| Country | Illicit drugs |
| Portugal | seizing record amounts of Latin American cocaine destined for Europe; a European gateway for Southwest Asian heroin; transshipment point for hashish from North Africa to Europe; consumer of Southwest Asian heroin |
| Puerto Rico | void |
| Qatar | void |
| Romania | major transshipment point for Southwest Asian heroin transiting the Balkan route and small amounts of Latin American cocaine bound for Western Europe; although not a significant financial center, role as a narcotics conduit leaves it vulnerable to laundering, which occurs via the banking system, currency exchange houses, and casinos |
| Russia | limited cultivation of illicit cannabis and opium poppy and producer of methamphetamine, mostly for domestic consumption; government has active illicit crop eradication program; used as transshipment point for Asian opiates, cannabis, and Latin American cocaine bound for growing domestic markets, to a lesser extent Western and Central Europe, and occasionally to the US; major source of heroin precursor chemicals; corruption and organized crime are key concerns; major consumer of opiates |
| Rwanda | void |
| Saint Barthelemy | void |
| Saint Helena | void |
| Saint Kitts and Nevis | transshipment point for South American drugs destined for the US and Europe; some money-laundering activity |
| Saint Lucia | transit point for South American drugs destined for the US and Europe |
| Saint Martin | void |
| Saint Pierre and Miquelon | void |
| Saint Vincent and the Grenadines | transshipment point for South American drugs destined for the US and Europe; small-scale cannabis cultivation |
| Samoa | void |
| San Marino | void |
| Sao Tome and Principe | void |
| Saudi Arabia | death penalty for traffickers; improving anti-money-laundering legislation and enforcement |
| Senegal | transshipment point for Southwest and Southeast Asian heroin and South American cocaine moving to Europe and North America; illicit cultivator of cannabis |
| Serbia | transshipment point for Southwest Asian heroin moving to Western Europe on the Balkan route; economy vulnerable to money laundering |
| Seychelles | void |
| Sierra Leone | void |
| Singapore | drug abuse limited because of aggressive law enforcement efforts; as a transportation and financial services hub, Singapore is vulnerable, despite strict laws and enforcement, as a venue for money laundering |
| Slovakia | transshipment point for Southwest Asian heroin bound for Western Europe; producer of synthetic drugs for regional market; consumer of ecstasy |
| Slovenia | minor transit point for cocaine and Southwest Asian heroin bound for Western Europe, and for precursor chemicals |
| Solomon Islands | void |
| Somalia | void |
| South Africa | transshipment center for heroin, hashish, and cocaine, as well as a major cultivator of marijuana in its own right; cocaine and heroin consumption on the rise; world's largest market for illicit methaqualone, usually imported illegally from India through various east African countries, but increasingly producing its own synthetic drugs for domestic consumption; attractive venue for money launderers given the increasing level of organized criminal and narcotics activity in the region and the size of the South African economy |
| South Georgia and the South Sandwich Islands | void |
| Southern Ocean | void |