wythe | 36 54 38 N | 080 57 58 W |
| Siloam Gospel Tabernacle | Church | 692 | Wythe | 36 54 40 N | 080 57 58 W |
| Simmerman | Populated Place | 685 | Wythe | 36 48 59 N | 081 08 25 W |
| Sindion Point | Summit | 919 | Wythe | 36 47 44 N | 081 11 50 W |
| Six Hollow | Valley | | Wythe | 37 00 42 N | 081 15 15 W |
| Six Valley | Valley | | Wythe | 36 58 58 N | 081 17 04 W |
| Slate Spring Branch | Stream | | Wythe | 36 50 27 N | 081 02 59 W |
| Slate Spring School (historical) | School | 679 | Wythe | 36 51 11 N | 081 04 25 W |
| South Fork Reed Creek | Stream | | Wythe | 36 55 46 N | 081 07 57 W |
| Speedwell | Populated Place | 707 | Wythe | 36 48 49 N | 081 10 18 W |
| Speedwell Elementary School | School | | Wythe | 37 22 04 N | 081 18 20 W |
| Speedwell Magisterial District | Civil | 779 | Wythe | 36 50 06 N | 081 08 24 W |
| Speedwell Methodist Cemetery | Cemetery | 729 | Wythe | 36 48 49 N | 081 11 29 W |
| Speedwell Methodist Church | Church | 729 | Wythe | 36 48 49 N | 081 11 29 W |
| Spiller School | School | 707 | Wythe | 36 57 06 N | 081 05 05 W |
| Spur Branch | Stream | | Wythe | 37 05 26 N | 080 55 19 W |
| Spur Branch School | School | 674 | Wythe | 37 05 31 N | 080 56 52 W |
| Staley Crossroads | Populated Place | 752 | Wythe | 36 54 35 N | 081 16 24 W |
| Star Cave | Populated Place | 669 | Wythe | 36 54 55 N | 080 47 21 W |
| Steffy Cemetery | Cemetery | 775 | Wythe | 36 52 25 N | 081 16 43 W |
| Stinson | Populated Place | 756 | Wythe | 36 54 59 N | 081 19 29 W |
| Stones Mill | Populated Place | 634 | Wythe | 36 56 07 N | 081 04 23 W |
| Stony Fork | Stream | | Wythe | 36 57 05 N | 081 10 39 W |
| Stony Fork Campground | Locale | 723 | Wythe | 37 00 32 N | 081 10 57 W |
| Stony Fork Church | Church | 730 | Wythe | 37 01 17 N | 081 12 13 W |
| Stringtown | Populated Place | 708 | Wythe | 36 58 37 N | 081 02 01 W |
| Stroupes Store | Locale | 822 | Wythe | 36 51 47 N | 081 08 29 W |
| Stuart Mountain | Summit | 993 | Wythe | 36 53 17 N | 081 06 35 W |
| Stuffle Run | Stream | | Wythe | 36 54 51 N | 081 07 37 W |
| Sugar Camp Hollow | Valley | | Wythe | 36 58 08 N | 081 18 25 W |
| Sugar Run | Stream | | Wythe | 36 49 28 N | 081 10 02 W |
| Suitor | Locale | 848 | Wythe | 37 01 35 N | 081 11 41 W |
| Summit | Populated Place | 798 | Wythe | 36 53 32 N | 081 18 02 W |
| Summit Hill Church (historical) | Church | 714 | Wythe | 36 59 50 N | 080 53 11 W |
| Sunnyside School (historical) | School | 768 | Wythe | 37 01 37 N | 081 02 13 W |
| Sunset Memorial Gardens Cemetery | Cemetery | 786 | Wythe | 36 54 23 N | 081 18 11 W |
| Sutherland | Populated Place | 708 | Wythe | 36 57 27 N | 081 09 40 W |
| Swecker Mountain | Summit | 912 | Wythe | 36 52 32 N | 081 03 22 W |
| Tate Run | Stream | | Wythe | 36 54 52 N | 081 07 11 W |
| The Brick Church | Church | 767 | Wythe | 37 01 34 N | 081 02 14 W |
| The Brick Church Cemetery | Cemetery | 768 | Wythe | 37 01 36 N | 081 02 15 W |
| Thorn Branch | Stream | | Wythe | 36 50 39 N | 081 01 55 W |
| Thorn Creek | Stream | | Wythe | 36 48 53 N | 081 07 29 W |
| Thorn Ferry | Populated Place | 594 | Wythe | 36 51 31 N | 080 55 44 W |
| Tickle Pink Hollow | Valley | | Wythe | 36 55 41 N | 081 18 28 W |
| Trinity Church | Church | 657 | Wythe | 36 50 57 N | 080 55 00 W |
| Union Church | Church | 792 | Wythe | 36 52 22 N | 081 18 36 W |
| Union County School (historical) | School | 803 | Wythe | 36 52 14 N | 081 18 49 W |
| Van Mater Shaft | Mine | 666 | Wythe | 36 50 48 N | 080 55 08 W |
| Venrick Run | Stream | | Wythe | 36 54 50 N | 081 07 04 W |
| Walker Mountain | Ridge | 1066 | Wythe | 37 02 43 N | 081 13 44 W |
| Walker Mountain Lookout | Locale | 1066 | Wythe | 37 02 44 N | 081 13 42 W |
| Walker Mountain Lookout Tower | Tower | 1203 | Wythe | 36 57 56 N | 081 21 06 W |
| Walker Mountain Trail | Trail | 1177 | Wythe | 37 01 26 N | 081 10 31 W |
| Walton Furnace | Populated Place | 635 | Wythe | 36 53 01 N | 080 56 04 W |
| Walton School (historical) | School | 634 | Wythe | 36 53 10 N | 080 56 09 W |
| Ward Branch | Stream | | Wythe | 36 48 58 N | 081 12 32 W |
