Feature Name | Class | Elev. meters | County | Latitude DMS | Longitude DMS |
| Creed Branch | Stream | | Bland | 37 02 31 N | 081 04 50 W |
| WYVE-AM (Wytheville) | Tower | 746 | Wythe | 36 57 54 N | 081 04 49 W |
| Cold Run | Stream | | Wythe | 36 50 13 N | 081 04 49 W |
| New Hope Church | Church | 720 | Wythe | 36 51 28 N | 081 04 47 W |
| Bethel African Methodist Episcopal Church | Church | 714 | Wythe | 36 57 10 N | 081 04 44 W |
| Franklin Street United Methodist Church | Church | 707 | Wythe | 36 57 03 N | 081 04 43 W |
| Mount View Church | Church | 770 | Wythe | 37 01 26 N | 081 04 42 W |
| Mountain View Cemetery | Cemetery | 767 | Wythe | 37 01 25 N | 081 04 41 W |
| Bibleway Baptist Church | Church | 684 | Wythe | 36 56 26 N | 081 04 39 W |
| Morning Star Church of God | Church | 706 | Wythe | 36 57 00 N | 081 04 38 W |
| Wytheville Seventh Day Adventist Church | Church | 718 | Wythe | 36 57 11 N | 081 04 38 W |
| East End Cemetery | Cemetery | 725 | Wythe | 36 57 20 N | 081 04 34 W |
| Little Rock Creek | Stream | | Grayson | 36 38 10 N | 081 04 34 W |
| Johns Creek School (historical) | School | 783 | Grayson | 36 37 37 N | 081 04 32 W |
| Oakwood Memorial Gardens | Cemetery | 742 | Wythe | 36 57 44 N | 081 04 30 W |
| Davis Cemetery | Cemetery | 707 | Wythe | 36 51 23 N | 081 04 30 W |
| Comfort Cemetery | Cemetery | 688 | Bland | 37 16 12 N | 081 04 28 W |
| Walker Creek School (historical) | School | 714 | Bland | 37 05 38 N | 081 04 27 W |
| Surrat Branch | Stream | | Bland | 37 02 40 N | 081 04 27 W |
| Clito Mill | Populated Place | 734 | Grayson | 36 41 36 N | 081 04 26 W |
| Slate Spring School (historical) | School | 679 | Wythe | 36 51 11 N | 081 04 25 W |
| Pembroke Fire Dept Community Center | Building | | Giles | 37 32 24 N | 081 04 25 W |
| Stones Mill | Populated Place | 634 | Wythe | 36 56 07 N | 081 04 23 W |
| Walker Creek Church (historical) | Church | 718 | Bland | 37 05 42 N | 081 04 21 W |
| Jones Knob | Summit | 1163 | Grayson | 36 45 57 N | 081 04 21 W |
| Crockett Cove | Valley | | Wythe | 37 00 24 N | 081 04 20 W |
| Shaw Ferry (historical) | Crossing | 683 | Grayson | 36 36 05 N | 081 04 20 W |
| Devils Den | Summit | 963 | Grayson | 36 47 29 N | 081 04 17 W |
| Ebenezer Cemetery | Cemetery | 768 | Grayson | 36 44 24 N | 081 04 17 W |
| Ebenezer Church | Church | 769 | Grayson | 36 44 25 N | 081 04 14 W |
| Kimberling Creek Wilderness | Reserve | 927 | Bland | 37 10 54 N | 081 04 13 W |
| Scott Memorial Middle School | School | 696 | Wythe | 36 56 43 N | 081 04 13 W |
| Wytheville Community College | School | 717 | Wythe | 36 57 24 N | 081 04 12 W |
| Pleasant Hill Church | Church | 817 | Grayson | 36 40 36 N | 081 04 12 W |
| Raven Cliff Campground | Locale | 679 | Wythe | 36 50 12 N | 081 04 11 W |
