Feature Name | Class | Elev. meters | County | Latitude DMS | Longitude DMS |
| The Devils Hopper | Basin | 1194 | Grayson | 36 41 04 N | 081 09 04 W |
| Independence | Populated Place | 817 | Grayson | 36 37 20 N | 081 09 03 W |
| Berea Church | Church | 714 | Wythe | 36 54 27 N | 081 09 02 W |
| Bastian | Populated Place | 664 | Bland | 37 09 07 N | 081 09 00 W |
| Forest Church | Church | 805 | Grayson | 36 44 37 N | 081 09 00 W |
| High Knob | Summit | 1150 | Grayson | 36 45 24 N | 081 08 59 W |
| Rose Hill Cemetery | Cemetery | 664 | Bland | 37 09 46 N | 081 08 54 W |
| Flemming School (historical) | School | 755 | Wythe | 36 50 29 N | 081 08 52 W |
| Dublin Police Department | Building | | Pulaski | 37 10 46 N | 081 08 51 W |
| Claybank Hollow | Valley | | Wythe | 36 48 58 N | 081 08 50 W |
| Grayson County High School | School | 807 | Grayson | 36 37 17 N | 081 08 50 W |
| Tims Knob | Summit | 897 | Grayson | 36 42 59 N | 081 08 48 W |
| Independence Middle School | School | 805 | Grayson | 36 37 16 N | 081 08 48 W |
| Rudy School (historical) | School | 769 | Grayson | 36 42 28 N | 081 08 43 W |
| Forest School (historical) | School | 800 | Grayson | 36 44 29 N | 081 08 42 W |
| Wythe County Sheriffs Office | Building | | Wythe | 37 35 17 N | 081 08 42 W |
| Roof Branch | Stream | | Bland | 37 11 28 N | 081 08 41 W |
| Flemming Church | Church | 782 | Wythe | 36 50 12 N | 081 08 41 W |
| Perkins Knob Trail | Trail | 1028 | Grayson | 36 45 40 N | 081 08 41 W |
| Hussy Mountain Horse Camp | Locale | 877 | Wythe | 36 46 17 N | 081 08 39 W |
| Horse Heaven | Summit | 1176 | Wythe | 36 47 03 N | 081 08 37 W |
| Wytheville Police Department | Building | | Wythe | 37 35 07 N | 081 08 37 W |
| Wolf Hill | Summit | 886 | Grayson | 36 37 00 N | 081 08 35 W |
| Wythe County Rescue Squad Auxiliary | Building | | Wythe | 37 35 24 N | 081 08 34 W |
| Hunting Camp Creek | Stream | | Bland | 37 10 12 N | 081 08 32 W |
| Greenhill School (historical) | School | 796 | Bland | 37 03 20 N | 081 08 32 W |
| West Wytheville Magisterial District | Civil | 744 | Wythe | 36 58 28 N | 081 08 32 W |
| Wytheville Fire Department | Building | | Wythe | 37 35 26 N | 081 08 32 W |
| Sunny Point School (historical) | School | 646 | Bland | 37 13 56 N | 081 08 31 W |
| Kegleys | Populated Place | 718 | Wythe | 36 58 54 N | 081 08 30 W |
| Wytheville National Fish Hatchery Number 1 | Locale | 671 | Wythe | 36 55 17 N | 081 08 30 W |
| Green Hill Church | Church | 797 | Bland | 37 03 22 N | 081 08 29 W |
| Sunny Point Church (historical) | Church | 648 | Bland | 37 13 58 N | 081 08 29 W |
| Sand Mountain | Summit | 922 | Wythe | 36 52 25 N | 081 08 29 W |
| Stroupes Store | Locale | 822 | Wythe | 36 51 47 N | 081 08 29 W |
| Pine Grove Church | Church | 667 | Bland | 37 10 37 N | 081 08 27 W |
| Cana Volunteer Fire Department | Building | | Carroll | 37 00 21 N | 081 08 27 W |
| Simmerman | Populated Place | 685 | Wythe | 36 48 59 N | 081 08 25 W |
| Speedwell Magisterial District | Civil | 779 | Wythe | 36 50 06 N | 081 08 24 W |
| Government Siding | Locale | 686 | Wythe | 36 55 34 N | 081 08 16 W |
| Lead Mines Volunteer Rescue Squad | Building | | Wythe | 37 34 57 N | 081 08 16 W |
| Lick Mountain School (historical) | School | 884 | Wythe | 36 52 25 N | 081 08 15 W |
| Rosenbaum Church | Church | 771 | Wythe | 36 51 12 N | 081 08 15 W |
| Interchange 58 | Crossing | 658 | Bland | 37 10 35 N | 081 08 14 W |
| Lick Mountain Church | Church | 889 | Wythe | 36 52 24 N | 081 08 14 W |
| Spurlin Ford | Crossing | 695 | Grayson | 36 34 20 N | 081 08 13 W |
| Pool Spring Branch | Stream | | Wythe | 36 48 49 N | 081 08 12 W |
| Byron | Populated Place | 636 | Bland | 37 14 01 N | 081 08 11 W |
| Low Gap | Gap | 1097 | Grayson | 36 40 40 N | 081 08 11 W |
| Poor Knob | Summit | 941 | Grayson | 36 42 01 N | 081 08 09 W |
| Roaring Branch | Stream | | Grayson | 36 38 07 N | 081 08 09 W |
| Hicksville | Populated Place | 646 | Bland | 37 11 35 N | 081 08 05 W |
| Fairview | Populated Place | 783 | Wythe | 36 59 24 N | 081 08 04 W |
| Fairview United Methodist Church | Church | 786 | Wythe | 36 59 25 N | 081 08 01 W |