| WCRR-AM (Rural Retreat) | Tower | 779 | Wythe | 36 55 17 N | 081 14 33 W |
| WCRR-FM (Rural Retreat) | Tower | 744 | Wythe | 36 54 15 N | 081 10 50 W |
| West Dry Run Fork | Stream | | Wythe | 36 46 32 N | 081 10 49 W |
| West End Cemetery | Cemetery | 724 | Wythe | 36 56 29 N | 081 06 59 W |
| West End United Methodist Church | Church | 718 | Wythe | 36 56 43 N | 081 05 34 W |
| West Fork Miller Creek | Stream | | Wythe | 37 00 47 N | 080 57 21 W |
| West Piney | Populated Place | 697 | Wythe | 36 53 03 N | 081 00 34 W |
| West Wytheville Magisterial District | Civil | 744 | Wythe | 36 58 28 N | 081 08 32 W |
| Whetstone Hollow | Valley | | Wythe | 36 58 39 N | 081 16 21 W |
| Willard | Populated Place | 739 | Wythe | 36 55 17 N | 081 17 54 W |
| Willow Branch Hollow | Valley | | Wythe | 36 58 40 N | 081 17 53 W |
| Wilson | Populated Place | 734 | Wythe | 36 55 54 N | 081 13 35 W |
| Wyrick Spring | Spring | 746 | Wythe | 36 52 20 N | 081 11 50 W |
| Wythe County | Civil | 893 | Wythe | 36 55 00 N | 081 02 59 W |
| Wythe County Community Hospital | Hospital | 736 | Wythe | 36 57 15 N | 081 05 49 W |
| Wythe County Community Hospital Heliport | Airport | 699 | Wythe | 36 57 00 N | 081 04 59 W |
| Wythe County Courthouse | Building | 701 | Wythe | 36 56 49 N | 081 05 04 W |
| Wythe County Jail | Building | 699 | Wythe | 36 56 59 N | 081 05 08 W |
| Wythe County Rescue Squad Auxiliary | Building | | Wythe | 37 35 24 N | 081 08 34 W |
| Wythe County Sheriffs Office | Building | | Wythe | 37 35 17 N | 081 08 42 W |
| Wythe County Technical Center | School | | Wythe | 37 34 15 N | 081 10 23 W |
| Wythe High School | School | 711 | Wythe | 36 56 27 N | 081 06 09 W |
| Wytheville | Populated Place | 698 | Wythe | 36 56 54 N | 081 05 05 W |
| Wytheville Baptist Church | Church | 693 | Wythe | 36 56 54 N | 081 04 57 W |
| Wytheville City Hall | Building | 693 | Wythe | 36 56 53 N | 081 05 00 W |
| Wytheville Community College | School | 717 | Wythe | 36 57 24 N | 081 04 12 W |
| Wytheville Fire Department | Building | | Wythe | 37 35 26 N | 081 08 32 W |
| Wytheville Golf Club | Locale | 726 | Wythe | 36 56 38 N | 081 06 27 W |
| Wytheville National Fish Hatchery Number 1 | Locale | 671 | Wythe | 36 55 17 N | 081 08 30 W |
| Wytheville National Fish Hatchery Number 2 | Locale | 603 | Wythe | 36 55 56 N | 080 53 55 W |
| Wytheville Pentecostal Holiness Church | Church | 705 | Wythe | 36 56 24 N | 081 05 23 W |
| Wytheville Police Department | Building | | Wythe | 37 35 07 N | 081 08 37 W |
| Wytheville Post Office | Post Office | 697 | Wythe | 36 56 59 N | 081 04 58 W |
| Wytheville Presbyterian Church | Church | 693 | Wythe | 36 56 53 N | 081 04 56 W |
| Wytheville Primary School | School | 702 | Wythe | 36 57 05 N | 081 05 09 W |
| Wytheville Ranger Station | Building | 726 | Wythe | 36 56 32 N | 081 06 53 W |
| Wytheville Sanitarium and Hospital | Hospital | 654 | Wythe | 36 56 33 N | 081 02 44 W |
| Wytheville Seventh Day Adventist Church | Church | 718 | Wythe | 36 57 11 N | 081 04 38 W |
| Wytheville Work Center | Building | 723 | Wythe | 36 56 29 N | 081 06 53 W |
| WYVE Radio Tower (Galax) | Tower | 754 | Wythe | 36 57 57 N | 081 04 52 W |
| WYVE-AM (Wytheville) | Tower | 746 | Wythe | 36 57 54 N | 081 04 49 W |
| Zion Cemetery | Cemetery | 746 | Wythe | 36 50 28 N | 081 13 22 W |
| Zion Church | Church | 756 | Wythe | 36 50 28 N | 081 13 20 W |
| Zion School (historical) | School | 766 | Wythe | 36 50 40 N | 081 13 31 W |
| Acree Acres | Populated Place | 15 | York | 37 10 33 N | 076 28 07 W |
| Ascension Of Our Lord Byzantine Church | Church | | York | 37 17 12 N | 076 42 55 W |
| Ashe Industrial Park | Locale | 9 | York | 37 07 17 N | 076 27 11 W |
| Back Creek | Stream | | York | 37 12 24 N | 076 25 03 W |
| Back Creek Park | Park | 2 | York | 37 12 23 N | 076 26 18 W |
| Ballard Creek | Stream | | York | 37 14 33 N | 076 31 27 W |
| Banbury Cross | Populated Place | | York | 37 21 29 N | 076 43 16 W |
| Baptist Run | Stream | | York | 37 12 37 N | 076 31 05 W |