| Carsonville | Populated Place | 813 | Grayson | 36 40 38 N | 081 04 10 W |
| Todd Ford | Crossing | 684 | Grayson | 36 37 28 N | 081 04 08 W |
| Sand Mountain | Summit | 1135 | Wythe | 36 54 27 N | 081 04 06 W |
| Johns Creek | Stream | | Grayson | 36 37 23 N | 081 04 05 W |
| East Wytheville Magisterial District | Civil | 719 | Wythe | 37 00 31 N | 081 04 04 W |
| Crab Orchard School (historical) | School | 720 | Grayson | 36 34 53 N | 081 04 03 W |
| Sulphur Spring Fork | Stream | | Bland | 37 08 41 N | 081 04 01 W |
| Church Branch | Stream | | Bland | 37 02 46 N | 081 04 01 W |
| Gleaves Knob | Summit | 854 | Wythe | 36 50 28 N | 081 04 01 W |
| Interchange 41 | Crossing | 720 | Wythe | 36 58 07 N | 081 04 00 W |
| Peach Bottom | Populated Place | 718 | Grayson | 36 35 20 N | 081 04 00 W |
| Baxter Ferry (historical) | Crossing | 690 | Grayson | 36 38 56 N | 081 03 59 W |
| First Assembly of God Church | Church | 699 | Wythe | 36 57 12 N | 081 03 58 W |
| Mikes Gap | Gap | 869 | Wythe | 36 48 06 N | 081 03 58 W |
| Little Creek School (historical) | School | 732 | Bland | 37 02 47 N | 081 03 57 W |
| Spring Valley | Populated Place | 766 | Grayson | 36 44 17 N | 081 03 57 W |
| Rock Creek | Stream | | Grayson | 36 38 47 N | 081 03 55 W |
| Lundy Knob | Summit | 905 | Grayson | 36 41 18 N | 081 03 54 W |
| Strader Church | Church | 736 | Bland | 37 02 49 N | 081 03 53 W |
| Interchange 40 | Crossing | 712 | Wythe | 36 57 39 N | 081 03 49 W |
| Interchange 72 | Crossing | 712 | Wythe | 36 57 39 N | 081 03 49 W |
| Lick Mountain | Summit | 1074 | Wythe | 36 53 24 N | 081 03 46 W |
| Little River | Stream | | Grayson | 36 36 17 N | 081 03 40 W |
| Chimney Rocks | Summit | 1013 | Wythe | 36 54 54 N | 081 03 38 W |
| High Rocks | Summit | 1112 | Wythe | 36 54 26 N | 081 03 36 W |
| Raven Cliff Furnace | Locale | 647 | Wythe | 36 50 03 N | 081 03 30 W |
| Mount Carmel School (historical) | School | 722 | Grayson | 36 41 55 N | 081 03 29 W |
| Rock Creek | Stream | | Wythe | 36 50 01 N | 081 03 28 W |
| Opossum Hollow | Valley | | Bland | 37 15 18 N | 081 03 26 W |
| Fellowship Church | Church | 706 | Wythe | 36 58 17 N | 081 03 26 W |
| Raven Cliff | Cliff | 695 | Wythe | 36 49 49 N | 081 03 26 W |
| Mount Carmel Church | Church | 703 | Grayson | 36 41 54 N | 081 03 26 W |
| Providence Magisterial District | Civil | 741 | Grayson | 36 43 13 N | 081 03 24 W |
| Knob Fork | Stream | | Grayson | 36 41 57 N | 081 03 23 W |
| Polly Branch | Stream | | Bland | 37 03 00 N | 081 03 22 W |
| Swecker Mountain | Summit | 912 | Wythe | 36 52 32 N | 081 03 22 W |
| Round Bottom | Populated Place | 586 | Bland | 37 15 16 N | 081 03 20 W |
| Little Walker Mountain | Summit | 974 | Wythe | 37 02 21 N | 081 03 20 W |