| Perkins Knob | Summit | 1166 | Grayson | 36 45 34 N | 081 08 01 W |
| Bland County | Civil | 785 | Bland | 37 09 00 N | 081 07 59 W |
| Crab Orchard Creek Dam | Dam | 765 | Bland | 37 06 24 N | 081 07 59 W |
| Crab Orchard Lake | Reservoir | 765 | Bland | 37 06 25 N | 081 07 58 W |
| Maple Shade Church (historical) | Church | 799 | Grayson | 36 37 54 N | 081 07 58 W |
| Newberry Cemetery | Cemetery | 785 | Bland | 37 04 19 N | 081 07 57 W |
| South Fork Reed Creek | Stream | | Wythe | 36 55 46 N | 081 07 57 W |
| Mount Pleasant School (historical) | School | 727 | Wythe | 36 57 38 N | 081 07 56 W |
| Chestnut Hill Church | Church | 829 | Grayson | 36 39 03 N | 081 07 55 W |
| Chestnut Hill School (historical) | School | 839 | Grayson | 36 39 07 N | 081 07 55 W |
| Mount Pleasant Church | Church | 734 | Wythe | 36 57 41 N | 081 07 53 W |
| Bethel Church (historical) | Church | 825 | Grayson | 36 35 42 N | 081 07 52 W |
| Big Walker Mountain Tunnel | Tunnel | 1102 | Bland | 37 02 19 N | 081 07 50 W |
| Divide Trail | Trail | 1001 | Wythe | 36 46 18 N | 081 07 45 W |
| Turkey Fork | Stream | | Grayson | 36 42 28 N | 081 07 45 W |
| Interchange 52 | Crossing | 768 | Bland | 37 06 04 N | 081 07 43 W |
| Horse Heaven Trail | Trail | 937 | Wythe | 36 46 43 N | 081 07 42 W |
| Rocky Hollow Trail | Trail | 807 | Wythe | 36 48 08 N | 081 07 39 W |
| Stuffle Run | Stream | | Wythe | 36 54 51 N | 081 07 37 W |
| Roger Branch | Stream | | Grayson | 36 37 50 N | 081 07 33 W |
| Laurel Hollow | Valley | | Wythe | 36 48 44 N | 081 07 32 W |
| Thorn Creek | Stream | | Wythe | 36 48 53 N | 081 07 29 W |
| Town Creek | Stream | | Bland | 37 06 00 N | 081 07 27 W |
| Newberry Chapel (historical) | Church | 785 | Bland | 37 04 43 N | 081 07 27 W |
| East River Mountain Tunnel | Tunnel | 1091 | Bland | 37 16 31 N | 081 07 25 W |
| East River Mountain Tunnel | Tunnel | 1020 | Bland | 37 16 26 N | 081 07 24 W |
| McKenney Hill | Summit | 801 | Grayson | 36 36 37 N | 081 07 24 W |
| Cattrons Mill (historical) | Locale | 763 | Grayson | 36 42 32 N | 081 07 19 W |
| Petunia | Populated Place | 711 | Wythe | 36 56 32 N | 081 07 17 W |
| Interchange 66 | Crossing | 721 | Bland | 37 15 51 N | 081 07 16 W |
| Matney Flat | Flat | 837 | Wythe | 36 52 13 N | 081 07 12 W |
| Tate Run | Stream | | Wythe | 36 54 52 N | 081 07 11 W |
| Rocky Hollow | Valley | | Wythe | 36 48 51 N | 081 07 11 W |
| Catrons Mill | Locale | 760 | Grayson | 36 42 30 N | 081 07 11 W |
| Hines Branch | Stream | | Grayson | 36 42 29 N | 081 07 11 W |
| Bland County Volunteer Rescue Squad | Building | | Bland | 37 06 08 N | 081 07 10 W |
| Temple Hill Cemetery | Cemetery | 770 | Bland | 37 06 29 N | 081 07 09 W |
| Interchange 47 | Crossing | 803 | Bland | 37 01 52 N | 081 07 09 W |
| Gibson Cemetery | Cemetery | 650 | Bland | 37 15 28 N | 081 07 06 W |
| Henley School (historical) | School | 745 | Wythe | 36 51 04 N | 081 07 05 W |
| Venrick Run | Stream | | Wythe | 36 54 50 N | 081 07 04 W |
| Bethany Church | Church | 749 | Wythe | 36 51 06 N | 081 07 02 W |
| Dry Fork | Stream | | Bland | 37 15 18 N | 081 07 00 W |
| Chestnut Flat | Flat | 793 | Grayson | 36 41 30 N | 081 07 00 W |
| West End Cemetery | Cemetery | 724 | Wythe | 36 56 29 N | 081 06 59 W |
| Bland | Populated Place | 743 | Bland | 37 06 07 N | 081 06 58 W |
| Hines Branch Church | Church | 789 | Grayson | 36 42 38 N | 081 06 58 W |
| North Gap | Populated Place | 634 | Bland | 37 15 23 N | 081 06 57 W |
| Bland County Courthouse | Building | 751 | Bland | 37 06 00 N | 081 06 54 W |
| Evergreen Church | Church | 664 | Wythe | 36 54 24 N | 081 06 54 W |
| Saint Peters Church | Church | 688 | Wythe | 36 49 31 N | 081 06 54 W |
| Wytheville Ranger Station | Building | 726 | Wythe | 36 56 32 N | 081 06 53 W |
| Wytheville Work Center | Building | 723 | Wythe | 36 56 29 N | 081 06 53 W |
| Little Horse Heaven | Summit | 918 | Wythe | 36 47 47 N | 081 06 53 W |
| Bland County Volunteer Fire Department | Building | | Bland | 37 05 57 N | 081 06 53 W |
| Rocky Gap Volunteer Fire Department | Building | | Bland | 37 15 22 N | 081 06 53 W |