| Crockett Cemetery | Cemetery | 730 | Wythe | 37 00 56 N | 081 03 17 W |
| Brush Creek School (historical) | School | 737 | Grayson | 36 46 52 N | 081 03 17 W |
| Miles Gap Trail | Trail | 840 | Grayson | 36 47 53 N | 081 03 16 W |
| Long Ridge | Ridge | 987 | Grayson | 36 46 20 N | 081 03 14 W |
| Hole School (historical) | School | 744 | Grayson | 36 38 23 N | 081 03 13 W |
| Interchange 73 | Locale | 658 | Wythe | 36 56 53 N | 081 03 12 W |
| Tynes and Ferguson Cemetery | Cemetery | 750 | Bland | 37 16 43 N | 081 03 11 W |
| Ewing Mountain | Summit | 928 | Wythe | 36 47 58 N | 081 03 08 W |
| Coon Branch | Stream | | Grayson | 36 47 00 N | 081 03 00 W |
| Wythe County | Civil | 893 | Wythe | 36 55 00 N | 081 02 59 W |
| Slate Spring Branch | Stream | | Wythe | 36 50 27 N | 081 02 59 W |
| Eagle Furnace | Populated Place | 639 | Wythe | 36 50 23 N | 081 02 54 W |
| Eagle Cliff | Cliff | 659 | Wythe | 36 50 31 N | 081 02 49 W |
| Cove Branch | Stream | | Wythe | 36 49 59 N | 081 02 45 W |
| Wytheville Sanitarium and Hospital | Hospital | 654 | Wythe | 36 56 33 N | 081 02 44 W |
| Collins Cove | Bay | 703 | Wythe | 36 49 00 N | 081 02 44 W |
| Boyer Ferry (historical) | Crossing | 683 | Grayson | 36 36 43 N | 081 02 44 W |
| Eagle (historical) | Populated Place | 646 | Wythe | 36 50 11 N | 081 02 43 W |
| Kings Branch | Stream | | Grayson | 36 36 51 N | 081 02 42 W |
| Bob King Branch | Stream | | Bland | 37 03 20 N | 081 02 41 W |
| Cove Branch School (historical) | School | 687 | Wythe | 36 49 18 N | 081 02 38 W |
| Shields Cemetery | Cemetery | 756 | Bland | 37 16 47 N | 081 02 37 W |
| Willie Knob | Summit | 916 | Grayson | 36 34 23 N | 081 02 35 W |
| Raven Cliff Horse Camp | Locale | 665 | Wythe | 36 50 00 N | 081 02 33 W |
| Cold Springs Church | Church | 738 | Grayson | 36 46 52 N | 081 02 30 W |
| Bournes Branch Trail | Trail | 768 | Grayson | 36 45 59 N | 081 02 29 W |
| Kindrick | Populated Place | 707 | Wythe | 36 58 33 N | 081 02 24 W |
| Moore Ferry (historical) | Crossing | 676 | Grayson | 36 40 10 N | 081 02 22 W |
| Middle Fork Kimberling Creek | Stream | | Bland | 37 09 37 N | 081 02 21 W |
| Jones Branch | Stream | | Grayson | 36 46 56 N | 081 02 21 W |
| Moore Creek | Stream | | Grayson | 36 40 08 N | 081 02 20 W |
| Providence School | School | 761 | Grayson | 36 42 37 N | 081 02 18 W |
| The Brick Church Cemetery | Cemetery | 768 | Wythe | 37 01 36 N | 081 02 15 W |
| The Brick Church | Church | 767 | Wythe | 37 01 34 N | 081 02 14 W |
| Sunnyside School (historical) | School | 768 | Wythe | 37 01 37 N | 081 02 13 W |
| Bethel Church | Church | 706 | Wythe | 36 58 36 N | 081 02 13 W |
| Tynes Chapel | Church | 748 | Bland | 37 16 45 N | 081 02 12 W |